{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:03:37Z","timestamp":1790953417213,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":1002,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1038\/s41385-019-0143-7","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T12:04:17Z","timestamp":1549886657000},"page":"668-678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice"],"prefix":"10.1016","volume":"12","author":[{"given":"Anny-Claude","family":"Luissint","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Flemming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Azcutia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland S.","family":"Hilgarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique N. O'","family":"Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Denning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Nusrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Parkos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-019-0143-7_bib1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1152\/physrev.00004.2017","article-title":"Junctional adhesion molecules (JAMs): Cell adhesion receptors with pleiotropic functions in cell physiology and development","volume":"97","author":"Ebnet","year":"2017","journal-title":"Physiol. Rev."},{"issue":"Pt 13","key":"10.1038\/s41385-019-0143-7_bib2","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1242\/jcs.113.13.2363","article-title":"Human junction adhesion molecule regulates tight junction resealing in epithelia","volume":"113","author":"Liu","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1038\/s41385-019-0143-7_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1083\/jcb.142.1.117","article-title":"Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration","volume":"142","author":"Martin-Padura","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1038\/s41385-019-0143-7_bib4","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0161-5890(99)00122-4","article-title":"Identification and characterisation of human Junctional Adhesion Molecule (JAM)","volume":"36","author":"Williams","year":"1999","journal-title":"Mol. Immunol."},{"issue":"Pt 3","key":"10.1038\/s41385-019-0143-7_bib5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1242\/jcs.01661","article-title":"Expression of junctional adhesion molecule-A prevents spontaneous and random motility","volume":"118","author":"Bazzoni","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1038\/s41385-019-0143-7_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00281-014-0421-0","article-title":"JAM-related proteins in mucosal homeostasis and inflammation","volume":"36","author":"Luissint","year":"2014","journal-title":"Semin. Immunopathol."},{"key":"10.1038\/s41385-019-0143-7_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1749-6632.2012.06521.x","article-title":"Intracellular mediators of JAM-A-dependent epithelial barrier function","volume":"1257","author":"Monteiro","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1038\/s41385-019-0143-7_bib8","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/01.ATV.0000093982.84451.87","article-title":"Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migration","volume":"23","author":"Naik","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1038\/s41385-019-0143-7_bib9","doi-asserted-by":"crossref","first-page":"10634","DOI":"10.1073\/pnas.0500147102","article-title":"Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury","volume":"102","author":"Corada","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-019-0143-7_bib10","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1084\/jem.190.9.1351","article-title":"Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM)","volume":"190","author":"Del Maschio","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0143-7_bib11","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1182\/blood-2004-11-4416","article-title":"Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration","volume":"106","author":"Khandoga","year":"2005","journal-title":"Blood"},{"key":"10.1038\/s41385-019-0143-7_bib12","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/315765","article-title":"Antibodies to the junctional adhesion molecule cause disruption of endothelial cells and do not prevent leukocyte influx into the meninges after viral or bacterial infection","volume":"182","author":"Lechner","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1038\/s41385-019-0143-7_bib13","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood-2006-09-047431","article-title":"JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration","volume":"110","author":"Woodfin","year":"2007","journal-title":"Blood"},{"key":"10.1038\/s41385-019-0143-7_bib14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ni755","article-title":"JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes","volume":"3","author":"Ostermann","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-019-0143-7_bib15","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1084\/jem.20040965","article-title":"Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration","volume":"200","author":"Shaw","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0143-7_bib16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/CIRCRESAHA.116.304035","article-title":"Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice","volume":"116","author":"Karshovska","year":"2015","journal-title":"Circ. Res."},{"key":"10.1038\/s41385-019-0143-7_bib17","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1182\/blood-2013-04-496232","article-title":"Junctional adhesion molecule-A suppresses platelet integrin alphaIIbbeta3 signaling by recruiting Csk to the integrin-c-Src complex","volume":"123","author":"Naik","year":"2014","journal-title":"Blood"},{"key":"10.1038\/s41385-019-0143-7_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1081\/RRS-120034252","article-title":"Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa","volume":"24","author":"Sobocka","year":"2004","journal-title":"J. Recept. Signal. Transduct. Res."},{"key":"10.1038\/s41385-019-0143-7_bib19","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1172\/JCI21231","article-title":"Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice","volume":"114","author":"Cera","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"Pt 2","key":"10.1038\/s41385-019-0143-7_bib20","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1242\/jcs.037127","article-title":"JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling","volume":"122","author":"Cera","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1038\/s41385-019-0143-7_bib21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.immuni.2012.06.017","article-title":"Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis","volume":"37","author":"Khounlotham","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/s41385-019-0143-7_bib22","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1084\/jem.20071416","article-title":"JAM-A regulates permeability and inflammation in the intestine in vivo","volume":"204","author":"Laukoetter","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0143-7_bib23","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.4049\/jimmunol.155.7.3660","article-title":"Growth-related gene product alpha. A chemotactic cytokine for neutrophils in rheumatoid arthritis","volume":"155","author":"Koch","year":"1995","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0143-7_bib24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1084\/jem.153.2.482","article-title":"Novel structural determinants of the human neutrophil chemotactic activity of leukotriene B","volume":"153","author":"Goetzl","year":"1981","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0143-7_bib25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jlb.63.1.108","article-title":"Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model","volume":"63","author":"Ajuebor","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"10.1038\/s41385-019-0143-7_bib26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1083\/jcb.96.1.160","article-title":"Yeast mannans inhibit binding and phagocytosis of zymosan by mouse peritoneal macrophages","volume":"96","author":"Sung","year":"1983","journal-title":"J. Cell Biol."