{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:48:10Z","timestamp":1792180090827,"version":"4.4.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":575,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1038\/s41385-020-0262-1","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T10:16:11Z","timestamp":1581070571000},"page":"637-651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPAR\u03b3-FOXA2-phosphatase signaling"],"prefix":"10.1016","volume":"13","author":[{"given":"Woosuk","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Choe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Borchers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Kosmider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Limper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gee W.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-020-0262-1_bib1","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMra0910061","article-title":"Airway mucus function and dysfunction","volume":"363","author":"Fahy","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-020-0262-1_bib2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chest.2017.11.008","article-title":"Mucins, mucus, and goblet cells","volume":"154","author":"Ma","year":"2018","journal-title":"Chest"},{"key":"10.1038\/s41385-020-0262-1_bib3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/BST20170455","article-title":"Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease","volume":"46","author":"Symmes","year":"2018","journal-title":"Biochem Soc. Trans."},{"key":"10.1038\/s41385-020-0262-1_bib4","doi-asserted-by":"crossref","first-page":"E112","DOI":"10.3390\/jcm6120112","article-title":"Airway mucus and asthma: the role of MUC5AC and MUC5B","volume":"6","author":"Bonser","year":"2018","journal-title":"J. Clin. Med."},{"key":"10.1038\/s41385-020-0262-1_bib5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00441-016-2562-z","article-title":"Airway mucus, inflammation and remodeling: emerging links in the pathogenesis of chronic lung diseases","volume":"367","author":"Zhou-Suckow","year":"2017","journal-title":"Cell Tissue Res."},{"key":"10.1038\/s41385-020-0262-1_bib6","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1164\/rccm.201609-1954OC","article-title":"Restoring cystic fibrosis transmembrane conductance regulator function reduces airway bacteria and inflammation in people with cystic fibrosis and chronic lung infections","volume":"195","author":"Hisert","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1038\/s41385-020-0262-1_bib7","doi-asserted-by":"crossref","first-page":"1800328","DOI":"10.1183\/13993003.00328-2018","article-title":"The overlap between bronchiectasis and chronic airways diseases: state of the art and future directions","volume":"52","author":"Polverino","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1038\/s41385-020-0262-1_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.molimm.2012.09.011","article-title":"Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis","volume":"55","author":"Chalmers","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1038\/s41385-020-0262-1_bib9","doi-asserted-by":"crossref","first-page":"170103","DOI":"10.1183\/16000617.0103-2017","article-title":"Exacerbations of COPD","volume":"27","author":"Viniol","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1038\/s41385-020-0262-1_bib10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1574-6976.2010.00237.x","article-title":"Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary disease","volume":"35","author":"D\u00f6ring","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1038\/s41385-020-0262-1_bib11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/MCP.0b013e328321861a","article-title":"Pseudomonas aeruginosa in adults with chronic obstructive pulmonary disease","volume":"15","author":"Murphy","year":"2009","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1038\/s41385-020-0262-1_bib12","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1159\/000487515","article-title":"Pseudomonas aeruginosaKlebsiella pneumoniae adaptation to innate immune clearance mechanisms in the lung","volume":"10","author":"Riquelme","year":"2018","journal-title":"J. Innate Immun."},{"key":"10.1038\/s41385-020-0262-1_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.tim.2005.05.011","article-title":"Modulation of lung epithelial functions by Pseudomonas aeruginosa","volume":"13","author":"Lau","year":"2005","journal-title":"Trends Microbiol."},{"key":"10.1038\/s41385-020-0262-1_bib14","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.2353\/ajpath.2009.090166","article-title":"Pseudomonas aeruginosa pyocyanin causes cystic fibrosis airway pathogenesis","volume":"175","author":"Caldwell","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1038\/s41385-020-0262-1_bib15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1462-5822.2011.01727.x","article-title":"Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2","volume":"14","author":"Hao","year":"2012","journal-title":"Cell Microbiol."},{"key":"10.1038\/s41385-020-0262-1_bib16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1465-9921-14-82","article-title":"Pyocyanin-induced mucin production is associated with redox modification of FOXA2","volume":"14","author":"Hao","year":"2013","journal-title":"Respir. Res."},{"key":"10.1038\/s41385-020-0262-1_bib17","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/mi.2015.119","article-title":"Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis X to increase binding to airway epithelial cells","volume":"9","author":"Jeffries","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-020-0262-1_bib18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/mi.2010.62","article-title":"Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin","volume":"4","author":"Rada","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-020-0262-1_bib19","doi-asserted-by":"crossref","first-page":"e12957","DOI":"10.1111\/cmi.12957","article-title":"FOXA2 depletion leads to mucus hypersecretion in canine airways with respiratory diseases","volume":"21","author":"Choi","year":"2019","journal-title":"Cell Microbiol."