{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:31:36Z","timestamp":1790515896814,"version":"4.1.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1038\/s41385-021-00410-w","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T03:06:35Z","timestamp":1622171195000},"page":"1144-1159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa"],"prefix":"10.1016","volume":"14","author":[{"given":"Alessia","family":"Corrado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Ramonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Woodruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Tipton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"DelGaudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merin E.","family":"Kuruvilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly R.","family":"Magliocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"Garimalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Scharer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Boss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Gumber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Fucile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-5942","authenticated-orcid":false,"given":"F. Eun-Hyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-021-00410-w_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jaci.2011.10.029","article-title":"The who, where, and when of IgE in allergic airway disease","volume":"129","author":"Dullaers","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib2","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/j.1365-2222.2012.04030.x","article-title":"The majority of allergen-specific IgE in the blood of allergic patients does not originate from blood-derived B cells or plasma cells","volume":"42","author":"Eckl-Dorna","year":"2012","journal-title":"Clin. Exp. Allergy"},{"key":"10.1038\/s41385-021-00410-w_bib3","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nri1886","article-title":"Competence and competition: the challenge of becoming a long-lived plasma cell","volume":"6","author":"Radbruch","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib4","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3389\/fimmu.2017.01277","article-title":"B cell intrinsic mechanisms constraining IgE memory","volume":"8","author":"Laffleur","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib5","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.4049\/jimmunol.178.10.6200","article-title":"Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection","volume":"178","author":"Cunningham","year":"2007","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.immuni.2015.06.013","article-title":"Salmonella infection drives promiscuous B cell activation followed by extrafollicular affinity maturation","volume":"43","author":"Di Niro","year":"2015","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00410-w_bib7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1128\/IAI.02471-14","article-title":"CD4+ T cells promote antibody production but not sustained affinity maturation during Borrelia burgdorferi infection","volume":"83","author":"Elsner","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-021-00410-w_bib8","doi-asserted-by":"crossref","first-page":"e1004976","DOI":"10.1371\/journal.ppat.1004976","article-title":"Suppression of long-lived humoral immunity following Borrelia burgdorferi infection","volume":"11","author":"Elsner","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-021-00410-w_bib9","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1016\/j.celrep.2019.10.069","article-title":"IL-12 blocks Tfh cell differentiation during Salmonella infection, thereby contributing to germinal center suppression","volume":"29","author":"Elsner","year":"2019","journal-title":"Cell Rep."},{"key":"10.1038\/s41385-021-00410-w_bib10","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.4049\/jimmunol.1103735","article-title":"Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection","volume":"188","author":"Hastey","year":"2012","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib11","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1111\/j.1476-5381.1996.tb15332.x","article-title":"In vitro pharmacological profile of YM-43611, a novel D2-like receptor antagonist with high affinity and selectivity for dopamine D3 and D4 receptors","volume":"117","author":"Hidaka","year":"1996","journal-title":"Br. J. Pharm."},{"key":"10.1038\/s41385-021-00410-w_bib12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/eji.201444540","article-title":"Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development","volume":"45","author":"Nanton","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib13","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.4049\/jimmunol.1900484","article-title":"TNF-alpha contributes to lymphoid tissue disorganization and germinal center B cell suppression during intracellular bacterial infection","volume":"203","author":"Popescu","year":"2019","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib14","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.4049\/jimmunol.0902710","article-title":"Impaired germinal center responses and suppression of local IgG production during intracellular bacterial infection","volume":"184","author":"Racine","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1034\/j.1600-065X.2003.00058.x","article-title":"Extrafollicular antibody responses","volume":"194","author":"MacLennan","year":"2003","journal-title":"Immunological Rev."},{"key":"10.1038\/s41385-021-00410-w_bib16","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.immuni.2018.08.015","article-title":"Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus","volume":"49","author":"Jenks","year":"2018","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00410-w_bib17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/imr.12741","article-title":"Extrafollicular responses in humans and SLE","volume":"288","author":"Jenks","year":"2019","journal-title":"Immunol. Rev."