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He received research grants from Zai Lab, AstraZeneca, Novartis, Biogen. FDS was a co-founder of New Terrain from August, 2018 to December, 2019; Akriva from November, 2023 to September, 2025. The other authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Experimental procedures involving human samples were approved by the Human Research Ethics Board of the General Hospital of Tianjin Medical University ((IRB2023-YX-079-01) and the Ethics Committee of the Third Affiliated Hospital of Zhengzhou University (2022-340-01). All clinical procedures complied with the respective hospital\u2019s research guidelines. All animal studies and experimental procedures were approved by the Ethics Committee of the General Hospital of Tianjin Medical University (IRB2021-WDFL-139) and the Animal Ethics Committee of Beijing Vital River Laboratory Animal Technology Co., Ltd. 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