{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:32:11Z","timestamp":1789065131493,"version":"build-2803163510"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1038\/s41386-019-0512-7","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T12:04:24Z","timestamp":1568030664000},"page":"233-234","source":"Crossref","is-referenced-by-count":6,"title":["Role for kappa-opioid system in stress-induced cocaine use uncovered with PET"],"prefix":"10.1038","volume":"45","author":[{"given":"Derek","family":"Blevins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"issue":"Suppl 1","key":"512_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neuropharm.2008.07.043","volume":"56","author":"GF Koob","year":"2009","unstructured":"Koob GF. Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology. 2009;56(Suppl 1):18\u201331.","journal-title":"Neuropharmacology"},{"key":"512_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00213-008-1122-y","volume":"200","author":"VA Redila","year":"2008","unstructured":"Redila VA, Chavkin C. Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology (Berl). 2008;200:59\u201370.","journal-title":"Psychopharmacology (Berl)"},{"key":"512_CR3","doi-asserted-by":"publisher","first-page":"8225","DOI":"10.1523\/JNEUROSCI.17-21-08225.1997","volume":"17","author":"JK Staley","year":"1997","unstructured":"Staley JK, Rothman RB, Rice KC, Partilla J, Mash DC. \u03ba2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. J Neurosci. 1997;17:8225.","journal-title":"J Neurosci"},{"key":"512_CR4","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41386-019-0398-4","volume":"44","author":"D Martinez","year":"2019","unstructured":"Martinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF. et al. Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study. Neuropsychopharmacology. 2019;44:1720\u20137.","journal-title":"Neuropsychopharmacology"},{"key":"512_CR5","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1111\/add.13375","volume":"111","author":"W Ling","year":"2016","unstructured":"Ling W, Hillhouse MP, Saxon AJ, Mooney LJ, Thomas CM, Ang A, et al. Buprenorphine+naloxone plus naltrexone for the treatment of cocaine dependence: the Cocaine Use Reduction with Buprenorphine (CURB) study. Addiction (Abingdon, Engl). 2016;111:1416\u201327.","journal-title":"Addiction (Abingdon, Engl)"},{"key":"512_CR6","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/npp.2017.205","volume":"43","author":"B Reed","year":"2018","unstructured":"Reed B, Butelman ER, Fry RS, Kimani R, Kreek MJ. Repeated administration of Opra Kappa (LY2456302), a novel, short-acting, selective KOP-r antagonist, in persons with and without cocaine dependence. Neuropsychopharmacology. 2018;43:739\u201350.","journal-title":"Neuropsychopharmacology"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0512-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0512-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41386-019-0512-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:07:15Z","timestamp":1684616835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41386-019-0512-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,9]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["512"],"URL":"https:\/\/doi.org\/10.1038\/s41386-019-0512-7","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,9]]}}}