{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T03:45:26Z","timestamp":1783309526984,"version":"3.54.6"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1038\/s41385-021-00442-2","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T09:03:05Z","timestamp":1629104585000},"page":"165-175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["The IL-33-ILC2 pathway protects from amebic colitis"],"prefix":"10.1016","volume":"15","author":[{"given":"Md Jashim","family":"Uddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhansi L.","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Oakland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuresh","family":"Abhyankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Revilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyse","family":"Frisbee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra N.","family":"Donlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-1218","authenticated-orcid":false,"given":"William A.","family":"Petri Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-021-00442-2_bib1","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","article-title":"Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000","volume":"379","author":"Liu","year":"2012","journal-title":"Lancet"},{"key":"10.1038\/s41385-021-00442-2_bib2","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.trstmh.2005.12.012","article-title":"Entamoeba histolytica-associated diarrheal illness is negatively associated with the growth of preschool children: evidence from a prospective study","volume":"100","author":"Mondal","year":"2006","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1038\/s41385-021-00442-2_bib3","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1038\/s41385-021-00442-2_bib4","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/clinids\/14.4.889","article-title":"Asymptomatic intestinal colonization by pathogenic Entamoeba histolytica in amebic liver abscess: prevalence, response to therapy, and pathogenic potential","volume":"14","author":"Irusen","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"10.1038\/s41385-021-00442-2_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pt.2020.09.015","article-title":"Host protective mechanisms to intestinal amebiasis","volume":"37","author":"Uddin","year":"2021","journal-title":"Trends Parasitol."},{"key":"10.1038\/s41385-021-00442-2_bib6","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nature13242","article-title":"Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion","volume":"508","author":"Ralston","year":"2014","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00442-2_bib7","doi-asserted-by":"crossref","first-page":"e551","DOI":"10.1371\/journal.pntd.0000551","article-title":"An ex-vivo human intestinal model to study Entamoeba histolytica pathogenesis","volume":"3","author":"Bansal","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1038\/s41385-021-00442-2_bib8","doi-asserted-by":"crossref","first-page":"e1006513","DOI":"10.1371\/journal.ppat.1006513","article-title":"Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis","volume":"13","author":"Watanabe","year":"2017","journal-title":"PLOS Pathog."},{"key":"10.1038\/s41385-021-00442-2_bib9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0171-2985(88)80018-4","article-title":"In vitro killing of Entamoeba histolytica trophozoites by interferon-\u03b3-activated mouse macrophages","volume":"176","author":"Ghadiriani","year":"1988","journal-title":"Immunobiology"},{"key":"10.1038\/s41385-021-00442-2_bib10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4269\/ajtmh.2007.76.340","article-title":"Correlation of interferon-\u03b3 production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis","volume":"76","author":"Petri","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1038\/s41385-021-00442-2_bib11","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4269\/ajtmh.2010.09-0493","article-title":"Association between TNF-\u03b1 and Entamoeba histolytica diarrhea","volume":"82","author":"Mondal","year":"2010","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1038\/s41385-021-00442-2_bib12","doi-asserted-by":"crossref","unstructured":"Noor, Z. et al. Role of eosinophils and tumor necrosis factor alpha in interleukin-25-mediated protection from amebic colitis. MBio8, e02329\u201316 (2017).","DOI":"10.1128\/mBio.02329-16"},{"key":"10.1038\/s41385-021-00442-2_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature16161","article-title":"Tuft-cell-derived IL-25 regulates an intestinal ILC2\u2013epithelial response circuit","volume":"529","author":"Moltke","year":"2016","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00442-2_bib14","doi-asserted-by":"crossref","first-page":"27704","DOI":"10.18632\/oncotarget.15984","article-title":"IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis","volume":"8","author":"Tu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1038\/s41385-021-00442-2_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10733-9","article-title":"IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection","volume":"10","author":"Frisbee","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-021-00442-2_bib16","doi-asserted-by":"crossref","first-page":"10762","DOI":"10.1073\/pnas.1509070112","article-title":"IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin\u2013EGFR interactions","volume":"112","author":"Monticelli","year":"2015","journal-title":"Proc. Natl Acad. Sci."