{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:06:33Z","timestamp":1792166793243,"version":"4.4.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1038\/s41386-021-01191-3","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T13:17:56Z","timestamp":1633958276000},"page":"570-579","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The efficacy and safety of zolpidem and zopiclone to treat insomnia in Alzheimer\u2019s disease: a randomized, triple-blind, placebo-controlled trial"],"prefix":"10.1038","volume":"47","author":[{"given":"Luciana L.","family":"Louzada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio V.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana L.","family":"Quintas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme A.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica V.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayde L.","family":"Mendon\u00e7a-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno S. B.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ot\u00e1vio T.","family":"N\u00f3brega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-5529","authenticated-orcid":false,"given":"Einstein F.","family":"Camargos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"1191_CR1","unstructured":"Alzheimer\u2019s Disease International. Dementia facts & figures. 2021. https:\/\/www.alzint.org\/about\/dementia-facts-figures\/. Accessed 14 June 2021."},{"key":"1191_CR2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","volume":"18","author":"E Nichols","year":"2019","unstructured":"Nichols E, Szoeke CEI, Vollset SE, Abbasi N, Abd-Allah F, Abdela J, et al. Global, regional, and national burden of Alzheimer\u2019s disease and other dementias, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:88\u2013106.","journal-title":"Lancet Neurol."},{"key":"1191_CR3","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jalz.2018.02.001","volume":"14","author":"Alzheimer Association.","year":"2018","unstructured":"Alzheimer Association. 2018 Alzheimer\u2019 s disease facts and figures. Alzheimer\u2019s Dement. 2018;14:367\u2013429.","journal-title":"Alzheimer\u2019s Dement"},{"key":"1191_CR4","doi-asserted-by":"publisher","first-page":"777","DOI":"10.2165\/00023210-200115100-00004","volume":"15","author":"MV Vitiello","year":"2001","unstructured":"Vitiello MV, Borson S. Sleep Disturbances in Patients with Alzheimer\u2019s Disease. CNS Drugs. 2001;15:777\u201396.","journal-title":"CNS Drugs"},{"key":"1191_CR5","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1177\/0898264318795567","volume":"31","author":"SL Burke","year":"2018","unstructured":"Burke SL, Hu T, Spadola CE, Burgess A, Li T, Cadet T. Treatment of Sleep Disturbance May Reduce the Risk of Future Probable Alzheimer\u2019 s Disease. J Aging Health. 2018;31:322\u201342.","journal-title":"J Aging Health"},{"key":"1191_CR6","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000335363","volume":"33","author":"B Guarnieri","year":"2012","unstructured":"Guarnieri B, Adorni F, Musicco M, Appollonio I, Bonanni E, Caffarra P, et al. Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord. 2012;33:50\u20138.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"1191_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s11920-009-0004-2","volume":"11","author":"CL Deschenes","year":"2009","unstructured":"Deschenes CL, McCurry SM. Current treatments for sleep disturbances in individuals with dementia. Curr Psychiatry Rep. 2009;11:20\u20136.","journal-title":"Curr Psychiatry Rep."},{"key":"1191_CR8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s11940-003-0017-9","volume":"5","author":"SM Mccurry","year":"2003","unstructured":"Mccurry SM, Ancoli-israel S. Sleep Dysfunction in Alzheimer\u2019s Disease and Other Dementias. Curr Treat Options Neurol. 2003;5:261\u201372.","journal-title":"Curr Treat Options Neurol"},{"key":"1191_CR9","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1097\/JGP.0b013e318252e3ff","volume":"20","author":"EIS Most","year":"2012","unstructured":"Most EIS, Aboudan S, Scheltens P, Van Someren EJW. Discrepancy Between Subjective and Objective Sleep Disturbances in Early- and Moderate-Stage Alzheimer Disease. Am J Geriatr Psychiatry. 2012;20:460\u20137.","journal-title":"Am J Geriatr Psychiatry"},{"key":"1191_CR10","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/gerona\/50A.6.M303","volume":"50","author":"DL Bliwise","year":"1995","unstructured":"Bliwise DL, Hughes M, Mcmahon PM, Kutner N. Observed Sleep\/Wakefulness and Severity of Dementia in an Alzheimer\u2019s Disease Special Care Unit. J Gerontol Ser A Biol Sci Med Sci. 1995;50:303\u20136.","journal-title":"J Gerontol Ser A Biol Sci Med Sci"},{"key":"1191_CR11","doi-asserted-by":"crossref","unstructured":"Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390:2673\u2013734.","DOI":"10.1016\/S0140-6736(17)31363-6"},{"key":"1191_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2147\/NSS.S76706","volume":"8","author":"E Urrestarazu","year":"2016","unstructured":"Urrestarazu E, Iriarte J. Clinical management of sleep disturbances in Alzheimer\u2019s disease: current and emerging strategies. Nat Sci Sleep. 