{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:54:19Z","timestamp":1790751259950,"version":"4.1.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000026","name":"U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA041356"],"award-info":[{"award-number":["R01 DA041356"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01-DA030074"],"award-info":[{"award-number":["R01-DA030074"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["P50-MH106428"],"award-info":[{"award-number":["P50-MH106428"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1038\/s41386-021-01178-0","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T11:02:41Z","timestamp":1632567761000},"page":"891-901","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT1B receptors"],"prefix":"10.1038","volume":"47","author":[{"given":"Harrison M.","family":"Fontaine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlie","family":"Neiswanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachelle","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony D.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin B.","family":"Land","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1763-7118","authenticated-orcid":false,"given":"John F.","family":"Neumaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-476X","authenticated-orcid":false,"given":"Charles","family":"Chavkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"1178_CR1","doi-asserted-by":"publisher","first-page":"5674","DOI":"10.1523\/JNEUROSCI.23-13-05674.2003","volume":"23","author":"JP McLaughlin","year":"2003","unstructured":"McLaughlin JP, Marton-Popovici M, Chavkin C. \u03ba opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J Neurosci. 2003;23:5674\u201383.","journal-title":"J Neurosci"},{"key":"1178_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00213-008-1122-y","volume":"200","author":"VA Redila","year":"2008","unstructured":"Redila VA, Chavkin C. Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology. 2008;200:59\u201370.","journal-title":"Psychopharmacology"},{"key":"1178_CR3","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1196\/annals.1441.030","volume":"1141","author":"R Sinha","year":"2008","unstructured":"Sinha R. Chronic stress, drug use, and vulnerability to addiction. Ann N. Y Acad Sci. 2008;1141:105\u201330.","journal-title":"Ann N. Y Acad Sci"},{"key":"1178_CR4","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.neuropharm.2013.07.021","volume":"76","author":"JR Mantsch","year":"2014","unstructured":"Mantsch JR, Vranjkovic O, Twining RC, Gasser PJ, McReynolds JR, Blacktop JM. Neurobiological mechanisms that contribute to stress-related cocaine use. Neuropharmacology. 2014;76:383\u201394.","journal-title":"Neuropharmacology."},{"key":"1178_CR5","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/sj.npp.1300860","volume":"31","author":"JP McLaughlin","year":"2006","unstructured":"McLaughlin JP, Land BB, Li S, Pintar JE, Chavkin C. Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacol Publ Am Coll Neuropsychopharmacol. 2006;31:787\u201394.","journal-title":"Neuropsychopharmacol Publ Am Coll Neuropsychopharmacol"},{"key":"1178_CR6","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.1523\/JNEUROSCI.1978-13.2015","volume":"35","author":"TW Whitfield","year":"2015","unstructured":"Whitfield TW, Schlosburg JE, Wee S, Gould A, George O, Grant Y, et al. Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci. 2015;35:4296\u2013305.","journal-title":"J Neurosci"},{"key":"1178_CR7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nrd.2017.229","volume":"17","author":"JS Smith","year":"2018","unstructured":"Smith JS, Lefkowitz RJ, Rajagopal S. Biased signalling: from simple switches to allosteric microprocessors. Nat Rev Drug Discov. 2018;17:243\u201360.","journal-title":"Nat Rev Drug Discov"},{"key":"1178_CR8","doi-asserted-by":"publisher","first-page":"19168","DOI":"10.1073\/pnas.0910705106","volume":"106","author":"BB Land","year":"2009","unstructured":"Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, et al. