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We report developmental and sex-specific behavioral changes in mice carrying a heterozygous mutation in\n                    <jats:italic>Chd2<\/jats:italic>\n                    . Notably,\n                    <jats:italic>Chd2<\/jats:italic>\n                    mutants display a range of abnormal behaviors including impairments in multiple forms of memory and social interaction. Memory impairments and memory-relevant transcriptional changes observed in\n                    <jats:italic>Chd2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice are largely recapitulated in both sexes by conditional\n                    <jats:italic>Chd2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    in adulthood. However, deficits in social behaviors and neuromodulatory system genes remain largely unaffected in conditional mutants. Reductions in interneuron density were identified throughout the brain of\n                    <jats:italic>Chd2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice, and the GABA\n                    <jats:sub>A<\/jats:sub>\n                    positive allosteric modulator, L-838,417, was effective in treating abnormal social behavior. Our results suggest a postdevelopmental role for\n                    <jats:italic>Chd2<\/jats:italic>\n                    in memory whereas neuropsychiatric conditions may be driven by more complex circuit mechanisms involving sexually dimorphic disruptions in brain development.\n                  <\/jats:p>","DOI":"10.1038\/s41380-026-03539-x","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:18:29Z","timestamp":1774286309000},"page":"4270-4281","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncoupling memory impairments from autism-associated behaviors in Chd2 deficient mice"],"prefix":"10.1038","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-1593","authenticated-orcid":false,"given":"Sang Ho","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-8718","authenticated-orcid":false,"given":"Robert F.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"3539_CR1","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/nature11011","volume":"485","author":"BM Neale","year":"2012","unstructured":"Neale BM, Kou Y, Liu L, Ma\u2019ayan A, Samocha KE, Sabo A, et al. 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