2016;8:21\u201333.","journal-title":"Nat Sci Sleep"},{"key":"1191_CR13","unstructured":"O\u2019Neil ME, Freeman M, Christensen V, Telerant R, Addleman A, Kansagara D. A Systematic Evidence Review of Non-pharmacological Interventions for Behavioral Symptoms of Dementia. Department of Veterans Affairs, Washington (DC); 2011. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK54971\/."},{"key":"1191_CR14","doi-asserted-by":"publisher","unstructured":"Wilfling D, Junghans A, Marshall L, Eisemann N, Meyer G, M\u00f6hler R, et al. Non-pharmacological interventions for sleep disturbances in people with dementia. Cochrane Database Syst Rev. 2015. September 2015. https:\/\/doi.org\/10.1002\/14651858.CD011881.","DOI":"10.1002\/14651858.CD011881"},{"key":"1191_CR15","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.maturitas.2019.06.007","volume":"127","author":"R O\u2019Caoimh","year":"2019","unstructured":"O\u2019Caoimh R, Mannion H, Sezgin D, O\u2019Donovan MR, Liew A, Molloy DW. Non-pharmacological treatments for sleep disturbance in mild cognitive impairment and dementia: a systematic review and meta-analysis. Maturitas. 2019;127:82\u201394.","journal-title":"Maturitas."},{"key":"1191_CR16","doi-asserted-by":"crossref","unstructured":"Verdelho A, Bentes C. Insomnia in dementia: a practical approach. In: Verdelho A, Gon\u00e7alves-Pereira M, editors. Neuropsychiatr. Symptoms Cogn. Impair. Dement., Cham: Springer International Publishing; 2017.","DOI":"10.1007\/978-3-319-39138-0_12"},{"key":"1191_CR17","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s40266-018-0569-8","volume":"35","author":"VC Abad","year":"2018","unstructured":"Abad VC, Guilleminault C. Insomnia in elderly patients: recommendations for pharmacological management. Drugs Aging. 2018;35:791\u2013817.","journal-title":"Drugs Aging"},{"key":"1191_CR18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/jsr.12594","volume":"26","author":"D Riemann","year":"2017","unstructured":"Riemann D, Baglioni C, Bassetti C, Bjorvatn B, Dolenc Groselj L, Ellis JG, et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017;26:675\u2013700.","journal-title":"J Sleep Res"},{"key":"1191_CR19","doi-asserted-by":"publisher","first-page":"487","DOI":"10.5664\/jcsm.27286","volume":"4","author":"S Schutte-Rodin","year":"2008","unstructured":"Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008;4:487\u2013504.","journal-title":"J Clin Sleep Med"},{"key":"1191_CR20","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1517\/14656566.2012.667074","volume":"13","author":"DJ Greenblatt","year":"2012","unstructured":"Greenblatt DJ, Roth T. Zolpidem for insomnia. Expert Opin Pharmacother. 2012;13:879\u201393.","journal-title":"Expert Opin Pharmacother"},{"key":"1191_CR21","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1001\/jamainternmed.2018.3031","volume":"178","author":"TJ Moore","year":"2018","unstructured":"Moore TJ, Mattison DR. Assessment of Patterns of Potentially Unsafe Use of Zolpidem. JAMA Intern Med. 2018;178:1275.","journal-title":"JAMA Intern Med"},{"key":"1191_CR22","doi-asserted-by":"publisher","first-page":"142","DOI":"10.2165\/00003088-199529030-00002","volume":"29","author":"P Salva","year":"1995","unstructured":"Salva P, Costa J. Clinical Pharmacokinetics and Pharmacodynamics of Zolpidem Therapeutic Implications. J Clin Pharmacokinet. 1995;29:142\u201353.","journal-title":"J Clin Pharmacokinet"},{"key":"1191_CR23","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1124\/pr.117.014381","volume":"70","author":"T Atkin","year":"2018","unstructured":"Atkin T, Comai S, Gobbi G. Drugs for Insomnia beyond Benzodiazepines: pharmacology, clinical applications, and discovery. Pharm Rev. 2018;70:197\u2013245.","journal-title":"Pharm Rev"},{"key":"1191_CR24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1159\/000137911","volume":"27","author":"L Julou","year":"1983","unstructured":"Julou L, Bardone MC, Blanchard JC, Garret C, Stutzmann JM. Pharmacological Studies on Zopiclone. Pharmacology. 1983;27:46\u201358.","journal-title":"Pharmacology."},{"key":"1191_CR25","doi-asserted-by":"publisher","first-page":"117s","DOI":"10.1016\/0924-9338(96)80093-9","volume":"10","author":"A Doble","year":"1995","unstructured":"Doble A, Canton T, Malgouris C, Stutzmann J, Piot O, Bardone M, et al. The mechanism of action of zopiclone. Eur Psychiatry. 1995;10:117s\u2013128s.","journal-title":"Eur Psychiatry"},{"key":"1191_CR26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2165\/00003088-200443040-00002","volume":"43","author":"APDR Drover","year":"2004","unstructured":"Drover APDR. Comparative Pharmacokinetics and Pharmacodynamics of Short-Acting Hypnosedatives. Clin Pharmacokinet. 