},{"key":"10.1038\/s41385-020-0262-1_bib20","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1073\/pnas.95.10.5718","article-title":"Activation of NF-\u03baB via a Src dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells","volume":"95","author":"Li","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-020-0262-1_bib21","doi-asserted-by":"crossref","first-page":"e39888","DOI":"10.1371\/journal.pone.0039888","article-title":"A crucial role of Flagellin in the induction of airway mucus production by Pseudomonas aeruginosa","volume":"7","author":"Ben Mohamed","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1038\/s41385-020-0262-1_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/(SICI)1099-0496(199903)27:3<174::AID-PPUL4>3.0.CO;2-A","article-title":"Pseudomonas aeruginosa alginate is a potent secretagogue in the isolated ferret trachea","volume":"27","author":"Kishioka","year":"1999","journal-title":"Pediatr. Pulmonol."},{"key":"10.1038\/s41385-020-0262-1_bib23","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1172\/JCI111583","article-title":"Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium","volume":"74","author":"Klinger","year":"1984","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-020-0262-1_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2180-7-45","article-title":"Widespread pyocyanin over-production among isolates of a cystic fibrosis epidemic strain","volume":"7","author":"Fothergill","year":"2007","journal-title":"BMC Microbiol."},{"key":"10.1038\/s41385-020-0262-1_bib25","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1128\/iai.56.9.2515-2517.1988","article-title":"Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium","volume":"56","author":"Wilson","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-020-0262-1_bib26","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1165\/rcmb.2012-0088OC","article-title":"Phenazine content in the cystic fibrosis respiratory tract negatively correlates with lung function and microbial complexity","volume":"47","author":"Hunter","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/s41385-020-0262-1_bib27","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1128\/IAI.72.7.4275-4278.2004","article-title":"Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice","volume":"72","author":"Lau","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-020-0262-1_bib28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1164\/ajrccm.149.3.8118638","article-title":"Extracellular metabolites of Pseudomonas aeruginosa produce bronchoconstriction by different mechanisms","volume":"149","author":"Forteza","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1038\/s41385-020-0262-1_bib29","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1152\/jappl.1989.67.1.316","article-title":"Effect of pyocyanin and 1- hydroxyphenazine on in vivo tracheal mucus velocity","volume":"67","author":"Munro","year":"1989","journal-title":"J. Appl Physiol."},{"key":"10.1038\/s41385-020-0262-1_bib30","first-page":"455","article-title":"Effect of Pseudomonas aeruginosa-derived pyocyanin and 1-hydroxyphenazine on pulmonary mucociliary clearance monitored scintigraphically in the baboon model","volume":"18","author":"Dormehl","year":"1991","journal-title":"Nucl. Med Biol."},{"key":"10.1038\/s41385-020-0262-1_bib31","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1242\/dev.00966","article-title":"Foxa2 regulates alveolarization and goblet cell hyperplasia","volume":"131","author":"Wan","year":"2004","journal-title":"Development"},{"key":"10.1038\/s41385-020-0262-1_bib32","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1164\/rccm.200811-1768OC","article-title":"Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma","volume":"180","author":"Park","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1038\/s41385-020-0262-1_bib33","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.4049\/jimmunol.1000223","article-title":"Foxa2 programs Th2 cell mediated innate immunity in the developing lung","volume":"184","author":"Chen","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-020-0262-1_bib34","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1165\/rcmb.2013-0122OC","article-title":"Foxa2 regulates leukotrienes to inhibit Th2-mediated pulmonary inflammation","volume":"49","author":"Tang","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/s41385-020-0262-1_bib35","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.187.6.939","article-title":"Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production","volume":"187","author":"Kuperman","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-020-0262-1_bib36","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1172\/JCI29176","article-title":"SPDEF regulates goblet cell hyperplasia in the airway epithelium","volume":"117","author":"Park","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-020-0262-1_bib37","first-page":"2914","article-title":"SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production","volume":"119","author":"Chen","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-020-0262-1_bib38","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1183\/09031936.02.00001402","article-title":"Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor","volume":"20","author":"Kohri","year":"2002","journal-title":"Eur. Respir. J."