{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:54:07Z","timestamp":1793354047191,"version":"4.5.0"},"reference-count":142,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":87,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1038\/s41385-021-00420-8","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T07:02:46Z","timestamp":1625122966000},"page":"1259-1270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Intestinal immune compartmentalization: implications of tissue specific determinants in health and disease"],"prefix":"10.1016","volume":"14","author":[{"given":"Hailey","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2427-9873","authenticated-orcid":false,"given":"Daria","family":"Esterh\u00e1zy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-021-00420-8_bib1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nri3738","article-title":"Regional specialization within the intestinal immune system","volume":"14","author":"Mowat","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib2","doi-asserted-by":"crossref","unstructured":"Agace, W. W. & McCoy, K. D. (2017). Regionalized development and maintenance of the intestinal adaptive immune landscape. Immunity. 46, 532\u2013548, https:\/\/doi.org\/10.1016\/j.immuni.2017.04.004","DOI":"10.1016\/j.immuni.2017.04.004"},{"key":"10.1038\/s41385-021-00420-8_bib3","doi-asserted-by":"crossref","unstructured":"Sujino, T., et al (2016). Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation. Science. https:\/\/doi.org\/10.1126\/science.aaf3892","DOI":"10.1126\/science.aaf3892"},{"key":"10.1038\/s41385-021-00420-8_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"10.1038\/s41385-021-00420-8_bib5","doi-asserted-by":"crossref","unstructured":"Hapfelmeier, S., et al (2010). Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science. https:\/\/doi.org\/10.1126\/science.1188454","DOI":"10.1126\/science.1188454"},{"key":"10.1038\/s41385-021-00420-8_bib6","doi-asserted-by":"crossref","unstructured":"Cerovic, V., et al (2013). Intestinal CD103- dendritic cells migrate in lymph and prime effector T cells. Mucosal Immunology. https:\/\/doi.org\/10.1038\/mi.2012.53","DOI":"10.1038\/mi.2012.53"},{"key":"10.1038\/s41385-021-00420-8_bib7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ni.3408","article-title":"Classical dendritic cells are required for dietary antigen\u2013mediated induction of peripheral Treg cells and tolerance","volume":"17","author":"Esterh\u00e1zy","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib8","first-page":"354","article-title":"Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific","volume":"163","author":"Fonseca","year":"2015","journal-title":"Immun. Cell"},{"key":"10.1038\/s41385-021-00420-8_bib9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.immuni.2015.08.007","article-title":"Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A","volume":"43","author":"Bunker","year":"2015","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00420-8_bib10","doi-asserted-by":"crossref","unstructured":"Reynoso-Paz, S., et al (1999). The immunobiology of bile and biliary epithelium. Hepatology. https:\/\/doi.org\/10.1002\/hep.510300218","DOI":"10.1002\/hep.510300218"},{"key":"10.1038\/s41385-021-00420-8_bib11","first-page":"1","article-title":"Gut biogeography of the bacterial microbiota","volume":"14","author":"Donaldson","year":"2015","journal-title":"Nat. Publ. Group"},{"key":"10.1038\/s41385-021-00420-8_bib12","doi-asserted-by":"crossref","unstructured":"Saffouri, G. B., et al (2019). Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders. Nat. Commun. 10, 2012. https:\/\/doi.org\/10.1038\/s41467-019-09964-7","DOI":"10.1038\/s41467-019-09964-7"},{"key":"10.1038\/s41385-021-00420-8_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41586-020-2193-0","article-title":"Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells","volume":"581","author":"Campbell","year":"2020","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00420-8_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41564-019-0602-7","article-title":"The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon","volume":"5","author":"Grau","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1038\/s41385-021-00420-8_bib15","doi-asserted-by":"crossref","unstructured":"Hang, S., et al (2020). Bile acid metabolites control TH17 and Treg cell differentiation. Nature, 1\u201325. https:\/\/doi.org\/10.1038\/s41586-019-1785-z","DOI":"10.1038\/s41586-020-2030-5"},{"key":"10.1038\/s41385-021-00420-8_bib16","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nrgastro.2017.79","article-title":"Intestinal lymphatic vasculature: structure, mechanisms and functions","volume":"14","author":"Bernier-Latmani","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1038\/s41385-021-00420-8_bib17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1194\/jlr.M800156-JLR200","article-title":"Chylomicrons promote intestinal absorption of