{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:31:04Z","timestamp":1793039464797,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":1063,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1038\/s41385-018-0093-5","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T05:14:05Z","timestamp":1539839645000},"page":"312-322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["The emergence of pathogenic TNF\/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4"],"prefix":"10.1016","volume":"12","author":[{"given":"Bruno","family":"Galv\u00e3o-Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Teixeira","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Marta","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Gon\u00e7alves","family":"Rosmaninho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis Ribeiro do Valle","family":"Antonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Tostes","family":"Gazzinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-018-0093-5_bib1","unstructured":"WHO. World Malaria Report, 2016"},{"key":"10.1038\/s41385-018-0093-5_bib2","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nri3742","article-title":"Innate sensing of malaria parasites","volume":"14","author":"Gazzinelli","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-018-0093-5_bib3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/cr.2013.25","article-title":"Monoclonal antibody against CXCL-10\/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury","volume":"23","author":"Wang","year":"2013","journal-title":"Cell Res."},{"key":"10.1038\/s41385-018-0093-5_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5455\/medarh.2015.69.62-63","article-title":"Acute Respiratory Distress Syndrome (ARDS) from Endemic Influenza A\/H1N1: Prehospital Management","volume":"69","author":"Salihefendic","year":"2015","journal-title":"Med. Arch."},{"key":"10.1038\/s41385-018-0093-5_bib5","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1086\/497697","article-title":"Lung injury in uncomplicated and severe falciparum malaria: a longitudinal study in papua, Indonesia","volume":"192","author":"Maguire","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1038\/s41385-018-0093-5_bib6","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1097\/CCM.0b013e31827466d2","article-title":"Fluid resuscitation of adults with severe falciparum malaria: effects on acid-base status, renal function, and extravascular lung water","volume":"41","author":"Hanson","year":"2013","journal-title":"Crit. Care Med."},{"key":"10.1038\/s41385-018-0093-5_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4103\/0972-9062.117493","article-title":"Acute pancreatitis and acute respiratory distress syndrome complicating Plasmodium vivax malaria","volume":"50","author":"Atam","year":"2013","journal-title":"J. Vector Borne. Dis."},{"key":"10.1038\/s41385-018-0093-5_bib8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3347\/kjp.2013.51.5.551","article-title":"A case of vivax malaria complicated by adult respiratory distress syndrome and successful management with extracorporeal membrane oxygenation","volume":"51","author":"Lee","year":"2013","journal-title":"Korean J. Parasitol."},{"key":"10.1038\/s41385-018-0093-5_bib9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s15010-004-4060-6","article-title":"Respiratory distress in nonimmune adults with imported malaria","volume":"32","author":"Habib","year":"2004","journal-title":"Infection"},{"key":"10.1038\/s41385-018-0093-5_bib10","first-page":"219","article-title":"A study on pulmonary manifestations in patients with malaria from northwestern India (Bikaner)","volume":"48","author":"Nayak","year":"2011","journal-title":"J. Vector Borne. Dis."},{"key":"10.1038\/s41385-018-0093-5_bib11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1086\/510756","article-title":"Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation","volume":"195","author":"Anstey","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1038\/s41385-018-0093-5_bib12","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.4049\/jimmunol.1202354","article-title":"Regulatory T cells migrate to airways via CCR4 and attenuate the severity of airway allergic inflammation","volume":"190","author":"Faustino","year":"2013","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0093-5_bib13","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1172\/JCI12655","article-title":"The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics","volume":"107","author":"Panina-Bordignon","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-018-0093-5_bib14","first-page":"422","article-title":"CCL17 and CCL22 chemokines within tumor microenvironment are related to infiltration of regulatory T cells in esophageal squamous cell carcinoma","volume":"23","author":"Maruyama","year":"2010","journal-title":"Dis. Esophagus"},{"key":"10.1038\/s41385-018-0093-5_bib15","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jhep.2010.07.014","article-title":"Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection","volume":"54","author":"Riezu-Boj","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1038\/s41385-018-0093-5_bib16","doi-asserted-by":"crossref","first-page":"19495","DOI":"10.1074\/jbc.270.33.19495","article-title":"Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line","volume":"270","author":"Power","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1038\/s41385-018-0093-5_bib17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1164\/rccm.200905-0786OC","article-title":"Immunopathology and dexamethasone therapy in a new model for malaria-associated acute respiratory distress syndrome","volume":"181","author":"Van den Steen","year":"2010","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"10.1038\/s41385-018-0093-5_bib18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1165\/rcmb.2012-0450OC","article-title":"Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome","volume":"48","author":"Deroost","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/s41385-018-0093-5_bib19","doi-asserted-by":"crossref","first-page":"e0143195","DOI":"10.1371\/journal.pone.0143195","article-title":"Altered lipid composition of surfactant and lung tissue in murine experimental malaria-associated acute respiratory distress syndrome","volume":"10","author":"Scaccabarozzi","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1038\/s41385-018-0093-5_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/4158698","article-title":"Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI\/ARDS","volume":"2016","author":"Pereira","year":"2016","journal-title":"Mediators of Inflammation"},{"key":"10.1038\/s41385-018-0093-5_bib21","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.4049\/jimmunol.1100241","article-title":"Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection","volume":"187","author":"Villegas-Mendez","year":"2011","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0093-5_bib22","doi-asserted-by":"crossref","first-page":"7341","DOI":"10.1128\/IAI.69.12.7341-7348.2001","article-title":"CD8(+)-T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice","volume":"69","author":"Chang","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-018-0093-5_bib23","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.immuni.2012.03.026","article-title":"NK cell-derived interferon-gamma orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection","volume":"36","author":"Goldszmid","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/s41385-018-0093-5_bib24","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.4049\/jimmunol.1401482","article-title":"Reprogramming of monocytes by GM-CSF contributes to regulatory immune functions during intestinal inflammation","volume":"194","author":"Dabritz","year":"2015","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0093-5_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13277","article-title":"Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+monocyte-derived dendritic cells in the brain during cerebral malaria","volume":"7","author":"Hirako","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-018-0093-5_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0014-4894(64)90017-7","article-title":"Role of P-aminobenzoic acid in Plasmodium Berghei infection in the mouse","volume":"15","author":"Jacobs","year":"1964","journal-title":"Exp. Parasitol."