{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T11:05:51Z","timestamp":1794049551254,"version":"4.8.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1038\/s41380-026-03525-3","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:52:06Z","timestamp":1773917526000},"page":"4096-4112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mechanistic insights into cannabidiol-mediated TrkB activation via FRS2 interaction in attenuating Alzheimer\u2019s disease pathology and cognitive impairment"],"prefix":"10.1038","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9832-2049","authenticated-orcid":false,"given":"Jiantao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangyu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiulian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-5612","authenticated-orcid":false,"given":"Xiaohui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-074X","authenticated-orcid":false,"given":"Xiubo","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"3525_CR1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.pharep.2015.07.006","volume":"68","author":"J Godyn","year":"2016","unstructured":"Godyn J, Jonczyk J, Panek D, Malawska B. Therapeutic strategies for Alzheimer\u2019s disease in clinical trials. Pharmacological Reports. 2016;68:127\u201338.","journal-title":"Pharmacological Reports"},{"key":"3525_CR2","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev-med-042915-103753","volume":"68","author":"WV Graham","year":"2017","unstructured":"Graham WV, Bonito-Oliva A, Sakmar TP. Update on Alzheimer\u2019s disease therapy and prevention strategies. Annu Rev Med. 2017;68:413\u201330.","journal-title":"Annu Rev Med"},{"key":"3525_CR3","first-page":"505","volume":"3","author":"SQ Zhang","year":"2023","unstructured":"Zhang SQ, Dong H, Bian J, Li D, Liu C. Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases. Fund Res-China. 2023;3:505\u201319.","journal-title":"Fund Res-China"},{"key":"3525_CR4","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1093\/nsr\/nwz215","volume":"7","author":"WK Zhang","year":"2020","unstructured":"Zhang WK, Gao GB, Ma ZJ, Luo ZY, He M, Sun TL. Au(CR) nanocluster restores fibril A\u03b2\u2018s unfolded state with abolished cytotoxicity and dissolves endogenous A\u03b2 plaques. Natl Sci Rev. 2020;7:763\u201374.","journal-title":"Natl Sci Rev"},{"key":"3525_CR5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00109-005-0025-1","volume":"84","author":"G Esposito","year":"2006","unstructured":"Esposito G, De Filippis D, Carnuccio R, Izzo AA, Iuvone T. The marijuana component cannabidiol inhibits \u03b2-amyloid-induced tau protein hyperphosphorylation through Wnt\/\u03b2-catenin pathway rescue in PC12 cells. J Mol Med. 2006;84:253\u20138.","journal-title":"J Mol Med"},{"key":"3525_CR6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.neulet.2006.01.047","volume":"399","author":"G Esposito","year":"2006","unstructured":"Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, Iuvone T. Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in \u03b2-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-\u03baB involvement. Neurosci Lett. 2006;399:91\u201395.","journal-title":"Neurosci Lett"},{"key":"3525_CR7","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1007\/s00213-014-3478-5","volume":"231","author":"D Cheng","year":"2014","unstructured":"Cheng D, Low JK, Logge W, Garner B, Karl T. Chronic cannabidiol treatment improves social and object recognition in double transgenic APP\/PS1a\u0394E9 mice. Psychopharmacology. 