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This study investigates whether higher LOAD-PGR is associated with differences in structural brain imaging and cognitive values in a relatively large sample of non-demented, generally healthy adults (UK Biobank). Summary statistics were used to create PGR scores for\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932,790 participants using LDpred. Outcomes included 12 structural MRI volumes and 6 concurrent cognitive measures. Models were adjusted for age, sex, body mass index, genotyping chip, 8 genetic principal components, lifetime smoking, apolipoprotein (\n                    <jats:italic>APOE<\/jats:italic>\n                    ) e4 genotype and socioeconomic deprivation. We tested for statistical interactions between\n                    <jats:italic>APOE<\/jats:italic>\n                    e4 allele dose and LOAD-PGR vs. all outcomes. In fully adjusted models, LOAD-PGR was associated with worse fluid intelligence (standardised beta [\u03b2]\u2009=\u2009\u22120.080 per LOAD-PGR standard deviation,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), matrix completion (\u03b2\u2009=\u2009\u22120.102,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), smaller left hippocampal total (\u03b2\u2009=\u2009\u22120.118,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and body (\u03b2\u2009=\u2009\u22120.069,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) volumes, but not other hippocampal subdivisions. There were no significant\n                    <jats:italic>APOE<\/jats:italic>\n                    x LOAD-PGR score interactions for any outcomes in fully adjusted models. This is the largest study to date investigating LOAD-PGR and non-demented structural brain MRI and cognition phenotypes. LOAD-PGR was associated with smaller hippocampal volumes and aspects of cognitive ability in healthy adults and could supplement\n                    <jats:italic>APOE<\/jats:italic>\n                    status in risk stratification of cognitive impairment\/LOAD.\n                  <\/jats:p>","DOI":"10.1038\/s41386-021-01190-4","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T03:26:09Z","timestamp":1633577169000},"page":"564-569","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Association between polygenic risk for Alzheimer\u2019s disease, brain structure and cognitive abilities in UK Biobank"],"prefix":"10.1038","volume":"47","author":[{"given":"Rachana","family":"Tank","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin E.","family":"Flegal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-1951","authenticated-orcid":false,"given":"Daniel J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E. 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