{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:47:18Z","timestamp":1793929638640,"version":"4.8.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1038\/s41385-022-00511-0","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T13:03:53Z","timestamp":1650891833000},"page":"799-808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":273,"title":["Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection"],"prefix":"10.1016","volume":"15","author":[{"given":"Salma","family":"Sheikh-Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baweleta","family":"Isho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary Y.C.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmit","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Lustig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Nahass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Salomon-Shulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Blacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahya","family":"Fazel-Zarandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavisha","family":"Rathod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Colwill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alainna","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keelia Quinn","family":"de Launay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson","family":"Takaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Garnham-Takaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Fahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel Xinliu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazrana","family":"Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Barati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Mozafarihashjin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Samaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Budylowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter L.","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Mubareka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Ostrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Rini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga L.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving L.","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal Caspi","family":"Tal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"McGeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gili","family":"Regev-Yochay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Straus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Claude","family":"Gingras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4576-6168","authenticated-orcid":false,"given":"Jennifer L.","family":"Gommerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-022-00511-0_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1038\/s41385-022-00511-0_bib2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJMc2001737","article-title":"SARS-CoV-2 viral load in upper respiratory specimens of infected patients","volume":"382","author":"Zou","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-022-00511-0_bib3","doi-asserted-by":"crossref","first-page":"eabe5511","DOI":"10.1126\/sciimmunol.abe5511","article-title":"Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients","volume":"5","author":"Isho","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1038\/s41385-022-00511-0_bib4","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/s41591-021-01296-8","article-title":"SARS-CoV-2 infection of the oral cavity and saliva","volume":"27","author":"Huang","year":"2021","journal-title":"Nat. Med"},{"key":"10.1038\/s41385-022-00511-0_bib5","doi-asserted-by":"crossref","first-page":"e10640","DOI":"10.7554\/eLife.10640","article-title":"The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins","volume":"5","author":"Stadtmueller","year":"2016","journal-title":"Elife"},{"key":"10.1038\/s41385-022-00511-0_bib6","doi-asserted-by":"crossref","first-page":"eabf1555","DOI":"10.1126\/scitranslmed.abf1555","article-title":"Enhanced SARS-CoV-2 neutralization by dimeric IgA","volume":"13","author":"Wang","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1038\/s41385-022-00511-0_bib7","author":"Sterlin"},{"key":"10.1038\/s41385-022-00511-0_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00281-018-0726-5","article-title":"Sex differences in vaccine-induced humoral immunity","volume":"41","author":"Fischinger","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"10.1038\/s41385-022-00511-0_bib9","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/infdis\/jiab314","article-title":"COVID-19 mRNA vaccination generates greater IgG levels in women compared to men","volume":"224","author":"Demonbreun","year":"2021","journal-title":"J. Infect. Dis."},{"key":"10.1038\/s41385-022-00511-0_bib10","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1056\/NEJMoa2109072","article-title":"Covid-19 breakthrough infections in vaccinated health care workers","volume":"385","author":"Bergwerk","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/s41385-022-00511-0_bib11","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/cid\/ciab617","article-title":"COVID-19 outbreak associated with a SARS-CoV-2 P.1 Lineage in a long-term care home after implementation of a vaccination program\u2014Ontario, April-May 2021","volume":"74","author":"Williams","year":"2021","journal-title":"Clin. Infect. Dis"},{"key":"10.1038\/s41385-022-00511-0_bib12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.20411\/pai.v6i1.441","article-title":"Antibody responses to SARS-CoV-2 mRNA vaccines are detectable in saliva","volume":"6","author":"Ketas","year":"2021","journal-title":"Pathog. Immun."},{"key":"10.1038\/s41385-022-00511-0_bib13","author":"Sano"},{"key":"10.1038\/s41385-022-00511-0_bib14","doi-asserted-by":"crossref","first-page":"103788","DOI":"10.1016\/j.ebiom.2021.103788","article-title":"Mucosal immune response in BNT162b2 COVID-19 vaccine recipients","volume":"75","author":"Azzi","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1038\/s41385-022-00511-0_bib15","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4049\/jimmunol.2100990","article-title":"Cutting edge: serum but not mucosal antibody responses are associated with pre-existing SARS-CoV-2 spike cross-reactive CD4(+) T cells following BNT162b2 vaccination in the elderly","volume":"208","author":"Meyer-Arndt","year":"2022","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00511-0_bib16","author":"Nahass"},{"key":"10.1038\/s41385-022-00511-0_bib17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/cid\/ciab465","article-title":"Circulating SARS-CoV-2 vaccine antigen detected in the plasma of mRNA-1273 vaccine recipients","volume":"74","author":"Ogata","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1038\/s41385-022-00511-0_bib18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ijos.2016.38","article-title":"Saliva in the diagnosis of diseases","volume":"8","author":"Zhang","year":"2016","journal-title":"Int J. Oral. Sci."},{"key":"10.1038\/s41385-022-00511-0_bib19","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2018.11.035","article-title":"Recirculating Intestinal IgA-producing cells regulate neuroinflammation via IL-10","volume":"176","author":"Rojas","year":"2019","journal-title":"Cell"},{"key":"10.1038\/s41385-022-00511-0_bib20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1084\/jem.20090858","article-title":"Dynamic T cell migration program provides resident memory within intestinal epithelium","volume":"207","author":"Masopust","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00511-0_bib21","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1172\/JCI119286","article-title":"Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses","volume":"99","author":"Quiding-Jarbrink","year":"1997","journal-title":"J. Clin. Investig."},{"key":"10.1038\/s41385-022-00511-0_bib22","author":"Abe"},{"key":"10.1038\/s41385-022-00511-0_bib23","author":"Langel"},{"key":"10.1038\/s41385-022-00511-0_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27063-4","article-title":"Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization","volume":"12","author":"Lapuente","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-022-00511-0_bib25","first-page":"100010","article-title":"Detection of the novel SARS-CoV-2 European lineage B.1.177 in Ontario, Canada","volume":"1","author":"Guthrie","year":"2021","journal-title":"J. Clin. Virol."},{"key":"10.1038\/s41385-022-00511-0_bib26","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.abb2507","article-title":"Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation","volume":"367","author":"Wrapp","year":"2020","journal-title":"Science"},{"key":"10.1038\/s41385-022-00511-0_bib27","doi-asserted-by":"crossref","first-page":"e1380","DOI":"10.1002\/cti2.1380","article-title":"A scalable serology solution for profiling humoral immune responses to SARS-CoV-2 infection and vaccination","volume":"11","author":"Colwill","year":"2022","journal-title":"Clin Transl Immunology"},{"key":"10.1038\/s41385-022-00511-0_bib28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.chom.2020.06.021","article-title":"Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2","volume":"28","author":"Case","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1038\/s41385-022-00511-0_bib29","doi-asserted-by":"crossref","first-page":"32105","DOI":"10.1073\/pnas.2012197117","article-title":"Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion","volume":"117","author":"Zang","year":"2020","journal-title":"Proc. Natl Acad. Sci. U.S.A."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41385-022-00511-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-022-00511-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922000010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922000010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-022-00511-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:05:59Z","timestamp":1761829559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922000010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S1933021922000010"],"URL":"https:\/\/doi.org\/10.1038\/s41385-022-00511-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.01.21261297","asserted-by":"object"}]},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-022-00511-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}