2014;231:3009\u201317.","journal-title":"Psychopharmacology"},{"key":"3525_CR8","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.3233\/JAD-140921","volume":"42","author":"D Cheng","year":"2014","unstructured":"Cheng D, Spiro AS, Jenner AM, Garner B, Karl T. Long-Term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer\u2019s disease transgenic mice. J Alzheimers Dis. 2014;42:1383\u201396.","journal-title":"J Alzheimers Dis"},{"key":"3525_CR9","doi-asserted-by":"publisher","first-page":"973","DOI":"10.3233\/JAD-210026","volume":"80","author":"H Khodadadi","year":"2021","unstructured":"Khodadadi H, Salles \u00c9L, Jarrahi A, Costigliola V, Khan MB, Yu JC, et al. Cannabidiol ameliorates cognitive function via regulation of IL-33 and TREM2 Upregulation in a murine model of Alzheimer\u2019s disease. J Alzheimers Dis. 2021;80:973\u20137.","journal-title":"J Alzheimers Dis"},{"key":"3525_CR10","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/prot.24523","volume":"82","author":"L Zeng","year":"2014","unstructured":"Zeng L, Kuti M, Mujtaba S, Zhou MM. Structural insights into FRS2\u03b1 PTB domain recognition by neurotrophin receptor TrkB. Proteins. 2014;82:1534\u201341.","journal-title":"Proteins"},{"key":"3525_CR11","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41586-022-04463-0","volume":"603","author":"J Xiong","year":"2022","unstructured":"Xiong J, Kang SS, Wang Z, Liu X, Kuo TC, Korkmaz F, et al. FSH blockade improves cognition in mice with Alzheimer\u2019s disease. Nature. 2022;603:470\u20136.","journal-title":"Nature"},{"key":"3525_CR12","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","volume":"620","author":"MF Gulen","year":"2023","unstructured":"Gulen MF, Samson N, Keller A, Schwabenland M, Liu C, Gluck S, et al. cGAS-STING drives ageing-related inflammation and neurodegeneration. Nature. 2023;620:374\u201380.","journal-title":"Nature"},{"key":"3525_CR13","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/nm1782","volume":"14","author":"GM Shankar","year":"2008","unstructured":"Shankar GM, Li SM, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, et al. Amyloid-\u03b2 protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory. Nat Med. 2008;14:837\u201342.","journal-title":"Nat Med"},{"key":"3525_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.neuroscience.2014.04.052","volume":"273","author":"ZF Wang","year":"2014","unstructured":"Wang ZF, Li Q, Liu SB, Mi WL, Hu S, Zhao J, et al. Aspirin-Triggered lipoxin a attenuates mechanical allodynia in association with inhibiting spinal Jak2\/Stat3 signaling in neuropathic pain in rats. Neuroscience. 2014;273:65\u201378.","journal-title":"Neuroscience"},{"key":"3525_CR15","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.celrep.2019.06.054","volume":"28","author":"ZH Wang","year":"2019","unstructured":"Wang ZH, Xiang J, Liu X, Yu SP, Manfredsson FP, Sandoval IM, et al. Deficiency in BDNF\/TrkB neurotrophic activity stimulates \u03b4-Secretase by upregulating C\/EBP\u03b2 in Alzheimer\u2019s disease. Cell Reports. 2019;28:655\u201369.","journal-title":"Cell Reports"},{"key":"3525_CR16","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1007\/s10875-010-9507-1","volume":"31","author":"S Agrawal","year":"2011","unstructured":"Agrawal S, Gollapudi S, Su HF, Gupta S. Leptin activates human B cells to secrete TNF-\u03b1, IL-6, and IL-10 via JAK2\/STAT3 and p38MAPK\/ERK1\/2 signaling pathway. J Clin Immunol. 2011;31:472\u20138.","journal-title":"J Clin Immunol"},{"key":"3525_CR17","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1002\/jcb.22936","volume":"112","author":"KM Zhang","year":"2011","unstructured":"Zhang KM, Guo W, Yang Y, Wu JR. JAK2\/STAT3 pathway is involved in the early stage of adipogenesis through regulating C\/EBP\u03b2 transcription. J Cell Biochem. 2011;112:488\u201397.","journal-title":"J Cell Biochem"},{"key":"3525_CR18","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1172\/JCI59903","volume":"122","author":"K Talbot","year":"2012","unstructured":"Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, et al. Demonstrated brain insulin resistance in Alzheimer\u2019s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012;122:1316\u201338.","journal-title":"J Clin Invest"},{"key":"3525_CR19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3233\/JAD-2005-7107","volume":"7","author":"E Steen","year":"2005","unstructured":"Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer\u2019s disease - is this type 3 diabetes? Journal of Alzheimers Disease. 2005;7:63\u201380.","journal-title":"Journal of Alzheimers Disease"},{"key":"3525_CR20","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.it.2009.07.001","volume":"30","author":"BJ Baker","year":"2009","unstructured":"Baker BJ, Akhtar LN, Benveniste EN. SOCS1 and SOCS3 in the control of CNS immunity. Trends Immunol. 