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proc Natl Acad Sci USA. 2009;106:19168\u201373.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1178_CR9","doi-asserted-by":"publisher","first-page":"17582","DOI":"10.1523\/JNEUROSCI.3220-12.2012","volume":"32","author":"AG Schindler","year":"2012","unstructured":"Schindler AG, Messinger DI, Smith JS, Shankar H, Gustin RM, Schattauer SS, et al. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. J Neurosci. 2012;32:17582\u201396.","journal-title":"J Neurosci"},{"key":"1178_CR10","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1101\/lm.037317.114","volume":"22","author":"M Luo","year":"2015","unstructured":"Luo M, Zhou J, Liu Z. Reward processing by the dorsal raphe nucleus: 5-HT and beyond. Learn Mem. 2015;22:452\u201360.","journal-title":"Learn Mem"},{"key":"1178_CR11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neulet.2018.08.023","volume":"685","author":"J Yuanyuan","year":"2018","unstructured":"Yuanyuan J, Rui S, hua T, Jingjing C, Cuola D, Yuhui S, et al. Genetic association analyses and meta-analysis of Dynorphin-Kappa Opioid system potential functional variants with heroin dependence. Neurosci Lett. 2018;685:75\u201382.","journal-title":"Neurosci Lett"},{"key":"1178_CR12","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/ajmg.b.30510","volume":"144B","author":"G Gerra","year":"2018","unstructured":"Gerra G, Leonardi C, Cortese E, D\u2019Amore A, Lucchini A, Strepparola G, et al. Human Kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction. Am J Med Genet B Neuropsychiatr Genet. 2018;144B:771\u20135.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"1178_CR13","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1749-6632.2009.05275.x","volume":"1187","author":"V Yuferov","year":"2010","unstructured":"Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ. Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction, and treatment. Ann N. Y Acad Sci. 2010;1187:184\u2013207.","journal-title":"Ann N. Y Acad Sci"},{"key":"1178_CR14","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1126\/science.1083968","volume":"301","author":"A Caspi","year":"2003","unstructured":"Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386\u20139.","journal-title":"Science."},{"key":"1178_CR15","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1523\/JNEUROSCI.4458-07.2008","volume":"28","author":"BB Land","year":"2008","unstructured":"Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C. The dysphoric component of stress is encoded by activation of the dynorphin-opioid system. J Neurosci. 2008;28:407\u201314.","journal-title":"J Neurosci"},{"key":"1178_CR16","doi-asserted-by":"publisher","first-page":"12917","DOI":"10.1523\/JNEUROSCI.2444-15.2015","volume":"35","author":"JM Ehrich","year":"2015","unstructured":"Ehrich JM, Messinger DI, Knakal CR, Kuhar JR, Schattauer SS, Bruchas MR, et al. Kappa opioid receptor-induced aversion requires p38 MAPK activation in VTA dopamine neurons. J Neurosci. 2015;35:12917\u201331.","journal-title":"J Neurosci"},{"key":"1178_CR17","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.neuron.2011.06.011","volume":"71","author":"MR Bruchas","year":"2011","unstructured":"Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, et al. Selective p38\u03b1 MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron. 2011;71:498\u2013511.","journal-title":"Neuron."},{"key":"1178_CR18","doi-asserted-by":"publisher","first-page":"12325","DOI":"10.1523\/JNEUROSCI.2053-12.2012","volume":"32","author":"JC Lemos","year":"2012","unstructured":"Lemos JC, Roth CA, Messinger DI, Gill HK, Phillips PEM, Chavkin C. Repeated stress dysregulates-opioid receptor signaling in the dorsal raphe through a p38 MAPK-dependent mechanism. J Neurosci. 