lipopolysaccharides","volume":"50","author":"Ghoshal","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1038\/s41385-021-00420-8_bib18","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.immuni.2018.07.016","article-title":"A map of toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns","volume":"49","author":"Price","year":"2018","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00420-8_bib19","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.4049\/jimmunol.0802318","article-title":"Hyporesponsiveness of intestinal dendritic cells to TLR stimulation is limited to TLR4","volume":"182","author":"Cerovic","year":"2009","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41586-019-1125-3","article-title":"Compartmentalized gut lymph node drainage dictates adaptive immune responses","volume":"569","author":"Esterh\u00e1zy","year":"2019","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00420-8_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.foodchem.2014.09.021","article-title":"Fat-soluble vitamin intestinal absorption: absorption sites in the intestine and interactions for absorption","volume":"172","author":"Goncalves","year":"2015","journal-title":"Food Chem."},{"key":"10.1038\/s41385-021-00420-8_bib22","unstructured":"Jaensson-Gyllenb\u00e4ck, E., et al (2019). Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells. Mucosal Immunol., 1\u201310. about:client"},{"key":"10.1038\/s41385-021-00420-8_bib23","doi-asserted-by":"crossref","unstructured":"Hou, J., et al (2014). A regulatory network controls nephrocan expression and midgut patterning. Development (Cambridge). https:\/\/doi.org\/10.1242\/dev.108274","DOI":"10.1242\/dev.108274"},{"key":"10.1038\/s41385-021-00420-8_bib24","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.immuni.2019.09.020","article-title":"Western diet and the immune system: an inflammatory connection","volume":"51","author":"Christ","year":"2019","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00420-8_bib25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2011.09.025","article-title":"Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation","volume":"147","author":"Li","year":"2011","journal-title":"Cell"},{"key":"10.1038\/s41385-021-00420-8_bib26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature21080","article-title":"Feedback control of AHR signalling regulates intestinal immunity","volume":"542","author":"Schiering","year":"2017","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00420-8_bib27","doi-asserted-by":"crossref","unstructured":"Subramanian, S., et al (2014). Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature. https:\/\/doi.org\/10.1038\/nature13421","DOI":"10.1038\/nature13421"},{"key":"10.1038\/s41385-021-00420-8_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53997-3","article-title":"Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract","volume":"9","author":"Sch\u00fctz","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-021-00420-8_bib29","doi-asserted-by":"crossref","unstructured":"Schneider, C., et al (2018). A metabolite-triggered tuft Cell-ILC2 circuit drives small intestinal remodeling. Cell 174. https:\/\/doi.org\/10.1016\/j.cell.2018.05.014","DOI":"10.1016\/j.cell.2018.05.014"},{"key":"10.1038\/s41385-021-00420-8_bib30","doi-asserted-by":"crossref","unstructured":"Chu, D. K., et al (2014). Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. J. Exp. Med.https:\/\/doi.org\/10.1084\/jem.20131800","DOI":"10.1084\/jem.20131800"},{"key":"10.1038\/s41385-021-00420-8_bib31","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Saiz, R., et al (2020). Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity. Front. Immunol. https:\/\/doi.org\/10.3389\/fimmu.2020.00155","DOI":"10.3389\/fimmu.2020.00155"},{"key":"10.1038\/s41385-021-00420-8_bib32","unstructured":"Marshall, J. S., Wells, P. D. & Bell, E. B. Accelerated elimination of N. brasiliensis from the small intestine after auto-anti-IgE induction. Immunology. 60, 303\u2013308 (1987)."},{"key":"10.1038\/s41385-021-00420-8_bib33","doi-asserted-by":"crossref","unstructured":"Yazdani, R., Azizi, G., Abolhassani, H., & Aghamohammadi, A. (2017). Selective IgA deficiency: epidemiology, pathogenesis, clinical phenotype, diagnosis, prognosis and management. In Scand. J. Immunol. https:\/\/doi.org\/10.1111\/sji.12499","DOI":"10.1111\/sji.12499"},{"key":"10.1038\/s41385-021-00420-8_bib34","doi-asserted-by":"crossref","unstructured":"Zinneman, H. H., & Kaplan, A. P. (1972). The association of giardiasis with reduced intestinal secretory immunoglobulin A. Am. J. Digest. Dis. https:\/\/doi.org\/10.1007\/BF02231148","DOI":"10.1007\/BF02231148"},{"key":"10.1038\/s41385-021-00420-8_bib35","doi-asserted-by":"crossref","unstructured":"Zhu, S., et al (2017). Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. https:\/\/doi.org\/10.1038\/nature22967","DOI":"10.1038\/nature22967"},{"key":"10.1038\/s41385-021-00420-8_bib36","doi-asserted-by":"crossref","unstructured":"Troeger, H., et al (2009). Structural and functional changes of the duodenum in human norovirus infection. Gut. https:\/\/doi.org\/10.1136\/gut.2008.160150","DOI":"10.1136\/gut.2008.160150"},{"key":"10.1038\/s41385-021-00420-8_bib37","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1126\/science.aar3799","article-title":"Tropism for tuft cells determines immune promotion of norovirus pathogenesis","volume":"360","author":"Wilen","year":"2018","journal-title":"Science"},{"key":"10.1038\/s41385-021-00420-8_bib38","doi-asserted-by":"crossref","unstructured":"Karst, S. M., & Wobus, C. E. (2015). A Working Model of How Noroviruses Infect the Intestine. PLoS Pathogens. https:\/\/doi.org\/10.1371\/journal.ppat.1004626","DOI":"10.1371\/journal.ppat.1004626"},{"key":"10.1038\/s41385-021-00420-8_bib39","doi-asserted-by":"crossref","unstructured":"Bouziat, R., et al (2017). Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science 356.","DOI":"10.1126\/science.aah5298"},{"key":"10.1038\/s41385-021-00420-8_bib40","doi-asserted-by":"crossref","unstructured":"Catassi, C., Bonucci, A., Coppa, G. V., Carlucci, A., & Giorgi, P. L. (1995). Intestinal permeability changes during the first month: Effect of natural versus artificial feeding. J. Pediatric Gastroenterol. Nutr. https:\/\/doi.org\/10.1097\/00005176-199511000-00003","DOI":"10.1002\/j.1536-4801.1995.tb11955.x"},{"key":"10.1038\/s41385-021-00420-8_bib41","doi-asserted-by":"crossref","unstructured":"Ponziani, F. R., Gerardi, V., & Gasbarrini, A. (2016). Diagnosis and treatment of small intestinal bacterial overgrowth. Expert Rev. Gastroenterol. Hepatol. https:\/\/doi.org\/10.1586\/17474124.2016.1110017","DOI":"10.1586\/17474124.2016.1110017"},{"key":"10.1038\/s41385-021-00420-8_bib42","doi-asserted-by":"crossref","unstructured":"Erdogan, A., & Rao, S. S. C. (2015). Small intestinal fungal overgrowth. In Current Gastroenterology Reports. https:\/\/doi.org\/10.1007\/s11894-015-0436-2","DOI":"10.1007\/s11894-015-0436-2"},{"key":"10.1038\/s41385-021-00420-8_bib43","doi-asserted-by":"crossref","unstructured":"Brown, I. S., Bettington, A., Bettington, M., & Rosty, C. (2014). Tropical sprue: Revisiting an underrecognized disease. Am. J. Surg. Pathol. https:\/\/doi.org\/10.1097\/PAS.0000000000000153","DOI":"10.1097\/PAS.0000000000000153"},{"key":"10.1038\/s41385-021-00420-8_bib44","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.aac5560","article-title":"Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine","volume":"351","author":"Kim","year":"2016","journal-title":"Science"},{"key":"10.1038\/s41385-021-00420-8_bib45","doi-asserted-by":"crossref","unstructured":"Tordesillas, L., et al (2014). Skin exposure promotes a Th2-dependent sensitization to peanut allergens. Journal of Clinical Investigation 124. https:\/\/doi.org\/10.1172\/JCI75660","DOI":"10.1172\/JCI75660"},{"key":"10.1038\/s41385-021-00420-8_bib46","doi-asserted-by":"crossref","unstructured":"Sollid, L. M. (2000). Molecular basis of celiac disease. Ann. Rev. Immunol. https:\/\/doi.org\/10.1146\/annurev.immunol.18.1.53","DOI":"10.1146\/annurev.immunol.18.1.53"},{"key":"10.1038\/s41385-021-00420-8_bib47","doi-asserted-by":"crossref","unstructured":"Bl\u00e1zquez, A. B., & Berin, M. C. (2017). Microbiome and food allergy. In Transl. Res. https:\/\/doi.org\/10.1016\/j.trsl.2016.09.003","DOI":"10.1016\/j.trsl.2016.09.003"},{"key":"10.1038\/s41385-021-00420-8_bib48","doi-asserted-by":"crossref","unstructured":"Caminero, A., Meisel, M., Jabri, B., & Verdu, E. F. (2019). Mechanisms by which gut microorganisms influence food sensitivities. Nat. Rev. Gastroenterol. Hepatol. https:\/\/doi.org\/10.1038\/s41575-018-0064-z","DOI":"10.1038\/s41575-018-0064-z"},{"key":"10.1038\/s41385-021-00420-8_bib49","doi-asserted-by":"crossref","DOI":"10.1186\/1471-230X-13-113","article-title":"Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease","volume":"13","author":"Cheng","year":"2013","journal-title":"BMC Gastroenterol."},{"key":"10.1038\/s41385-021-00420-8_bib50","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.chom.2018.10.004","article-title":"Murine norovirus infection induces TH1 inflammatory responses to dietary antigens","volume":"24","author":"Bouziat","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1038\/s41385-021-00420-8_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nature10863","article-title":"Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine","volume":"483","author":"McDole","year":"2012","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00420-8_bib52","doi-asserted-by":"crossref","unstructured":"Rios, D., et al (2016). Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. https:\/\/doi.org\/10.1038\/mi.2015.121","DOI":"10.1038\/mi.2015.121"},{"key":"10.1038\/s41385-021-00420-8_bib53","doi-asserted-by":"crossref","unstructured":"Kulkarni, D. H., et al (2018). Goblet cell associated antigen passages are inhibited during Salmonella typhimurium infection to prevent pathogen dissemination and limit responses to dietary antigens. Mucosal Immunol., 1\u201311. https:\/\/doi.org\/10.1038\/s41385-018-0007-6","DOI":"10.1038\/s41385-018-0007-6"},{"key":"10.1038\/s41385-021-00420-8_bib54","doi-asserted-by":"crossref","unstructured":"Houten, S. M., Volle, D. H., Cummins, C. L., Mangelsdorf, D. J., & Auwerx, J. (2007). In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. Mol. Endocrinol. https:\/\/doi.org\/10.1210\/me.2007-0113","DOI":"10.1210\/me.2007-0113"},{"key":"10.1038\/s41385-021-00420-8_bib55","doi-asserted-by":"crossref","unstructured":"Inagaki, T., et al (2006). Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc. Natl. Acad. Sci. USA. https:\/\/doi.org\/10.1073\/pnas.0509592103","DOI":"10.1073\/pnas.0509592103"},{"key":"10.1038\/s41385-021-00420-8_bib56","doi-asserted-by":"crossref","first-page":"eaat4042","DOI":"10.1126\/science.aat4042","article-title":"Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis","volume":"363","author":"Ladinsky","year":"2019","journal-title":"Science"},{"key":"10.1038\/s41385-021-00420-8_bib57","doi-asserted-by":"crossref","first-page":"E8141","DOI":"10.1073\/pnas.1617460113","article-title":"Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice","volume":"113","author":"Tan","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1038\/s41385-021-00420-8_bib58","first-page":"1","article-title":"Th17 cell induction by adhesion of microbes to intestinal epithelial cells","volume":"163","author":"Atarashi","year":"2016","journal-title":"Cell"},{"key":"10.1038\/s41385-021-00420-8_bib59","doi-asserted-by":"crossref","unstructured":"Eken, A., Singh, A. K., Treuting, P. M., & Oukka, M. (2014). IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism. Mucosal Immunol. 7. https:\/\/doi.org\/10.1038\/mi.2013.33","DOI":"10.1038\/mi.2013.33"},{"key":"10.1038\/s41385-021-00420-8_bib60","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2015.08.061","article-title":"An IL-23R\/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses","volume":"163","author":"Sano","year":"2015","journal-title":"Cell"},{"key":"10.1038\/s41385-021-00420-8_bib61","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.180.1.15","article-title":"Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches","volume":"180","author":"Jones","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00420-8_bib62","doi-asserted-by":"crossref","unstructured":"Lala, S., et al (2003). Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology. https:\/\/doi.org\/10.1016\/S0016-5085(03)00661-9","DOI":"10.1016\/S0016-5085(03)00661-9"},{"key":"10.1038\/s41385-021-00420-8_bib63","doi-asserted-by":"crossref","unstructured":"Ahmad, T., et al (2002). The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology. https:\/\/doi.org\/10.1053\/gast.2002.32413","DOI":"10.1053\/gast.2002.32413"},{"key":"10.1038\/s41385-021-00420-8_bib64","doi-asserted-by":"crossref","unstructured":"Cadwell, K., et al (2008). A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. https:\/\/doi.org\/10.1038\/nature07416","DOI":"10.1038\/nature07416"},{"key":"10.1038\/s41385-021-00420-8_bib65","doi-asserted-by":"crossref","first-page":"eaao1314","DOI":"10.1126\/sciimmunol.aao1314","article-title":"Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria","volume":"2","author":"Knoop","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib66","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of colonic regulatory T cells by indigenous Clostridium species","volume":"331","author":"Atarashi","year":"2011","journal-title":"Science"},{"key":"10.1038\/s41385-021-00420-8_bib67","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1126\/science.aaa9420","article-title":"Individual intestinal symbionts induce a distinct population of ROR\u03b3+ regulatory T cells","volume":"349","author":"Sefik","year":"2015","journal-title":"Science"},{"key":"10.1038\/s41385-021-00420-8_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.aac4263","article-title":"The microbiota regulates type 2 immunity through ROR\u03b3t+ T cells","volume":"349","author":"Ohnmacht","year":"2015","journal-title":"Science"},{"key":"10.1038\/s41385-021-00420-8_bib69","doi-asserted-by":"crossref","first-page":"12204 LP","DOI":"10.1073\/pnas.0909122107","article-title":"Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota","volume":"107","author":"Round","year":"2010","journal-title":"Proc. Natl Acad. Sci."},{"key":"10.1038\/s41385-021-00420-8_bib70","doi-asserted-by":"crossref","unstructured":"Ramanan, D., et al (2020). An immunologic mode of multigenerational transmission governs a Gut Treg Setpoint. Cell, 1\u201329. https:\/\/doi.org\/10.1016\/j.cell.2020.04.030","DOI":"10.1016\/j.cell.2020.04.030"},{"key":"10.1038\/s41385-021-00420-8_bib71","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.cell.2017.01.022","article-title":"Mining the human Gut microbiota for immunomodulatory organisms","volume":"168","author":"Geva-Zatorsky","year":"2017","journal-title":"Cell"},{"key":"10.1038\/s41385-021-00420-8_bib72","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41590-020-0602-z","article-title":"Distinct microbial and immune niches of the human colon","volume":"21","author":"James","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib73","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10\u2212\/\u2212 mice","volume":"487","author":"Devkota","year":"2012","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00420-8_bib74","doi-asserted-by":"crossref","unstructured":"Arpaia, N., et al (2013). Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504. https:\/\/doi.org\/10.1038\/nature12726","DOI":"10.1038\/nature12726"},{"key":"10.1038\/s41385-021-00420-8_bib75","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00420-8_bib76","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1206025","article-title":"Predicting a human gut microbiota's response to diet in gnotobiotic mice","volume":"333","author":"Faith","year":"2011","journal-title":"Science"},{"key":"10.1038\/s41385-021-00420-8_bib77","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2019.08.011","article-title":"Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber- Derived Glycans","volume":"179","author":"Patnode","year":"2019","journal-title":"Cell"},{"key":"10.1038\/s41385-021-00420-8_bib78","doi-asserted-by":"crossref","unstructured":"Woodward, S. E., Krekhno, Z., & Finlay, B. B. (2019). Here, there, and everywhere: How pathogenic Escherichia coli sense and respond to gastrointestinal biogeography. Cell. Microbiol. https:\/\/doi.org\/10.1111\/cmi.13107","DOI":"10.1111\/cmi.13107"},{"key":"10.1038\/s41385-021-00420-8_bib79","doi-asserted-by":"crossref","unstructured":"Philpott, D. J., Edgeworth, J. D., & Sansonetti, P. J. (2000). The pathogenesis of Shigella flexneri infection: Lessons from in vitro and in vivo studies. Philos. Trans. R. Soc. B: Biological Sci. https:\/\/doi.org\/10.1098\/rstb.2000.0599","DOI":"10.1142\/9781848161610_0003"},{"key":"10.1038\/s41385-021-00420-8_bib80","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature13828","article-title":"Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile","volume":"517","author":"Buffie","year":"2014","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00420-8_bib81","unstructured":"Ek, W. E., D'Amato, M., & Halfvarson, J. (2014). The history of genetics in inflammatory bowel disease. Ann. Gastroenterol."},{"key":"10.1038\/s41385-021-00420-8_bib82","doi-asserted-by":"crossref","unstructured":"Khor, B., Gardet, A., & Xavier, R. J. (2011). Genetics and pathogenesis of inflammatory bowel disease. Nature. https:\/\/doi.org\/10.1038\/nature10209","DOI":"10.1038\/nature10209"},{"key":"10.1038\/s41385-021-00420-8_bib83","doi-asserted-by":"crossref","unstructured":"Chellappa, K., et al (2016). Opposing roles of nuclear receptor HNF4\u03b1 isoforms in colitis and colitis-associated colon cancer. ELife. https:\/\/doi.org\/10.7554\/eLife.10903","DOI":"10.7554\/eLife.10903.022"},{"key":"10.1038\/s41385-021-00420-8_bib84","doi-asserted-by":"crossref","unstructured":"Leystra, A. A. & Clapper, M. L. (2019). Gut microbiota influences experimental outcomes in mouse models of colorectal cancer. Genes. https:\/\/doi.org\/10.3390\/genes10110900","DOI":"10.3390\/genes10110900"},{"key":"10.1038\/s41385-021-00420-8_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.2007.123166","article-title":"The forgotten role of lymphangitis in Crohn's disease","volume":"57","author":"Van Kruiningen","year":"2008","journal-title":"Gut"},{"key":"10.1038\/s41385-021-00420-8_bib86","doi-asserted-by":"crossref","unstructured":"Wan, Y., et al (2020). Unconjugated and secondary bile acid profiles in response to higher-fat, lower-carbohydrate diet and associated with related gut microbiota: A 6-month randomized controlled-feeding trial. Clin. Nutr. https:\/\/doi.org\/10.1016\/j.clnu.2019.02.037","DOI":"10.1016\/j.clnu.2019.02.037"},{"key":"10.1038\/s41385-021-00420-8_bib87","doi-asserted-by":"crossref","unstructured":"Sehgal, R., et al (2014). Lynch syndrome: an updated review. Genes. https:\/\/doi.org\/10.3390\/genes5030497","DOI":"10.3390\/genes5030497"},{"key":"10.1038\/s41385-021-00420-8_bib88","doi-asserted-by":"crossref","unstructured":"Rustgi, A. K. (2007). The genetics of hereditary colon cancer. Genes Dev. https:\/\/doi.org\/10.1101\/gad.1593107","DOI":"10.1101\/gad.1593107"},{"key":"10.1038\/s41385-021-00420-8_bib89","doi-asserted-by":"crossref","unstructured":"Taketo, M. M. (2006). Mouse models of gastrointestinal tumors. Cancer Sci. 97. https:\/\/doi.org\/10.1111\/j.1349-7006.2006.00190.x","DOI":"10.1111\/j.1349-7006.2006.00190.x"},{"key":"10.1038\/s41385-021-00420-8_bib90","doi-asserted-by":"crossref","unstructured":"Babbs, C. F. (1990). Free radicals and the etiology of colon cancer. Free Radical Biol Med. https:\/\/doi.org\/10.1016\/0891-5849(90)90091-V","DOI":"10.1016\/0891-5849(90)90769-F"},{"key":"10.1038\/s41385-021-00420-8_bib91","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S2468-1253(16)30026-7","article-title":"The