{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:48:21Z","timestamp":1790801301424,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":1063,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1038\/s41385-018-0110-8","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T07:50:23Z","timestamp":1544082623000},"page":"378-389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life"],"prefix":"10.1016","volume":"12","author":[{"given":"Takashi","family":"Senda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranay","family":"Dogra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Granot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Furuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin J.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puspa","family":"Thapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Miron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna L.","family":"Farber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-018-0110-8_bib1","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1542\/peds.2011-0204","article-title":"The prevalence, severity, and distribution of childhood food allergy in the United States","volume":"128","author":"Gupta","year":"2011","journal-title":"Pediatrics"},{"key":"10.1038\/s41385-018-0110-8_bib2","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1111\/j.1572-0241.2006.00603.x","article-title":"The epidemiology of inflammatory bowel disease in Canada: a population-based study","volume":"101","author":"Bernstein","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"10.1038\/s41385-018-0110-8_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0029-1242458","article-title":"Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors","volume":"22","author":"Haggar","year":"2009","journal-title":"Clin. Colon Rectal Surg."},{"key":"10.1038\/s41385-018-0110-8_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4049\/jimmunol.168.1.57","article-title":"Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine","volume":"168","author":"Hamada","year":"2002","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/eji.200425432","article-title":"Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes","volume":"35","author":"Pabst","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/mi.2013.64","article-title":"Limited expression of APRIL and its receptors prior to intestinal IgA plasma cell development during human infancy","volume":"7","author":"Gustafson","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.it.2012.04.004","article-title":"Lymphoid microenvironments and innate lymphoid cells in the gut","volume":"33","author":"Pearson","year":"2012","journal-title":"Trends Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib9","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI44632","article-title":"Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae","volume":"121","author":"Chassaing","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-018-0110-8_bib10","first-page":"457","article-title":"Heterogeneity of M-cell-associated B and T cells in human Peyer's patches","volume":"83","author":"Farstad","year":"1994","journal-title":"Immunology"},{"key":"10.1038\/s41385-018-0110-8_bib11","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cell.2014.10.026","article-title":"Spatial map of human T cell compartmentalization and maintenance over decades of life","volume":"159","author":"Thome","year":"2014","journal-title":"Cell"},{"key":"10.1038\/s41385-018-0110-8_bib12","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.4049\/jimmunol.176.4.2079","article-title":"Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population","volume":"176","author":"Masopust","year":"2006","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1084\/jem.20090858","article-title":"Dynamic T cell migration program provides resident memory within intestinal epithelium","volume":"207","author":"Masopust","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-018-0110-8_bib14","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.celrep.2017.08.078","article-title":"Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites","volume":"20","author":"Kumar","year":"2017","journal-title":"Cell Rep."},{"key":"10.1038\/s41385-018-0110-8_bib15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"10.1038\/s41385-018-0110-8_bib16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.0105-2896.2005.00250.x","article-title":"Regulatory T cells and intestinal homeostasis","volume":"204","author":"Coombes","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1038\/s41385-018-0110-8_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.immunol.021908.132657","article-title":"Regulatory lymphocytes and intestinal inflammation","volume":"27","author":"Izcue","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib18","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.imbio.2011.05.007","article-title":"Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa","volume":"216","author":"Santiago","year":"2011","journal-title":"Immunobiology"},{"key":"10.1038\/s41385-018-0110-8_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/ajt.14434","article-title":"Human immunology studies using organ donors: impact of clinical variations on immune parameters in tissues and circulation","volume":"18","author":"Carpenter","year":"2018","journal-title":"Am. J. Transplant."},{"key":"10.1038\/s41385-018-0110-8_bib20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nm.4008","article-title":"Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues","volume":"22","author":"Thome","year":"2016","journal-title":"Nat. Med."},{"key":"10.1038\/s41385-018-0110-8_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.immuni.2012.09.020","article-title":"Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets","volume":"38","author":"Sathaliyawala","year":"2013","journal-title":"Immunity"},{"key":"10.1038\/s41385-018-0110-8_bib22","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.immuni.2017.02.019","article-title":"Dendritic cells display subset and tissue-specific maturation dynamics over human life","volume":"46","author":"Granot","year":"2017","journal-title":"Immunity"},{"key":"10.1038\/s41385-018-0110-8_bib23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1084\/jem.20160758","article-title":"Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection","volume":"214","author":"Gordon","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-018-0110-8_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/gut.6.3.225","article-title":"Number, size, and distribution of Peyer's patches in the human small intestine: part I. The development of Peyer's