{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:18:35Z","timestamp":1792145915880,"version":"4.4.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000027","name":"U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R37AA08757"],"award-info":[{"award-number":["R37AA08757"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["NIAAA F32AA023434"],"award-info":[{"award-number":["NIAAA F32AA023434"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["NIAAAR37AA08757-12-14S1"],"award-info":[{"award-number":["NIAAAR37AA08757-12-14S1"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["NIAAAR37AA08757-19-22S1"],"award-info":[{"award-number":["NIAAAR37AA08757-19-22S1"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1038\/s41386-019-0326-7","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T04:05:23Z","timestamp":1548821123000},"page":"1579-1588","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Early life alcohol exposure primes hypothalamic microglia to later-life hypersensitivity to immune stress: possible epigenetic mechanism"],"prefix":"10.1038","volume":"44","author":[{"given":"Lucy G.","family":"Chastain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omkaram","family":"Gangisetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayani","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Shrivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaima","family":"Jabbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipak K.","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"326_CR1","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1001\/jama.2017.21896","volume":"319","author":"PA May","year":"2018","unstructured":"May PA, et al. Prevalence of fetal alcohol spectrum disorders in 4 US communities. JAMA. 2018;319:474\u201382.","journal-title":"JAMA"},{"key":"326_CR2","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1001\/jamapediatrics.2017.1919","volume":"171","author":"S Lange","year":"2017","unstructured":"Lange S, Probst C, Gmel G, Rehm J, Burd L, Popova S. Global prevalence of fetal alcohol spectrum disorder among children and youth: a systematic review and meta-analysis. JAMA Pediatr. 2017;171:948\u201356.","journal-title":"JAMA Pediatr"},{"key":"326_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s11065-011-9166-x","volume":"21","author":"EP Riley","year":"2011","unstructured":"Riley EP, Infante MA, Warren KR. Fetal alcohol spectrum disorders: an overview. Neuropsychol Rev. 2011;21:73\u201380.","journal-title":"Neuropsychol Rev"},{"key":"326_CR4","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/bdrc.21129","volume":"108","author":"C Caputo","year":"2016","unstructured":"Caputo C, Wood E, Jabbour L. Impact of fetal alcohol exposure on body systems: a systematic review. Birth Defects Res C. 2016;108:174\u201380.","journal-title":"Birth Defects Res C"},{"key":"326_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s40474-015-0053-7","volume":"2","author":"EM Moore","year":"2015","unstructured":"Moore EM, Riley EP. What happens when children with fetal alcohol spectrum disorders become adults? Curr Dev Disord Rep. 2015;2:219\u201327.","journal-title":"Curr Dev Disord Rep"},{"key":"326_CR6","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1177\/15353702-0323006-05","volume":"230","author":"X Zhang","year":"2005","unstructured":"Zhang X, Sliwowska JH, Weinberg J. Prenatal alcohol exposure and fetal programming: effects on neuroendocrine and immune function. Exp Biol Med. 2005;230:376\u201388.","journal-title":"Exp Biol Med"},{"key":"326_CR7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3389\/fgene.2014.00154","volume":"5","author":"EA Mead","year":"2014","unstructured":"Mead EA, Sarkar DK. Fetal alcohol spectrum disorders and their transmission through genetic and epigenetic mechanisms. Front Genet. 2014;5:154.","journal-title":"Front Genet"},{"key":"326_CR8","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1203\/00006450-198106000-00005","volume":"15","author":"S Johnson","year":"1981","unstructured":"Johnson S, Knight R, Marmer DJ, Steele RW. Immune deficiency in fetal alcohol syndrome. Pediatr Res. 1981;15:908\u201311.","journal-title":"Pediatr Res"},{"key":"326_CR9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.2174\/187152711794488575","volume":"10","author":"M Olah","year":"2011","unstructured":"Olah M, Biber K, Vinet J, Boddeke HW. Microglia phenotype diversity. CNS Neurol Disord Drug Targets. 