mesentery: structure, function, and role in disease","volume":"1","author":"Coffey","year":"2016","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1038\/s41385-021-00420-8_bib92","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/mi.2012.33","article-title":"Mesenteric fat\u2014control site for bacterial translocation in colitis?","volume":"5","author":"Batra","year":"2012","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib93","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/gutjnl-2011-300370","article-title":"Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease","volume":"61","author":"Peyrin-Biroulet","year":"2012","journal-title":"Gut"},{"key":"10.1038\/s41385-021-00420-8_bib94","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.cell.2020.09.009","article-title":"Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans","volume":"183","author":"Ha","year":"2020","journal-title":"Cell"},{"key":"10.1038\/s41385-021-00420-8_bib95","doi-asserted-by":"crossref","unstructured":"Mao, R., et al (2019). The mesenteric fat and intestinal muscle interface: creeping fat influencing stricture formation in Crohn's disease. Inflamm. Bowel Dis. https:\/\/doi.org\/10.1093\/ibd\/izy331","DOI":"10.1093\/ibd\/izy331"},{"key":"10.1038\/s41385-021-00420-8_bib96","doi-asserted-by":"crossref","unstructured":"McNamee, E. N., & Rivera-Nieves, J. (2016). Ectopic tertiary lymphoid tissue in inflammatory bowel disease: protective or provocateur? Front. Immunol. https:\/\/doi.org\/10.3389\/fimmu.2016.00308","DOI":"10.3389\/fimmu.2016.00308"},{"key":"10.1038\/s41385-021-00420-8_bib97","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/mi.2015.77","article-title":"The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct","volume":"9","author":"Houston","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib98","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/1521-4141(200204)32:4<1109::AID-IMMU1109>3.0.CO;2-K","article-title":"Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches","volume":"32","author":"Spahn","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib99","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/mi.2015.118","article-title":"Colonic tolerance develops in the iliac lymph nodes and can be established independent of CD103+ dendritic cells","volume":"9","author":"Veenbergen","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib100","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00420-8_bib101","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1145697","article-title":"Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid","volume":"317","author":"Mucida","year":"2007","journal-title":"Science"},{"key":"10.1038\/s41385-021-00420-8_bib102","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature01726","article-title":"Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells","volume":"424","author":"Mora","year":"2003","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00420-8_bib103","doi-asserted-by":"crossref","unstructured":"Bono, M. R., et al (2016). Retinoic acid as a modulator of T cell immunity. Nutrients 8. https:\/\/doi.org\/10.3390\/nu8060349","DOI":"10.3390\/nu8060349"},{"key":"10.1038\/s41385-021-00420-8_bib104","doi-asserted-by":"crossref","unstructured":"Takahashi, H., et al (2012). TGF-\u03b2 and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat. Immunol. 13. https:\/\/doi.org\/10.1038\/ni.2286","DOI":"10.1038\/ni.2286"},{"key":"10.1038\/s41385-021-00420-8_bib105","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.immuni.2011.03.003","article-title":"Essential role for retinoic acid in the promotion of CD4+ T cell effector responses via retinoic acid receptor alpha","volume":"34","author":"Hall","year":"2011","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00420-8_bib106","doi-asserted-by":"crossref","unstructured":"Jabri, B. & Abadie, V. (2015). IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction. In Nat. Rev Immunol. https:\/\/doi.org\/10.1038\/nri3919","DOI":"10.1038\/nri3919"},{"key":"10.1038\/s41385-021-00420-8_bib107","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/mi.2012.4","article-title":"Oral tolerance to food protein","volume":"5","author":"Pabst","year":"2012","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib108","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.immuni.2011.01.016","article-title":"Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the Lamina Propria","volume":"34","author":"Hadis","year":"2011","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00420-8_bib109","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1073\/pnas.1000082107","article-title":"Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis","volume":"108","author":"Lee","year":"2011","journal-title":"Proc. Natl Acad. Sci."