},{"key":"10.1038\/s41385-020-0262-1_bib39","doi-asserted-by":"crossref","first-page":"32258","DOI":"10.1074\/jbc.M204862200","article-title":"Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor\/Ras\/Raf\/extracellular signal-regulated kinase cascade and Sp1","volume":"277","author":"Perrais","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1038\/s41385-020-0262-1_bib40","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1165\/rcmb.2006-0180OC","article-title":"IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production","volume":"36","author":"Zhen","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/s41385-020-0262-1_bib41","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/S0140-6736(06)69705-5","article-title":"The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes","volume":"368","author":"Drucker","year":"2006","journal-title":"Lancet"},{"key":"10.1038\/s41385-020-0262-1_bib42","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cellsig.2012.11.009","article-title":"Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic \u03b2-cell impairments in type 2 diabetes","volume":"25","author":"Dalle","year":"2013","journal-title":"Cell Signal."},{"key":"10.1038\/s41385-020-0262-1_bib43","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/jcp.10143","article-title":"Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF-3\u03b2 transcription factors","volume":"192","author":"Zhou","year":"2002","journal-title":"J. Cell Physiol."},{"key":"10.1038\/s41385-020-0262-1_bib44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-4419-5632-3_11","article-title":"Murine model of chronic respiratory inflammation","volume":"780","author":"Lugade","year":"2011","journal-title":"Adv. Exp. Med Biol."},{"key":"10.1038\/s41385-020-0262-1_bib45","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1073\/pnas.1931483100","article-title":"Insulin regulates the activity of forkhead transcription factor HNF-3\u03b2\/Foxa-2 by Akt-mediated phosphorylation and nuclear\/cytosolic localization","volume":"100","author":"Wolfrum","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-020-0262-1_bib46","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.cmet.2013.01.014","article-title":"Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism","volume":"17","author":"von Meyenn","year":"2013","journal-title":"Cell Metab."},{"key":"10.1038\/s41385-020-0262-1_bib47","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1111\/j.1742-4658.2009.07091.x","article-title":"Tumour necrosis factor-\u03b1 attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells","volume":"276","author":"Pandey","year":"2009","journal-title":"FEBS J."},{"key":"10.1038\/s41385-020-0262-1_bib48","doi-asserted-by":"crossref","first-page":"e72528","DOI":"10.1371\/journal.pone.0072528","article-title":"Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT\/MEK-ERK MAP kinase signaling in pulmonary epithelial cells","volume":"8","author":"Xu","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1038\/s41385-020-0262-1_bib49","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1210\/en.2013-1666","article-title":"Glucagon-like peptide-1 (GLP-1) reduces mortality and improves lung function in a model of experimental obstructive lung disease in female mice","volume":"154","author":"Viby","year":"2013","journal-title":"Endocrinology"},{"key":"10.1038\/s41385-020-0262-1_bib50","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1478-3231.2011.02462.x","article-title":"Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis","volume":"31","author":"Svegliati-Baroni","year":"2011","journal-title":"Liver Int."},{"key":"10.1038\/s41385-020-0262-1_bib51","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbrc.2014.07.136","article-title":"The glucagon-like peptide-1 receptor agonist enhances intrinsic peroxisome proliferator-activated receptor-\u03b3 activity in endothelial cells","volume":"451","author":"Onuma","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1038\/s41385-020-0262-1_bib52","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1126\/science.280.5369.1614","article-title":"Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN","volume":"280","author":"Tamura","year":"1998","journal-title":"Science"},{"key":"10.1038\/s41385-020-0262-1_bib53","doi-asserted-by":"crossref","first-page":"8205","DOI":"10.1038\/sj.onc.1206878","article-title":"Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells","volume":"22","author":"Wan","year":"2003","journal-title":"Oncogene"},{"key":"10.1038\/s41385-020-0262-1_bib54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2119\/2003-00001.Wu","article-title":"Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium","volume":"9","author":"Wu","year":"2003","journal-title":"Mol. Med."},{"key":"10.1038\/s41385-020-0262-1_bib55","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ccr.2007.04.021","article-title":"Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN","volume":"11","author":"Vivanco","year":"2007","journal-title":"Cancer Cell."},{"key":"10.1038\/s41385-020-0262-1_bib56","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1073\/pnas.0911188107","article-title":"The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation","volume":"107","author":"Vivanco","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-020-0262-1_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10689","article-title":"PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7","volume":"7","author":"Shinde","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-020-0262-1_bib58","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1074\/jbc.M505266200","article-title":"A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells","volume":"281","author":"Akasaki","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1038\/s41385-020-0262-1_bib59","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1182\/blood-2008-03-148726","article-title":"PTP1B is a negative regulator of interleukin-4-induced STAT6 signaling","volume":"112","author":"Lu","year":"2008","journal-title":"Blood"},{"key":"10.1038\/s41385-020-0262-1_bib60","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/BST0370173","article-title":"Down-regulation of epidermal growth factor receptor signaling within multivesicular bodies","volume":"37","author":"Eden","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.1038\/s41385-020-0262-1_bib61","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/j.bpj.2012.03.037","article-title":"Computational analysis of the regulation of EGFR by protein tyrosine phosphatases","volume":"102","author":"Monast","year":"2012","journal-title":"Biophys. J."