{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:38:19Z","timestamp":1791527899022,"version":"4.3.4"},"reference-count":67,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1038\/s41385-022-00498-8","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T03:02:41Z","timestamp":1647226961000},"page":"1283-1295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Microbial regulation of intestinal motility provides resistance against helminth infection"],"prefix":"10.1016","volume":"15","author":[{"given":"Mati","family":"Moyat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Lebon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Perdijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshanie C.","family":"Wickramasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario M.","family":"Zaiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Mosconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Guenat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Coakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Bouchery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola L.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-022-00498-8_bib1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0020-7519(92)90046-N","article-title":"Understanding chronic nematode infections: evolutionary considerations, current hypotheses and the way forward","volume":"22","author":"Behnke","year":"1992","journal-title":"Int. J. Parasitol."},{"key":"10.1038\/s41385-022-00498-8_bib2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pt.2007.11.007","article-title":"Parasites as probes for prehistoric human migrations?","volume":"24","author":"Araujo","year":"2008","journal-title":"Trends Parasitol."},{"key":"10.1038\/s41385-022-00498-8_bib3","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.20082779","article-title":"Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions","volume":"206","author":"Fumagalli","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00498-8_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature23469","article-title":"Neuronal regulation of type 2 innate lymphoid cells via neuromedin U","volume":"549","author":"Cardoso","year":"2017","journal-title":"Nature"},{"key":"10.1038\/s41385-022-00498-8_bib5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"7","author":"Anthony","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/pim.12057","article-title":"Understanding the role of antibodies in murine infections with Heligmosomoides (polygyrus) bakeri: 35 years ago, now and 35 years ahead","volume":"36","author":"Harris","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.chom.2008.08.014","article-title":"Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection","volume":"4","author":"McCoy","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1038\/s41385-022-00498-8_bib8","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.4049\/jimmunol.167.4.2234","article-title":"The role of IL-4 in Heligmosomoides polygyrus-induced alterations in murine intestinal epithelial cell function","volume":"167","author":"Shea-Donohue","year":"2001","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-3024.2010.01258.x","article-title":"Changes in the mucosal barrier during acute and chronic Trichuris muris infection","volume":"33","author":"Hasnain","year":"2011","journal-title":"Parasite Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib10","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1084\/jem.20091268","article-title":"Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection","volume":"206","author":"Herbert","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00498-8_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrmicro2974","article-title":"The gut microbiota\u2014masters of host development and physiology","volume":"11","author":"Sommer","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1038\/s41385-022-00498-8_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.smim.2006.10.002","article-title":"Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota","volume":"19","author":"Smith","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1003730","article-title":"Colonization resistance: battle of the bugs or m\u00e9nage \u00e0 trois with the host?","volume":"9","author":"Spees","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-022-00498-8_bib14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.it.2018.06.002","article-title":"Helminth-bacterial interactions: cause and consequence","volume":"39","author":"Rapin","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib15","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.171.4.2127","article-title":"A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62","volume":"171","author":"McInnes","year":"2003","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib16","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.immuni.2015.09.012","article-title":"The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation","volume":"43","author":"Zaiss","year":"2015","journal-title":"Immunity"},{"key":"10.1038\/s41385-022-00498-8_bib17","doi-asserted-by":"crossref","first-page":"e0009052","DOI":"10.1371\/journal.pntd.0009052","article-title":"Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge","volume":"15","author":"Brosschot","year":"2021","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1038\/s41385-022-00498-8_bib18","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.pt.2011.03.010","article-title":"Advances in helminth immunology: optimism for future vaccine design?","volume":"27","author":"Harris","year":"2011","journal-title":"Trends Parasitol."},{"key":"10.1038\/s41385-022-00498-8_bib19","doi-asserted-by":"crossref","unstructured":"Camberis, M., Le Gros, G. & Urban, J. Jr. Animal Model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus. Curr. Protoc. Immunol.55, 19.12.1\u201319.12.27. (2003). https:\/\/doi.org\/10.1002\/0471142735.im1912s55.","DOI":"10.1002\/0471142735.im1912s55"},{"key":"10.1038\/s41385-022-00498-8_bib20","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00281-012-0347-3","article-title":"Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus","volume":"34","author":"Reynolds","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"10.1038\/s41385-022-00498-8_bib21","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1128\/IAI.00266-15","article-title":"Parasite proximity drives the expansion of regulatory T cells in Peyer's patches following intestinal helminth infection","volume":"83","author":"Mosconi","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-022-00498-8_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2307\/3277341","article-title":"Host-parasite relationships of Nematospiroides dubius in the mouse","volume":"55","author":"Panter","year":"1969","journal-title":"J. Parasitol."