{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:16:56Z","timestamp":1790727416011,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000026","name":"U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA033436"],"award-info":[{"award-number":["DA033436"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA045140"],"award-info":[{"award-number":["DA045140"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P50 DA015369"],"award-info":[{"award-number":["P50 DA015369"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1038\/s41386-019-0452-2","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T02:02:27Z","timestamp":1562032947000},"page":"441-450","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone"],"prefix":"10.1038","volume":"45","author":[{"given":"Bethany A.","family":"Stennett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Padovan-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Knackstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"452_CR1","unstructured":"Center for Behavioral Health Statistics and Quality. Behavioral Health Trends in the United States: Results from the 2014 National Survey on Drug Use and Health. 2015;37. \nhttps:\/\/www.samhsa.gov\/data\/sites\/default\/files\/NSDUH-FRR1-2014\/NSDUH-FRR1-2014.htm"},{"key":"452_CR2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1037\/1064-1297.2.3.244","volume":"2","author":"JC Anthony","year":"1994","unstructured":"Anthony JC, Warner LA, Kessler RC. Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the National Comorbidity Survey. Exp Clin Psychopharmacol. 1994;2:244\u2013268.","journal-title":"Exp Clin Psychopharmacol"},{"key":"452_CR3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0196-0644(96)70266-4","volume":"27","author":"D Brookoff","year":"1996","unstructured":"Brookoff D, Rotondo MF, Shaw LM, Campbell EA, Fields L. Coacaethylene levels in patients who test positive for cocaine. Ann Emerg Med 1996;27:316\u2013320.","journal-title":"Ann Emerg Med"},{"key":"452_CR4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0376-8716(90)90147-7","volume":"25","author":"BF Grant","year":"1990","unstructured":"Grant BF, Harford TC. Concurrent and simultaneous use of alcohol with cocaine: results of national survey. Drug Alcohol Depend 1990;25:97\u2013104.","journal-title":"Drug Alcohol Depend"},{"key":"452_CR5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1747-597X-2-33","volume":"2","author":"S Kedia","year":"2007","unstructured":"Kedia S, Sell MA, Relyea G. Mono- versus polydrug abuse patterns among publicly funded clients. Subst Abus Treat Prev Policy. 2007;2:33.","journal-title":"Subst Abus Treat Prev Policy"},{"key":"452_CR6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/archpsyc.1991.01810250045005","volume":"48","author":"BJ Rounsaville","year":"1991","unstructured":"Rounsaville BJ, Anton SF, Carroll K, Budde D, Prusoff BA, Gawin F. Psychiatric diagnoses of treatment-seeking cocaine abusers. Arch Gen Psychiatry. 1991;48:43\u201351.","journal-title":"Arch Gen Psychiatry"},{"key":"452_CR7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.drugalcdep.2018.07.025","volume":"192","author":"Y Liu","year":"2018","unstructured":"Liu Y, Williamson V, Setlow B, Cottler LB, Knackstedt LA. The importance of considering polysubstance use: lessons from cocaine research. Drug Alcohol Depend 2018;192:16\u201328.","journal-title":"Drug Alcohol Depend"},{"key":"452_CR8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.15288\/jsa.1993.54.199","volume":"54","author":"KM Carroll","year":"1993","unstructured":"Carroll KM, Rounsaville BJ, Bryant KJ. Alcoholism in treatment-seeking cocaine abusers: clinical and prognostic significance. J Stud Alcohol. 1993;54:199\u2013208.","journal-title":"J Stud Alcohol"},{"key":"452_CR9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00005053-199302000-00001","volume":"181","author":"KM Carroll","year":"1993","unstructured":"Carroll KM, Power ME, Bryant K, Rounsaville BJ. One-year follow-up status of treatment-seeking cocaine abusers. Psychopathology and dependence severity as predictors of outcome. J Nerv Ment Dis 1993;181:71\u201379.","journal-title":"J Nerv Ment Dis"},{"key":"452_CR10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.drugalcdep.2009.04.015","volume":"104","author":"AL Anderson","year":"2009","unstructured":"Anderson AL, Reid MS, Li S-H, Holmes T, Shemanski L, Slee A, et al. Modafinil for the treatment of cocaine dependence. Drug Alcohol Depend 