{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:33:28Z","timestamp":1790728408098,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":818,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1038\/s41385-019-0202-0","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T11:03:14Z","timestamp":1568026994000},"page":"1268-1279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Class-switch recombination to IgA in the Peyer's patches requires natural thymus-derived Tregs and appears to be antigen independent"],"prefix":"10.1016","volume":"12","author":[{"given":"Inta","family":"Gribonika","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dubravka Grdic","family":"Eliasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Chandode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Sch\u00f6n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneli","family":"Str\u00f6mberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Bemark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils Y.","family":"Lycke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-019-0202-0_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nri982","article-title":"Intestinal IgA synthesis: regulation of front-line body defences","volume":"3","author":"Fagarasan","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10144-w","article-title":"Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome","volume":"10","author":"Komban","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-019-0202-0_bib3","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/mi.2017.62","article-title":"The regulation of gut mucosal IgA B-cell responses: recent developments","volume":"10","author":"Lycke","year":"2017","journal-title":"Mucosal. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1084\/jem.157.2.433","article-title":"Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. I. T cells derived from Peyer's patches that switch sIgM B cells to sIgA B cells in vitro","volume":"157","author":"Kawanishi","year":"1983","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0202-0_bib5","doi-asserted-by":"crossref","first-page":"19256","DOI":"10.1073\/pnas.0812681106","article-title":"A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota","volume":"106","author":"Cong","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-019-0202-0_bib6","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/ni.2552","article-title":"Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses","volume":"14","author":"Hirota","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib7","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib8","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.1169152","article-title":"Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches","volume":"323","author":"Tsuji","year":"2009","journal-title":"Science"},{"key":"10.1038\/s41385-019-0202-0_bib9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/icb.2010.76","article-title":"Polyclonal Treg cells enhance the activity of a mucosal adjuvant","volume":"88","author":"Vendetti","year":"2010","journal-title":"Immunol. Cell Biol."},{"key":"10.1038\/s41385-019-0202-0_bib10","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/mi.2015.20","article-title":"T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-induced colitis","volume":"8","author":"Wang","year":"2015","journal-title":"Mucosal. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1084\/jem.170.3.1039","article-title":"Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes","volume":"170","author":"Coffman","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0202-0_bib12","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.4049\/jimmunol.163.4.1951","article-title":"Partial IgA-deficiency with increased Th2-type cytokines in TGF-\u03b21 knockout mice","volume":"163","author":"van Ginkel","year":"1999","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)00044-3","article-title":"TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo","volume":"13","author":"Cazac","year":"2000","journal-title":"Immunity"},{"key":"10.1038\/s41385-019-0202-0_bib14","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1038\/cti.2017.9","article-title":"Transforming growth factor \u03b2: a master regulator of the gut microbiota and immune cell interactions","volume":"6","author":"Bauch\u00e9","year":"2017","journal-title":"Clin. Transl. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib15","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/mi.2014.134","article-title":"Interleukin (IL)-21 promotes intestinal IgA response to microbiota","volume":"8","author":"Cao","year":"2015","journal-title":"Mucosal. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/embor.2011.248","article-title":"Regulation and function of innate and adaptive interleukin-17-producing cells","volume":"13","author":"Hirota","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1038\/s41385-019-0202-0_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/icb.2013.54","article-title":"Gut TFH and IgA: key players for regulation of bacterial communities and immune homeostasis","volume":"92","author":"Kato","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"10.1038\/s41385-019-0202-0_bib18","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.4049\/jimmunol.1200955","article-title":"Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis","volume":"189","author":"Cao","year":"2012","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib19","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.4049\/jimmunol.175.11.7135","article-title":"CD4+CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells","volume":"175","author":"DiPaolo","year":"2005","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fimmu.2014.00017","article-title":"Thymus-derived, peripherally derived, and in vitro-induced T regulatory cells","volume":"5","author":"Elkord","year":"2014","journal-title":"Front Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s13258-012-0062-4","article-title":"TGF-\u03b2 and BAFF derived from CD4+CD25+Foxp3+ T cells mediate mouse IgA isotype switching","volume":"34","author":"Park","year":"2012","journal-title":"Genes Genomics."