{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:07:52Z","timestamp":1782562072175,"version":"3.54.5"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM008181"],"award-info":[{"award-number":["GM008181"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH107615"],"award-info":[{"award-number":["MH107615"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1038\/s41386-019-0380-1","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T15:00:04Z","timestamp":1554217204000},"page":"1788-1796","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Group II metabotropic glutamate receptor blockade promotes stress resilience in mice"],"prefix":"10.1038","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-2830","authenticated-orcid":false,"given":"Jaclyn N.","family":"Highland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panos","family":"Zanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polymnia","family":"Georgiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd D.","family":"Gould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"380_CR1","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","volume":"163","author":"AJ Rush","year":"2006","unstructured":"Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163:1905\u201317.","journal-title":"Am J Psychiatry"},{"key":"380_CR2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1600-0447.2009.01519.x","volume":"122","author":"F Hardeveld","year":"2010","unstructured":"Hardeveld F, Spijker J, De Graaf R, Nolen WA, Beekman AT. Prevalence and predictors of recurrence of major depressive disorder in the adult population. Acta Psychiatr Scand. 2010;122:184\u201391.","journal-title":"Acta Psychiatr Scand"},{"key":"380_CR3","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.cpr.2007.02.005","volume":"27","author":"SL Burcusa","year":"2007","unstructured":"Burcusa SL, Iacono WG. Risk for recurrence in depression. Clin Psychol Rev. 2007;27:959\u201385.","journal-title":"Clin Psychol Rev"},{"key":"380_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev.psych.48.1.191","volume":"48","author":"RC Kessler","year":"1997","unstructured":"Kessler RC. The effects of stressful life events on depression. Annu Rev Psychol. 1997;48:191\u2013214.","journal-title":"Annu Rev Psychol"},{"key":"380_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2174\/1570159X14666160309114549","volume":"15","author":"ES Wohleb","year":"2017","unstructured":"Wohleb ES, Gerhard D, Thomas A, Duman RS. Molecular and cellular mechanisms of rapid-acting antidepressants ketamine and scopolamine. Curr Neuropharmacol. 2017;15:11\u201320.","journal-title":"Curr Neuropharmacol"},{"key":"380_CR6","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.tins.2015.03.003","volume":"38","author":"SM Thompson","year":"2015","unstructured":"Thompson SM, Kallarackal AJ, Kvarta MD, Van Dyke AM, LeGates TA, Cai X. An excitatory synapse hypothesis of depression. Trends Neurosci. 2015;38:279\u201394.","journal-title":"Trends Neurosci"},{"key":"380_CR7","doi-asserted-by":"publisher","first-page":"15669","DOI":"10.1523\/JNEUROSCI.2588-13.2013","volume":"33","author":"AJ Kallarackal","year":"2013","unstructured":"Kallarackal AJ, Kvarta MD, Cammarata E, Jaberi L, Cai X, Bailey AM, et al. Chronic stress induces a selective decrease in AMPA receptor-mediated synaptic excitation at hippocampal temporoammonic-CA1 synapses. J Neurosci. 2013;33:15669\u201374.","journal-title":"J Neurosci"},{"key":"380_CR8","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.neuroscience.2008.04.005","volume":"154","author":"J Amat","year":"2008","unstructured":"Amat J, Paul E, Watkins LR, Maier SF. Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control. Neuroscience. 2008;154:1178\u201386.","journal-title":"Neuroscience"},{"key":"380_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1146\/annurev.pharmtox.37.1.205","volume":"37","author":"PJ Conn","year":"1997","unstructured":"Conn PJ, Pin JP. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol. 1997;37:205\u201337.