},{"key":"10.1038\/s41385-019-0143-7_bib27","doi-asserted-by":"crossref","unstructured":"Flemming S., Luissint A. C., Nusrat A. & Parkos C. A. Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model. JCI Insight. 3, pii: 99722 (2018).","DOI":"10.1172\/jci.insight.99722"},{"key":"10.1038\/s41385-019-0143-7_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6603(03)01009-2","article-title":"Fine tuning the transcriptional regulation of the CXCL1 chemokine","volume":"74","author":"Amiri","year":"2003","journal-title":"Prog. Nucleic Acid. Res. Mol. Biol."},{"key":"10.1038\/s41385-019-0143-7_bib29","doi-asserted-by":"crossref","unstructured":"Liu T., Zhang L., Joo D. & Sun S.C. NF-\u03baB signaling in inflammation. Signal Transduct Target Ther. 2, e17023 (2017).","DOI":"10.1038\/sigtrans.2017.23"},{"key":"10.1038\/s41385-019-0143-7_bib30","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1182\/blood.V97.6.1854","article-title":"Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane","volume":"97","author":"Thompson","year":"2001","journal-title":"Blood"},{"key":"10.1038\/s41385-019-0143-7_bib31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jcmgh.2017.06.001","article-title":"The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeability","volume":"4","author":"Edelblum","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1038\/s41385-019-0143-7_bib32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.7326\/0003-4819-105-6-883","article-title":"Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor","volume":"105","author":"Hollander","year":"1986","journal-title":"Ann. Intern. Med."},{"key":"10.1038\/s41385-019-0143-7_bib33","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.bbamcr.2017.03.007","article-title":"Disruption of the epithelial barrier during intestinal inflammation: Quest for new molecules and mechanisms","volume":"1864","author":"Lechuga","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1038\/s41385-019-0143-7_bib34","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/0140-6736(93)90882-H","article-title":"Intestinal permeability and the prediction of relapse in Crohn's disease","volume":"341","author":"Wyatt","year":"1993","journal-title":"Lancet"},{"key":"10.1038\/s41385-019-0143-7_bib35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fcimb.2014.00028","article-title":"The gut microbiota in mouse models of inflammatory bowel disease","volume":"4","author":"Gkouskou","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1038\/s41385-019-0143-7_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00054725-199911000-00004","article-title":"Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora","volume":"5","author":"Madsen","year":"1999","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1038\/s41385-019-0143-7_bib37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-019-0143-7_bib38","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1128\/IAI.66.11.5224-5231.1998","article-title":"Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice","volume":"66","author":"Sellon","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-019-0143-7_bib39","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1053\/j.gastro.2016.06.022","article-title":"Loss of junctional adhesion molecule a promotes severe steatohepatitis in mice on a diet high in saturated fat, fructose, and cholesterol","volume":"151","author":"Rahman","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1038\/s41385-019-0143-7_bib40","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.4049\/jimmunol.1402077","article-title":"IFN-gamma priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment","volume":"194","author":"Hoeksema","year":"2015","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0143-7_bib41","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1084\/jem.20070891","article-title":"Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection","volume":"205","author":"Didierlaurent","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0143-7_bib42","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1172\/JCI35412","article-title":"Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice","volume":"119","author":"Shahangian","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-019-0143-7_bib43","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/SHK.0b013e318150776f","article-title":"Endotoxin pretreatment improves bacterial clearance and decreases mortality in mice challenged with Staphylococcus aureus","volume":"29","author":"Murphey","year":"2008","journal-title":"Shock"},{"key":"10.1038\/s41385-019-0143-7_bib44","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00011-011-0342-5","article-title":"LPS pretreatment ameliorates multiple organ injuries and improves survival in a murine model of polymicrobial sepsis","volume":"60","author":"Shi","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1038\/s41385-019-0143-7_bib45","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/SHK.0b013e318162c190","article-title":"Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis","volume":"30","author":"Wheeler","year":"2008","journal-title":"Shock"},{"key":"10.1038\/s41385-019-0143-7_bib46","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1158\/0008-5472.CAN-09-1703","article-title":"Inactivation of junctional adhesion molecule-A enhances antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration","volume":"70","author":"Murakami","year":"2010","journal-title":"Cancer Res."},{"key":"10.1038\/s41385-019-0143-7_bib47","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/gene.20042","article-title":"Tissue-specific and inducible Cre-mediated recombination in the gut epithelium","volume":"39","author":"el Marjou","year":"2004","journal-title":"Genesis"},{"key":"10.1038\/s41385-019-0143-7_bib48","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0076-6879(09)05417-2","article-title":"Zymosan-induced peritonitis as a simple experimental system for the study of inflammation","volume":"461","author":"Cash","year":"2009","journal-title":"Methods Enzymol."},{"key":"10.1038\/s41385-019-0143-7_bib49","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.120.3.785","article-title":"Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion","volume":"120","author":"Colgan","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1038\/s41385-019-0143-7_bib50","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1091\/mbc.e13-06-0298","article-title":"JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function","volume":"24","author":"Monteiro","year":"2013","journal-title":"Mol. Biol. Cell."},{"key":"10.1038\/s41385-019-0143-7_bib51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3109\/00365513.2011.572182","article-title":"ImageStream cytometry extends the analysis of phagocytosis and oxidative burst","volume":"71","author":"Ploppa","year":"2011","journal-title":"Scand. J. Clin. Lab. Invest."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41385-019-0143-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-019-0143-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922004135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922004135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-019-0143-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:15:48Z","timestamp":1761830148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922004135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S1933021922004135"],"URL":"https:\/\/doi.org\/10.1038\/s41385-019-0143-7","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-019-0143-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}