2009;104:133\u2013139.","journal-title":"Drug Alcohol Depend"},{"key":"452_CR11","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.drugalcdep.2015.05.016","volume":"153","author":"PW Czoty","year":"2015","unstructured":"Czoty PW. Effects of chronic binge-like ethanol consumption on cocaine self-administration in rhesus monkeys. Drug Alcohol Depend 2015;153:278\u2013285.","journal-title":"Drug Alcohol Depend"},{"key":"452_CR12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1471-4159.2012.07738.x","volume":"122","author":"LP Pattison","year":"2012","unstructured":"Pattison LP, McIntosh S, Budygin EA, Hemby SE. Differential regulation of accumbal dopamine transmission in rats following cocaine, heroin and speedball self-administration. J Neurochem 2012;122:138\u2013146.","journal-title":"J Neurochem"},{"key":"452_CR13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/syn.21755","volume":"68","author":"LP Pattison","year":"2014","unstructured":"Pattison LP, McIntosh S, Sexton T, Childers SR, Hemby SE. Changes in dopamine transporter binding in nucleus accumbens following chronic self-administration cocaine: heroin combinations. Synapse. 2014;68:437\u2013444.","journal-title":"Synapse"},{"key":"452_CR14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/sj.npp.1300786","volume":"31","author":"JE Smith","year":"2006","unstructured":"Smith JE, Co C, Coller MD, Hemby SE, Martin TJ. Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine. Neuropsychopharmacology. 2006;31:139\u2013150.","journal-title":"Neuropsychopharmacology"},{"key":"452_CR15","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nn1069","volume":"6","author":"DA Baker","year":"2003","unstructured":"Baker DA, McFarland K, Lake RW, Shen H, Tang X-C, Toda S, et al. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 2003;6:743\u2013749.","journal-title":"Nat Neurosci"},{"key":"452_CR16","doi-asserted-by":"crossref","first-page":"RC89","DOI":"10.1523\/JNEUROSCI.20-15-j0006.2000","volume":"20","author":"JL Cornish","year":"2000","unstructured":"Cornish JL, Kalivas PW. Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. J Neurosci 2000;20:RC89.","journal-title":"J Neurosci"},{"key":"452_CR17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.euroneuro.2015.12.022","volume":"26","author":"AL LaCrosse","year":"2016","unstructured":"LaCrosse AL, Hill K, Knackstedt LA. Ceftriaxone attenuates cocaine relapse after abstinence through modulation of nucleus accumbens AMPA subunit expression. Eur Neuropsychopharmacol 2016;26:186\u2013194.","journal-title":"Eur Neuropsychopharmacol"},{"key":"452_CR18","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1369-1600.2012.00493.x","volume":"19","author":"V Lutgen","year":"2014","unstructured":"Lutgen V, Kong L, Kau KS, Madayag A, Mantsch JR, Baker DA. Time course of cocaine-induced behavioral and neurochemical plasticity. Addict Biol 2014;19:529\u2013538.","journal-title":"Addict Biol"},{"key":"452_CR19","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1523\/JNEUROSCI.1342-09.2010","volume":"30","author":"A Madayag","year":"2010","unstructured":"Madayag A, Kau KS, Lobner D, Mantsch JR, Wisniewski S, Baker DA. Drug-induced plasticity contributing to heightened relapse susceptibility: neurochemical changes and augmented reinstatement in high-intake rats. J Neurosci 2010;30:210\u2013217.","journal-title":"J Neurosci"},{"key":"452_CR20","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1523\/JNEUROSCI.23-08-03531.2003","volume":"23","author":"K McFarland","year":"2003","unstructured":"McFarland K, Lapish CC, Kalivas PW. Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 2003;23:3531\u20133537.","journal-title":"J Neurosci"},{"key":"452_CR21","doi-asserted-by":"crossref","first-page":"12406","DOI":"10.1523\/JNEUROSCI.1976-12.2012","volume":"32","author":"H Trantham-Davidson","year":"2012","unstructured":"Trantham-Davidson H, LaLumiere RT, Reissner KJ, Kalivas PW, Knackstedt LA. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. J Neurosci 2012;32:12406\u201312410.","journal-title":"J Neurosci"},{"key":"452_CR22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1369-1600.2011.00432.x","volume":"18","author":"X Wang","year":"2013","unstructured":"Wang X, Moussawi K, Knackstedt L, Shen H, Kalivas PW. Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addict Biol. 2013;18:40\u201349.","journal-title":"Addict Biol"},{"key":"452_CR23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biopsych.2009.07.018","volume":"67","author":"LA Knackstedt","year":"2010","unstructured":"Knackstedt LA, Melendez RI, Kalivas PW. Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biol Psychiatry. 2010;67:81\u201384.","journal-title":"Biol Psychiatry"},{"key":"452_CR24","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1523\/JNEUROSCI.3717-16.2017","volume":"37","author":"AL LaCrosse","year":"2017","unstructured":"LaCrosse AL, O\u2019Donovan SM, Sepulveda-Orengo MT, McCullumsmith RE, Reissner KJ, Schwendt M, et al. Contrasting the role of xCT and GLT-1 upregulation in the ability of ceftriaxone to attenuate the cue-induced reinstatement of cocaine seeking and normalize AMPA receptor subunit expression. J Neurosci 2017;37:5809\u20135821.","journal-title":"J Neurosci"},{"key":"452_CR25","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/npp.2017.244","volume":"43","author":"MT Sepulveda-Orengo","year":"2018","unstructured":"Sepulveda-Orengo MT, Healey KL, Kim R, Auriemma AC, Rojas J, Woronoff N, et al. Riluzole impairs cocaine reinstatement and restores adaptations in intrinsic excitability and GLT-1 expression. Neuropsychopharmacology. 2018;43:1212\u20131223.","journal-title":"Neuropsychopharmacology"},{"key":"452_CR26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/adb.12127","volume":"20","author":"KJ Reissner","year":"2015","unstructured":"Reissner KJ, Gipson CD, Tran PK, Knackstedt LA, Scofield MD, Kalivas PW. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addict Biol. 2015;20:316\u2013323.","journal-title":"Addict Biol"},{"key":"452_CR27","doi-asserted-by":"crossref","first-page":"9239","DOI":"10.1523\/JNEUROSCI.1746-09.2009","volume":"29","author":"Y Sari","year":"2009","unstructured":"Sari Y, Smith KD, Ali PK, Rebec GV. Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. J Neurosci 2009;29:9239\u20139243.","journal-title":"J Neurosci"},{"key":"452_CR28","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00213-017-4802-7","volume":"235","author":"AR Bechard","year":"2018","unstructured":"Bechard AR, Hamor PU, Schwendt M, Knackstedt LA. The effects of ceftriaxone on cue-primed reinstatement of cocaine-seeking in male and female rats: estrous cycle effects on behavior and protein expression in the nucleus accumbens. Psychopharmacology. 2018;235:837\u2013848.","journal-title":"Psychopharmacology"},{"key":"452_CR29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pbb.2017.07.001","volume":"159","author":"BA Stennett","year":"2017","unstructured":"Stennett BA, Frankowski JC, Peris J, Knackstedt LA. Ceftriaxone reduces alcohol intake in outbred rats while upregulating xCT in the nucleus accumbens core. Pharmacol Biochem Behav 2017;159:18\u201323.","journal-title":"Pharmacol Biochem Behav"},{"key":"452_CR30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fphar.2015.00044","volume":"6","author":"A Weiland","year":"2015","unstructured":"Weiland A, Garcia S, Knackstedt LA. Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking. Front Pharmacol 2015;6:44.","journal-title":"Front Pharmacol"},{"key":"452_CR31","first-page":"100193","volume":"2","author":"S MacDonald","year":"2015","unstructured":"MacDonald S, MacIntyre P, Joordens C, Stockwell T, Martin G. Factors related to simultaneous cocaine and alcohol use for clients in treatment. J Alcohol Drug Depend 2015;2:100193.","journal-title":"J Alcohol Drug Depend"},{"key":"452_CR32","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1360-0443.2006.01497.x","volume":"101","author":"M Gossop","year":"2006","unstructured":"Gossop M, Manning V, Ridge G. Concurrent use and order of use of cocaine and alcohol: behavioural differences between users of crack cocaine and cocaine powder Addiction 2006;101:1292\u20131298.","journal-title":"Addiction"},{"key":"452_CR33","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/ejn.13284","volume":"44","author":"D Pati","year":"2016","unstructured":"Pati D, Kelly K, Stennett B, Frazier CJ, Knackstedt LA. Alcohol consumption increases basal extracellular glutamate in the nucleus accumbens core of Sprague-Dawley rats without increasing spontaneous glutamate release. Eur J Neurosci 2016;44:1896\u20131905.","journal-title":"Eur J Neurosci"},{"key":"452_CR34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuropharm.2018.03.022","volume":"135","author":"CN Logan","year":"2018","unstructured":"Logan CN, LaCrosse AL, Knackstedt LA. Nucleus accumbens GLT-1a overexpression reduces glutamate efflux during reinstatement of cocaine-seeking but is not sufficient to attenuate reinstatement. Neuropharmacology. 