},{"key":"10.1038\/s41385-020-0262-1_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/srep26236","article-title":"Structural insight into antibody-mediated antagonism of the glucagon-like peptide-1 receptor","volume":"6","author":"Hennen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-020-0262-1_bib63","doi-asserted-by":"crossref","first-page":"29520","DOI":"10.1074\/jbc.M103721200","article-title":"Insulin stimulates tyrosine phosphorylation and inactivation of protein-tyrosine phosphatase 1B in vivo","volume":"276","author":"Tao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1038\/s41385-020-0262-1_bib64","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1210\/mend.15.10.0711","article-title":"Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor","volume":"15","author":"Ravichandran","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1038\/s41385-020-0262-1_bib65","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1210\/endo.142.5.8128","article-title":"Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate\/protein kinase A-dependent mechanism","volume":"142","author":"Wang","year":"2001","journal-title":"Endocrinology"},{"key":"10.1038\/s41385-020-0262-1_bib66","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1159\/000490167","article-title":"LINC01121 inhibits cell apoptosis while facilitating proliferation, migration, and invasion though negative regulation of the cAMP\/PKA signaling pathway via GLP1R","volume":"47","author":"Qian","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"10.1038\/s41385-020-0262-1_bib67","doi-asserted-by":"crossref","first-page":"L84","DOI":"10.1152\/ajplung.00388.2005","article-title":"Peroxisome proliferator-activated receptor-\u03b3 inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells","volume":"291","author":"Lee","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1038\/s41385-020-0262-1_bib68","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/dom.12824","article-title":"Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: a systematic analysis of published clinical trials","volume":"19","author":"Bettge","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"10.1038\/s41385-020-0262-1_bib69","first-page":"67","article-title":"An updated review on cancer risk associated with incretin mimetics and enhancers","volume":"33","author":"Tseng","year":"2015","journal-title":"J. Environ. Sci. Health C. Environ. Carcinog. Ecotoxicol. Rev."},{"key":"10.1038\/s41385-020-0262-1_bib70","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1517\/14740338.2014.955013","article-title":"Are incretin mimetics and enhancers linked to pancreatitis and malignant transformations in pancreas?","volume":"13","author":"De Heer","year":"2014","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1038\/s41385-020-0262-1_bib71","doi-asserted-by":"crossref","first-page":"E48","DOI":"10.25011\/cim.v39i2.26481","article-title":"Safety and efficacy of dipeptidyl peptidase-4 inhibitors vs sulfonylurea in metformin-based combination therapy for type 2 diabetes mellitus: systematic review and meta-analysis","volume":"39","author":"Foroutan","year":"2016","journal-title":"Clin. Invest Med."},{"key":"10.1038\/s41385-020-0262-1_bib72","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cmet.2006.10.001","article-title":"GLP-1 receptor activation improves \u03b2-cell function and survival following induction of endoplasmic reticulum stress","volume":"4","author":"Yusta","year":"2006","journal-title":"Cell Metab."},{"key":"10.1038\/s41385-020-0262-1_bib73","doi-asserted-by":"crossref","first-page":"e1004946","DOI":"10.1371\/journal.ppat.1004946","article-title":"Virulence factors of Pseudomonas aeruginosa induce both the unfolded protein and integrated stress responses in airway epithelial cells","volume":"11","author":"Van't Wout","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-020-0262-1_bib74","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4014\/jmb.1501.01052","article-title":"15-Hydroxyeicosatetraenoic acid inhibits phorbol-12-myristate-13-Acetate-induced MUC5AC expression in NCI-H292 respiratory epithelial cells","volume":"25","author":"Song","year":"2015","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1038\/s41385-020-0262-1_bib75","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1165\/rcmb.2013-0026OC","article-title":"The glutathione peroxidase-1\u2013protein tyrosine phosphatase- 1B\u2013protein phosphatase 2A Axis. A key determinant of airway inflammation and alveolar destruction","volume":"49","author":"Geraghty","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/s41385-020-0262-1_bib76","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1476-511X-9-50","article-title":"Glutathione deficiency down-regulates hepatic lipogenesis in rats","volume":"9","author":"Brandsch","year":"2010","journal-title":"Lipids Health Dis."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41385-020-0262-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-020-0262-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922003294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922003294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-020-0262-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:11:54Z","timestamp":1761829914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922003294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1933021922003294"],"URL":"https:\/\/doi.org\/10.1038\/s41385-020-0262-1","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPAR\u03b3-FOXA2-phosphatase signaling","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-020-0262-1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}