{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:28:58Z","timestamp":1793042938333,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1038\/s41385-019-0132-x","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T11:07:16Z","timestamp":1547550436000},"page":"1070-1081","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Regulation of HMGB1 release protects chemoradiotherapy-associated mucositis"],"prefix":"10.1016","volume":"12","author":[{"given":"Keon-Il","family":"Im","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Sun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunejin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Sol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Yeon","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Woo","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Goo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-019-0132-x_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc1318","article-title":"The pathobiology of mucositis","volume":"4","author":"Sonis","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1038\/s41385-019-0132-x_bib2","first-page":"3","article-title":"Pathobiology of oral mucositis: novel insights and opportunities","volume":"5","author":"Sonis","year":"2007","journal-title":"J. Support Oncol."},{"key":"10.1038\/s41385-019-0132-x_bib3","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1200\/JCO.2010.32.4103","article-title":"Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: a randomized, placebo-controlled trial","volume":"29","author":"Henke","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1038\/s41385-019-0132-x_bib4","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1200\/JCO.2010.32.4095","article-title":"Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study","volume":"29","author":"Le","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1038\/s41385-019-0132-x_bib5","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1126\/science.1112521","article-title":"Mitogenic influence of human R-spondin1 on the intestinal epithelium","volume":"309","author":"Kim","year":"2005","journal-title":"Science"},{"key":"10.1038\/s41385-019-0132-x_bib6","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1073\/pnas.0805159106","article-title":"R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt\/beta-catenin pathway","volume":"106","author":"Zhao","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-019-0132-x_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature12416","article-title":"Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection","volume":"501","author":"Zhou","year":"2013","journal-title":"Nature"},{"key":"10.1038\/s41385-019-0132-x_bib8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.stem.2012.06.007","article-title":"mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis","volume":"11","author":"Iglesias-Bartolome","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1038\/s41385-019-0132-x_bib9","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1172\/JCI88410","article-title":"Inhibition of CDK4\/6 protects against radiation-induced intestinal injury in mice","volume":"126","author":"Wei","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1038\/s41385-019-0132-x_bib10","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1073\/pnas.1118857109","article-title":"The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations","volume":"109","author":"Yan","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-019-0132-x_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/sj.bmt.1704521","article-title":"A randomized trial of amifostine as a cytoprotectant for patients receiving myeloablative therapy for allogeneic hematopoietic stem cell transplantation","volume":"34","author":"Hwang","year":"2004","journal-title":"Bone Marrow Transplant."},{"key":"10.1038\/s41385-019-0132-x_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nm.3118","article-title":"Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis","volume":"19","author":"Han","year":"2013","journal-title":"Nat. Med."},{"key":"10.1038\/s41385-019-0132-x_bib13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-065X.2007.00579.x","article-title":"The grateful dead: damage-associated molecular pattern molecules and reduction\/oxidation regulate immunity","volume":"220","author":"Lotze","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1038\/s41385-019-0132-x_bib14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.it.2007.08.004","article-title":"Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox","volume":"28","author":"Rubartelli","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1038\/s41385-019-0132-x_bib15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1038\/s41385-019-0132-x_bib16","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/0022034516641890","article-title":"Host-microbiome cross-talk in oral mucositis","volume":"95","author":"Vasconcelos","year":"2016","journal-title":"J. Dent. Res"},{"key":"10.1038\/s41385-019-0132-x_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrrheum.2011.222","article-title":"HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease","volume":"8","author":"Harris","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1038\/s41385-019-0132-x_bib18","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2796.2003.01302.x","article-title":"Extracellular role of HMGB1 in inflammation and sepsis","volume":"255","author":"Wang","year":"2004","journal-title":"J. Intern. Med."},{"key":"10.1038\/s41385-019-0132-x_bib19","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1158\/1078-0432.CCR-13-0495","article-title":"HMGB1 in cancer: good, bad, or both?","volume":"19","author":"Kang","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1038\/s41385-019-0132-x_bib20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-019-0132-x_bib21","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s12272-010-1114-4","article-title":"NecroX as a novel class of mitochondrial reactive oxygen species and ONOO(-) scavenger","volume":"33","author":"Kim","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"10.1038\/s41385-019-0132-x_bib22","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.immuni.2014.12.011","article-title":"Dysfunctional HIV-specific CD8 + T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis","volume":"41","author":"Gaiha","year":"2014","journal-title":"Immunity"},{"key":"10.1038\/s41385-019-0132-x_bib23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2013.03.022","article-title":"TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species","volume":"153","author":"Roca","year":"2013","journal-title":"Cell"},{"key":"10.1038\/s41385-019-0132-x_bib24","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/bcp.13213","article-title":"Pharmacokinetics and safety of a single dose of the novel necrosis inhibitor LC28-0126 in healthy male subjects","volume":"83","author":"Kim","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1038\/s41385-019-0132-x_bib25","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.4049\/jimmunol.1402609","article-title":"The free radical scavenger NecroX-7 attenuates acute graft-versus-host disease via reciprocal regulation of Th1\/regulatory T cells and inhibition of HMGB1 release","volume":"194","author":"Im","year":"2015","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0132-x_bib26","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1601-0825.2010.01681.x","article-title":"New thoughts on the initiation of mucositis","volume":"16","author":"Sonis","year":"2010","journal-title":"Oral Dis."