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"380_CR10","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.neuropharm.2015.04.003","volume":"95","author":"T Kiritoshi","year":"2015","unstructured":"Kiritoshi T, Neugebauer V. Group II mGluRs modulate baseline and arthritis pain-related synaptic transmission in the rat medial prefrontal cortex. Neuropharmacology. 2015;95:388\u201394.","journal-title":"Neuropharmacology"},{"key":"380_CR11","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1111\/j.1471-4159.2010.07066.x","volume":"115","author":"ER Hascup","year":"2010","unstructured":"Hascup ER, Hascup KN, Stephens M, Pomerleau F, Huettl P, Gratton A, et al. Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex. J Neurochem. 2010;115:1608\u201320.","journal-title":"J Neurochem"},{"key":"380_CR12","doi-asserted-by":"publisher","first-page":"7503","DOI":"10.1523\/JNEUROSCI.17-19-07503.1997","volume":"17","author":"R Shigemoto","year":"1997","unstructured":"Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, et al. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci. 1997;17:7503\u201322.","journal-title":"J Neurosci"},{"key":"380_CR13","first-page":"12","volume":"299","author":"DD Schoepp","year":"2001","unstructured":"Schoepp DD. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther. 2001;299:12\u201320.","journal-title":"J Pharmacol Exp Ther"},{"key":"380_CR14","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/s41386-018-0192-8","volume":"44","author":"ME Joffe","year":"2018","unstructured":"Joffe ME, Conn PJ. Antidepressant potential of metabotropic glutamate receptor mGlu2 and mGlu3 negative allosteric modulators. Neuropsychopharmacology. 2018;44:214\u201336.","journal-title":"Neuropsychopharmacology"},{"key":"380_CR15","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/cne.903350209","volume":"335","author":"H Ohishi","year":"1993","unstructured":"Ohishi H, Shigemoto R, Nakanishi S, Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study. J Comp Neurol. 1993;335:252\u201366.","journal-title":"J Comp Neurol"},{"key":"380_CR16","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.neuropharm.2003.10.009","volume":"46","author":"S Chaki","year":"2004","unstructured":"Chaki S, Yoshikawa R, Hirota S, Shimazaki T, Maeda M, Kawashima N, et al. MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology. 2004;46:457\u201367.","journal-title":"Neuropharmacology"},{"key":"380_CR17","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1017\/S1461145711001702","volume":"15","author":"JM Dwyer","year":"2012","unstructured":"Dwyer JM, Lepack AE, Duman RS. mTOR activation is required for the antidepressant effects of mGluR(2)\/(3) blockade. Int J Neuropsychopharmacol. 2012;15:429\u201334.","journal-title":"Int J Neuropsychopharmacol"},{"key":"380_CR18","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbr.2012.10.023","volume":"238","author":"H Koike","year":"2013","unstructured":"Koike H, Fukumoto K, Iijima M, Chaki S. Role of BDNF\/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression. Behav Brain Res. 2013;238:48\u201352.","journal-title":"Behav Brain Res"},{"key":"380_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/2049-9256-1-15","volume":"1","author":"JM Dwyer","year":"2013","unstructured":"Dwyer JM, Lepack AE, Duman RS. mGluR2\/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure. J Mol Psychiatry. 2013;1:15.","journal-title":"J Mol Psychiatry"},{"key":"380_CR20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuropharm.2012.09.008","volume":"65","author":"Y Ago","year":"2013","unstructured":"Ago Y, Yano K, Araki R, Hiramatsu N, Kita Y, Kawasaki T, et al. Metabotropic glutamate 2\/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. Neuropharmacology. 2013;65:29\u201338.","journal-title":"Neuropharmacology"},{"key":"380_CR21","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3109\/01677063.2011.627485","volume":"25","author":"B Campo","year":"2011","unstructured":"Campo B, Kalinichev M, Lambeng N, El Yacoubi M, Royer-Urios I, Schneider M, et al. Characterization of an mGluR2\/3 negative allosteric modulator in rodent models of depression. J Neurogenet. 