2011;10:108\u201318.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"326_CR10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/B978-0-12-801284-0.00004-X","volume":"118","author":"LG Chastain","year":"2014","unstructured":"Chastain LG, Sarkar DK. Role of microglia in regulation of ethanol neurotoxic action. Int Rev Neurobiol. 2014;118:81\u2013103.","journal-title":"Int Rev Neurobiol"},{"key":"326_CR11","first-page":"331","volume":"37","author":"FT Crews","year":"2015","unstructured":"Crews FT, Sarkar DK, Qin L, Zou J, Boyadjieva N, Vetreno RP. Neuroimmune function and the consequences of alcohol exposure. Alcohol Res. 2015;37:331\u201341. 344-51","journal-title":"Alcohol Res"},{"key":"326_CR12","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.expneurol.2007.11.017","volume":"210","author":"J He","year":"2008","unstructured":"He J, Crews FT. Increased MCP-1 and microglia in various regions of the human alcoholic brain. Exp Neurol. 2008;210:349\u201358.","journal-title":"Exp Neurol"},{"key":"326_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.tox.2013.03.001","volume":"311","author":"S Alfonso-Loeches","year":"2013","unstructured":"Alfonso-Loeches S, Pascual M, Guerri C. Gender differences in alcohol-induced neurotoxicity and brain damage. Toxicology. 2013;311:27\u201334.","journal-title":"Toxicology"},{"key":"326_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fnsyn.2017.00011","volume":"9","author":"EL Wong","year":"2017","unstructured":"Wong EL, Stowell RD, Majewska AK. What the spectrum of microglial functions can teach us about fetal alcohol spectrum disorder. Front Synaptic Neurosci. 2017;9:11.","journal-title":"Front Synaptic Neurosci"},{"key":"326_CR15","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1111\/j.1530-0277.2010.01271.x","volume":"34","author":"NI Boyadjieva","year":"2010","unstructured":"Boyadjieva NI, Sarkar DK. Role of microglia in ethanol's apoptotic action on hypothalamic neuronal cells in primary cultures. Alcohol Clin Exp Res. 2010;34:1835\u201342.","journal-title":"Alcohol Clin Exp Res"},{"key":"326_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0844-3","volume":"14","author":"P Shrivastava","year":"2017","unstructured":"Shrivastava P, et al. Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronalapoptosis in the hypothalamus: effects of neonatal alcohol. J Neuroinflamm. 2017;14:83.","journal-title":"J Neuroinflamm"},{"key":"326_CR17","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.bbi.2016.05.022","volume":"58","author":"TS Bodnar","year":"2016","unstructured":"Bodnar TS, Hill LA, Weinberg J. Evidence for an immune signature of prenatalalcohol exposure in female rats. Brain Behav Immun. 2016;58:130\u201341.","journal-title":"Brain Behav Immun"},{"key":"326_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0382-9","volume":"12","author":"LA Topper","year":"2015","unstructured":"Topper LA, Baculis BC, Valenzuela CF. Exposure of neonatal rats to alcohol has differential effects on neuroinflammation and neuronal survival in the cerebellum and hippocampus. J Neuroinflamm. 2015;12:160.","journal-title":"J Neuroinflamm"},{"key":"326_CR19","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.neuint.2013.02.012","volume":"62","author":"V Tiwari","year":"2013","unstructured":"Tiwari V, Chopra K. Resveratrol abrogates alcohol-induced cognitive deficits by attenuating oxidative-nitrosative stress and inflammatory cascade in the adult rat brain. Neurochem Int. 2013;62:861\u20139.","journal-title":"Neurochem Int"},{"issue":"Suppl 1","key":"326_CR20","doi-asserted-by":"publisher","first-page":"S120","DOI":"10.1016\/j.bbi.2011.01.006","volume":"25","author":"JA McClain","year":"2011","unstructured":"McClain JA, et al. Adolescent binge alcohol exposure induces long-lasting partial activation of microglia. Brain Behav Immun. 