{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:55:31Z","timestamp":1785552931703,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":210,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1038\/s41385-021-00405-7","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T14:58:39Z","timestamp":1618930719000},"page":"963-972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["DP1 prostanoid receptor activation increases the severity of an acute lower respiratory viral infection in mice via TNF-\u03b1-induced immunopathology"],"prefix":"10.1016","volume":"14","author":[{"given":"Md Ashik","family":"Ullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Rittchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaira Z.","family":"Hasnain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Phipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-021-00405-7_bib1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/jamapediatrics.2015.4276","article-title":"Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013: findings from the global burden of disease 2013 study","volume":"170","author":"Global Burden of Disease Pediatrics Collaboration","year":"2016","journal-title":"JAMA Pediatr."},{"key":"10.1038\/s41385-021-00405-7_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0140-6736(16)30951-5","article-title":"Viral bronchiolitis","volume":"389","author":"Florin","year":"2017","journal-title":"Lancet"},{"key":"10.1038\/s41385-021-00405-7_bib3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/adc.71.5.428","article-title":"Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection","volume":"71","author":"Everard","year":"1994","journal-title":"Arch. Dis. Child."},{"key":"10.1038\/s41385-021-00405-7_bib4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nri2075","article-title":"Innate immunity of the newborn: basic mechanisms and clinical correlates","volume":"7","author":"Levy","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-021-00405-7_bib5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nm.2768","article-title":"Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment","volume":"18","author":"Holt","year":"2012","journal-title":"Nat. Med."},{"key":"10.1038\/s41385-021-00405-7_bib6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fimmu.2017.00156","article-title":"The influence of the microbiome on early-life severe viral lower respiratory infections and asthma-food for thought?","volume":"8","author":"Lynch","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1038\/s41385-021-00405-7_bib7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1542\/peds.2007-2087","article-title":"Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan","volume":"122","author":"Carroll","year":"2008","journal-title":"Pediatrics"},{"key":"10.1038\/s41385-021-00405-7_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3389\/fimmu.2017.00259","article-title":"Type I interferons as regulators of lung inflammation","volume":"8","author":"Makris","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1038\/s41385-021-00405-7_bib9","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/modpathol.3800725","article-title":"The histopathology of fatal untreated human respiratory syncytial virus infection","volume":"20","author":"Johnson","year":"2007","journal-title":"Mod. Pathol."},{"key":"10.1038\/s41385-021-00405-7_bib10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/path.4462","article-title":"Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis","volume":"235","author":"Pickles","year":"2015","journal-title":"J. Pathol."},{"key":"10.1038\/s41385-021-00405-7_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrd2266","article-title":"Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases","volume":"6","author":"Pettipher","year":"2007","journal-title":"Nat. Rev. Drug Disco."},{"key":"10.1038\/s41385-021-00405-7_bib12","doi-asserted-by":"crossref","unstructured":"Rittchen S. & Heinemann, A. Therapeutic potential of hematopoietic prostaglandin D2 synthase in allergic inflammation. Cells8, 619 (2019).","DOI":"10.3390\/cells8060619"},{"key":"10.1038\/s41385-021-00405-7_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJM198407263110401","article-title":"The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men","volume":"311","author":"Hardy","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-021-00405-7_bib14","doi-asserted-by":"crossref","first-page":"e56058","DOI":"10.1371\/journal.pone.0056058","article-title":"Characterising the mechanism of airway smooth muscle \u03b22 adrenoceptor desensitization by rhinovirus infected bronchial epithelial cells","volume":"8","author":"Van Ly","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1038\/s41385-021-00405-7_bib15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1084\/jem.20061196","article-title":"Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells","volume":"204","author":"Hammad","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00405-7_bib16","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s40265-017-0777-2","article-title":"Targeting the PGD2\/CRTH2\/DP1 signaling pathway in asthma and allergic disease: current status and future perspectives","volume":"77","author":"Kupczyk","year":"2017","journal-title":"Drugs"},{"key":"10.1038\/s41385-021-00405-7_bib17","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.jaci.2015.11.012","article-title":"Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung","volume":"137","author":"Jandl","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00405-7_bib18","doi-asserted-by":"crossref","first-page":"E5444","DOI":"10.1073\/pnas.1704099114","article-title":"Virus-induced inflammasome activation is suppressed by prostaglandin D2\/DP1 signaling","volume":"114","author":"Vijay","year":"2017","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-021-00405-7_bib19","doi-asserted-by":"crossref","unstructured":"Werder, R. B. et al. PGD2\/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-lambda production. Sci. Transl. Med.10,\u00a0eaao0052 (2018).","DOI":"10.1126\/scitranslmed.aao0052"},{"key":"10.1038\/s41385-021-00405-7_bib20","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jaci.2016.02.039","article-title":"Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity","volume":"138","author":"Lynch","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00405-7_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-02564-9","article-title":"The absence of interferon-beta promotor stimulator-1 (IPS-1) predisposes to bronchiolitis and asthma-like pathology in response to pneumoviral infection in mice","volume":"7","author":"Simpson","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-021-00405-7_bib22","doi-asserted-by":"crossref","unstructured":"Simpson, J. et al. Respiratory Syncytial Virus infection promotes necroptosis and HMGB1 release by airway epithelial cells. Am. J. Respir. Crit. Care Med.