2011;25:152\u201366.","journal-title":"J Neurogenet"},{"key":"380_CR22","first-page":"228","volume":"20","author":"C Dong","year":"2017","unstructured":"Dong C, Zhang JC, Yao W, Ren Q, Ma M, Yang C, et al. Rapid and sustained antidepressant action of the mGlu2\/3 receptor antagonist MGS0039 in the social defeat stress model: comparison with ketamine. Int J Neuropsychopharmacol. 2017;20:228\u201336.","journal-title":"Int J Neuropsychopharmacol"},{"key":"380_CR23","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/j.neuropharm.2011.08.034","volume":"61","author":"H Koike","year":"2011","unstructured":"Koike H, Iijima M, Chaki S. Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists. Neuropharmacology. 2011;61:1419\u201323.","journal-title":"Neuropharmacology"},{"key":"380_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.bbr.2014.05.065","volume":"271","author":"H Koike","year":"2014","unstructured":"Koike H, Chaki S. Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats. Behav Brain Res. 2014;271:111\u20135.","journal-title":"Behav Brain Res"},{"key":"380_CR25","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/npp.2015.233","volume":"41","author":"K Fukumoto","year":"2016","unstructured":"Fukumoto K, Iijima M, Chaki S. The antidepressant effects of an mGlu2\/3 receptor antagonist and ketamine require AMPA receptor stimulation in the mPFC and Subsequent activation of the 5-HT neurons in the DRN. Neuropsychopharmacology. 2016;41:1046\u201356.","journal-title":"Neuropsychopharmacology"},{"key":"380_CR26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2174\/187152707780363302","volume":"6","author":"JM Witkin","year":"2007","unstructured":"Witkin JM, Marek GJ, Johnson BG, Schoepp DD. Metabotropic glutamate receptors in the control of mood disorders. CNS Neurol Disord Drug Targets. 2007;6:87\u2013100.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"380_CR27","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.tips.2017.03.008","volume":"38","author":"S Chaki","year":"2017","unstructured":"Chaki S. mGlu2\/3 receptor antagonists as novel antidepressants. Trends Pharmacol Sci. 2017;38:569\u201380.","journal-title":"Trends Pharmacol Sci"},{"key":"380_CR28","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1124\/jpet.116.238121","volume":"361","author":"JM Witkin","year":"2017","unstructured":"Witkin JM, Mitchell SN, Wafford KA, Carter G, Gilmour G, Li J, et al. Comparative effects of LY3020371, a potent and selective metabotropic glutamate (mGlu) 2\/3 receptor antagonist, and ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist in rodents: evidence supporting the use of mGlu2\/3 antagonists, for the treatment of depression. J Pharmacol Exp Ther. 2017;361:68\u201386.","journal-title":"J Pharmacol Exp Ther"},{"key":"380_CR29","doi-asserted-by":"publisher","first-page":"554","DOI":"10.2174\/18715273113129990079","volume":"12","author":"SD Gleason","year":"2013","unstructured":"Gleason SD, Li X, Smith IA, Ephlin JD, Wang XS, Heinz BA, et al. mGlu2\/3 agonist-induced hyperthermia: an in vivo assay for detection of mGlu2\/3 receptor antagonism and its relation to antidepressant-like efficacy in mice. CNS Neurol Disord Drug Targets. 2013;12:554\u201366.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"380_CR30","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1021\/jm970498o","volume":"41","author":"PL Ornstein","year":"1998","unstructured":"Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, et al. 2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability. J Med Chem. 1998;41:358\u201378.","journal-title":"J Med Chem"},{"key":"380_CR31","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s00213-004-2098-x","volume":"179","author":"AM Linden","year":"2005","unstructured":"Linden AM, Shannon H, Baez M, Yu JL, Koester A, Schoepp DD. Anxiolytic-like activity of the mGLU2\/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice. Psychopharmacology (Berl). 2005;179:284\u201391.","journal-title":"Psychopharmacology (Berl)"},{"key":"380_CR32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neuropharm.2012.01.019","volume":"66","author":"RA Wright","year":"2013","unstructured":"Wright RA, Johnson BG, Zhang C, Salhoff C, Kingston AE, Calligaro DO, et al. CNS distribution of metabotropic glutamate 2 and 3 receptors: transgenic mice and [(3)H]LY459477 autoradiography. Neuropharmacology. 