},{"key":"10.1038\/s41385-021-00442-2_bib17","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jaci.2013.05.012","article-title":"IL-33 is more potent than IL-25 in provoking IL-13\u2013producing nuocytes (type 2 innate lymphoid cells) and airway contraction","volume":"132","author":"Barlow","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00442-2_bib18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.parint.2011.04.005","article-title":"The expression of REG 1A and REG 1B is increased during acute amebic colitis","volume":"60","author":"Peterson","year":"2011","journal-title":"Parasitol. Int."},{"key":"10.1038\/s41385-021-00442-2_bib19","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.4049\/jimmunol.169.8.4496","article-title":"The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4 + T cells","volume":"169","author":"Houpt","year":"2002","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00442-2_bib20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00442-2_bib21","doi-asserted-by":"crossref","first-page":"26369","DOI":"10.1074\/jbc.M704916200","article-title":"Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation","volume":"282","author":"Hayakawa","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1038\/s41385-021-00442-2_bib22","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.4049\/jimmunol.180.4.2443","article-title":"IL-33, a potent inducer of adaptive immunity to intestinal nematodes","volume":"180","author":"Humphreys","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00442-2_bib23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4049\/jimmunol.1800292","article-title":"IL-33 induces murine intestinal goblet cell differentiation indirectly via innate lymphoid cell IL-13 secretion","volume":"202","author":"Waddell","year":"2019","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-021-00442-2_bib24","doi-asserted-by":"crossref","first-page":"9298","DOI":"10.1073\/pnas.0600623103","article-title":"Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel","volume":"103","author":"Lidell","year":"2006","journal-title":"Proc. Natl Acad. Sci."},{"key":"10.1038\/s41385-021-00442-2_bib25","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1172\/JCI113199","article-title":"Rat and human colonic mucins bind to and inhibit adherence lectin of Entamoeba histolytica","volume":"80","author":"Chadee","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-021-00442-2_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1084\/jem.167.1.43","article-title":"Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors","volume":"167","author":"Yamaguchi","year":"1988","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-021-00442-2_bib27","doi-asserted-by":"crossref","unstructured":"Sutherland, T. E. et al. Ym1 induces RELM\u03b1 and rescues IL-4R\u03b1 deficiency in lung repair during nematode infection. PLoS Pathog. 14, e1007423 (2018).","DOI":"10.1371\/journal.ppat.1007423"},{"key":"10.1038\/s41385-021-00442-2_bib28","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature13577","article-title":"The alarmin IL-33 promotes regulatory T-cell function in the intestine","volume":"513","author":"Schiering","year":"2014","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00442-2_bib29","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1172\/JCI88625","article-title":"IL-33 regulates the IgA-microbiota axis to restrain IL-1\u03b1\u2013dependent colitis and tumorigenesis","volume":"126","author":"Malik","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1038\/s41385-021-00442-2_bib30","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s00535-010-0245-1","article-title":"Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis","volume":"45","author":"Kobori","year":"2010","journal-title":"J. Gastroenterol."},{"key":"10.1038\/s41385-021-00442-2_bib31","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nri.2016.95","article-title":"Interleukin-33 in health and disease","volume":"16","author":"Liew","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-021-00442-2_bib32","doi-asserted-by":"crossref","first-page":"108233","DOI":"10.1016\/j.celrep.2020.108233","article-title":"Hyperactivity of innate immunity triggers pain via TLR2-IL-33-mediated neuroimmune crosstalk","volume":"33","author":"Huang","year":"2020","journal-title":"Cell Rep."},{"key":"10.1038\/s41385-021-00442-2_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/254521","article-title":"The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica","volume":"2010","author":"Wong-Baeza","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1038\/s41385-021-00442-2_bib34","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/infdis\/jiz671","article-title":"Inhibition of amebic cysteine proteases blocks amebic trogocytosis but not phagocytosis","volume":"221","author":"Gilmartin","year":"2020","journal-title":"J. Infect. Dis."},{"key":"10.1038\/s41385-021-00442-2_bib35","doi-asserted-by":"crossref","unstructured":"Pichery, M. et al. Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33\u2013LacZ gene trap reporter strain. J. Immunol. 