2018;135:297\u2013307.","journal-title":"Neuropharmacology"},{"key":"452_CR35","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1530-0277.2008.00753.x","volume":"32","author":"JA Simms","year":"2008","unstructured":"Simms JA, Steensland P, Medina B, Abernathy KE, Chandler LJ, Wise R, et al. Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcohol Clin Exp Res 2008;32:1816\u20131823.","journal-title":"Alcohol Clin Exp Res"},{"key":"452_CR36","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1523\/JNEUROSCI.1244-10.2010","volume":"30","author":"LA Knackstedt","year":"2010","unstructured":"Knackstedt LA, Moussawi K, Lalumiere R, Schwendt M, Klugmann M, Kalivas PW. Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. J Neurosci 2010;30:7984\u20137992.","journal-title":"J Neurosci"},{"key":"452_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/9312508","volume":"2016","author":"Lori A. Knackstedt","year":"2016","unstructured":"Knackstedt LA, Schwendt M. mGlu5 Receptors and relapse to cocaine-seeking: the role of receptor trafficking in postrelapse extinction learning deficits. Neural Plast. 2016;2016:9312508. \nhttps:\/\/www.hindawi.com\/journals\/np\/2016\/9312508\/","journal-title":"Neural Plasticity"},{"key":"452_CR38","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.pbb.2006.10.010","volume":"85","author":"J Peris","year":"2006","unstructured":"Peris J, Zharikova A, Li Z, Lingis M, MacNeill M, Wu MT, et al. Brain ethanol levels in rats after voluntary ethanol consumption using a sweetened gelatin vehicle. Pharmacol Biochem Behav 2006;85:562\u2013568.","journal-title":"Pharmacol Biochem Behav"},{"key":"452_CR39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jchromb.2008.08.026","volume":"874","author":"E Jagerdeo","year":"2008","unstructured":"Jagerdeo E, Montgomery MA, Lebeau MA, Sibum M. An automated SPE\/LC\/MS\/MS method for the analysis of cocaine and metabolites in whole blood. J Chromatogr B, Anal Technol Biomed Life Sci 2008;874:15\u201320.","journal-title":"J Chromatogr B, Anal Technol Biomed Life Sci"},{"key":"452_CR40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1369-1600.2010.00272.x","volume":"16","author":"V Chefer","year":"2011","unstructured":"Chefer V, Meis J, Wang G, Kuzmin A, Bakalkin G, Shippenberg T. Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release. Addict Biol 2011;16:229\u2013237.","journal-title":"Addict Biol"},{"key":"452_CR41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/00221309.1994.9921213","volume":"121","author":"DW Zimmerman","year":"1994","unstructured":"Zimmerman DW. A note on the influence of outliers on parametric and nonparametrictests. J Gen Psychol 1994;121:391\u2013401.","journal-title":"J Gen Psychol"},{"key":"452_CR42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1021\/js980282p","volume":"88","author":"WJ Pan","year":"1999","unstructured":"Pan WJ, Hedaya MA. Cocaine and alcohol interactions in the rat: effect on cocaine pharmacokinetics and pharmacodynamics. J Pharm Sci 1999;88:459\u2013467.","journal-title":"J Pharm Sci"},{"key":"452_CR43","doi-asserted-by":"crossref","first-page":"8700","DOI":"10.1523\/JNEUROSCI.1291-15.2016","volume":"36","author":"EM McGlinchey","year":"2016","unstructured":"McGlinchey EM, James MH, Mahler SV, Pantazis C, Aston-Jones G. Prelimbic to accumbens core pathway is recruited in a dopamine-dependent manner to drive cued reinstatement of cocaine seeking. J Neurosci 2016;36:8700\u20138711.","journal-title":"J Neurosci"},{"key":"452_CR44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pbb.2006.08.012","volume":"85","author":"LA Knackstedt","year":"2006","unstructured":"Knackstedt LA, Ben-Shahar O, Ettenberg A. Alcohol consumption is preferred to water in rats pretreated with intravenous cocaine. Pharmacol Biochem Behav 2006;85:281\u2013286.","journal-title":"Pharmacol Biochem Behav"},{"key":"452_CR45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mcn.2017.04.008","volume":"82","author":"AM Hammad","year":"2017","unstructured":"Hammad AM, Althobaiti YS, Das SC, Sari Y. Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats. Mol Cell Neurosci 2017;82:58\u201365.","journal-title":"Mol. Cell. Neurosci."},{"key":"452_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2017.09.019","volume":"128","author":"R Kim","year":"2018","unstructured":"Kim R, Sepulveda-Orengo MT, Healey KL, Williams EA, Reissner KJ. Regulation of glutamate transporter 1 (GLT-1) gene expression by cocaine self-administration and withdrawal. Neuropharmacology. 