2011;25(Suppl 1):S120\u20138.","journal-title":"Brain Behav Immun"},{"key":"326_CR21","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3389\/fnins.2018.00200","volume":"12","author":"RP Vetreno","year":"2018","unstructured":"Vetreno RP, Lawrimore CJ, Rowsey PJ, Crews FT. Persistent adult neuroimmune activation and loss of hippocampal neurogenesis following adolescent ethanol exposure: blockade by exercise and the anti-inflammatory drug indomethacin. Front Neurosci. 2018;12:200.","journal-title":"Front Neurosci"},{"key":"326_CR22","doi-asserted-by":"publisher","first-page":"15511","DOI":"10.1523\/JNEUROSCI.3688-11.2011","volume":"31","author":"LL Williamson","year":"2011","unstructured":"Williamson LL, Sholar PW, Mistry RS, Smith SH, Bilbo SD. Microglia and memory: modulation by early-life infection. J Neurosci. 2011;31:15511\u201321.","journal-title":"J Neurosci"},{"key":"326_CR23","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.biopsych.2013.10.014","volume":"76","author":"AM Fenn","year":"2014","unstructured":"Fenn AM, Gensel JC, Huang Y, Popovich PG, Lifshitz J, Godbout JP. Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia. Biol Psychiatry. 2014;76:575\u201384.","journal-title":"Biol Psychiatry"},{"key":"326_CR24","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/npp.2016.185","volume":"42","author":"A Niraula","year":"2017","unstructured":"Niraula A, Sheridan JF, Godbout JP. Microglia priming with aging and stress. Neuropsychopharmacology. 2017;42:318\u201333.","journal-title":"Neuropsychopharmacology"},{"key":"326_CR25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","volume":"10","author":"VH Perry","year":"2014","unstructured":"Perry VH, Holmes C. Microglial priming in neurodegenerative disease. Nat Rev Neurol. 2014;10:217\u201324.","journal-title":"Nat Rev Neurol"},{"key":"326_CR26","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.bbadis.2015.10.026","volume":"1862","author":"B Kaminska","year":"2016","unstructured":"Kaminska B, Mota M, Pizzi M. Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation. Biochim Biophys Acta. 2016;1862:339\u201351.","journal-title":"Biochim Biophys Acta"},{"key":"326_CR27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.alcohol.2017.01.005","volume":"60","author":"EJ Chater-Diehl","year":"2017","unstructured":"Chater-Diehl EJ, Laufer BI, Singh SM. Changes to histone modifications following prenatal alcohol exposure: an emerging picture. Alcohol. 2017;60:41\u201352.","journal-title":"Alcohol"},{"key":"326_CR28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.alcohol.2016.11.009","volume":"60","author":"BI Laufer","year":"2017","unstructured":"Laufer BI, Chater-Diehl EJ, Kapalanga J, Singh SM. Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: from mouse models to human children with fetal alcohol spectrum disorders. Alcohol. 2017;60:67\u201375.","journal-title":"Alcohol"},{"key":"326_CR29","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.neubiorev.2009.06.004","volume":"34","author":"KG Hellemans","year":"2010","unstructured":"Hellemans KG, et al. Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders. Neurosci Biobehav Rev. 2010;34:791\u2013807.","journal-title":"Neurosci Biobehav Rev"},{"key":"326_CR30","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.1365-2826.2008.01669.x","volume":"20","author":"J Weinberg","year":"2008","unstructured":"Weinberg J, et al. Prenatal alcohol exposure: foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome. J Neuroendocrinol. 2008;20:470\u201388.","journal-title":"J Neuroendocrinol"},{"key":"326_CR31","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.yhbeh.2013.02.017","volume":"63","author":"SD Bilbo","year":"2013","unstructured":"Bilbo SD, Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system. Horm Behav. 2013;63:684\u201391.","journal-title":"Horm Behav"},{"key":"326_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/brainsci3010001","volume":"3","author":"AY Klintsova","year":"2012","unstructured":"Klintsova AY, Hamilton GF, Boschen KE. Long-term consequences of developmental alcohol exposure on brain structure and function: therapeutic benefits of physical activity. Brain Sci. 2012;3:1\u201338.","journal-title":"Brain Sci"},{"key":"326_CR33","volume-title":"The mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2001","unstructured":"Paxinos G, Franklin KBJ. The mouse brain in stereotaxic coordinates. San Diego, CA: Academic; 2001."