188, 3488\u20133495 (2012).","DOI":"10.4049\/jimmunol.1101977"},{"key":"10.1038\/s41385-021-00442-2_bib36","doi-asserted-by":"crossref","first-page":"e3331","DOI":"10.1371\/journal.pone.0003331","article-title":"The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel \u2018alarmin\u2018?","volume":"3","author":"Moussion","year":"2008","journal-title":"PLoS One"},{"key":"10.1038\/s41385-021-00442-2_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/srep25171","article-title":"Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation","volume":"6","author":"Stojkovic","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-021-00442-2_bib38","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1359-6101(02)00027-8","article-title":"IL-6 in autoimmune disease and chronic inflammatory proliferative disease","volume":"13","author":"Ishihara","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1038\/s41385-021-00442-2_bib39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jaci.2003.10.050","article-title":"The role of eosinophils in host defense against helminth parasites","volume":"113","author":"Klion","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-021-00442-2_bib40","doi-asserted-by":"crossref","unstructured":"Gil\u2010Recasens, M. E. et al. Increased leucocyte histamine release by Entamoeba histolytica antigen in patients with amoebic abscess of the liver. Parasite Immunol. 6, 211\u2013222 (1984).","DOI":"10.1111\/j.1365-3024.1984.tb00794.x"},{"key":"10.1038\/s41385-021-00442-2_bib41","doi-asserted-by":"crossref","unstructured":"Lee, Y. A. et al. Entamoeba histolytica-secreted cysteine proteases induce IL-8 production in human mast cells via a PAR2-independent mechanism. Parasite21, 1 (2014).","DOI":"10.1051\/parasite\/2014001"},{"key":"10.1038\/s41385-021-00442-2_bib42","doi-asserted-by":"crossref","first-page":"aaa6566","DOI":"10.1126\/science.aaa6566","article-title":"Innate lymphoid cells: a new paradigm in immunology","volume":"348","author":"Eberl","year":"2015","journal-title":"Science"},{"key":"10.1038\/s41385-021-00442-2_bib43","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"10.1038\/s41385-021-00442-2_bib44","doi-asserted-by":"crossref","first-page":"101544","DOI":"10.1016\/j.isci.2020.101544","article-title":"Group 2 innate lymphoid cells exacerbate amebic liver abscess in mice","volume":"23","author":"Nakamura","year":"2020","journal-title":"iScience"},{"key":"10.1038\/s41385-021-00442-2_bib45","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41590-020-0745-y","article-title":"ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung","volume":"21","author":"Schuijs","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-021-00442-2_bib46","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-021-00442-2_bib47","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2013.07.018","article-title":"Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis","volume":"39","author":"Mchedlidze","year":"2013","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00442-2_bib48","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.immuni.2020.09.002","article-title":"In situ maturation and tissue adaptation of type 2 innate lymphoid cell progenitors","volume":"53","author":"Zeis","year":"2020","journal-title":"Immunity"},{"key":"10.1038\/s41385-021-00442-2_bib49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0035-9203(78)90144-X","article-title":"A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba","volume":"72","author":"Diamond","year":"1978","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1038\/s41385-021-00442-2_bib50","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.celrep.2016.06.007","article-title":"Microbiota-regulated IL-25 increases eosinophil number to provide protection during Clostridium difficile infection","volume":"16","author":"Buonomo","year":"2016","journal-title":"Cell Rep."},{"key":"10.1038\/s41385-021-00442-2_bib51","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1038\/s41385-021-00442-2_bib52","doi-asserted-by":"crossref","first-page":"D793","DOI":"10.1093\/nar\/gks1055","article-title":"The ConsensusPathDB interaction database: 2013 update","volume":"41","author":"Kamburov","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1038\/s41385-021-00442-2_bib53","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1128\/IAI.01383-12","article-title":"Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica","volume":"81","author":"Mackey-Lawrence","year":"2013","journal-title":"Infect. Immun."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00442-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00442-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922000368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922000368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-021-00442-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:07:14Z","timestamp":1761829634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922000368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1933021922000368"],"URL":"https:\/\/doi.org\/10.1038\/s41385-021-00442-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.14.448450","asserted-by":"object"}]},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The IL-33-ILC2 pathway protects from amebic colitis","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-021-00442-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}