},{"issue":"Jun","key":"10.1038\/s41385-019-0202-0_bib22","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.4049\/jimmunol.180.12.8153","article-title":"Cell intrinsic TGF-beta 1 regulation of B cells","volume":"180","author":"Gros","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib23","doi-asserted-by":"crossref","first-page":"aaf4822","DOI":"10.1126\/science.aaf4822","article-title":"IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches","volume":"352","author":"Reboldi","year":"2016","journal-title":"Science"},{"key":"10.1038\/s41385-019-0202-0_bib24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-\u03b2 activation and function in immunity","volume":"32","author":"Travis","year":"2014","journal-title":"Annu Rev. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ni.3732","article-title":"Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota","volume":"18","author":"Nagashima","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/mi.2015.121","article-title":"Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria","volume":"9","author":"Rios","year":"2016","journal-title":"Mucosal. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s13258-010-0168-5","article-title":"Retinoic acid induces expression of Ig germ line \u03b1 transcript, an IgA isotype switching indicative, through retinoic acid receptor","volume":"33","author":"Park","year":"2011","journal-title":"Genes Genome"},{"key":"10.1038\/s41385-019-0202-0_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1600-065X.2011.01067.x","article-title":"Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease","volume":"244","author":"Rickert","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1038\/s41385-019-0202-0_bib29","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1073\/pnas.0307348101","article-title":"Impaired IgA class switching in APRIL-deficient mice","volume":"101","author":"Castigli","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-019-0202-0_bib30","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nri3251","article-title":"Recent progress in mucosal vaccine development: potential and limitations","volume":"12","author":"Lycke","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib31","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.2125367","article-title":"Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo","volume":"250","author":"Murphy","year":"1990","journal-title":"Science"},{"key":"10.1038\/s41385-019-0202-0_bib32","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.4049\/jimmunol.164.9.4706","article-title":"DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope","volume":"164","author":"Robertson","year":"2000","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib33","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1517\/17425247.3.6.747","article-title":"Delivery systems and adjuvants for oral vaccines","volume":"3","author":"Lavelle","year":"2006","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1038\/s41385-019-0202-0_bib34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.coph.2018.03.015","article-title":"ADP-ribosylating enterotoxins as vaccine adjuvants","volume":"41","author":"Lycke","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1038\/s41385-019-0202-0_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1432-0436.1973.tb00143.x","article-title":"Athymic development in the mouse","volume":"1","author":"Pantelouris","year":"1973","journal-title":"Differentiation"},{"key":"10.1038\/s41385-019-0202-0_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2017.07.004","article-title":"History and mechanisms of oral tolerance","volume":"30","author":"Rezende","year":"2017","journal-title":"Semin Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.20052016","article-title":"Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells","volume":"203","author":"Worbs","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0202-0_bib38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1398-9995.2009.02225.x","article-title":"Hypersensitivity and oral tolerance in the absence of a secretory immune system","volume":"65","author":"Karlsson","year":"2010","journal-title":"Allergy"},{"key":"10.1038\/s41385-019-0202-0_bib39","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/mi.2012.4","article-title":"Oral tolerance to food protein","volume":"5","author":"Pabst","year":"2012","journal-title":"Mucosal. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ni776","article-title":"Role of antigen receptor affinity in T cell-independent antibody responses in vivo","volume":"3","author":"Shih","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib41","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1128\/iai.21.2.532-539.1978","article-title":"Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin","volume":"21","author":"Moreau","year":"1978","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-019-0202-0_bib42","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.4049\/jimmunol.157.12.5300","article-title":"Memory T cell development in the absence of specific antigen priming","volume":"157","author":"Lee","year":"1996","journal-title":"J. Immunol."},{"issue":"Feb","key":"10.1038\/s41385-019-0202-0_bib43","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.4049\/jimmunol.172.3.1515","article-title":"Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens","volume":"172","author":"Zhou","year":"2004","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib44","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1073\/pnas.94.8.3920","article-title":"Functional differentiation of T cells in the intestine of T cell receptor transgenic mice","volume":"94","author":"Hurst","year":"1997","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-019-0202-0_bib45","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/mi.2012.56","article-title":"Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses","volume":"6","author":"Bergqvist","year":"2013","journal-title":"Mucosal. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib46","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1124\/mol.105.017483","article-title":"Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression","volume":"69","author":"Jinnin","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1038\/s41385-019-0202-0_bib47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.immuni.2007.07.007","article-title":"Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude","volume":"27","author":"Moon","year":"2007","journal-title":"Immunity"},{"key":"10.1038\/s41385-019-0202-0_bib48","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/ni.2286","article-title":"TGF-\u03b2 and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells","volume":"13","author":"Takahashi","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib49","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.intimp.2015.03.050","article-title":"Molecular control of CD4(+) T cell lineage plasticity and integrity","volume":"28","author":"Ellmeier","year":"2015","journal-title":"Int Immunopharmacol."},{"key":"10.1038\/s41385-019-0202-0_bib50","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","article-title":"Plasticity of CD4+ T cell lineage differentiation","volume":"30","author":"Zhou","year":"2009","journal-title":"Immunity"},{"key":"10.1038\/s41385-019-0202-0_bib51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/MOT.0000000000000261","article-title":"The highly alloreactive nature of dual TCR T cells","volume":"21","author":"Balakrishnan","year":"2016","journal-title":"Curr. Opin. Organ Transplant."},{"key":"10.1038\/s41385-019-0202-0_bib52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4049\/jimmunol.1700406","article-title":"Cutting edge: dual TCR\u03b1 expression poses an autoimmune hazard by limiting regulatory T cell generation","volume":"199","author":"Schuldt","year":"2017","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib53","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.4049\/jimmunol.0901895","article-title":"T cell-independent IgA class switch recombination is restricted to the GALT and occurs prior to manifest germinal center formation","volume":"184","author":"Bergqvist","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib54","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/12971","article-title":"Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response","volume":"1","author":"Ashcroft","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1038\/s41385-019-0202-0_bib55","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.4049\/jimmunol.176.4.2389","article-title":"B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate","volume":"176","author":"Klein","year":"2006","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib56","doi-asserted-by":"crossref","first-page":"E2975","DOI":"10.1073\/pnas.1611428114","article-title":"Sensing relative signal in the Tgf-\u03b2\/Smad pathway","volume":"114","author":"Frick","year":"2017","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-019-0202-0_bib57","doi-asserted-by":"crossref","first-page":"18326","DOI":"10.1073\/pnas.0605077103","article-title":"Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration","volume":"103","author":"Luo","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-019-0202-0_bib58","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1126\/science.1191996","article-title":"Stability of the regulatory T cell lineage in vivo","volume":"329","author":"Rubtsov","year":"2010","journal-title":"Science"},{"key":"10.1038\/s41385-019-0202-0_bib59","first-page":"2","article-title":"Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response","volume":"20","author":"Laidlaw","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib60","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.it.2015.05.005","article-title":"T follicular regulatory cells in the regulation of B cell responses","volume":"36","author":"Sage","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib61","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1084\/jem.20171940","article-title":"Spatial distribution and function of T follicular regulatory cells in human lymph nodes","volume":"215","author":"Sayin","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-019-0202-0_bib62","first-page":"19","article-title":"Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells","volume":"Unit3","author":"Lefran\u00e7ois","year":"2001","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1038\/s41385-019-0202-0_bib63","first-page":"7.14.1","article-title":"ELISPOT assay for measurement of antigen-specific and polyclonal antibody responses","volume":"108","author":"Lycke","year":"2015","journal-title":"Curr. Protoc. Immunol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41385-019-0202-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-019-0202-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922004482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922004482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-019-0202-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:13:42Z","timestamp":1761830022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922004482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S1933021922004482"],"URL":"https:\/\/doi.org\/10.1038\/s41385-019-0202-0","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Class-switch recombination to IgA in the Peyer's patches requires natural thymus-derived Tregs and appears to be antigen independent","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-019-0202-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}