},{"key":"10.1038\/s41385-021-00410-w_bib18","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ni.3175","article-title":"Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus","volume":"16","author":"Tipton","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib19","doi-asserted-by":"crossref","unstructured":"Woodruff, M. C. et al. Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19. Nat. Immunol.https:\/\/doi.org\/10.1038\/s41590-020-00814-z (2020).","DOI":"10.1038\/s41590-020-00814-z"},{"key":"10.1038\/s41385-021-00410-w_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-065X.2012.01124.x","article-title":"Germinal center selection and the development of memory B and plasma cells","volume":"247","author":"Shlomchik","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1038\/s41385-021-00410-w_bib21","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.20012065","article-title":"Visualization of the genesis and fate of isotype-switched B cells during a primary immune response","volume":"197","author":"Pape","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00410-w_bib22","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.4049\/jimmunol.0901690","article-title":"Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts","volume":"183","author":"Chan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.immuni.2019.07.001","article-title":"Class-switch recombination occurs infrequently in germinal centers","volume":"51","author":"Roco","year":"2019","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00410-w_bib24","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/382462a0","article-title":"Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice","volume":"382","author":"Matsumoto","year":"1996","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00410-w_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ni.2256","article-title":"IgE(+) memory B cells and plasma cells generated through a germinal-center pathway","volume":"13","author":"Talay","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib26","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.immuni.2012.02.009","article-title":"Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition","volume":"36","author":"Yang","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00410-w_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.immuni.2006.12.006","article-title":"Unique maturation program of the IgE response in vivo","volume":"26","author":"Erazo","year":"2007","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00410-w_bib28","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1084\/jem.20131539","article-title":"The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response","volume":"210","author":"He","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00410-w_bib29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1084\/jem.20111941","article-title":"Sequential class switching is required for the generation of high affinity IgE antibodies","volume":"209","author":"Xiong","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00410-w_bib30","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jaci.2015.07.014","article-title":"Human B-cell isotype switching origins of IgE","volume":"137","author":"Looney","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/all.12054","article-title":"Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps","volume":"68","author":"Gevaert","year":"2013","journal-title":"Allergy"},{"key":"10.1038\/s41385-021-00410-w_bib32","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.4049\/jimmunol.174.8.5024","article-title":"Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis","volume":"174","author":"Takhar","year":"2005","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib33","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.4049\/jimmunol.171.7.3816","article-title":"S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination","volume":"171","author":"Cameron","year":"2003","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib34","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1172\/JCI27628","article-title":"Mature B cells class switched to IgD are autoreactive in healthy individuals","volume":"117","author":"Koelsch","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1038\/s41385-021-00410-w_bib35","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1016\/j.vaccine.2010.02.088","article-title":"Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization","volume":"28","author":"Halliley","year":"2010","journal-title":"Vaccine"},{"key":"10.1038\/s41385-021-00410-w_bib36","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.4049\/jimmunol.1002932","article-title":"Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect","volume":"186","author":"Lee","year":"2011","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1398-9995.2011.02628.x","article-title":"The role of IgG antibodies in allergy and immunotherapy","volume":"95","author":"Aalberse","year":"2011","journal-title":"Allergy"},{"key":"10.1038\/s41385-021-00410-w_bib38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0385-8146(99)00038-3","article-title":"Inflammatory cells in nasal mucosa and nasal polyps","volume":"27","author":"Morinaka","year":"2000","journal-title":"Auris Nasus Larynx"},{"key":"10.1038\/s41385-021-00410-w_bib39","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.jaci.2009.10.038","article-title":"Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome","volume":"124","author":"Engelhardt","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib40","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.1077002","article-title":"A critical role for IL-21 in regulating immunoglobulin production","volume":"298","author":"Ozaki","year":"2002","journal-title":"Science"},{"key":"10.1038\/s41385-021-00410-w_bib41","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1182\/blood-2002-04-1115","article-title":"Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells","volume":"100","author":"Suto","year":"2002","journal-title":"Blood"},{"key":"10.1038\/s41385-021-00410-w_bib42","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.4049\/jimmunol.1103302","article-title":"p110delta phosphoinositide 3-kinase represses IgE switch by potentiating BCL6 