2013;66:89\u201398.","journal-title":"Neuropharmacology"},{"key":"380_CR33","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.biopsych.2008.09.031","volume":"65","author":"T Hajszan","year":"2009","unstructured":"Hajszan T, Dow A, Warner-Schmidt JL, Szigeti-Buck K, Sallam NL, Parducz A, et al. Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression. Biol Psychiatry. 2009;65:392\u2013400.","journal-title":"Biol Psychiatry"},{"key":"380_CR34","first-page":"139","volume":"7","author":"BS Carter","year":"2013","unstructured":"Carter BS, Hamilton DE, Thompson RC. Acute and chronic glucocorticoid treatments regulate astrocyte-enriched mRNAs in multiple brain regions in vivo. Front Neurosci. 2013;7:139.","journal-title":"Front Neurosci"},{"key":"380_CR35","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","volume":"131","author":"V Krishnan","year":"2007","unstructured":"Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007;131:391\u2013404.","journal-title":"Cell"},{"key":"380_CR36","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/nprot.2011.361","volume":"6","author":"SA Golden","year":"2011","unstructured":"Golden SA, Covington HE III, Berton O, Russo SJ. A standardized protocol for repeated social defeat stress in mice. Nat Protoc. 2011;6:1183\u201391.","journal-title":"Nat Protoc"},{"key":"380_CR37","doi-asserted-by":"publisher","first-page":"6159","DOI":"10.1523\/JNEUROSCI.0577-11.2011","volume":"31","author":"ML Lehmann","year":"2011","unstructured":"Lehmann ML, Herkenham M. Environmental enrichment confers stress resiliency to social defeat through an infralimbic cortex-dependent neuroanatomical pathway. J Neurosci. 2011;31:6159\u201373.","journal-title":"J Neurosci"},{"key":"380_CR38","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.psyneuen.2016.04.009","volume":"69","author":"A Ashokan","year":"2016","unstructured":"Ashokan A, Hegde A, Mitra R. Short-term environmental enrichment is sufficient to counter stress-induced anxiety and associated structural and molecular plasticity in basolateral amygdala. Psychoneuroendocrinology. 2016;69:189\u201396.","journal-title":"Psychoneuroendocrinology"},{"key":"380_CR39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s12017-008-8029-y","volume":"10","author":"BN Greenwood","year":"2008","unstructured":"Greenwood BN, Fleshner M. Exercise, learned helplessness, and the stress-resistant brain. Neuromolecular Med. 2008;10:81\u201398.","journal-title":"Neuromolecular Med"},{"key":"380_CR40","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.biopsych.2015.04.022","volume":"79","author":"RA Brachman","year":"2016","unstructured":"Brachman RA, McGowan JC, Perusini JN, Lim SC, Pham TH, Faye C, et al. Ketamine as a prophylactic against stress-induced depressive-like behavior. Biol Psychiatry. 2016;79:776\u201386.","journal-title":"Biol Psychiatry"},{"key":"380_CR41","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1038\/npp.2017.19","volume":"42","author":"JC McGowan","year":"2017","unstructured":"McGowan JC, LaGamma CT, Lim SC, Tsitsiklis M, Neria Y, Brachman RA, et al. Prophylactic ketamine attenuates learned fear. Neuropsychopharmacology. 2017;42:1577\u201389.","journal-title":"Neuropsychopharmacology"},{"key":"380_CR42","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1523\/JNEUROSCI.3114-15.2016","volume":"36","author":"J Amat","year":"2016","unstructured":"Amat J, Dolzani SD, Tilden S, Christianson JP, Kubala KH, Bartholomay K, et al. Previous ketamine produces an enduring blockade of neurochemical and behavioral effects of uncontrollable stress. J Neurosci. 2016;36:153\u201361.","journal-title":"J Neurosci"},{"key":"380_CR43","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.biopsych.2018.02.011","volume":"84","author":"A Mastrodonato","year":"2018","unstructured":"Mastrodonato A, Martinez R, Pavlova IP, LaGamma CT, Brachman RA, Robison AJ, et al. Ventral CA3 activation mediates prophylactic ketamine efficacy against stress-induced depressive-like behavior. Biol Psychiatry. 