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Due to current sample size limitations, identifying TS\/PTD risk genes has been challenging. This study addressed this issue by conducting a meta-analysis of microarray copy number variant (CNV) studies from three TS\/PTD genomics consortia, supplemented with new data from 3291 cases. This approach more than doubled the sample size of previous TS\/PTD CNV studies, with CNV calls generated from 5725 TS\/PTD cases and 10,982 matched controls. The results confirmed that TS\/PTD cases 1) have a higher burden of ultra-rare deletions overlapping loss-of-function intolerant genes (OR\u2009=\u20091.68, P\u2009=\u20099.3\u00d710\n                    <jats:sup>\u22125<\/jats:sup>\n                    ) and 2) are more likely to carry established neurodevelopmental CNVs (OR\u2009=\u20091.42, P\u2009=\u20093.9\u00d710\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) compared to controls. Additionally, a novel, genome-wide significant CNV locus for TS\/PTD was discovered, involving duplications at 17q12 (hg19 chr17:34.8 - 36.2\u2009Mb). This locus is associated with a known duplication syndrome associated with variable neuropsychiatric traits, but has not been previously linked to tic disorders. Eight cases and one control carried the canonical ~1.4\u2009Mb duplication at chr17:34.8\u201336.2\u2009Mb, while one additional case had a smaller 110\u2009kb duplication within this known CNV that included only one gene,\n                    <jats:italic>ACACA<\/jats:italic>\n                    (acetyl-CoA carboxylase, OR\u2009=\u200926.7, P\u2009=\u20095.69\u00d710\n                    <jats:sup>\u22127<\/jats:sup>\n                    ). Overall, this study provides further evidence that rare, genic CNVs play a substantial role in the genetic architecture of TS\/PTD and identifies a new genome-wide significant association with this neurodevelopmental disorder.\n                  <\/jats:p>","DOI":"10.1038\/s41380-026-03849-0","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:08:37Z","timestamp":1789556917000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Persistent tic disorders are associated with 17q12 duplications"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-2418","authenticated-orcid":false,"given":"Matthew W.","family":"Halvorsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyne 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