\u00a0201, 1358\u20131371 (2020).","DOI":"10.1164\/rccm.201906-1149OC"},{"key":"10.1038\/s41385-021-00405-7_bib23","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1182\/blood.V92.10.3495","article-title":"Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis","volume":"92","author":"Peters","year":"1998","journal-title":"Blood"},{"key":"10.1038\/s41385-021-00405-7_bib24","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jaci.2015.02.032","article-title":"Allergen-induced IL-6 trans-signaling activates gammadelta T cells to promote type 2 and type 17 airway inflammation","volume":"136","author":"Ullah","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00405-7_bib25","doi-asserted-by":"crossref","first-page":"eaaw0268","DOI":"10.1126\/scitranslmed.aaw0268","article-title":"Immune profiles provide insights into respiratory syncytial virus disease severity in young children","volume":"12","author":"Heinonen","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1038\/s41385-021-00405-7_bib26","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1136\/adc.88.10.922","article-title":"Bronchoalveolar lavage cellularity in infants with severe respiratory syncytial virus bronchiolitis","volume":"88","author":"McNamara","year":"2003","journal-title":"Arch. Dis. Child."},{"key":"10.1038\/s41385-021-00405-7_bib27","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1073\/pnas.1218091110","article-title":"Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement","volume":"110","author":"Murata","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-021-00405-7_bib28","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1089\/vim.2018.0090","article-title":"Prostaglandin D2 levels regulate CD103(+) conventional dendritic cell activation in neonates during respiratory viral infection","volume":"31","author":"Tumala","year":"2018","journal-title":"Viral Immunol."},{"key":"10.1038\/s41385-021-00405-7_bib29","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1172\/JCI59777","article-title":"Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice","volume":"121","author":"Zhao","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-021-00405-7_bib30","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.4049\/jimmunol.172.6.3822","article-title":"Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses","volume":"172","author":"Angeli","year":"2004","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00405-7_bib31","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.chom.2020.04.009","article-title":"Complex immune dysregulation in COVID-19 patients with severe respiratory failure","volume":"27","author":"Giamarellos-Bourboulis","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1038\/s41385-021-00405-7_bib32","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00228-011-1161-x","article-title":"Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases","volume":"68","author":"Zarogoulidis","year":"2012","journal-title":"Eur. J. Clin. Pharm."},{"key":"10.1038\/s41385-021-00405-7_bib33","doi-asserted-by":"crossref","unstructured":"Chua, R. L. et al. COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis. Nat. Biotechnol.\u00a038, 970\u2013979 (2020).","DOI":"10.1038\/s41587-020-0602-4"},{"key":"10.1038\/s41385-021-00405-7_bib34","doi-asserted-by":"crossref","unstructured":"Del Valle, D. M. et al. An inflammatory cytokine signature predicts COVID-19 severity and survival. Nat. Med.26, 1636\u20131643 (2020).","DOI":"10.1038\/s41591-020-1051-9"},{"key":"10.1038\/s41385-021-00405-7_bib35","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"10.1038\/s41385-021-00405-7_bib36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3389\/fimmu.2019.00452","article-title":"Contribution of cytokines to tissue damage during human respiratory syncytial virus infection","volume":"10","author":"Bohmwald","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1038\/s41385-021-00405-7_bib37","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of microorganisms and activation of the immune response","volume":"449","author":"Medzhitov","year":"2007","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00405-7_bib38","doi-asserted-by":"crossref","first-page":"110122","DOI":"10.1016\/j.mehy.2020.110122","article-title":"Prostaglandin D2 as a mediator of lymphopenia and a therapeutic target in COVID-19 disease","volume":"143","author":"Gupta","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1038\/s41385-021-00405-7_bib39","doi-asserted-by":"crossref","unstructured":"Rizk, J. G. et al. Pharmaco-immunomodulatory therapy in COVID-19. Drugs\u00a080, 1267\u20131292 (2020).","DOI":"10.1007\/s40265-020-01367-z"},{"key":"10.1038\/s41385-021-00405-7_bib40","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature13608","article-title":"RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis","volume":"513","author":"Dannappel","year":"2014","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00405-7_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32576-y","article-title":"Respiratory syncytial virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation","volume":"8","author":"Muraro","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-021-00405-7_bib42","doi-asserted-by":"crossref","unstructured":"Sebina, I. & Phipps, S. The contribution of neutrophils to the pathogenesis of RSV bronchiolitis. Viruses12, 808 (2020).","DOI":"10.3390\/v12080808"},{"key":"10.1038\/s41385-021-00405-7_bib43","doi-asserted-by":"crossref","first-page":"e1008651","DOI":"10.1371\/journal.ppat.1008651","article-title":"HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling","volume":"16","author":"Loh","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-021-00405-7_bib44","doi-asserted-by":"crossref","unstructured":"Ullah, M. A. et al. PAG1 limits allergen-induced type 2 inflammation in the murine lung. Allergy\u00a075, 336\u2013345 (2020).","DOI":"10.1111\/all.13991"},{"key":"10.1038\/s41385-021-00405-7_bib45","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1007\/s10753-014-9873-6","article-title":"Protective effect of curcumin on acute airway inflammation of allergic asthma in mice through Notch1-GATA3 signaling pathway","volume":"37","author":"Chong","year":"2014","journal-title":"Inflammation"},{"key":"10.1038\/s41385-021-00405-7_bib46","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1084\/jem.20170298","article-title":"Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion","volume":"215","author":"Lynch","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00405-7_bib47","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.ajpath.2014.02.026","article-title":"IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice","volume":"184","author":"Spann","year":"2014","journal-title":"Am. J. Pathol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41385-021-00405-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-021-00405-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922001933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922001933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41385-021-00405-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:10:40Z","timestamp":1761829840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922001933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1933021922001933"],"URL":"https:\/\/doi.org\/10.1038\/s41385-021-00405-7","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DP1 prostanoid receptor activation increases the severity of an acute lower respiratory viral infection in mice via TNF-\u03b1-induced immunopathology","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-021-00405-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}