expression","volume":"188","author":"Zhang","year":"2012","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib43","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1136\/thorax.55.suppl_2.S79","article-title":"Nasal polyposis, eosinophil dominated inflammation, and allergy","volume":"55","author":"Mygind","year":"2000","journal-title":"Thorax"},{"key":"10.1038\/s41385-021-00410-w_bib44","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/cea.12878","article-title":"Chronic airway inflammation provides a unique environment for B cell activation and antibody production","volume":"47","author":"Feldman","year":"2017","journal-title":"Clin. Exp. Allergy"},{"key":"10.1038\/s41385-021-00410-w_bib45","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.immuni.2015.06.016","article-title":"Long-lived plasma cells are contained within the CD19(-)CD38(hi)CD138(+) subset in human bone marrow","volume":"43","author":"Halliley","year":"2015","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00410-w_bib46","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1084\/jem.194.3.365","article-title":"Quantitative regulation of class switch recombination by switch region transcription","volume":"194","author":"Lee","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00410-w_bib47","first-page":"127","article-title":"Molecular processes that regulate class switching","volume":"245","author":"Stavnezer","year":"2000","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib48","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.4049\/jimmunol.155.6.3021","article-title":"Human Ig S gamma regions and their participation in sequential switching to IgE","volume":"155","author":"Mills","year":"1995","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib49","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.4049\/jimmunol.151.9.4528","article-title":"Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL-4 and hydrocortisone","volume":"151","author":"Jabara","year":"1993","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib50","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41590-019-0419-9","article-title":"Epigenetic programming underpins B cell dysfunction in human SLE","volume":"20","author":"Scharer","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib51","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3109\/10428194.2013.802782","article-title":"Plasma cell CD20 expression: primary aberrant expression or receptor up-regulation","volume":"55","author":"Ajaz","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"10.1038\/s41385-021-00410-w_bib52","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.jaci.2017.05.032","article-title":"Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis","volume":"140","author":"min","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib53","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.4049\/jimmunol.169.7.3526","article-title":"Expression of human complement receptor type 2 (CD21) in mice during early B cell development results in a reduction in mature B cells and hypogammaglobulinemia","volume":"169","author":"Marchbank","year":"2002","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib54","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s00018-002-8455-1","article-title":"CD23 (the low-affinity IgE receptor) as a C-type lectin: a multidomain and multifunctional molecule","volume":"59","author":"Kijimoto-Ochiai","year":"2002","journal-title":"Cell. Mol. life Sci."},{"key":"10.1038\/s41385-021-00410-w_bib55","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/ni1357","article-title":"Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination","volume":"7","author":"Klein","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.imlet.2010.09.021","article-title":"Expression of SLAM (CD150) cell-surface receptors on human B-cell subsets: from pro-B to plasma cells","volume":"134","author":"De Salort","year":"2011","journal-title":"Immunol. Lett."},{"key":"10.1038\/s41385-021-00410-w_bib57","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4049\/jimmunol.190.Supp.174.9","article-title":"Nr4a1 (Nur77) regulates B cell survival and activation. (P1453)","volume":"190","author":"Park","year":"2013","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib58","doi-asserted-by":"crossref","first-page":"657","DOI":"10.4049\/jimmunol.1601301","article-title":"Endogenous Nur77 is a specific indicator of antigen receptor signaling in human T and B cells","volume":"198","author":"Ashouri","year":"2017","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib59","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.3389\/fimmu.2019.02458","article-title":"Challenges and opportunities for consistent classification of human B Cell and plasma cell populations","volume":"10","author":"Sanz","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib60","doi-asserted-by":"crossref","unstructured":"Zumaquero, E. et al. IFNgamma induces epigenetic programming of human T-bet(hi) B cells and promotes TLR7\/8 and IL-21 induced differentiation. Elife8https:\/\/doi.org\/10.7554\/eLife.41641 (2019).","DOI":"10.7554\/eLife.41641"},{"key":"10.1038\/s41385-021-00410-w_bib61","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1126\/science.1073924","article-title":"Evolution of autoantibody responses via somatic hypermutation outside of germinal centers","volume":"297","author":"William","year":"2002","journal-title":"Science"},{"key":"10.1038\/s41385-021-00410-w_bib62","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41590-019-0398-x","article-title":"The immune cell landscape in kidneys of patients with lupus nephritis","volume":"20","author":"Arazi","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib63","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1748","article-title":"Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils","volume":"10","author":"Chen","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib64","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.immuni.2018.08.013","article-title":"Secreted IgD amplifies humoral T helper 2 cell responses by binding basophils via Galectin-9 and CD44","volume":"49","author":"Shan","year":"2018","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00410-w_bib65","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.molimm.2008.07.032","article-title":"A