{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:46:35Z","timestamp":1792755995623,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1038\/s41385-021-00425-3","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T02:08:40Z","timestamp":1624327720000},"page":"1055-1066","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates"],"prefix":"10.1016","volume":"14","author":[{"given":"Shunsuke","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickiana E.","family":"Lora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Kauffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle E.","family":"Dorosky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangmi","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaranjani","family":"Namasivayam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Fleegle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janard L.","family":"Bleach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley L.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmuanual K.","family":"Dayao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela K.","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn M.","family":"Repoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky Y.","family":"Slone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle K.","family":"Sutphin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Vatthauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April M.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Woodcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia S. Lindestam","family":"Arlehamn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Sher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon J.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Via","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton E.","family":"Barry III","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Barber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-021-00425-3_bib1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41590-019-0444-8","article-title":"The biology and functional importance of MAIT cells","volume":"20","author":"Godfrey","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.coi.2017.04.002","article-title":"MAIT cells and MR1-antigen recognition","volume":"46","author":"Keller","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature13160","article-title":"T-cell activation by transitory neo-antigens derived from distinct microbial pathways","volume":"509","author":"Corbett","year":"2014","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00425-3_bib4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nature01433","article-title":"Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1","volume":"422","author":"Treiner","year":"2003","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00425-3_bib5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/imcb.1034","article-title":"MAIT cells: an historical and evolutionary perspective","volume":"96","author":"Lantz","year":"2018","journal-title":"Immunol. Cell Biol."},{"key":"10.1038\/s41385-021-00425-3_bib6","doi-asserted-by":"crossref","first-page":"eaax6624","DOI":"10.1126\/science.aax6624","article-title":"MAIT cells are imprinted by the microbiota in early life and promote tissue repair","volume":"366","author":"Constantinides","year":"2019","journal-title":"Science"},{"key":"10.1038\/s41385-021-00425-3_bib7","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1016\/j.celrep.2019.07.039","article-title":"Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality","volume":"28","author":"Hinks","year":"2019","journal-title":"Cell Rep."},{"key":"10.1038\/s41385-021-00425-3_bib8","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1016\/j.celrep.2019.08.050","article-title":"TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions","volume":"28","author":"Leng","year":"2019","journal-title":"Cell Rep."},{"key":"10.1038\/s41385-021-00425-3_bib9","doi-asserted-by":"crossref","first-page":"E3119","DOI":"10.1073\/pnas.1302799110","article-title":"MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection","volume":"110","author":"Meierovics","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-021-00425-3_bib10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/ni.1890","article-title":"Antimicrobial activity of mucosal-associated invariant T cells","volume":"11","author":"Le Bourhis","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib11","article-title":"MAIT cells protect against pulmonary Legionella longbeachae infection","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-021-00425-3_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/mi.2016.39","article-title":"Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals","volume":"10","author":"Chen","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib13","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1016\/j.vaccine.2019.04.050","article-title":"Harnessing donor unrestricted T-cells for new vaccines against tuberculosis","volume":"37","author":"Joosten","year":"2019","journal-title":"Vaccine"},{"key":"10.1038\/s41385-021-00425-3_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41385-020-0332-4","article-title":"MAIT cell-directed therapy of Mycobacterium tuberculosis infection","volume":"14","author":"Sakai","year":"2021","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib15","article-title":"Artificially induced MAIT cells inhibit M. bovis BCG but not M. tuberculosis during in vivo pulmonary infection","volume":"10","author":"Yu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-021-00425-3_bib16","doi-asserted-by":"crossref","first-page":"e00520","DOI":"10.1128\/IAI.00524-20","article-title":"Efficient 5-OP-RU-induced enrichment of Mucosal-associated invariant T cells in the murine lung does not enhance control of aerosol Mycobacterium tuberculosis