},{"key":"10.1038\/s41385-022-00498-8_bib23","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.4049\/jimmunol.1401645","article-title":"Antibody-mediated trapping of helminth larvae requires CD11b and Fcgamma receptor I","volume":"194","author":"Esser-von Bieren","year":"2015","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1164\/rccm.201010-1574OC","article-title":"Dysregulation of allergic airway inflammation in the absence of microbial colonization","volume":"184","author":"Herbst","year":"2011","journal-title":"Am. J. Respiratory Crit. Care Med."},{"key":"10.1038\/s41385-022-00498-8_bib25","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1126\/science.1187703","article-title":"Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris","volume":"328","author":"Hayes","year":"2010","journal-title":"Science"},{"key":"10.1038\/s41385-022-00498-8_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S0022149X00027693","article-title":"The distribution of Nematospiroides dubius within the small intestine of laboratory mice","volume":"50","author":"Lewis","year":"1976","journal-title":"J. Helminthol."},{"key":"10.1038\/s41385-022-00498-8_bib27","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.chom.2020.01.011","article-title":"Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps","volume":"27","author":"Bouchery","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1038\/s41385-022-00498-8_bib28","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41385-020-0318-2","article-title":"IL-17A both initiates, via IFNgamma suppression, and limits the pulmonary type-2 immune response to nematode infection","volume":"13","author":"Ajendra","year":"2020","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib29","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.4049\/jimmunol.1400762","article-title":"Microbiota-derived compounds drive steady-state granulopoiesis via MyD88\/TICAM signaling","volume":"193","author":"Balmer","year":"2014","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib30","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.chom.2014.02.006","article-title":"Gut microbiota promote hematopoiesis to control bacterial infection","volume":"15","author":"Khosravi","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1038\/s41385-022-00498-8_bib31","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1053\/j.gastro.2012.06.034","article-title":"Gut microbial products regulate murine gastrointestinal motility via toll-like receptor 4 signaling","volume":"143","author":"Anitha","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1038\/s41385-022-00498-8_bib32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cell.2014.04.050","article-title":"Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility","volume":"158","author":"Muller","year":"2014","journal-title":"Cell"},{"key":"10.1038\/s41385-022-00498-8_bib33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4161\/gmic.28203","article-title":"Association of germ-free mice with a simplified human intestinal microbiota results in a shortened intestine","volume":"5","author":"Slezak","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1038\/s41385-022-00498-8_bib34","doi-asserted-by":"crossref","first-page":"iv15","DOI":"10.1136\/gut.47.suppl_4.iv15","article-title":"Anatomy and physiology of the enteric nervous system","volume":"47","author":"Costa","year":"2000","journal-title":"Gut"},{"key":"10.1038\/s41385-022-00498-8_bib35","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1038\/s41385-022-00498-8_bib36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0014-4894(72)90060-4","article-title":"Infectivity, fecundity, and survival of Nematospiroides dubius in gnotobiotic mice","volume":"32","author":"Chang","year":"1972","journal-title":"Exp. Parasitol."},{"key":"10.1038\/s41385-022-00498-8_bib37","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.3389\/fimmu.2018.02282","article-title":"Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation","volume":"9","author":"Rausch","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4161\/gmic.32155","article-title":"Commensal-pathogen interactions in the intestinal tract: Lactobacilli promote infection with, and are promoted by, helminth parasites","volume":"5","author":"Reynolds","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1038\/s41385-022-00498-8_bib39","doi-asserted-by":"crossref","unstructured":"Reynolds, L. V. et al. MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus. J. Immunol.193, 2984\u20132993 (2014).","DOI":"10.4049\/jimmunol.1401056"},{"key":"10.1038\/s41385-022-00498-8_bib40","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1002\/eji.200324264","article-title":"Essential role for TLR4 and MyD88 in the development of chronic intestinal nematode infection","volume":"33","author":"Helmby","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib41","doi-asserted-by":"crossref","first-page":"eabe6723","DOI":"10.1126\/science.abe6723","article-title":"Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection","volume":"374","author":"Hu","year":"2021","journal-title":"Science"},{"key":"10.1038\/s41385-022-00498-8_bib42","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41385-019-0231-8","article-title":"NK cell recruitment limits tissue damage during an enteric helminth infection","volume":"13","author":"Gentile","year":"2020","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib43","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1017\/S0031182000082081","article-title":"Villus length influences habitat selection by Heligmosomoides polygyrus","volume":"113","author":"Bansemir","year":"1996","journal-title":"Parasitology"},{"key":"10.1038\/s41385-022-00498-8_bib44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0020-7519(81)90079-5","article-title":"The location of parasites within their hosts: bile and the site selection behaviour of Nematospiroides dubius","volume":"11","author":"Sukhdeo","year":"1981","journal-title":"Int. J. Parasitol."