},{"key":"10.1038\/s41385-019-0132-x_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrd4236","article-title":"Drugging the p53 pathway: understanding the route to clinical efficacy","volume":"13","author":"Khoo","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1038\/s41385-019-0132-x_bib28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.stem.2008.03.009","article-title":"PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome","volume":"2","author":"Qiu","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1038\/s41385-019-0132-x_bib29","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1126\/science.1090072","article-title":"p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa","volume":"302","author":"Villunger","year":"2003","journal-title":"Science"},{"key":"10.1038\/s41385-019-0132-x_bib30","first-page":"137","article-title":"[Prevalence of mental disorders in adults in Subtiava, Leon, Nicaragua]","volume":"113","author":"Penayo","year":"1992","journal-title":"Bol. Oficina Sanit. Panam."},{"key":"10.1038\/s41385-019-0132-x_bib31","article-title":"High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-019-0132-x_bib32","doi-asserted-by":"crossref","first-page":"51665","DOI":"10.18632\/oncotarget.10076","article-title":"Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype","volume":"7","author":"Reed","year":"2016","journal-title":"Oncotarget"},{"key":"10.1038\/s41385-019-0132-x_bib33","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1172\/JCI91786","article-title":"HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis","volume":"128","author":"Hernandez","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1038\/s41385-019-0132-x_bib34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.20160217","article-title":"High mobility group box 1 orchestrates tissue regeneration via CXCR4","volume":"215","author":"Tirone","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0132-x_bib35","first-page":"e4463","article-title":"Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert","volume":"115","author":"Lee","year":"2018","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-019-0132-x_bib36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1084\/jem.20141318","article-title":"MD-2 is required for disulfide HMGB1-dependent TLR4 signaling","volume":"212","author":"Yang","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0132-x_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4492","article-title":"Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome","volume":"5","author":"Takemura","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-019-0132-x_bib38","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0016-5085(00)70363-5","article-title":"Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism","volume":"118","author":"Riehl","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1038\/s41385-019-0132-x_bib39","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/gutjnl-2011-300367","article-title":"Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2\/cyclo-oxygenase-2-dependent manner","volume":"61","author":"Ciorba","year":"2012","journal-title":"Gut"},{"key":"10.1038\/s41385-019-0132-x_bib40","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1056\/NEJMoa040125","article-title":"Palifermin for oral mucositis after intensive therapy for hematologic cancers","volume":"351","author":"Spielberger","year":"2004","journal-title":"N. Engl. J. Med"},{"key":"10.1038\/s41385-019-0132-x_bib41","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1200\/JCO.2007.13.7349","article-title":"Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma","volume":"26","author":"Brizel","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"10.1038\/s41385-019-0132-x_bib42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/bmt.2012.115","article-title":"Palifermin is efficacious in recipients of TBI-based but not chemotherapy-based allogeneic hematopoietic stem cell transplants","volume":"48","author":"Goldberg","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"10.1038\/s41385-019-0132-x_bib43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/med.21386","article-title":"Radioprotective agents: strategies and translational advances","volume":"36","author":"Kamran","year":"2016","journal-title":"Med. Res. Rev."},{"key":"10.1038\/s41385-019-0132-x_bib44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/bmt.2014.34","article-title":"N-acetyl cysteine for prevention of oral mucositis in hematopoietic SCT: a double-blind, randomized, placebo-controlled trial","volume":"49","author":"Moslehi","year":"2014","journal-title":"Bone Marrow Transplant."},{"key":"10.1038\/s41385-019-0132-x_bib45","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1053\/j.gastro.2003.12.004","article-title":"Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor","volume":"126","author":"Beck","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1038\/s41385-019-0132-x_bib46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2147\/tcrm.2006.2.3.251","article-title":"Cancer treatment-induced mucositis pain: strategies for assessment and management","volume":"2","author":"Harris","year":"2006","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1038\/s41385-019-0132-x_bib47","doi-asserted-by":"crossref","first-page":"e2229","DOI":"10.1038\/cddis.2016.136","article-title":"beta-Arrestin1 inhibits chemotherapy-induced intestinal stem cell apoptosis and mucositis","volume":"7","author":"Zhan","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1038\/s41385-019-0132-x_bib48","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/mi.2013.124","article-title":"IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice","volume":"7","author":"Guabiraba","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-019-0132-x_bib49","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00280-003-0682-0","article-title":"Alleviation of side effects induced by irinotecan hydrochloride (CPT-11) in rats by intravenous infusion","volume":"52","author":"Kurita","year":"2003","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1038\/s41385-019-0132-x_bib50","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1158\/1078-0432.CCR-05-0403","article-title":"Evaluation of radiation-induced oral mucositis by optical coherence tomography","volume":"11","author":"Muanza","year":"2005","journal-title":"Clin. Cancer Res."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41385-019-0132-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-019-0132-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922004317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922004317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-019-0132-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:13:31Z","timestamp":1761830011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922004317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1933021922004317"],"URL":"https:\/\/doi.org\/10.1038\/s41385-019-0132-x","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of HMGB1 release protects chemoradiotherapy-associated mucositis","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-019-0132-x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}