2009;30:392\u2013400.","journal-title":"Trends Immunol"},{"key":"3525_CR21","doi-asserted-by":"publisher","first-page":"e2706","DOI":"10.1002\/jmr.2706","volume":"31","author":"R Dumpati","year":"2018","unstructured":"Dumpati R, Ramatenki V, Vadija R, Vellanki S, Vuruputuri U. Structural insights into suppressor of cytokine signaling 1 protein- identification of new leads for type 2 diabetes mellitus. J Mol Recognit. 2018;31:e2706.","journal-title":"J Mol Recognit"},{"key":"3525_CR22","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.neuropharm.2011.06.003","volume":"61","author":"CC Lee","year":"2011","unstructured":"Lee CC, Huang CC, Hsu KS. Insulin promotes dendritic spine and synapse formation by the PI3K\/Akt\/mTOR and Rac1 signaling pathways. Neuropharmacology. 2011;61:867\u201379.","journal-title":"Neuropharmacology"},{"key":"3525_CR23","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.molmet.2016.06.011","volume":"5","author":"SH Lee","year":"2016","unstructured":"Lee SH, Zabolotny JM, Huang H, Lee H, Kim YB. Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood. Mol Metab. 2016;5:589\u2013601.","journal-title":"Mol Metab"},{"key":"3525_CR24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.psyneuen.2017.12.023","volume":"89","author":"L Schmitz","year":"2018","unstructured":"Schmitz L, Kuglin R, Bae-Gartz I, Janoschek R, Appel S, Mesaros A, et al. Hippocampal insulin resistance links maternal obesity with impaired neuronal plasticity in adult offspring. Psychoneuroendocrino. 2018;89:46\u201352.","journal-title":"Psychoneuroendocrino"},{"key":"3525_CR25","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/41792","volume":"388","author":"Q Wan","year":"1997","unstructured":"Wan Q, Xiong ZG, Man YH, Ackerley CA, Braunton J, Lu WY, et al. Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin. Nature. 1997;388:686\u201390.","journal-title":"Nature"},{"key":"3525_CR26","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.2174\/092986708785909111","volume":"15","author":"CX Gong","year":"2008","unstructured":"Gong CX, Iqbal K. Hyperphosphorylation of microtubule-associated protein tau: A promising therapeutic target for alzheimer disease. Curr Med Chem. 2008;15:2321\u20138.","journal-title":"Curr Med Chem"},{"key":"3525_CR27","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1146\/annurev.biochem.72.121801.161629","volume":"72","author":"EJ Huang","year":"2003","unstructured":"Huang EJ, Reichardt LF. Trk receptors: Roles in neuronal signal transduction. Annu Rev Biochem. 2003;72:609\u201342.","journal-title":"Annu Rev Biochem"},{"key":"3525_CR28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s42003-020-0795-6","volume":"3","author":"KA Ball","year":"2020","unstructured":"Ball KA, Webb KJ, Coleman SJ, Cozzolino KA, Jacobsen J, Jones KR, et al. An isothermal shift assay for proteome scale drug-target identification. Commun Biol. 2020;3:75.","journal-title":"Commun Biol"},{"key":"3525_CR29","doi-asserted-by":"publisher","first-page":"3738","DOI":"10.1093\/brain\/awt273","volume":"136","author":"CH Andrade-Moraes","year":"2013","unstructured":"Andrade-Moraes CH, Oliveira-Pinto AV, Castro-Fonseca E, da Silva CG, Guimaraes DM, Szczupak D, et al. Cell number changes in Alzheimer\u2019s disease relate to dementia, not to plaques and tangles. Brain. 2013;136:3738\u201352.","journal-title":"Brain"},{"key":"3525_CR30","doi-asserted-by":"publisher","first-page":"5338","DOI":"10.1007\/s12035-021-02479-7","volume":"58","author":"E Meyer","year":"2021","unstructured":"Meyer E, Bonato JM, Mori MA, Mattos BA, Guimaraes FS, Milani H, et al. Cannabidiol confers neuroprotection in rats in a model of transient global cerebral ischemia: Impact of hippocampal synaptic neuroplasticity. Molecular Neurobiology. 