infection","volume":"89","author":"Vorkas","year":"2020","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-021-00425-3_bib17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1084\/jem.20142110","article-title":"Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers","volume":"212","author":"Rahimpour","year":"2015","journal-title":"J. Exp. Med"},{"key":"10.1038\/s41385-021-00425-3_bib18","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.4049\/jimmunol.1900674","article-title":"MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria","volume":"203","author":"Suliman","year":"2019","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib19","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/mi.2016.91","article-title":"MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates","volume":"10","author":"Greene","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib20","doi-asserted-by":"crossref","first-page":"a018564","DOI":"10.1101\/cshperspect.a018564","article-title":"Modeling tuberculosis in nonhuman primates","volume":"4","author":"Scanga","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"10.1038\/s41385-021-00425-3_bib21","doi-asserted-by":"crossref","first-page":"e1007337","DOI":"10.1371\/journal.ppat.1007337","article-title":"Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques","volume":"14","author":"Ganchua","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-021-00425-3_bib22","doi-asserted-by":"crossref","first-page":"e00505","DOI":"10.1128\/IAI.00505-17","article-title":"Rhesus macaques are more susceptible to progressive tuberculosis than cynomolgus macaques: a quantitative comparison","volume":"86","author":"Maiello","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-021-00425-3_bib23","doi-asserted-by":"crossref","first-page":"e00418","DOI":"10.1128\/IAI.00431-18","article-title":"Limited pulmonary mucosal-associated invariant T cell accumulation and activation during Mycobacterium tuberculosis infection in rhesus macaques","volume":"86","author":"Kauffman","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-021-00425-3_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-66964-0","article-title":"Mucosal-associated invariant T (MAIT) cells provide B-cell help in vaccinated and subsequently SIV-infected Rhesus Macaques","volume":"10","author":"Rahman","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-021-00425-3_bib25","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.aaz4014","article-title":"Immune cells for microbiota surveillance","volume":"366","author":"Oh","year":"2019","journal-title":"Science"},{"key":"10.1038\/s41385-021-00425-3_bib26","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1126\/science.aaw2719","article-title":"Microbial metabolites control the thymic development of mucosal-associated invariant T cells","volume":"366","author":"Legoux","year":"2019","journal-title":"Science"},{"key":"10.1038\/s41385-021-00425-3_bib27","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.4049\/jimmunol.1801405","article-title":"MAIT cells upregulate alpha4beta7 in response to acute simian immunodeficiency virus\/simian HIV infection but are resistant to peripheral depletion in pigtail macaques","volume":"202","author":"Juno","year":"2019","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1164\/rccm.201401-0106OC","article-title":"Mucosal-associated invariant T-cell function is modulated by programmed death-1 signaling in patients with active tuberculosis","volume":"190","author":"Jiang","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1038\/s41385-021-00425-3_bib29","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.tube.2019.04.006","article-title":"Mucosal-activated invariant T cells do not exhibit significant lung recruitment and proliferation profiles in macaques in response to infection with Mycobacterium tuberculosis CDC1551","volume":"116S","author":"Bucsan","year":"2019","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1038\/s41385-021-00425-3_bib30","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1182\/blood-2012-07-445429","article-title":"Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection","volume":"121","author":"Leeansyah","year":"2013","journal-title":"Blood"},{"key":"10.1038\/s41385-021-00425-3_bib31","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1002\/eji.201646447","article-title":"Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy","volume":"46","author":"Hengst","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib32","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1158\/1078-0432.CCR-18-3040","article-title":"Activated and exhausted MAIT cells foster disease progression and indicate poor outcome in hepatocellular carcinoma","volume":"25","author":"Duan","year":"2019","journal-title":"Clin. Cancer Res"},{"key":"10.1038\/s41385-021-00425-3_bib33","doi-asserted-by":"crossref","first-page":"e55615","DOI":"10.7554\/eLife.55615","article-title":"Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis","volume":"9","author":"Trivedi","year":"2020","journal-title":"Elife"},{"key":"10.1038\/s41385-021-00425-3_bib34","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/jvh.13341","article-title":"Mucosal-associated invariant T-cells are severely reduced and exhausted in humans with chronic HBV infection","volume":"27","author":"Huang","year":"2020","journal-title":"J. Viral Hepat."},{"key":"10.1038\/s41385-021-00425-3_bib35","doi-asserted-by":"crossref","first-page":"e1008585","DOI":"10.1371\/journal.ppat.1008585","article-title":"MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection","volume":"16","author":"Ellis","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-021-00425-3_bib36","doi-asserted-by":"crossref","unstructured":"Parrot, T. et al. MAIT cell activation and dynamics associated with COVID-19 disease severity. Sci Immunol5, eabe1670 (2020).","DOI":"10.1101\/2020.08.27.20182550"},{"key":"10.1038\/s41385-021-00425-3_bib37","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4049\/immunohorizons.2000031","article-title":"Quantitative and qualitative perturbations of CD8(+) MAITs in healthy mycobacterium tuberculosis-infected individuals","volume":"4","author":"Pomaznoy","year":"2020","journal-title":"Immunohorizons"},{"key":"10.1038\/s41385-021-00425-3_bib38","doi-asserted-by":"crossref","first-page":"e83474","DOI":"10.1371\/journal.pone.0083474","article-title":"Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV\/TB co-infection","volume":"8","author":"Wong","year":"2013","journal-title":"PLoS One"},{"key":"10.1038\/s41385-021-00425-3_bib39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tube.2015.03.004","article-title":"Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity","volume":"95","author":"Kwon","year":"2015","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1038\/s41385-021-00425-3_bib40","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-immunol-041015-055318","article-title":"CD8 T cell exhaustion during chronic viral infection and cancer","volume":"37","author":"McLane","year":"2019","journal-title":"Annu Rev. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib41","doi-asserted-by":"crossref","first-page":"E5434","DOI":"10.1073\/pnas.1705759114","article-title":"Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines","volume":"114","author":"Dias","year":"2017","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-021-00425-3_bib42","doi-asserted-by":"crossref","first-page":"eaaw0402","DOI":"10.1126\/sciimmunol.aaw0402","article-title":"IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection","volume":"4","author":"Wang","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib43","doi-asserted-by":"crossref","first-page":"e1003681","DOI":"10.1371\/journal.ppat.1003681","article-title":"MAIT cells detect and efficiently lyse bacterially-infected epithelial cells","volume":"9","author":"Le Bourhis","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-021-00425-3_bib44","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fimmu.2017.00398","article-title":"Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells","volume":"8","author":"Salerno-Goncalves","year":"2017","journal-title":"Front Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02540-x","article-title":"MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A","volume":"9","author":"Howson","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-021-00425-3_bib46","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00134-013-3163-x","article-title":"Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections","volume":"40","author":"Grimaldi","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1038\/s41385-021-00425-3_bib47","doi-asserted-by":"crossref","first-page":"e1000407","DOI":"10.1371\/journal.pbio.1000407","article-title":"Human mucosal associated invariant T cells detect bacterially infected cells","volume":"8","author":"Gold","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1038\/s41385-021-00425-3_bib48","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jcmgh.2020.01.003","article-title":"Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal Inflammation","volume":"9","author":"Ibidapo-Obe","year":"2020","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1038\/s41385-021-00425-3_bib49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s42003-019-0442-2","article-title":"TRAV1-2(+) CD8(+) T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis","volume":"2","author":"Wong","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1038\/s41385-021-00425-3_bib50","doi-asserted-by":"crossref","first-page":"eabc9492","DOI":"10.1126\/sciimmunol.abc9492","article-title":"Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1","volume":"5","author":"Howson","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molimm.2020.12.007","article-title":"Mouse models illuminate MAIT cell biology","volume":"130","author":"Wang","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib52","doi-asserted-by":"crossref","first-page":"e122940","DOI":"10.1172\/jci.insight.122940","article-title":"Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV","volume":"3","author":"Mylvaganam","year":"2018","journal-title":"JCI Insight"},{"key":"10.1038\/s41385-021-00425-3_bib53","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/mi.2017.60","article-title":"Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques","volume":"11","author":"Kauffman","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-021-00425-3_bib54","doi-asserted-by":"crossref","unstructured":"White, A. G. et al. Analysis of 18FDG PET\/CT Imaging as a tool for studying mycobacterium tuberculosis infection and treatment in non-human primates. J. Vis. Exp. 56375 (2017).","DOI":"10.3791\/56375-v"},{"key":"10.1038\/s41385-021-00425-3_bib55","doi-asserted-by":"crossref","first-page":"e1005760","DOI":"10.1371\/journal.ppat.1005760","article-title":"A quantitative analysis of complexity of human pathogen-specific CD4 T cell responses in healthy M. tuberculosis infected South Africans","volume":"12","author":"Lindestam Arlehamn","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-021-00425-3_bib56","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-017-0286-2","article-title":"Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy","volume":"5","author":"Namasivayam","year":"2017","journal-title":"Microbiome"},{"key":"10.1038\/s41385-021-00425-3_bib57","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1038\/s41385-021-00425-3_bib58","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1038\/s41385-021-00425-3_bib59","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00425-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00425-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193302192200201X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193302192200201X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00425-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:12:00Z","timestamp":1761829920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193302192200201X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S193302192200201X"],"URL":"https:\/\/doi.org\/10.1038\/s41385-021-00425-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.01.29.428844","asserted-by":"object"}]},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-021-00425-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}