{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T12:07:31Z","timestamp":1794571651600,"version":"4.9.1"},"reference-count":89,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1038\/s41385-022-00513-y","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T07:03:26Z","timestamp":1650006206000},"page":"1257-1269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Tissue-based IL-10 signalling in helminth infection limits IFN\u03b3 expression and promotes the intestinal Th2 response"],"prefix":"10.1016","volume":"15","author":[{"given":"Holly C.","family":"Webster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Gamino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna T.","family":"Andrusaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia J.","family":"Ridgewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"McCowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Shergold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham A.","family":"Heieis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon W.F.","family":"Milling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Maizels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Perona-Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41385-022-00513-y_bib1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI34261","article-title":"Helminth infections: the great neglected tropical diseases","volume":"118","author":"Hotez","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1038\/s41385-022-00513-y_bib2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1471-4906(03)00101-7","article-title":"The immune response to parasitic helminths: insights from murine models","volume":"24","author":"Gause","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/0014-4894(91)90074-7","article-title":"Heligmosomoides polygyrus: CD4+ but not CD8+ T cells regulate the IgE response and protective immunity in mice","volume":"73","author":"Urban","year":"1991","journal-title":"Exp. Parasitol."},{"key":"10.1038\/s41385-022-00513-y_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3476","article-title":"Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths","volume":"13","author":"Gause","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.296.5567.490","article-title":"Allergy, parasites, and the hygiene hypothesis","volume":"296","author":"Yazdanbakhsh","year":"2002","journal-title":"Science"},{"key":"10.1038\/s41385-022-00513-y_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2015.07.007","article-title":"Barrier epithelial cells and the control of type 2 immunity","volume":"43","author":"Hammad","year":"2015","journal-title":"Immunity"},{"key":"10.1038\/s41385-022-00513-y_bib7","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.jaci.2014.02.033","article-title":"Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, Th2-inducing allergen exposures","volume":"133","author":"Gold","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib8","doi-asserted-by":"crossref","first-page":"15820","DOI":"10.1038\/ncomms15820","article-title":"Different populations of CD11b(+) dendritic cells drive Th2 responses in the small intestine and colon","volume":"8","author":"Mayer","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1038\/s41385-022-00513-y_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/eji.201747073","article-title":"Functional specialization of intestinal dendritic cell subsets during Th2 helminth infection in mice","volume":"48","author":"Redpath","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib10","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"7","author":"Anthony","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib11","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1084\/jem.20091903","article-title":"Regulation of pathogenesis and immunity in helminth infections","volume":"206","author":"Maizels","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/ni.2182","article-title":"Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity","volume":"13","author":"Liang","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib13","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.20090313","article-title":"IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells","volume":"206","author":"King","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib14","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/ni.3582","article-title":"A tissue checkpoint regulates type 2 immunity","volume":"17","author":"Van Dyken","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1073\/pnas.1714348115","article-title":"Thymic stromal lymphopoietin drives the development of IL-13(+) Th2 cells","volume":"115","author":"Ochiai","year":"2018","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-022-00513-y_bib16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cyto.2015.02.026","article-title":"Spatial regulation of IL-4 signalling in vivo","volume":"5","author":"Redpath","year":"2015","journal-title":"Cytokine"},{"key":"10.1038\/s41385-022-00513-y_bib17","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the Interleukin-10 Receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib18","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1084\/jem.170.6.2081","article-title":"Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones","volume":"170","author":"Fiorentino","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib19","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.4049\/jimmunol.0711996","article-title":"Th1\/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort","volume":"182","author":"Halonen","year":"2009","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib20","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1126\/science.271.5256.1728","article-title":"Induction of Th1 and Th2 immunity in neonatal mice","volume":"271","author":"Forsthuber","year":"1996","journal-title":"Science"},{"key":"10.1038\/s41385-022-00513-y_bib21","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1172\/JCI18246","article-title":"IL-10 is critical for Th2 responses in a murine model of allergic dermatitis","volume":"112","author":"Laouini","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1038\/s41385-022-00513-y_bib22","doi-asserted-by":"crossref","first-page":"e20190742","DOI":"10.1084\/jem.20190742","article-title":"Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung","volume":"217","author":"He","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib23","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/mi.2016.47","article-title":"CD4 + Th2 cells are directly regulated by IL-10 during allergic airway inflammation","volume":"10","author":"Coomes","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib24","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.183.3.937","article-title":"Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes","volume":"183","author":"Malisan","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib25","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/eji.200324082","article-title":"Contrasting roles for IL-10 in protective immunity to different life cycle stages of intestinal nematode parasites","volume":"33","author":"Helmby","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1084\/jem.173.2.507","article-title":"Interleukin 10: a novel stimulatory factor for mast cells and their progenitors","volume":"173","author":"Thompson-Snipes","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib27","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.4049\/jimmunol.149.6.2123","article-title":"IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice","volume":"149","author":"Ghildyal","year":"1992","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis","volume":"75","author":"K\u00fchn","year":"1993","journal-title":"Cell"},{"key":"10.1038\/s41385-022-00513-y_bib29","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI118861","article-title":"Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses","volume":"98","author":"Berg","year":"1996","journal-title":"J. Clin. Investig."},{"key":"10.1038\/s41385-022-00513-y_bib30","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI21404","article-title":"IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6","volume":"116","author":"Yen","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1038\/s41385-022-00513-y_bib31","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1128\/IAI.66.11.5157-5166.1998","article-title":"Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism","volume":"66","author":"Kullberg","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-022-00513-y_bib32","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1128\/IAI.66.11.5224-5231.1998","article-title":"Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice","volume":"66","author":"Sellon","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-022-00513-y_bib33","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/pim.12113","article-title":"Protection and pathology during parasite infection: IL-10 strikes the balance","volume":"36","author":"Redpath","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib35","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/eji.200636751","article-title":"Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection","volume":"37","author":"Finney","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib36","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1128\/IAI.00358-07","article-title":"Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine","volume":"75","author":"Setiawan","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-022-00513-y_bib37","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/eji.201242794","article-title":"ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection","volume":"43","author":"Redpath","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib38","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.4049\/jimmunol.168.5.2383","article-title":"IL-10 is critical for host resistance and survival during gastrointestinal helminth infection","volume":"168","author":"Schopf","year":"2002","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib39","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1093\/intimm\/dxl075","article-title":"IL-4R signaling is required to induce IL-10 for the establishment of Th2 dominance","volume":"18","author":"Balic","year":"2006","journal-title":"Int. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib40","doi-asserted-by":"crossref","first-page":"112702","DOI":"10.1016\/j.jim.2019.112702","article-title":"Isolation and functional characterisation of lamina propria leukocytes from helminth-infected, murine small intestine","volume":"477","author":"Webster","year":"2020","journal-title":"J. Immunological Methods"},{"key":"10.1038\/s41385-022-00513-y_bib41","doi-asserted-by":"crossref","first-page":"e51678","DOI":"10.7554\/eLife.51678","article-title":"High-dimensional analysis of intestinal immune cells during helminth infection","volume":"9","author":"Ferrer-Font","year":"2020","journal-title":"eLife"},{"key":"10.1038\/s41385-022-00513-y_bib42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.4049\/jimmunol.1900978","article-title":"BHLHE40 promotes Th2 cell\u2013mediated antihelminth immunity and reveals cooperative CSF2RB family cytokines","volume":"204","author":"Jarjour","year":"2020","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib43","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.4049\/jimmunol.1201457","article-title":"Heligmosomoides polygyrus bakeri infection activates colonic Foxp3 + T cells enhancing their capacity to prevent colitis","volume":"191","author":"Hang","year":"2013","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib44","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2006.09.013","article-title":"Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse","volume":"25","author":"Kamanaka","year":"2006","journal-title":"Immunity"},{"key":"10.1038\/s41385-022-00513-y_bib45","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1073\/pnas.0501701102","article-title":"Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter","volume":"102","author":"Wan","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-022-00513-y_bib46","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.immuni.2006.02.014","article-title":"IFN-\u03b3 suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB\/AP-1 proteins","volume":"24","author":"Hu","year":"2006","journal-title":"Immunity"},{"key":"10.1038\/s41385-022-00513-y_bib47","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4049\/jimmunol.157.2.798","article-title":"In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha","volume":"157","author":"Gazzinelli","year":"1996","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/B978-0-12-800267-4.00005-5","article-title":"Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans","volume":"122","author":"Shouval","year":"2014","journal-title":"Adv. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib49","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/gene.2014.69","article-title":"Interleukin-10 receptor-1 expression in monocyte-derived antigen-presenting cell populations: dendritic cells partially escape from IL-10's inhibitory mechanisms","volume":"16","author":"von Lanzenauer","year":"2015","journal-title":"Genes Immun."},{"key":"10.1038\/s41385-022-00513-y_bib50","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2005.09.006","article-title":"A two-step process for cytokine production revealed by IL-4 dual-reporter mice","volume":"23","author":"Mohrs","year":"2005","journal-title":"Immunity"},{"key":"10.1038\/s41385-022-00513-y_bib51","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-4894(65)90016-0","article-title":"Pathology of nematospiroides dubius. I. Primary infections in C3H and webster mice","volume":"17","author":"Liu","year":"1965","journal-title":"Exp. Parasitol."},{"key":"10.1038\/s41385-022-00513-y_bib52","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00281-012-0347-3","article-title":"Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus","volume":"34","author":"Reynolds","year":"2012","journal-title":"Semin Immunopathol."},{"key":"10.1038\/s41385-022-00513-y_bib53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0169-4758(92)90084-F","article-title":"Heligmosomoides polygyrus: a model for chronic gastrointestinal helminthiasis","volume":"8","author":"Monroy","year":"1992","journal-title":"Parasitol. Today"},{"key":"10.1038\/s41385-022-00513-y_bib54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1128\/IAI.01100-15","article-title":"Parasite-specific CD4+ IFN-\u03b3+ IL-10+ T cells distribute within both lymphoid and nonlymphoid compartments and are controlled systemically by interleukin-27 and ICOS during blood-stage malaria infection","volume":"84","author":"Villegas-Mendez","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1038\/s41385-022-00513-y_bib55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1084\/jem.20062175","article-title":"Conventional T-bet+ Foxp3- Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection","volume":"204","author":"Jankovic","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib56","doi-asserted-by":"crossref","first-page":"18535","DOI":"10.1073\/pnas.1119133109","article-title":"Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response","volume":"109","author":"Perona-Wright","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/s41385-022-00513-y_bib57","doi-asserted-by":"crossref","first-page":"e0160118","DOI":"10.1371\/journal.pone.0160118","article-title":"Schistosoma mansoni Tegument (Smteg) induces IL-10 and modulates experimental airway inflammation","volume":"11","author":"Marinho","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1038\/s41385-022-00513-y_bib58","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.3389\/fimmu.2018.03019","article-title":"Identification of piecemeal degranulation and vesicular transport of MBP-1 in liver-infiltrating mouse eosinophils during acute experimental","volume":"9","author":"Dias","year":"2018","journal-title":"Front Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib59","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.4049\/jimmunol.164.12.6406","article-title":"IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis","volume":"164","author":"Hoffmann","year":"2000","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib60","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nri1589","article-title":"Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma","volume":"5","author":"Hawrylowicz","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib61","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.immuni.2020.12.013","article-title":"Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response","volume":"54","author":"Golebski","year":"2021","journal-title":"Immunity."},{"key":"10.1038\/s41385-022-00513-y_bib62","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1189\/jlb.0413207","article-title":"Location, location, location: tissue-specific regulation of immune responses","volume":"94","author":"Hu","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1038\/s41385-022-00513-y_bib63","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41577-019-0250-4","article-title":"Tissue immunity broadcasts near and far","volume":"20","author":"Molofsky","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib64","doi-asserted-by":"crossref","first-page":"15216","DOI":"10.3748\/wjg.v20.i41.15216","article-title":"Heterogeneity across the murine small and large intestine","volume":"20","author":"Bowcutt","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1038\/s41385-022-00513-y_bib65","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.it.2018.06.002","article-title":"Helminth-bacterial interactions: cause and consequence","volume":"39","author":"Rapin","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib66","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1220961","article-title":"Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses","volume":"337","author":"Hand","year":"2012","journal-title":"Science"},{"key":"10.1038\/s41385-022-00513-y_bib67","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4161\/gmic.32155","article-title":"Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites","volume":"5","author":"Reynolds","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1038\/s41385-022-00513-y_bib68","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/ibd.21299","article-title":"Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus","volume":"16","author":"Walk","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1038\/s41385-022-00513-y_bib69","doi-asserted-by":"crossref","first-page":"e1007265","DOI":"10.1371\/journal.ppat.1007265","article-title":"Exclusive dependence of IL-10R\u03b1 signalling on intestinal microbiota homeostasis and control of whipworm infection","volume":"15","author":"Duque-Correa","year":"2019","journal-title":"PLOS Pathog."