2018;128:1\u201310.","journal-title":"Neuropharmacology"},{"key":"452_CR47","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00213-007-0958-x","volume":"196","author":"M Migu\u00e9ns","year":"2008","unstructured":"Migu\u00e9ns M, Del Olmo N, Higuera-Matas A, Torres I, Garc\u00eda-Lecumberri C, Ambrosio E. Glutamate and aspartate levels in the nucleus accumbens during cocaine self-administration and extinction: a time course microdialysis study. Psychopharmacology 2008;196:303\u2013313.","journal-title":"Psychopharmacology"},{"key":"452_CR48","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/npp.2013.256","volume":"39","author":"WC Griffin","year":"2014","unstructured":"Griffin WC, Haun HL, Hazelbaker CL, Ramachandra VS, Becker HC. Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice. Neuropsychopharmacology 2014;39:707\u201317.","journal-title":"Neuropsychopharmacology"},{"key":"452_CR49","doi-asserted-by":"crossref","first-page":"9319","DOI":"10.1523\/JNEUROSCI.3278-12.2013","volume":"33","author":"KD Fischer","year":"2013","unstructured":"Fischer KD, Houston ACW, Rebec GV. Role of the major glutamate transporter GLT1 in nucleus accumbens core versus shell in cue-induced cocaine-seeking behavior. J Neurosci 2013;33:9319\u20139327.","journal-title":"J Neurosci"},{"key":"452_CR50","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/FBP.0b013e3283473c10","volume":"22","author":"SJ Ward","year":"2011","unstructured":"Ward SJ, Rasmussen BA, Corley G, Henry C, Kim JK, Walker EA, et al. Beta-lactam antibiotic decreases acquisition of and motivation to respond for cocaine, but not sweet food, in C57Bl\/6 mice. Behav Pharmacol 2011;22:370\u2013373.","journal-title":"Behav Pharmacol"},{"key":"452_CR51","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1523\/JNEUROSCI.2673-16.2016","volume":"37","author":"ACW Smith","year":"2017","unstructured":"Smith ACW, Scofield MD, Heinsbroek JA, Gipson CD, Neuhofer D, Roberts-Wolfe DJ, et al. Accumbens nNOS interneurons regulate cocaine relapse. J Neurosci 2017;37:742\u2013756.","journal-title":"J Neurosci"},{"key":"452_CR52","doi-asserted-by":"crossref","first-page":"9134","DOI":"10.1523\/JNEUROSCI.22-20-09134.2002","volume":"22","author":"DA Baker","year":"2002","unstructured":"Baker DA, Xi Z-X, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci 2002;22:9134\u20139141.","journal-title":"J. Neurosci."},{"key":"452_CR53","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1073\/pnas.87.17.6912","volume":"87","author":"AM Graybiel","year":"1990","unstructured":"Graybiel AM, Moratalla R, Robertson HA. Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc Natl Acad Sci USA. 1990;87:6912\u20136916.","journal-title":"Proc Natl Acad Sci USA"},{"key":"452_CR54","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0169-328X(98)00060-6","volume":"57","author":"JQ Wang","year":"1998","unstructured":"Wang JQ. Regulation of immediate early gene c-fos and zif\/268 mRNA expression in rat striatum by metabotropic glutamate receptor. Brain Res Mol Brain Res 1998;57:46\u201353.","journal-title":"Brain Res Mol Brain Res"},{"key":"452_CR55","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1523\/JNEUROSCI.22-03-01126.2002","volume":"22","author":"KM Kantak","year":"2002","unstructured":"Kantak KM, Black Y, Valencia E, Green-Jordan K, Eichenbaum HB. Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine-seeking behavior in rats. J Neurosci 2002;22:1126\u20131136.","journal-title":"J Neurosci"},{"key":"452_CR56","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnbeh.2013.00213","volume":"7","author":"MT Stefanik","year":"2013","unstructured":"Stefanik MT, Kalivas PW. Optogenetic dissection of basolateral amygdala projections during cue-induced reinstatement of cocaine seeking. Front Behav Neurosci 2013;7:213.","journal-title":"Front Behav Neurosci"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0452-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0452-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0452-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:06:49Z","timestamp":1684616809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41386-019-0452-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["452"],"URL":"https:\/\/doi.org\/10.1038\/s41386-019-0452-2","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]},"assertion":[{"value":"28 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}