{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:10:39Z","timestamp":1767903039769,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1038\/s41385-018-0111-7","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T07:51:53Z","timestamp":1544082713000},"page":"531-544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection"],"prefix":"10.1016","volume":"12","author":[{"given":"Wenkai","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexia","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiameng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoyao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jielin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinming","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congrui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R.","family":"Hardwidge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-018-0111-7_bib1","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.2741\/4539","article-title":"The immunological function of GABAergic system","volume":"22","author":"Wu","year":"2017","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1038\/s41385-018-0111-7_bib2","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1073\/pnas.0915139107","article-title":"Inhibitory role for GABA in autoimmune inflammation","volume":"107","author":"Bhat","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/s41385-018-0111-7_bib3","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.autrev.2015.07.011","article-title":"Immunological GABAergic interactions and therapeutic applications in autoimmune diseases","volume":"14","author":"Prud'homme","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"10.1038\/s41385-018-0111-7_bib4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bbi.2016.02.001","article-title":"Inhibiting neuroinflammation: the role and therapeutic potential of GABA in neuro-immune interactions","volume":"54","author":"Crowley","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1038\/s41385-018-0111-7_bib5","doi-asserted-by":"crossref","first-page":"L406","DOI":"10.1152\/ajplung.00107.2017","article-title":"GABAA receptor alpha4-subunit knockout enhances lung inflammation and airway reactivity in a murine asthma model","volume":"313","author":"Yocum","year":"2017","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1038\/s41385-018-0111-7_bib6","first-page":"685","article-title":"Intestinal microbiota-derived GABA mediates interleukin-17 expression during enterotoxigenic Escherichia coli infection","volume":"7","author":"Ren","year":"2016","journal-title":"Front Immunol."},{"key":"10.1038\/s41385-018-0111-7_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.neuropharm.2010.11.007","article-title":"An intrinsic GABAergic system in human lymphocytes","volume":"60","author":"Dionisio","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1038\/s41385-018-0111-7_bib8","doi-asserted-by":"crossref","first-page":"8226","DOI":"10.4049\/jimmunol.181.12.8226","article-title":"Gamma-aminobutyric acid transporter 1 negatively regulates T cell-mediated immune responses and ameliorates autoimmune inflammation in the CNS","volume":"181","author":"Wang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0111-7_bib9","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.4049\/jimmunol.0900767","article-title":"Gamma-aminobutyric acid transporter 1 negatively regulates T cell activation and survival through protein kinase C-dependent signaling pathways","volume":"183","author":"Wang","year":"2009","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0111-7_bib10","doi-asserted-by":"crossref","unstructured":"Ren, W. et al. Draft genome sequence of enterotoxigenic Escherichia coli strain W25K. Genome Announc. 2https:\/\/doi.org\/10.1128\/genomeA.00593-14 (2014).","DOI":"10.1128\/genomeA.00593-14"},{"key":"10.1038\/s41385-018-0111-7_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jpba.2017.04.049","article-title":"Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS","volume":"142","author":"Du","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1038\/s41385-018-0111-7_bib12","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s11306-015-0809-4","article-title":"An integrated targeted metabolomic platform for high-throughput metabolite profiling and automated data processing","volume":"11","author":"Cai","year":"2015","journal-title":"Metabolomics"},{"key":"10.1038\/s41385-018-0111-7_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3389\/fcimb.2017.00251","article-title":"Transcriptomic analysis on responses of murine lungs to Pasteurella multocida infection","volume":"7","author":"Wu","year":"2017","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1038\/s41385-018-0111-7_bib14","article-title":"Proteome analysis for the global proteins in the jejunum tissues of enterotoxigenic Escherichia coli-infected piglets","volume":"6","author":"Ren","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1038\/s41385-018-0111-7_bib15","doi-asserted-by":"crossref","first-page":"e12448","DOI":"10.1111\/jpi.12448","article-title":"Melatonin alleviates weanling stress in mice: Involvement of intestinal microbiota","volume":"64","author":"Ren","year":"2017","journal-title":"Journal of Pineal Research"},{"key":"10.1038\/s41385-018-0111-7_bib16","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/cam4.686","article-title":"GABAB R\/GSK-3beta\/NF-kappaB signaling pathway regulates the proliferation of colorectal cancer cells","volume":"5","author":"Shu","year":"2016","journal-title":"Cancer