},{"key":"10.1038\/s41385-018-0093-5_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0166-6851(92)90051-K","article-title":"p-Aminobenzoic acid transport by normal and Plasmodium falciparum-infected erythrocytes","volume":"52","author":"Zhang","year":"1992","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1038\/s41385-018-0093-5_bib28","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1172\/JCI40817","article-title":"Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte\/macrophage population","volume":"120","author":"Antonelli","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-018-0093-5_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity"},{"key":"10.1038\/s41385-018-0093-5_bib30","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1182\/blood-2009-04-217489","article-title":"Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria","volume":"114","author":"Sponaas","year":"2009","journal-title":"Blood"},{"key":"10.1038\/s41385-018-0093-5_bib31","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1073\/pnas.0801544105","article-title":"Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria","volume":"105","author":"Campanella","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-018-0093-5_bib32","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cell.2010.09.039","article-title":"Microbial stimulation fully differentiates monocytes to DC-SIGN\/CD209(+) dendritic cells for immune T cell areas","volume":"143","author":"Cheong","year":"2010","journal-title":"Cell"},{"key":"10.1038\/s41385-018-0093-5_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1365-2567.2003.01620.x","article-title":"Signalling events involved in interferon-gamma-inducible macrophage nitric oxide generation","volume":"108","author":"Blanchette","year":"2003","journal-title":"Immunology"},{"key":"10.1038\/s41385-018-0093-5_bib34","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1128\/IAI.01783-06","article-title":"CD4+CD25+regulatory T cells suppress CD4+T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis","volume":"75","author":"Nie","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-018-0093-5_bib35","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.4049\/jimmunol.0904019","article-title":"Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection","volume":"185","author":"Findlay","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0093-5_bib36","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/ni.1731","article-title":"The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation","volume":"10","author":"Koch","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-018-0093-5_bib37","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1189\/jlb.4HI0315-130RRR","article-title":"Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes","volume":"99","author":"Lagasse","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1038\/s41385-018-0093-5_bib38","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.4049\/jimmunol.173.7.4692","article-title":"The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis","volume":"173","author":"Belperio","year":"2004","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0093-5_bib39","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.4049\/jimmunol.179.5.3332","article-title":"Tumor-derived chemokine MCP-1\/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells","volume":"179","author":"Brown","year":"2007","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0093-5_bib40","doi-asserted-by":"crossref","first-page":"37714","DOI":"10.18632\/oncotarget.9265","article-title":"Blockade of MCP-1\/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma","volume":"7","author":"Sun","year":"2016","journal-title":"Oncotarget"},{"key":"10.1038\/s41385-018-0093-5_bib41","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1084\/jem.191.10.1755","article-title":"A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock","volume":"191","author":"Chvatchko","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-018-0093-5_bib42","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1073\/pnas.1114153109","article-title":"CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells","volume":"109","author":"Poppensieker","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-018-0093-5_bib43","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1465-9921-6-58","article-title":"Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury","volume":"6","author":"Genovese","year":"2005","journal-title":"Respir. Res."},{"key":"10.1038\/s41385-018-0093-5_bib44","doi-asserted-by":"crossref","first-page":"e1006054","DOI":"10.1371\/journal.ppat.1006054","article-title":"Targeting neutrophils to prevent malaria-associated acute lung injury\/acute respiratory distress syndrome in mice","volume":"12","author":"Sercundes","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-018-0093-5_bib45","doi-asserted-by":"crossref","first-page":"758","DOI":"10.4269\/ajtmh.2009.09-0348","article-title":"Histopathology of fatal respiratory distress caused by Plasmodium vivax malaria","volume":"81","author":"Valecha","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1038\/s41385-018-0093-5_bib46","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-3024.1994.tb00346.x","article-title":"Possible role of nitric oxide in malarial immunosuppression","volume":"16","author":"Rockett","year":"1994","journal-title":"Parasite Immunol."},{"key":"10.1038\/s41385-018-0093-5_bib47","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/j.1365-3156.2004.01312.x","article-title":"iNOS promoter variants and severe malaria in Ghanaian children","volume":"9","author":"Cramer","year":"2004","journal-title":"Trop. Med. Int. Health"},{"key":"10.1038\/s41385-018-0093-5_bib48","article-title":"A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-018-0093-5_bib49","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1172\/JCI82976","article-title":"A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer","volume":"127","author":"Berlato","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-018-0093-5_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10267-4","article-title":"Up-regulation of chemokine receptor CCR4 is associated with Human Hepatocellular Carcinoma malignant behavior","volume":"7","author":"Cheng","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41385-018-0093-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-018-0093-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922003804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922003804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-018-0093-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:15:56Z","timestamp":1761830156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922003804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1933021922003804"],"URL":"https:\/\/doi.org\/10.1038\/s41385-018-0093-5","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The emergence of pathogenic TNF\/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-018-0093-5","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}