patches","volume":"6","author":"Cornes","year":"1965","journal-title":"Gut"},{"key":"10.1038\/s41385-018-0110-8_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2567.2004.02006.x","article-title":"Age-related loss of naive T cells and dysregulation of T-cell\/B-cell interactions in human lymph nodes","volume":"114","author":"Lazuardi","year":"2005","journal-title":"Immunology"},{"key":"10.1038\/s41385-018-0110-8_bib26","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/S0016-5085(98)70020-4","article-title":"Lymphocyte-filled villi: comparison with other lymphoid aggregations in the mucosa of the human small intestine","volume":"115","author":"Moghaddami","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1038\/s41385-018-0110-8_bib27","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central memory and effector memory T cell subsets: function, generation, and maintenance","volume":"22","author":"Sallusto","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib28","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions [see comments]","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"10.1038\/s41385-018-0110-8_bib29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2014.09.007","article-title":"CD4+T cell help guides formation of CD103+lung-resident memory CD8+T cells during influenza viral infection","volume":"41","author":"Laidlaw","year":"2014","journal-title":"Immunity"},{"key":"10.1038\/s41385-018-0110-8_bib30","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature04606","article-title":"CD69 acts downstream of interferon-alpha\/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs","volume":"440","author":"Shiow","year":"2006","journal-title":"Nature"},{"key":"10.1038\/s41385-018-0110-8_bib31","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20060772","article-title":"CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+T reg cells","volume":"203","author":"Liu","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-018-0110-8_bib32","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMoa1414850","article-title":"Randomized trial of peanut consumption in infants at risk for peanut allergy","volume":"372","author":"Du Toit","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-018-0110-8_bib33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"key":"10.1038\/s41385-018-0110-8_bib34","doi-asserted-by":"crossref","first-page":"E2970","DOI":"10.1073\/pnas.1717139115","article-title":"Predicting cancer outcomes from histology and genomics using convolutional networks","volume":"115","author":"Mobadersany","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/s41385-018-0110-8_bib35","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41551-018-0195-0","article-title":"Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning","volume":"2","author":"Poplin","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1038\/s41385-018-0110-8_bib36","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1053\/j.gastro.2010.12.002","article-title":"Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases","volume":"140","author":"Hovhannisyan","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1038\/s41385-018-0110-8_bib37","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1182\/blood-2005-07-2860","article-title":"Gut-associated lymphoid tissue-primed CD4+T cells display CCR9-dependent and -independent homing to the small intestine","volume":"107","author":"Stenstad","year":"2006","journal-title":"Blood"},{"key":"10.1038\/s41385-018-0110-8_bib38","doi-asserted-by":"crossref","unstructured":"Thome, J. J., et al. Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites. Sci. Immunol. 1, eaah6506 (2016).","DOI":"10.1126\/sciimmunol.aah6506"},{"key":"10.1038\/s41385-018-0110-8_bib39","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.immuni.2012.02.006","article-title":"Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans","volume":"36","author":"den Braber","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/s41385-018-0110-8_bib40","first-page":"1151","article-title":"The efficacy of DPT and oral poliomyelitis immunization schedules initiated from birth to 12 weeks of age","volume":"63","author":"Halsey","year":"1985","journal-title":"Bull. World Health Organ"},{"key":"10.1038\/s41385-018-0110-8_bib41","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1053\/j.gastro.2009.03.055","article-title":"Sequential role of plasmacytoid dendritic cells and regulatory T cells in oral tolerance","volume":"137","author":"Dubois","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1038\/s41385-018-0110-8_bib42","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.immuni.2008.06.017","article-title":"Plasmacytoid dendritic cells mediate oral tolerance","volume":"29","author":"Goubier","year":"2008","journal-title":"Immunity"},{"key":"10.1038\/s41385-018-0110-8_bib43","first-page":"12","article-title":"Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow's milk allergy and 90 children with egg allergy","volume":"39","author":"Morisset","year":"2007","journal-title":"Eur. Ann. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib44","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jaci.2007.10.029","article-title":"Specific oral tolerance induction in children with very severe cow's milk-induced reactions","volume":"121","author":"Longo","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib45","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.jaci.2008.09.030","article-title":"A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy","volume":"122","author":"Skripak","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib46","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/ni.3408","article-title":"Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance","volume":"17","author":"Esterhazy","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-018-0110-8_bib47","unstructured":"Statsmodels: Econometric and Statistical Modeling with Python. Proc. 9th Python Science Conf. (SCIPY 2010) (2010)."},{"key":"10.1038\/s41385-018-0110-8_bib48","first-page":"2825","article-title":"Scikit-learn: machine learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41385-018-0110-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-018-0110-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922003853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922003853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-018-0110-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:13:40Z","timestamp":1761830020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922003853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1933021922003853"],"URL":"https:\/\/doi.org\/10.1038\/s41385-018-0110-8","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-018-0110-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}