2021;58:5338\u201355.","journal-title":"Molecular Neurobiology"},{"key":"3525_CR31","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1016\/j.freeradbiomed.2011.02.021","volume":"50","author":"P Mukhopadhyay","year":"2011","unstructured":"Mukhopadhyay P, Rajesh M, Horv\u00e1th B, B\u00e1tkai S, Park O, Tanchian G, et al. Cannabidiol protects against hepatic ischemia\/reperfusion injury by attenuating inflammatory signaling and response, oxidative\/nitrative stress, and cell death. Free Radical Bio Med. 2011;50:1368\u201381.","journal-title":"Free Radical Bio Med"},{"key":"3525_CR32","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/1742-2094-8-150","volume":"8","author":"J Zhao","year":"2011","unstructured":"Zhao J, O\u2019Connor T, Vassar R. The contribution of activated astrocytes to A\u03b2 production: Implications for Alzheimer\u2019s disease pathogenesis. J Neuroinflamm. 2011;8:150.","journal-title":"J Neuroinflamm"},{"key":"3525_CR33","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/S1474-4422(20)30231-3","volume":"19","author":"D Kellar","year":"2020","unstructured":"Kellar D, Craft S. Brain insulin resistance in Alzheimer\u2019s disease and related disorders: mechanisms and therapeutic approaches. Lancet Neurol. 2020;19:758\u201366.","journal-title":"Lancet Neurol"},{"key":"3525_CR34","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.tem.2010.09.003","volume":"22","author":"N Hay","year":"2011","unstructured":"Hay N. Akt isoforms and glucose homeostasis - the leptin connection. Trends Endocrin Met. 2011;22:66\u201373.","journal-title":"Trends Endocrin Met"},{"key":"3525_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.33549\/physiolres.930582","volume":"54","author":"J Zdychov\u00e1","year":"2005","unstructured":"Zdychov\u00e1 J, Komers R. Emerging role of Akt kinase\/protein kinase B signaling in pathophysiology of diabetes and its complications. Physiol Res. 2005;54:1\u201316.","journal-title":"Physiol Res"},{"key":"3525_CR36","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1002\/mog2.69","volume":"3","author":"TH Wei","year":"2024","unstructured":"Wei TH, Lu MY, Yao SH, Hong YQ, Yang J, Zhang MY, et al. Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics. Medcomm-Oncol. 2024;3:e69.","journal-title":"Medcomm-Oncol"},{"key":"3525_CR37","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.bbadis.2008.10.014","volume":"1792","author":"WQ Zhao","year":"2009","unstructured":"Zhao WQ, Townsend M. Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer\u2019s disease. Bba-Mol Basis Dis. 2009;1792:482\u201396.","journal-title":"Bba-Mol Basis Dis"},{"key":"3525_CR38","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1172\/JCI57256","volume":"122","author":"TR Bomfim","year":"2012","unstructured":"Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer\u2019s disease-associated A\u03b2 oligomers. J Clin Invest. 2012;122:1339\u201353.","journal-title":"J Clin Invest"},{"key":"3525_CR39","doi-asserted-by":"publisher","first-page":"33305","DOI":"10.1074\/jbc.M610390200","volume":"282","author":"M Townsend","year":"2007","unstructured":"Townsend M, Mehta T, Selkoe DJ. Soluble A\u03b2 inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem. 2007;282:33305\u201312.","journal-title":"J Biol Chem"},{"key":"3525_CR40","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bbr.2017.11.015","volume":"339","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Huang NQ, Yan F, Jin H, Zhou SY, Shi JS, et al. Diabetes mellitus and Alzheimer\u2019s disease: GSK-3\u03b2 as a potential link. Behav Brain Res. 2018;339:57\u201365.","journal-title":"Behav Brain Res"},{"key":"3525_CR41","first-page":"118664","volume":"1867","author":"E Lauretti","year":"2020","unstructured":"Lauretti E, Dincer O, Pratic\u00f2 D. Glycogen synthase kinase-3 signaling in Alzheimer\u2019s disease. Bba-Mol Cell Res. 2020;1867:118664.","journal-title":"Bba-Mol Cell Res"},{"key":"3525_CR42","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1172\/JCI64516","volume":"123","author":"PTT Ly","year":"2013","unstructured":"Ly PTT, Wu YL, Zou HY, Wang RT, Zhou WH, Kinoshita A, et al. Inhibition of GSK3\u03b2-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest. 2013;123:224\u201335.","journal-title":"J Clin Invest"},{"key":"3525_CR43","doi-asserted-by":"publisher","first-page":"112057","DOI":"10.1016\/j.biopha.2021.112057","volume":"142","author":"T Charytoniuk","year":"2021","unstructured":"Charytoniuk T, Sztolsztener K, Harasim-Symbor E, Berk K, Chabowski A, Konstantynowicz-Nowicka K. Cannabidiol-A phytocannabinoid that widely affects sphingolipid metabolism under conditions of brain insulin resistance. Biomedicine & Pharmacotherapy. 