model for the development of human IgD-only B cells: Genotypic analyses suggest their generation in superantigen driven immune responses","volume":"46","author":"Seifert","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib66","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.3389\/fimmu.2018.01976","article-title":"Local clonal diversification and dissemination of B lymphocytes in the human bronchial mucosa","volume":"9","author":"Ohm-Laursen","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib67","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80439-2","article-title":"Stat6 is required for mediating responses to IL-4 and for development of Th2 cells","volume":"4","author":"Kaplan","year":"1996","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00410-w_bib68","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/380630a0","article-title":"Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene","volume":"380","author":"Shimoda","year":"1996","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00410-w_bib69","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.1073\/pnas.85.21.8221","article-title":"Up-regulation of interleukin 4\/B-cell stimulatory factor 1 receptor expression","volume":"85","author":"Ohara","year":"1988","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-021-00410-w_bib70","doi-asserted-by":"crossref","first-page":"615","DOI":"10.4049\/jimmunol.0902408","article-title":"Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo","volume":"184","author":"Perona-Wright","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib71","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1056\/NEJMoa1403291","article-title":"Glucocorticoids and mepolizumab in eosinophilic asthma","volume":"371","author":"Bel","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-021-00410-w_bib72","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJMoa1403291","article-title":"Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma","volume":"371","author":"Bel","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-021-00410-w_bib73","first-page":"1205","article-title":"Glucocorticoid sparing of benralizumab in asthma","volume":"377","author":"Nair","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-021-00410-w_bib74","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1056\/NEJMoa1703501","article-title":"Oral Glucocorticoid-sparing effect of benralizumab in severe asthma","volume":"376","author":"Nair","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-021-00410-w_bib75","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/S0140-6736(16)31322-8","article-title":"Benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial","volume":"388","author":"FitzGerald","year":"2016","journal-title":"Lancet"},{"key":"10.1038\/s41385-021-00410-w_bib76","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1056\/NEJMoa1804093","article-title":"Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma","volume":"378","author":"Rabe","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-021-00410-w_bib77","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1056\/NEJMoa1804092","article-title":"Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma","volume":"378","author":"Castro","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-021-00410-w_bib78","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa1610020","article-title":"Two phase 3 trials of dupilumab versus placebo in atopic dermatitis","volume":"375","author":"Simpson","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-021-00410-w_bib79","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1056\/NEJMoa1314768","article-title":"Dupilumab treatment in adults with moderate-to-severe atopic dermatitis","volume":"371","author":"Beck","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-021-00410-w_bib80","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jim.2008.09.025","article-title":"Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells","volume":"340","author":"Kyu","year":"2009","journal-title":"J. Immunol. Methods"},{"key":"10.1038\/s41385-021-00410-w_bib81","doi-asserted-by":"crossref","unstructured":"Lee, F. E. et al. Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect. J. Immunol.https:\/\/doi.org\/10.4049\/jimmunol.1002932 (2011).","DOI":"10.4049\/jimmunol.1002932"},{"key":"10.1038\/s41385-021-00410-w_bib82","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1073\/pnas.82.2.511","article-title":"B cells that simultaneously express surface IgM and IgE in Nippostrongylus brasiliensis-infected SJA\/9 mice do not provide evidence for isotype switching without gene deletion","volume":"82","author":"Katona","year":"1985","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-021-00410-w_bib83","doi-asserted-by":"crossref","first-page":"350","DOI":"10.4049\/jimmunol.130.1.350","article-title":"Induction of an IgE response in mice by Nippostrongylus brasiliensis: characterization of lymphoid cells with intracytoplasmic or surface IgE","volume":"130","author":"Katona","year":"1983","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00410-w_bib84","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.etp.2014.07.004","article-title":"Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine","volume":"66","author":"Gumber","year":"2014","journal-title":"Exp. Toxicol. Pathol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00410-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00410-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922002094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922002094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00410-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:08:21Z","timestamp":1761829701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922002094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":84,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1933021922002094"],"URL":"https:\/\/doi.org\/10.1038\/s41385-021-00410-w","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-021-00410-w","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}