2012;32:12325\u201336.","journal-title":"J Neurosci"},{"key":"1178_CR19","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1016\/j.celrep.2014.08.037","volume":"8","author":"RA McDevitt","year":"2014","unstructured":"McDevitt RA, Tiran-Cappello A, Shen H, Balderas I, Britt JP, Marino RAM, et al. Serotonergic versus nonserotonergic dorsal raphe projection neurons: differential participation in reward circuitry. Cell Rep. 2014;8:1857\u201369.","journal-title":"Cell Rep"},{"key":"1178_CR20","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/j.neuron.2014.02.010","volume":"81","author":"Z Liu","year":"2014","unstructured":"Liu Z, Zhou J, Li Y, Hu F, Lu Y, Ma M, et al. Dorsal raphe neurons signal reward through 5-HT and glutamate. Neuron. 2014;81:1360\u201374.","journal-title":"Neuron."},{"key":"1178_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6390","volume":"5","author":"J Qi","year":"2014","unstructured":"Qi J, Zhang S, Wang H-L, Wang H, de Jesus Aceves Buendia J, Hoffman AF, et al. A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons. Nat Commun. 2014;5:5390.","journal-title":"Nat Commun"},{"key":"1178_CR22","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/j.celrep.2019.01.014","volume":"26","author":"H-L Wang","year":"2019","unstructured":"Wang H-L, Zhang S, Qi J, Wang H, Cachope R, Mejias-Aponte CA, et al. Dorsal raphe dual serotonin-glutamate neurons drive reward by establishing excitatory synapses on VTA mesoaccumbens dopamine neurons. Cell Rep. 2019;26:1128\u20131142.e7.","journal-title":"Cell Rep"},{"key":"1178_CR23","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41586-018-0416-4","volume":"560","author":"JJ Walsh","year":"2018","unstructured":"Walsh JJ, Christoffel DJ, Heifets BD, Ben-Dor GA, Selimbeyoglu A, Hung LW, et al. 5-HT release in nucleus accumbens rescues social deficits in mouse autism model. Nature. 2018;560:589.","journal-title":"Nature."},{"key":"1178_CR24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nature19318","volume":"537","author":"CA Marcinkiewcz","year":"2016","unstructured":"Marcinkiewcz CA, Mazzone CM, D\u2019Agostino G, Halladay LR, Hardaway JA, DiBerto JF, et al. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala., Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nat Nat. 2016;537:97\u2013101.","journal-title":"Nat Nat."},{"key":"1178_CR25","doi-asserted-by":"publisher","first-page":"8863","DOI":"10.1523\/JNEUROSCI.1181-17.2017","volume":"37","author":"W Zhong","year":"2017","unstructured":"Zhong W, Li Y, Feng Q, Luo M. Learning and stress shape the reward response patterns of serotonin neurons. J Neurosci. 2017;37:8863\u201375.","journal-title":"J Neurosci"},{"key":"1178_CR26","doi-asserted-by":"crossref","unstructured":"Cohen JY, Amoroso MW, Uchida N. Serotonergic neurons signal reward and punishment on multiple timescales. ELife. 2015;4.","DOI":"10.7554\/eLife.06346"},{"key":"1178_CR27","doi-asserted-by":"crossref","unstructured":"Steger JS, Land BB, Lemos JC, Chavkin C, Phillips PEM. Insidious transmission of a stress-related neuroadaptation. Front Behav Neurosci. 2020;14.","DOI":"10.3389\/fnbeh.2020.564054"},{"key":"1178_CR28","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1097\/WNR.0b013e32830dd655","volume":"19","author":"MR Bruchas","year":"2008","unstructured":"Bruchas MR, Xu M, Chavkin C. Repeated swim-stress induces kappa opioid-mediated activation of ERK1\/2 MAPK. Neuroreport. 2008;19:1417\u201322.","journal-title":"Neuroreport."},{"key":"1178_CR29","doi-asserted-by":"publisher","unstructured":"Lesiak AJ, Coffey K, Cohen JH, Liang KJ, Chavkin C, Neumaier JF. Sequencing the serotonergic neuron translatome reveals a new role for Fkbp5 in stress. Mol Psychiatry. 2020. https:\/\/doi.org\/10.1038\/s41380-020-0750-4.","DOI":"10.1038\/s41380-020-0750-4"},{"key":"1178_CR30","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1126\/science.1252367","volume":"344","author":"A Berndt","year":"2014","unstructured":"Berndt A, Lee SY, Ramakrishnan C, Deisseroth K. Structure-guided transformation of channelrhodopsin into a light-activated chloride channel. Science. 2014;344:420\u20134.","journal-title":"Science."},{"key":"1178_CR31","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1038\/mp.2017.159","volume":"23","author":"C-C Chen","year":"2018","unstructured":"Chen C-C, Lu J, Yang R, Ding JB, Zuo Y. Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects. Mol Psychiatry. 2018;23:1614.","journal-title":"Mol Psychiatry"},{"key":"1178_CR32","doi-asserted-by":"publisher","unstructured":"Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, et al. Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems. Cell. 2018. https:\/\/doi.org\/10.1016\/j.cell.2018.07.043.","DOI":"10.1016\/j.cell.2018.07.043"},{"key":"1178_CR33","doi-asserted-by":"publisher","first-page":"e49424","DOI":"10.7554\/eLife.49424","volume":"8","author":"J Ren","year":"2019","unstructured":"Ren J, Isakova A, Friedmann D, Zeng J, Grutzner SM, Pun A, et al. Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei. ELife. 2019;8:e49424.","journal-title":"ELife"},{"key":"1178_CR34","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.celrep.2015.10.061","volume":"13","author":"A Teissier","year":"2015","unstructured":"Teissier A, Chemiakine A, Inbar B, Bagchi S, Ray RS, Palmiter RD, et al. Activity of raph\u00e9 serotonergic neurons controls emotional behaviors. Cell Rep. 2015;13:1965\u201376.","journal-title":"Cell Rep"},{"key":"1178_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.brainres.2009.09.100","volume":"1314C","author":"RJ Valentino","year":"2010","unstructured":"Valentino RJ, Lucki I, Van Bockstaele E. Corticotropin-releasing factor in the dorsal raphe nucleus: linking stress coping and addiction. Brain Res. 2010;1314C:29.","journal-title":"Brain Res"},{"key":"1178_CR36","doi-asserted-by":"crossref","unstructured":"Okaty BW, Sturrock N, Escobedo Lozoya Y, Chang Y, Senft RA, Lyon KA, et al. A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons. ELife. 2020;9.","DOI":"10.7554\/eLife.55523"},{"key":"1178_CR37","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1523\/JNEUROSCI.20-05-01952.2000","volume":"20","author":"P Brown","year":"2000","unstructured":"Brown P, Molliver ME. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. J Neurosci. 2000;20:1952\u201363.","journal-title":"J Neurosci"},{"key":"1178_CR38","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.neuron.2016.09.021","volume":"92","author":"DGR Tervo","year":"2016","unstructured":"Tervo DGR, Hwang B-Y, Viswanathan S, Gaj T, Lavzin M, Ritola KD, et al. A designer AAV variant permits efficient retrograde access to projection neurons. Neuron. 2016;92:372\u201382.","journal-title":"Neuron."},{"key":"1178_CR39","doi-asserted-by":"publisher","first-page":"10856","DOI":"10.1523\/JNEUROSCI.22-24-10856.2002","volume":"22","author":"JF Neumaier","year":"2002","unstructured":"Neumaier JF, Vincow ES, Arvanitogiannis A, Wise RA, Carlezon WA. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. J Neurosci. 2002;22:10856\u201363.","journal-title":"J Neurosci"},{"key":"1178_CR40","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1111\/j.1460-9568.2009.06933.x","volume":"30","author":"SM Ferguson","year":"2009","unstructured":"Ferguson SM, Sandygren NA, Neumaier JF. Pairing mild stress with increased serotonin-1B receptor expression in the nucleus accumbens increases susceptibility to amphetamine. Eur J Neurosci. 2009;30:1576\u201384.","journal-title":"Eur J Neurosci"},{"key":"1178_CR41","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1177\/0269881117725915","volume":"31","author":"RL Carhart-Harris","year":"2017","unstructured":"Carhart-Harris RL, Nutt DJ. Serotonin and brain function: a tale of two receptors. J Psychopharmacol. 2017;31:1091\u2013120.","journal-title":"J Psychopharmacol"},{"key":"1178_CR42","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.bbr.2011.06.016","volume":"224","author":"AR Furay","year":"2011","unstructured":"Furay AR, McDevitt RA, Miczek KA, Neumaier JF. 5-HT1B mRNA expression after chronic social stress. Behav Brain Res. 2011;224:350\u20137.","journal-title":"Behav Brain Res"},{"key":"1178_CR43","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1037\/h0077817","volume":"95","author":"GT Taylor","year":"1981","unstructured":"Taylor GT. Fear and affiliation in domesticated male rats. J Comp Physiol Psychol. 