},{"key":"326_CR34","volume-title":"Atlas of the neonatal rat brain","author":"R Ramachandra","year":"2011","unstructured":"Ramachandra R, Subramanian T. Atlas of the neonatal rat brain. Boca Raton, FL: CRC Press; 2011."},{"issue":"Suppl 1","key":"326_CR35","doi-asserted-by":"publisher","first-page":"S137","DOI":"10.1016\/j.bbi.2011.02.016","volume":"25","author":"CJ Kane","year":"2011","unstructured":"Kane CJ, et al. Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-\u03b3 agonists. Brain Behav Immun. 2011;25(Suppl 1):S137\u201345.","journal-title":"Brain Behav Immun"},{"key":"326_CR36","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1002\/glia.22835","volume":"63","author":"KE Ahlers","year":"2015","unstructured":"Ahlers KE, Kara\u00e7ay B, Fuller L, Bonthius DJ, Dailey ME. Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration. Glia. 2015;63:1694\u2013713.","journal-title":"Glia"},{"key":"326_CR37","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.neuroscience.2016.03.033","volume":"324","author":"KE Boschen","year":"2016","unstructured":"Boschen KE, Ruggiero MJ, Klintsova AY. Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus. Neuroscience. 2016;324:355\u201366.","journal-title":"Neuroscience"},{"key":"326_CR38","doi-asserted-by":"publisher","first-page":"pii: E16","DOI":"10.3390\/brainsci6020016","volume":"6","author":"SA Marshall","year":"2016","unstructured":"Marshall SA, Geil CR, Nixon K. Prior binge ethanol exposure potentiates the microglial response in a model of alcohol-induced neurodegeneration. Brain Sci. 2016;6:pii: E16.","journal-title":"Brain Sci"},{"key":"326_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-10","volume":"5","author":"L Qin","year":"2008","unstructured":"Qin L, He J, Hanes RN, Pluzarev O, Hong JS, Crews FT. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J Neuroinflamm. 2008;5:10.","journal-title":"J Neuroinflamm"},{"key":"326_CR40","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1111\/acer.13511","volume":"41","author":"TJ Walter","year":"2017","unstructured":"Walter TJ, Vetreno RP, Crews FT. Alcohol and stress activation of microglia and neurons: brain regional effects. Alcohol Clin Exp Res. 2017;41:2066\u201381.","journal-title":"Alcohol Clin Exp Res"},{"key":"326_CR41","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1002\/glia.23007","volume":"64","author":"T M\u00f6ller","year":"2016","unstructured":"M\u00f6ller T, et al. Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor. Glia. 2016;64:1788\u201394.","journal-title":"Glia"},{"key":"326_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.54","volume":"4","author":"K Kobayashi","year":"2013","unstructured":"Kobayashi K, et al. Minocycline selectively inhibits M1 polarization of microglia. Cell Death Dis. 2013;4:e525.","journal-title":"Cell Death Dis"},{"key":"326_CR43","volume":"9","author":"L Qin","year":"2012","unstructured":"Qin L, Crews FT. Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration. J Neuroinflamm. 2012;9:130.","journal-title":"J Neuroinflamm"},{"issue":"Suppl 1","key":"326_CR44","doi-asserted-by":"publisher","first-page":"S165","DOI":"10.1016\/j.bbi.2011.03.002","volume":"25","author":"RG Agrawal","year":"2011","unstructured":"Agrawal RG, Hewetson A, George CM, Syapin PJ, Bergeson SE. Minocycline reduces ethanol drinking. Brain Behav Immun. 2011;25(Suppl 1):S165\u20139.","journal-title":"Brain Behav Immun"},{"key":"326_CR45","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1530-0277.1991.tb00536.x","volume":"15","author":"AJ Garro","year":"1991","unstructured":"Garro AJ, McBeth DL, Lima V, Lieber CS. Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome. Alcohol Clin Exp Res. 1991;15:395\u20138.","journal-title":"Alcohol Clin Exp Res"},{"key":"326_CR46","doi-asserted-by":"publisher","first-page":"e60503","DOI":"10.1371\/journal.pone.0060503","volume":"8","author":"Y Chen","year":"2013","unstructured":"Chen Y, Ozturk NC, Zhou FC. DNA methylation program in developing hippocampus and its alteration by alcohol. PLoS One. 2013;8:e60503.","journal-title":"PLoS One"},{"key":"326_CR47","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1007\/s11064-012-0960-5","volume":"38","author":"P Kim","year":"2013","unstructured":"Kim P, et al. Effects of ethanol exposure during early pregnancy in hyperactive, inattentive and impulsive behaviors and MeCP2 expression in rodent offspring. Neurochem Res. 2013;38:620\u201331.","journal-title":"Neurochem Res"},{"key":"326_CR48","doi-asserted-by":"publisher","first-page":"e113228","DOI":"10.1371\/journal.pone.0113228","volume":"9","author":"O Gangisetty","year":"2014","unstructured":"Gangisetty O, Bekdash R, Maglakelidze G, Sarkar DK. Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus. PLoS One. 2014;9:e113228.","journal-title":"PLoS One"},{"key":"326_CR49","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.biopsych.2013.01.012","volume":"73","author":"S Moonat","year":"2013","unstructured":"Moonat S, Sakharkar AJ, Zhang H, Tang L, Pandey SC. Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism. Biol Psychiatry. 2013;73:763\u201373.","journal-title":"Biol Psychiatry"},{"key":"326_CR50","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1017\/S1461145714000054","volume":"17","author":"AJ Sakharkar","year":"2014","unstructured":"Sakharkar AJ, et al. Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. Int J Neuropsychopharmacol. 2014;17:1207\u201320.","journal-title":"Int J Neuropsychopharmacol"},{"key":"326_CR51","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13072-015-0031-7","volume":"8","author":"KJ Veazey","year":"2015","unstructured":"Veazey KJ, Parnell SE, Miranda RC, Golding MC. Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. Epigenetics Chromatin. 2015;8:39.","journal-title":"Epigenetics Chromatin"},{"key":"326_CR52","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.1093\/nar\/gkm214","volume":"35","author":"N Rybtsova","year":"2007","unstructured":"Rybtsova N, Leimgruber E, Seguin-Est\u00e9vez Q, Dunand-Sauthier I, Krawczyk M, Reith W. Transcription-coupled deposition of histone modifications during MHC class II gene activation. Nucleic Acids Res. 2007;35:3431\u201341.","journal-title":"Nucleic Acids Res"},{"key":"326_CR53","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/B978-0-12-407708-9.00002-9","volume":"118","author":"JV Falvo","year":"2013","unstructured":"Falvo JV, Jasenosky LD, Kruidenier L, Goldfeld AE. Epigenetic control of cytokine gene expression: regulation of the TNF\/LT locus and T helper cell differentiation. Adv Immunol. 2013;118:37\u2013128.","journal-title":"Adv Immunol"},{"key":"326_CR54","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1182\/blood-2006-02-005520","volume":"108","author":"M Fann","year":"2006","unstructured":"Fann M, et al. Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response. Blood. 2006;108:3363\u201370.","journal-title":"Blood"},{"key":"326_CR55","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1056\/NEJMoa041892","volume":"352","author":"K Ito","year":"2005","unstructured":"Ito K, et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med. 2005;352:1967\u201376.","journal-title":"N Engl J Med"},{"key":"326_CR56","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nrg2540","volume":"10","author":"H Cedar","year":"2009","unstructured":"Cedar H, Bergman Y. Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet. 2009;10:295\u2013304.","journal-title":"Nat Rev Genet"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0326-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0326-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0326-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T17:05:12Z","timestamp":1684602312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41386-019-0326-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,30]]},"references-count":56,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["326"],"URL":"https:\/\/doi.org\/10.1038\/s41386-019-0326-7","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,30]]},"assertion":[{"value":"20 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}