2021;142:112057.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"3525_CR44","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1038\/s41380-020-00863-8","volume":"26","author":"YY Xia","year":"2021","unstructured":"Xia YY, Wang ZH, Liu P, Edgington-Mitchell L, Liu X, Wang XC, et al. TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer\u2019s disease pathologies. Mol Psychiatr. 2021;26:2943\u201363.","journal-title":"Mol Psychiatr"},{"key":"3525_CR45","doi-asserted-by":"publisher","first-page":"9094","DOI":"10.1073\/pnas.1901348116","volume":"116","author":"J Xiang","year":"2019","unstructured":"Xiang J, Wang ZH, Ahn EH, Liu X, Yu SP, Manfredsson FP, et al. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer\u2019s disease pathologies. P Natl Acad Sci USA. 2019;116:9094\u2013102.","journal-title":"P Natl Acad Sci USA"},{"key":"3525_CR46","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1007\/s12035-018-1143-4","volume":"56","author":"AJ Sales","year":"2019","unstructured":"Sales AJ, Foga\u00e7a MV, Sartim AG, Pereira VS, Wegener G, Guimaraes FS, et al. Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNF signaling and synaptogenesis in the prefrontal cortex. Molecular Neurobiology. 2019;56:1070\u201381.","journal-title":"Molecular Neurobiology"},{"key":"3525_CR47","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1111\/j.1471-4159.2006.03789.x","volume":"97","author":"JB Easton","year":"2006","unstructured":"Easton JB, Royer AR, Middlemas DS. The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS\/MAPK pathway by brain-derived neurotrophic factor. J Neurochem. 2006;97:834\u201345.","journal-title":"J Neurochem"},{"key":"3525_CR48","doi-asserted-by":"publisher","first-page":"18169","DOI":"10.1074\/jbc.M008870200","volume":"276","author":"SC Kao","year":"2001","unstructured":"Kao SC, Jaiswal RK, Kolch W, Landreth GE. Identification of the mechanisms regulating the differential activation of the MAPK cascade by epidermal growth factor and nerve growth factor in PC12 cells. J Biol Chem. 2001;276:18169\u201377.","journal-title":"J Biol Chem"},{"key":"3525_CR49","doi-asserted-by":"publisher","first-page":"3803","DOI":"10.1038\/sj.emboj.7600399","volume":"23","author":"DL Medina","year":"2004","unstructured":"Medina DL, Sciarretta C, Calella AM, von Bohlen und Halbach O, Unsicker K, Minichiello L. TrkB regulates neocortex formation through the Shc\/PLC\u03b3-mediated control of neuronal migration. Embo J. 2004;23:3803\u201314.","journal-title":"Embo J"}],"updated-by":[{"DOI":"10.1038\/s41380-026-03864-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000}}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-026-03525-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-026-03525-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-026-03525-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:42:07Z","timestamp":1788414127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-026-03525-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["3525"],"URL":"https:\/\/doi.org\/10.1038\/s41380-026-03525-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6659468\/v1","asserted-by":"object"}]},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"13 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: Following publication of the original article, it was identified that Figure 7 contained an incorrect chemical structure of CBD (cannabidiol). The figure has been replaced with the correct version. The original article has been corrected.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2026","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41380-026-03864-1","URL":"https:\/\/doi.org\/10.1038\/s41380-026-03864-1","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}