1981;95:685\u201393.","journal-title":"J Comp Physiol Psychol"},{"key":"1178_CR44","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.neuropharm.2006.08.013","volume":"52","author":"BJ Hoplight","year":"2007","unstructured":"Hoplight BJ, Vincow ES, Neumaier JF. Cocaine increases 5-HT1B mRNA in rat nucleus accumbens shell neurons. Neuropharmacology. 2007;52:444\u20139.","journal-title":"Neuropharmacology."},{"key":"1178_CR45","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1471-4159.2009.06313.x","volume":"111","author":"JF Neumaier","year":"2009","unstructured":"Neumaier JF, McDevitt RA, Polis IY, Parsons LH. Acquisition of and withdrawal from cocaine self-administration regulates 5-HT mRNA expression in rat striatum. J Neurochem. 2009;111:217\u201327.","journal-title":"J Neurochem"},{"key":"1178_CR46","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/nn798","volume":"5","author":"D Morgan","year":"2002","unstructured":"Morgan D, Grant KA, Gage HD, Mach RH, Kaplan JR, Prioleau O, et al. Social dominance in monkeys: dopamine D 2 receptors and cocaine self-administration. Nat Neurosci. 2002;5:169\u201374.","journal-title":"Nat Neurosci"},{"key":"1178_CR47","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1037\/adb0000412","volume":"32","author":"MA Hoyland","year":"2018","unstructured":"Hoyland MA, Latendresse SJ. Stressful life events influence transitions among latent classes of alcohol use. Psychol Addict Behav J Soc Psychol Addict Behav. 2018;32:727\u201337.","journal-title":"Psychol Addict Behav J Soc Psychol Addict Behav."},{"key":"1178_CR48","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1037\/0022-3514.51.3.564","volume":"51","author":"MD Newcomb","year":"1986","unstructured":"Newcomb MD, Harlow LL. Life events and substance use among adolescents: mediating effects of perceived loss of control and meaninglessness in life. J Pers Soc Psychol. 1986;51:564\u201377.","journal-title":"J Pers Soc Psychol"},{"key":"1178_CR49","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.brainres.2009.08.062","volume":"1314","author":"MR Bruchas","year":"2010","unstructured":"Bruchas MR, Land BB, Chavkin C. The dynorphin\/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res. 2010;1314:44\u201355.","journal-title":"Brain Res"},{"key":"1178_CR50","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/266730a0","volume":"266","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Le Pichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977;266:730\u20132.","journal-title":"Nature"},{"key":"1178_CR51","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/sj.npp.1300872","volume":"31","author":"JP McLaughlin","year":"2006","unstructured":"McLaughlin JP, Li S, Valdez J, Chavkin TA, Chavkin C. Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacol Publ Am Coll Neuropsychopharmacol. 2006;31:1241\u20138.","journal-title":"Neuropsychopharmacol Publ Am Coll Neuropsychopharmacol"},{"key":"1178_CR52","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuropharm.2011.02.012","volume":"61","author":"KA Nealey","year":"2011","unstructured":"Nealey KA, Smith AW, Davis SM, Smith DG, Walker BM. \u03ba-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats. Neuropharmacology. 2011;61:35\u201342.","journal-title":"Neuropharmacology."},{"key":"1178_CR53","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1111\/j.1471-4159.2004.02589.x","volume":"90","author":"Y Shirayama","year":"2004","unstructured":"Shirayama Y, Ishida H, Iwata M, Hazama G, Kawahara R, Duman RS. Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects. J Neurochem. 2004;90:1258\u201368.","journal-title":"J Neurochem"},{"key":"1178_CR54","doi-asserted-by":"publisher","first-page":"10883","DOI":"10.1523\/JNEUROSCI.22-24-10883.2002","volume":"22","author":"SS Newton","year":"2002","unstructured":"Newton SS, Thome J, Wallace TL, Shirayama Y, Schlesinger L, Sakai N, et al. Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J Neurosci. 