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To address this issue, rats were trained on a reward-guided decision-making task; reward value was manipulated by independently varying the size of or the delay to reward over several trial blocks. Subsequently, rats self-administered either a cocaine (experimental group) or sucrose (control) during 12 consecutive days, after which they underwent a 1-month withdrawal period. Upon completion of this period, rats performed the previously learned reward-guided decision-making task while we recorded from single neurons in ACC. We demonstrate that prior cocaine self-administration attenuates attention and attention-related ACC signals in an intake-dependent manner, and that changes in attention are decoupled from ACC firing. These effects likely contribute to the impaired decision-making\u2014typified by chronic substance abuse and relapse\u2014observed after drug use.<\/jats:p>","DOI":"10.1038\/s41386-019-0578-2","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T07:02:42Z","timestamp":1574838162000},"page":"833-841","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prior cocaine self-administration impairs attention signals in anterior cingulate cortex"],"prefix":"10.1038","volume":"45","author":[{"given":"Daniela","family":"V\u00e1zquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Pribut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Tennyson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Roesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"578_CR1","doi-asserted-by":"publisher","first-page":"5881","DOI":"10.1523\/JNEUROSCI.0323-06.2006","volume":"26","author":"JLC Lee","year":"2006","unstructured":"Lee JLC, Milton AL, Everitt BJ. 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