},{"key":"10.1038\/s41385-022-00498-8_bib45","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1152\/ajpgi.2002.282.2.G226","article-title":"Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells","volume":"282","author":"Akiho","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1038\/s41385-022-00498-8_bib46","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4291\/wjgp.v2.i5.72","article-title":"Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders","volume":"2","author":"Akiho","year":"2011","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1038\/s41385-022-00498-8_bib47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/nmo.12236","article-title":"Intestinal microbiota influence the early postnatal development of the enteric nervous system","volume":"26","author":"Collins","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1038\/s41385-022-00498-8_bib48","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/nmo.12049","article-title":"The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse","volume":"25","author":"McVey Neufeld","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1038\/s41385-022-00498-8_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms8735","article-title":"Microbiota and host determinants of behavioural phenotype in maternally separated mice","volume":"6","author":"De Palma","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-022-00498-8_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijpara.2019.09.005","article-title":"Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine","volume":"50","author":"Rapin","year":"2020","journal-title":"Int. J. Parasitol."},{"key":"10.1038\/s41385-022-00498-8_bib51","doi-asserted-by":"crossref","unstructured":"Roshchina, V. V. New Trends and Perspectives in the Evolution of Neurotransmitters in Microbial, Plant, and Animal Cells. Adv. Exp. Med. Biol. 874, 25\u201377 (2016).","DOI":"10.1007\/978-3-319-20215-0_2"},{"key":"10.1038\/s41385-022-00498-8_bib52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1053\/j.gastro.2019.03.045","article-title":"Interactions between commensal bacteria and enteric neurons, via FPR1 induction of ROS, increase gastrointestinal motility in mice","volume":"157","author":"Chandrasekharan","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1038\/s41385-022-00498-8_bib53","doi-asserted-by":"crossref","first-page":"948","DOI":"10.4049\/jimmunol.171.2.948","article-title":"Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves","volume":"171","author":"Zhao","year":"2003","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00498-8_bib54","doi-asserted-by":"crossref","first-page":"e1004636","DOI":"10.1371\/journal.ppat.1004636","article-title":"The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection","volume":"11","author":"Darby","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-022-00498-8_bib55","doi-asserted-by":"crossref","unstructured":"Roberts, L. B. et al. Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths. Sci. Immunol.6 eabd0359 (2021).","DOI":"10.1126\/sciimmunol.abd0359"},{"key":"10.1038\/s41385-022-00498-8_bib56","doi-asserted-by":"crossref","unstructured":"Chu, C. et al. The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity. Sci. Immunol.6 eabe3218 (2021).","DOI":"10.1126\/sciimmunol.abe3218"},{"key":"10.1038\/s41385-022-00498-8_bib57","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"10.1038\/s41385-022-00498-8_bib58","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/00365515809079910","article-title":"The effect of substance P on intestinal motility in man","volume":"10","author":"Liljedahl","year":"1958","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"10.1038\/s41385-022-00498-8_bib59","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2982.2006.00853.x","article-title":"The relationship between the effects of short\u2010chain fatty acids on intestinal motility in vitro and GPR43 receptor activation","volume":"19","author":"Dass","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1038\/s41385-022-00498-8_bib60","first-page":"251","article-title":"Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions","volume":"59","author":"Tazoe","year":"2008","journal-title":"J. Physiol. Pharm."},{"key":"10.1038\/s41385-022-00498-8_bib61","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cmet.2013.01.003","article-title":"Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist","volume":"17","author":"Sayin","year":"2013","journal-title":"Cell Metab."},{"key":"10.1038\/s41385-022-00498-8_bib62","doi-asserted-by":"crossref","unstructured":"Zhan, K. et al. Gut microbiota-bile acid crosstalk in diarrhea-irritable bowel syndrome. BioMed Res. Int.2020, 3828249 (2020).","DOI":"10.1155\/2020\/3828249"},{"key":"10.1038\/s41385-022-00498-8_bib63","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.immuni.2020.10.014","article-title":"Interleukin-33 promotes serotonin release from enterochromaffin cells for intestinal homeostasis","volume":"54","author":"Chen","year":"2021","journal-title":"Immunity"},{"key":"10.1038\/s41385-022-00498-8_bib64","doi-asserted-by":"crossref","first-page":"8998","DOI":"10.1523\/JNEUROSCI.6684-10.2011","article-title":"Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development\/survival of enteric dopaminergic neurons","volume":"31","author":"Li","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1038\/s41385-022-00498-8_bib65","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1126\/science.1188454","article-title":"Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses","volume":"328","author":"Hapfelmeier","year":"2010","journal-title":"Science"},{"key":"10.1038\/s41385-022-00498-8_bib66","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1084\/jem.20091268","article-title":"Intestinal epithelial cell secretion of RELM\u03b2 protects against gastrointestinal worm infection","volume":"206","author":"Herbert","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00498-8_bib67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-62703-604-7_7","article-title":"Methods to assess tissue permeability","volume":"1066","author":"Ibla","year":"2013","journal-title":"Methods Mol. Biol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41385-022-00498-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-022-00498-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922017548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922017548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-022-00498-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:37:42Z","timestamp":1761831462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922017548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1933021922017548"],"URL":"https:\/\/doi.org\/10.1038\/s41385-022-00498-8","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbial regulation of intestinal motility provides resistance against helminth infection","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-022-00498-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}