2002;22:10883\u201390.","journal-title":"J Neurosci"},{"key":"1178_CR55","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.neuron.2019.02.029","volume":"102","author":"N Massaly","year":"2019","unstructured":"Massaly N, Copits BA, Wilson-Poe AR, Hip\u00f3lito L, Markovic T, Yoon HJ, et al. Pain-induced negative affect is mediated via recruitment of the nucleus accumbens kappa opioid system. Neuron 2019;102:564\u2013573.e6.","journal-title":"Neuron"},{"key":"1178_CR56","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s002130100704","volume":"155","author":"CM Andrews","year":"2001","unstructured":"Andrews CM, Lucki I. Effects of cocaine on extracellular dopamine and serotonin levels in the nucleus accumbens. Psychopharmacol. 2001;155:221\u20139.","journal-title":"Psychopharmacol"},{"key":"1178_CR57","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1126\/science.aau8722","volume":"363","author":"C Seo","year":"2019","unstructured":"Seo C, Guru A, Jin M, Ito B, Sleezer BJ, Ho Y-Y, et al. Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode. Science. 2019;363:538\u201342.","journal-title":"Science."},{"key":"1178_CR58","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1002\/cne.23146","volume":"520","author":"SJ Bang","year":"2012","unstructured":"Bang SJ, Commons KG. Forebrain GABAergic projections from the dorsal raphe nucleus identified by using GAD67\u2013GFP knock-in mice. J Comp Neurol. 2012;520:4157\u201367.","journal-title":"J Comp Neurol"},{"key":"1178_CR59","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0006-8993(95)00349-U","volume":"682","author":"LG Kirby","year":"1995","unstructured":"Kirby LG, Allen AR, Lucki I. Regional differences in the effects of forced swimming on extracellular levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Res. 1995;682:189\u201396.","journal-title":"Brain Res"},{"key":"1178_CR60","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s00213-002-1114-2","volume":"162","author":"ML Price","year":"2002","unstructured":"Price ML, Kirby LG, Valentino RJ, Lucki I. Evidence for corticotropin-releasing factor regulation of serotonin in the lateral septum during acute swim stress: adaptation produced by repeated swimming. Psychopharmacol. 2002;162:406\u201314.","journal-title":"Psychopharmacol"},{"key":"1178_CR61","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.brainres.2004.06.052","volume":"1021","author":"R De La Garza","year":"2004","unstructured":"De La Garza R, Mahoney JJ. A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression. Brain Res. 2004;1021:209\u201318.","journal-title":"Brain Res"},{"key":"1178_CR62","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1124\/jpet.105.092304","volume":"316","author":"WA Carlezon","year":"2006","unstructured":"Carlezon WA, B\u00e9guin C, DiNieri JA, Baumann MH, Richards MR, Todtenkopf MS, et al. Depressive-like effects of the \u03ba-opioid receptor agonist salvinorin a on behavior and neurochemistry in rats. J Pharm Exp Ther. 2006;316:440\u20137.","journal-title":"J Pharm Exp Ther"},{"key":"1178_CR63","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1007\/s00210-002-0583-5","volume":"366","author":"M Filip","year":"2002","unstructured":"Filip M, Papla I, Nowak E, Jungersmith K, Przegali\u0144ski E. Effects of serotonin (5-HT) 1B receptor ligands, microinjected into accumbens subregions, on cocaine discrimination in rats. Naunyn Schmiedebergs Arch Pharm. 2002;366:226\u201334.","journal-title":"Naunyn Schmiedebergs Arch Pharm"},{"key":"1178_CR64","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S0091-3057(01)00717-1","volume":"71","author":"PJ Fletcher","year":"2002","unstructured":"Fletcher PJ, Azampanah A, Korth KM. Activation of 5-HT1B receptors in the nucleus accumbens reduces self-administration of amphetamine on a progressive ratio schedule. Pharm Biochem Behav. 