},{"key":"10.1038\/s41385-021-00420-8_bib110","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.immuni.2010.06.001","article-title":"Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells","volume":"32","author":"Wu","year":"2010","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00420-8_bib111","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/mi.2013.54","article-title":"The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes","volume":"7","author":"Cording","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib112","doi-asserted-by":"crossref","unstructured":"Pezoldt, J., et al (2018). Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes. Nat. Commun., 1\u201314. https:\/\/doi.org\/10.1038\/s41467-018-06423-7","DOI":"10.1038\/s41467-018-06423-7"},{"key":"#cr-split#-10.1038\/s41385-021-00420-8_bib113.1","doi-asserted-by":"crossref","unstructured":"Gray, H. Anatomy of the Human Body. Philadelphia: Lea & Febiger, 1918","DOI":"10.5962\/bhl.title.20311"},{"key":"#cr-split#-10.1038\/s41385-021-00420-8_bib113.2","unstructured":"Bartleby.com, 2000. www.bartleby.com\/107\/."},{"key":"10.1038\/s41385-021-00420-8_bib114","doi-asserted-by":"crossref","unstructured":"Craig, S. W., & Cebra, J. J. (1971). Peyer's patches: An enriched source of precursors for iga-producing immunocytes in the rabbit. J. Exp. Med. 134. https:\/\/doi.org\/10.1084\/jem.134.1.188","DOI":"10.1084\/jem.134.1.188"},{"key":"10.1038\/s41385-021-00420-8_bib115","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4704","article-title":"Generation of colonic IgA-secreting cells in the caecal patch","volume":"5","author":"Masahata","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-021-00420-8_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2020.02.001","article-title":"Immune profiling of human gut-associated lymphoid tissue identifies a role for isolated lymphoid follicles in priming of region-specific immunity","volume":"52","author":"Fenton","year":"2020","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00420-8_bib117","doi-asserted-by":"crossref","unstructured":"Rogier, E. W., Frantz, A. L., Bruno, M. E. C., & Kaetzel, C. S. (2014). Secretory IgA is concentrated in the outer layer of colonic mucus along with gut bacteria. Pathogens. https:\/\/doi.org\/10.3390\/pathogens3020390","DOI":"10.3390\/pathogens3020390"},{"key":"10.1038\/s41385-021-00420-8_bib118","doi-asserted-by":"crossref","unstructured":"Bunker, J. J., & Bendelac, A. (2018). IgA responses to microbiota. Immunity. https:\/\/doi.org\/10.1016\/j.immuni.2018.08.011","DOI":"10.1016\/j.immuni.2018.08.011"},{"key":"10.1038\/s41385-021-00420-8_bib119","doi-asserted-by":"crossref","unstructured":"Hoces, D., Arnoldini, M., Diard, M., Loverdo, C., & Slack, E. (2020). Growing, evolving and sticking in a flowing environment: understanding IgA interactions with bacteria in the gut. In Immunology. https:\/\/doi.org\/10.1111\/imm.13156","DOI":"10.1111\/imm.13156"},{"key":"10.1038\/s41385-021-00420-8_bib120","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1084\/jem.20060227","article-title":"Mesenteric lymph nodes at the center of immune anatomy","volume":"203","author":"Macpherson","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00420-8_bib121","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.20052016","article-title":"Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells","volume":"203","author":"Worbs","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00420-8_bib122","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1172\/JCI24487","article-title":"Oral tolerance in the absence of naturally occurring Tregs","volume":"115","author":"Mucida","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1038\/s41385-021-00420-8_bib123","doi-asserted-by":"crossref","unstructured":"Scher, J. U., et al (2013). Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. ELife. https:\/\/doi.org\/10.7554\/elife.01202","DOI":"10.7554\/eLife.01202.028"},{"key":"10.1038\/s41385-021-00420-8_bib124","doi-asserted-by":"crossref","unstructured":"Axelrad, J. E., Lichtiger, S., & Yajnik, V. (2016). Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. In World J. Gastroenterol. https:\/\/doi.org\/10.3748\/wjg.v22.i20.4794","DOI":"10.3748\/wjg.v22.i20.4794"},{"key":"10.1038\/s41385-021-00420-8_bib125","doi-asserted-by":"crossref","unstructured":"Som, A., et al (2019). Immune checkpoint inhibitor-induced colitis: a comprehensive review. In World J. Clin. Cases. https:\/\/doi.org\/10.12998\/wjcc.v7.i4.405","DOI":"10.12998\/wjcc.v7.i4.405"},{"key":"10.1038\/s41385-021-00420-8_bib126","doi-asserted-by":"crossref","unstructured":"Chaput, N., et al (2017). Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab. Ann. Oncol. https:\/\/doi.org\/10.1093\/annonc\/mdx108","DOI":"10.1093\/annonc\/mdx108"},{"key":"10.1038\/s41385-021-00420-8_bib127","doi-asserted-by":"crossref","unstructured":"Dubin, K., et al (2016). Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat. Commun. https:\/\/doi.org\/10.1038\/ncomms10391","DOI":"10.1038\/ncomms10391"},{"key":"10.1038\/s41385-021-00420-8_bib128","doi-asserted-by":"crossref","unstructured":"V\u00e9tizou, M., et al (2015). Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. https:\/\/doi.org\/10.1126\/science.aad1329","DOI":"10.1126\/science.aad1329"},{"key":"10.1038\/s41385-021-00420-8_bib129","doi-asserted-by":"crossref","unstructured":"Roberti, M. P., et al (2020). Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer. Nat. Med. https:\/\/doi.org\/10.1038\/s41591-020-0882-8","DOI":"10.1038\/s41591-020-0882-8"},{"key":"10.1038\/s41385-021-00420-8_bib130","doi-asserted-by":"crossref","unstructured":"Al Nabhani, Z., et al (2019). A weaning reaction to microbiota is required for resistance to immunopathologies in the adult. Immunity. https:\/\/doi.org\/10.1016\/j.immuni.2019.02.014","DOI":"10.1016\/j.immuni.2019.02.014"},{"key":"10.1038\/s41385-021-00420-8_bib131","doi-asserted-by":"crossref","unstructured":"Jabri, B., & Sollid, L. M. (2009). Tissue-mediated control of immunopathology in coeliac disease. Nat. Rev. Immunol. 9. https:\/\/doi.org\/10.1038\/nri2670","DOI":"10.1038\/nri2670"},{"key":"10.1038\/s41385-021-00420-8_bib132","doi-asserted-by":"crossref","unstructured":"Junker, Y., et al (2012). Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J. Exp. Med. 209. https:\/\/doi.org\/10.1084\/jem.20102660","DOI":"10.1084\/jem.20102660"},{"key":"10.1038\/s41385-021-00420-8_bib133","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-immunol-040210-092915","article-title":"Integration of genetic and immunological insights into a model of celiac disease pathogenesis","volume":"29","author":"Abadie","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib134","doi-asserted-by":"crossref","unstructured":"Yu, W., Freeland, D. M. H., & Nadeau, K. C. (2016). Food allergy: Immune mechanisms, diagnosis and immunotherapy. Nat. Rev. Immunol. (Vol. 16, Issue 12). https:\/\/doi.org\/10.1038\/nri.2016.111","DOI":"10.1038\/nri.2016.111"},{"key":"10.1038\/s41385-021-00420-8_bib135","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jaci.2014.04.015","article-title":"Do lipids influence the allergic sensitization process?","volume":"134","author":"Bublin","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00420-8_bib136","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/mnfr.201000011","article-title":"Digestion of peanut allergens Ara h 1, Ara h 2, Ara h 3, and Ara h 6: a comparative in vitro study and partial characterization of digestion-resistant peptide","volume":"54","author":"Koppelman","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1038\/s41385-021-00420-8_bib137","doi-asserted-by":"crossref","unstructured":"Balakireva, A. V., & Zamyatnin, A. A. (2016). Properties of gluten intolerance: Gluten structure, evolution, pathogenicity and detoxification capabilities. In Nutrients (Vol. 8, Issue 10). https:\/\/doi.org\/10.3390\/nu8100644","DOI":"10.3390\/nu8100644"},{"key":"10.1038\/s41385-021-00420-8_bib138","doi-asserted-by":"crossref","unstructured":"Friedrich, M., Pohin, M., & Powrie, F. (2019). Cytokine networks in the pathophysiology of inflammatory bowel disease. In Immunity. https:\/\/doi.org\/10.1016\/j.immuni.2019.03.017","DOI":"10.1016\/j.immuni.2019.03.017"},{"key":"10.1038\/s41385-021-00420-8_bib139","doi-asserted-by":"crossref","unstructured":"Sun, R., Hedl, M., & Abraham, C. (2020). IL23 group> IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes. Gut 69. https:\/\/doi.org\/10.1136\/gutjnl-2018-316830","DOI":"10.1136\/gutjnl-2018-316830"},{"key":"10.1038\/s41385-021-00420-8_bib140","doi-asserted-by":"crossref","unstructured":"Lee, J. S., et al (2015). Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability. Immunity 43. https:\/\/doi.org\/10.1016\/j.immuni.2015.09.003","DOI":"10.1016\/j.immuni.2015.10.019"},{"key":"10.1038\/s41385-021-00420-8_bib141","doi-asserted-by":"crossref","unstructured":"Maxwell, J. R. et al (2015). Differential roles for interleukin-23 and interleukin-17 in intestinal immunoregulation. Immunity 43. https:\/\/doi.org\/10.1016\/j.immuni.2015.08.019","DOI":"10.1016\/j.immuni.2015.08.019"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00420-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00420-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922002215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922002215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00420-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:11:15Z","timestamp":1761829875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922002215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":142,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1933021922002215"],"URL":"https:\/\/doi.org\/10.1038\/s41385-021-00420-8","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal immune compartmentalization: implications of tissue specific determinants in health and disease","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-021-00420-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}