Med"},{"key":"10.1038\/s41385-018-0111-7_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuroscience.2014.04.037","article-title":"GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone","volume":"273","author":"Paul","year":"2014","journal-title":"Neuroscience"},{"key":"10.1038\/s41385-018-0111-7_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/eji.201545886","article-title":"mTORC1 signaling and IL-17 expression: defining pathways and possible therapeutic targets","volume":"46","author":"Ren","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-018-0111-7_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/nyas.12059","article-title":"Role of PI3K\/Akt and mTOR complexes in Th17 cell differentiation","volume":"1280","author":"Nagai","year":"2013","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1038\/s41385-018-0111-7_bib20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrd3794","article-title":"Targeting IL-17 and TH17 cells in chronic inflammation","volume":"11","author":"Miossec","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1038\/s41385-018-0111-7_bib21","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ni1497","article-title":"Development, cytokine profile and function of human interleukin 17-producing helper T cells","volume":"8","author":"Wilson","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-018-0111-7_bib22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.smim.2007.10.011","article-title":"Transcriptional regulation of Th17 cell differentiation","volume":"19","author":"Ivanov","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1038\/s41385-018-0111-7_bib23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.5114\/pdia.2014.40954","article-title":"Interleukin-17 in human inflammatory diseases","volume":"31","author":"Shabgah","year":"2014","journal-title":"Post. Dermatol. Alergol."},{"key":"10.1038\/s41385-018-0111-7_bib24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.immuni.2008.03.001","article-title":"Th17 cell differentiation: the long and winding road","volume":"28","author":"McGeachy","year":"2008","journal-title":"Immunity"},{"key":"10.1038\/s41385-018-0111-7_bib25","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/ni.2607","article-title":"Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways","volume":"14","author":"Kim","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-018-0111-7_bib26","article-title":"Amino-acid transporters in T-cell activation and differentiation","volume":"8","author":"Ren","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1038\/s41385-018-0111-7_bib27","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2016.09.031","article-title":"L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity","volume":"167","author":"Geiger","year":"2016","journal-title":"Cell"},{"key":"10.1038\/s41385-018-0111-7_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2016.12.011","article-title":"Serine is an essential metabolite for effector T cell expansion","volume":"25","author":"Ma","year":"2017","journal-title":"Cell Metab."},{"key":"10.1038\/s41385-018-0111-7_bib29","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1038\/s41385-018-0111-7_bib30","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature09447","article-title":"Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling","volume":"467","author":"Ghoreschi","year":"2010","journal-title":"Nature"},{"key":"10.1038\/s41385-018-0111-7_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the T(H)17 lineage","volume":"441","author":"Mangan","year":"2006","journal-title":"Nature"},{"key":"10.1038\/s41385-018-0111-7_bib32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"10.1038\/s41385-018-0111-7_bib33","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.4049\/jimmunol.173.8.5298","article-title":"Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model","volume":"173","author":"Tian","year":"2004","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0111-7_bib34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/08916934.2011.571223","article-title":"Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis","volume":"44","author":"Tian","year":"2011","journal-title":"Autoimmunity"},{"key":"10.1038\/s41385-018-0111-7_bib35","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.4049\/jimmunol.1000630","article-title":"Anti-inflammatory effects of the neurotransmitter agonist Honokiol in a mouse model of allergic asthma","volume":"185","author":"Munroe","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-018-0111-7_bib36","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1600-0625.2010.01076.x","article-title":"Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis","volume":"19","author":"Duthey","year":"2010","journal-title":"Exp. Dermatol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41385-018-0111-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-018-0111-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922003981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922003981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-018-0111-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:14:31Z","timestamp":1761830071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922003981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1933021922003981"],"URL":"https:\/\/doi.org\/10.1038\/s41385-018-0111-7","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-018-0111-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}