},{"key":"10.1038\/s41385-022-00513-y_bib70","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.4049\/jimmunol.164.10.5375","article-title":"IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB\/c and susceptible C57BL\/6 mice following peroral infection with Toxoplasma gondii","volume":"164","author":"Suzuki","year":"2000","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib71","first-page":"381","article-title":"Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection","volume":"85","author":"Arai","year":"1995","journal-title":"Immunology"},{"key":"10.1038\/s41385-022-00513-y_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-38125-x","article-title":"IL-10 produced by macrophages regulates epithelial integrity in the small intestine","volume":"9","author":"Morhardt","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1038\/s41385-022-00513-y_bib73","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-3024.2003.00640.x","article-title":"Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice","volume":"25","author":"Menge","year":"2003","journal-title":"Parasite Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib74","doi-asserted-by":"crossref","first-page":"e20211140","DOI":"10.1084\/jem.20211140","article-title":"Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products","volume":"219","author":"Drurey","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib75","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.194.10.1497","article-title":"The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure","volume":"194","author":"Belkaid","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib76","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/mi.2010.8","article-title":"IL-10 production by CD4+ effector T cells: a mechanism for self-regulation","volume":"3","author":"Jankovic","year":"2010","journal-title":"Mucosal Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib77","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.4049\/jimmunol.1401056","article-title":"MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus","volume":"193","author":"Reynolds","year":"2014","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib78","doi-asserted-by":"crossref","first-page":"e20202726","DOI":"10.1084\/jem.20202726","article-title":"High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency","volume":"218","author":"Yang","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib79","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1084\/jem.20052165","article-title":"T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription","volume":"203","author":"Usui","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1038\/s41385-022-00513-y_bib80","doi-asserted-by":"crossref","first-page":"30","DOI":"10.12703\/r\/10-30","article-title":"Recent advances in understanding the Th1\/Th2 effector choice","volume":"10","author":"Butcher","year":"2021","journal-title":"Fac. Rev."},{"key":"10.1038\/s41385-022-00513-y_bib81","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cytogfr.2016.07.002","article-title":"Endocytic regulation of cytokine receptor signaling","volume":"32","author":"Cendrowski","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1038\/s41385-022-00513-y_bib82","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/ni.1866","article-title":"Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node","volume":"11","author":"Perona-Wright","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib83","doi-asserted-by":"crossref","first-page":"615","DOI":"10.4049\/jimmunol.0902408","article-title":"Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo","volume":"184","author":"Perona-Wright","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib84","doi-asserted-by":"crossref","first-page":"e1002273","DOI":"10.1371\/journal.ppat.1002273","article-title":"Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections","volume":"7","author":"Ingram","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1038\/s41385-022-00513-y_bib85","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.4049\/jimmunol.152.4.1821","article-title":"Expression cloning and characterization of a human IL-10 receptor","volume":"152","author":"Liu","year":"1994","journal-title":"J. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib86","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2249.2011.04424.x","article-title":"Interleukin-10 receptor expression and signalling were down-regulated in CD4+ T cells of lupus nephritis patients","volume":"165","author":"Cui","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"10.1038\/s41385-022-00513-y_bib87","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.21873\/anticanres.15110","article-title":"Cytokine-based cancer immunotherapy: challenges and opportunities for IL-10","volume":"41","author":"Rallis","year":"2021","journal-title":"Anticancer Res."},{"key":"10.1038\/s41385-022-00513-y_bib88","first-page":"e52412","article-title":"Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products","volume":"98","author":"Johnston","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1038\/s41385-022-00513-y_bib89","first-page":"4557","article-title":"A guide to histomorphological evaluation of intestinal inflammation in mouse models","volume":"7","author":"Erben","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41385-022-00513-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-022-00513-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922017524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922017524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41385-022-00513-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:37:25Z","timestamp":1761831445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922017524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":89,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1933021922017524"],"URL":"https:\/\/doi.org\/10.1038\/s41385-022-00513-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.10.455867","asserted-by":"object"}]},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue-based IL-10 signalling in helminth infection limits IFN\u03b3 expression and promotes the intestinal Th2 response","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41385-022-00513-y","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}