2002;71:717\u201325.","journal-title":"Pharm Biochem Behav"},{"key":"1178_CR65","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1369-1600.2009.00162.x","volume":"14","author":"NS Pentkowski","year":"2009","unstructured":"Pentkowski NS, Acosta JI, Browning JR, Hamilton EC, Neisewander JL. Stimulation of 5-HT1B receptors enhances cocaine reinforcement yet reduces cocaine-seeking behavior. Addict Biol. 2009;14:419\u201330.","journal-title":"Addict Biol"},{"key":"1178_CR66","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1021\/cn400155t","volume":"5","author":"NS Pentkowski","year":"2014","unstructured":"Pentkowski NS, Harder BG, Brunwasser SJ, Bastle RM, Peartree NA, Yanamandra K, et al. Pharmacological evidence for an abstinence-induced switch in 5-HT 1B receptor modulation of cocaine self-administration and cocaine-seeking behavior. ACS Chem Neurosci. 2014;5:168\u201376.","journal-title":"ACS Chem Neurosci"},{"key":"1178_CR67","first-page":"149","volume":"32","author":"B Ditzen","year":"2014","unstructured":"Ditzen B, Heinrichs M. Psychobiology of social support: the social dimension of stress buffering. Restor Neurol Neurosci. 2014;32:149\u201362.","journal-title":"Restor Neurol Neurosci"},{"key":"1178_CR68","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1111\/j.1460-9568.2007.05568.x","volume":"25","author":"SK Barot","year":"2007","unstructured":"Barot SK, Ferguson SM, Neumaier JF. 5-HT1B receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Eur J Neurosci. 2007;25:3125\u201331.","journal-title":"Eur J Neurosci"},{"key":"1178_CR69","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0006-3223(01)01366-X","volume":"51","author":"H-FS Sun","year":"2002","unstructured":"Sun H-FS, Chang Y-T, Fann CS-J, Chang C-J, Chen Y-H, Hsu Y-P, et al. Association study of novel human serotonin 5-HT1B polymorphisms with alcohol dependence in Taiwanese Han. Biol Psychiatry. 2002;51:896\u2013901.","journal-title":"Biol Psychiatry"},{"key":"1178_CR70","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/sj.npp.1300000","volume":"28","author":"Y Huang","year":"2003","unstructured":"Huang Y, Oquendo MA, Harkavy Friedman JM, Greenhill LL, Brodsky B, Malone KM, et al. Substance abuse disorder and major depression are associated with the human 5-HT 1B receptor gene (HTR1B) G861C polymorphism. Neuropsychopharmacology. 2003;28:163\u20139.","journal-title":"Neuropsychopharmacology."},{"key":"1178_CR71","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/ajmg.b.32128","volume":"162","author":"J Cao","year":"2013","unstructured":"Cao J, LaRocque E, Li D. Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse. Am J Med Genet B Neuropsychiatr Genet. 2013;162:169\u201376.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"1178_CR72","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.biopsych.2011.02.020","volume":"69","author":"JW Murrough","year":"2011","unstructured":"Murrough JW, Neumeister A. The serotonin 1B receptor: a new target for depression therapeutics? Biol Psychiatry. 2011;69:714\u20135.","journal-title":"Biol Psychiatry"},{"key":"1178_CR73","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.biopsych.2009.12.028","volume":"67","author":"J Hu","year":"2010","unstructured":"Hu J, Henry S, Gallezot J-D, Ropchan J, Neumaier JF, Potenza MN, et al. Serotonin 1B receptor imaging in alcohol dependence. Biol Psychiatry. 2010;67:800\u20133.","journal-title":"Biol Psychiatry"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41386-021-01178-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-021-01178-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-021-01178-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T17:03:24Z","timestamp":1675703004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41386-021-01178-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,25]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["1178"],"URL":"https:\/\/doi.org\/10.1038\/s41386-021-01178-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.27.450100","asserted-by":"object"}]},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,25]]},"assertion":[{"value":"25 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2021","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Supplementary Information has been corrected.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}