2018;84:846\u201356.","journal-title":"Biol Psychiatry"},{"key":"380_CR44","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s40263-018-0492-x","volume":"32","author":"P Zanos","year":"2018","unstructured":"Zanos P, Thompson SM, Duman RS, Zarate CA Jr., Gould TD. Convergent mechanisms underlying rapid antidepressant action. CNS Drugs. 2018;32:197\u2013227.","journal-title":"CNS Drugs"},{"key":"380_CR45","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1124\/jpet.116.233627","volume":"358","author":"JM Witkin","year":"2016","unstructured":"Witkin JM, Monn JA, Schoepp DD, Li X, Overshiner C, Mitchell SN, et al. The rapidly acting antidepressant ketamine and the mGlu2\/3 receptor antagonist LY341495 rapidly engage dopaminergic mood circuits. J Pharmacol Exp Ther. 2016;358:71\u201382.","journal-title":"J Pharmacol Exp Ther"},{"key":"380_CR46","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00213-010-1978-5","volume":"212","author":"A Palucha-Poniewiera","year":"2010","unstructured":"Palucha-Poniewiera A, Wieronska JM, Branski P, Stachowicz K, Chaki S, Pilc A. On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039. Psychopharmacology (Berl). 2010;212:523\u201335. PMCID: 2981731","journal-title":"Psychopharmacology (Berl)"},{"key":"380_CR47","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nature10130","volume":"475","author":"AE Autry","year":"2011","unstructured":"Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF, et al. NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature. 2011;475:91\u20135.","journal-title":"Nature"},{"key":"380_CR48","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1037\/rev0000033","volume":"123","author":"SF Maier","year":"2016","unstructured":"Maier SF, Seligman ME. Learned helplessness at fifty: insights from neuroscience. Psychol Rev. 2016;123:349\u201367.","journal-title":"Psychol Rev"},{"key":"380_CR49","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.neubiorev.2005.03.021","volume":"29","author":"SF Maier","year":"2005","unstructured":"Maier SF, Watkins LR. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev. 2005;29:829\u201341.","journal-title":"Neurosci Biobehav Rev"},{"key":"380_CR50","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.neuroscience.2009.11.005","volume":"165","author":"J Amat","year":"2010","unstructured":"Amat J, Aleksejev RM, Paul E, Watkins LR, Maier SF. Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat. Neuroscience. 2010;165:1031\u20138.","journal-title":"Neuroscience"},{"key":"380_CR51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.neuropharm.2005.05.006","volume":"49","author":"AM Linden","year":"2005","unstructured":"Linden AM, Bergeron M, Schoepp DD. Comparison of c-Fos induction in the brain by the mGlu2\/3 receptor antagonist LY341495 and agonist LY354740: evidence for widespread endogenous tone at brain mGlu2\/3 receptors in vivo. Neuropharmacology. 2005;49:120\u201334.","journal-title":"Neuropharmacology"},{"key":"380_CR52","doi-asserted-by":"publisher","first-page":"4804","DOI":"10.1073\/pnas.1216100110","volume":"110","author":"C Nasca","year":"2013","unstructured":"Nasca C, Xenos D, Barone Y, Caruso A, Scaccianoce S, Matrisciano F, et al. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. Proc Natl Acad Sci USA. 2013;110:4804\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"380_CR53","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/mp.2014.96","volume":"20","author":"C Nasca","year":"2015","unstructured":"Nasca C, Bigio B, Zelli D, Nicoletti F, McEwen BS. Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility. Mol Psychiatry. 2015;20:755\u201363.","journal-title":"Mol Psychiatry"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0380-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0380-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0380-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:05:59Z","timestamp":1684616759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41386-019-0380-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,2]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["380"],"URL":"https:\/\/doi.org\/10.1038\/s41386-019-0380-1","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,2]]},"assertion":[{"value":"30 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}