2004;43:227\u201338.","journal-title":"Clin Pharmacokinet"},{"key":"1191_CR27","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/j.jagp.2013.12.174","volume":"22","author":"EF Camargos","year":"2014","unstructured":"Camargos EF, Louzada LL, Quintas JL, Naves JOS, Louzada FM, N\u00f3brega OT. Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind, and placebo-controlled study. Am J Geriatr Psychiatry. 2014;22:1565\u201374.","journal-title":"Am J Geriatr Psychiatry"},{"key":"1191_CR28","doi-asserted-by":"publisher","unstructured":"McCleery J, Sharpley AL. Pharmacotherapies for sleep disturbances in dementia. Cochrane Database Syst Rev. 2020. November 2020. https:\/\/doi.org\/10.1002\/14651858.CD009178.pub4.","DOI":"10.1002\/14651858.CD009178.pub4"},{"key":"1191_CR29","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association A. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. 5th ed. Washington, D.C.: American Psychiatric Association, c2013.; 2013.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"1191_CR30","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease. Neurology. 1984;34:939\u2013939.","journal-title":"Neurology."},{"key":"1191_CR31","doi-asserted-by":"publisher","first-page":"10S","DOI":"10.1212\/WNL.48.5_Suppl_6.10S","volume":"48","author":"JL Cummings","year":"1997","unstructured":"Cummings JL. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology. 1997;48:10S\u201316S.","journal-title":"Neurology."},{"key":"1191_CR32","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR. \u2018Mini-mental state\u2019. A practical state method for the clinician. J Psychiatr Res. 1975;12:189\u201398.","journal-title":"J Psychiatr Res"},{"key":"1191_CR33","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/ana.410070516","volume":"7","author":"WG Rosen","year":"1980","unstructured":"Rosen WG, Terry RD, Fuld PA, Katzman R, Peck A. Pathological verification of ischemic score in differentiation of dementias. Ann Neurol. 1980;7:486\u20138.","journal-title":"Ann Neurol"},{"key":"1191_CR34","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0006-3223(88)90038-8","volume":"23","author":"G Alexopoulos","year":"1988","unstructured":"Alexopoulos G, Abrams R, Young R. Cornell scale for depression in dementia. Biol Psychiatry. 1988;23:271\u201384.","journal-title":"Biol Psychiatry"},{"key":"1191_CR35","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1590\/S0102-37722007000300010","volume":"23","author":"VLM De Figueiredo","year":"2007","unstructured":"De Figueiredo VLM. Desempenhos nas Duas Tarefas do Subteste D\u00edgitos do WISC-III e do WAIS-III. Psicol Teor e Pesqui. 2007;23:313\u20138.","journal-title":"Psicol Teor e Pesqui"},{"key":"1191_CR36","doi-asserted-by":"crossref","unstructured":"Wechsler D. Wechsler Adult Intelligence Scale. 3rd ed. The Psychological Corporation. Pearson\u2019s Clinical Assessment Group: San Antonio, TX; 1997.","DOI":"10.1037\/t49755-000"},{"key":"1191_CR37","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0887-6177(03)00039-8","volume":"19","author":"TN Tombaugh","year":"2004","unstructured":"Tombaugh TN. Trail Making Test A and B: Normative data stratified by age and education. Arch Clin Neuropsychol. 2004;19:203\u201314.","journal-title":"Arch Clin Neuropsychol"},{"key":"1191_CR38","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1590\/S0004-282X1997000100009","volume":"55","author":"SMD Brucki","year":"1997","unstructured":"Brucki SMD, Malheiros SMF, Okamoto IH, Bertolucci PHF. Dados normativos para o teste de flu\u00eancia verbal categoria animais em nosso meio. Arq Neuropsiquiatr. 1997;55:56\u201361.","journal-title":"Arq Neuropsiquiatr"},{"key":"1191_CR39","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1590\/S0102-311X2008000100010","volume":"24","author":"VTS Lino","year":"2008","unstructured":"Lino VTS, Pereira SRM, Camacho LAB, Filho STR, Buksman S. Adapta\u00e7\u00e3o transcultural da Escala de Independ\u00eancia em Atividades da Vida Di\u00e1ria (Escala de Katz). Cad Sa\u00fade P\u00fablica. 2008;24:103\u201312.","journal-title":"Cad Sa\u00fade P\u00fablica"},{"key":"1191_CR40","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","volume":"43","author":"JC Morris","year":"1993","unstructured":"Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412\u20132412.","journal-title":"Neurology."},{"key":"1191_CR41","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1590\/S0034-89102005000600007","volume":"39","author":"MBM Macedo Monta\u00f1o","year":"2005","unstructured":"Macedo Monta\u00f1o MBM, Ramos LR. Validade da vers\u00e3o em portugu\u00eas da Clinical Dementia Rating. Rev Saude Publica. 2005;39:912\u20137.","journal-title":"Rev Saude Publica"},{"key":"1191_CR42","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","volume":"44","author":"JL Cummings","year":"1994","unstructured":"Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44:2308\u20132308.","journal-title":"Neurology."},{"key":"1191_CR43","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/sleep\/15.5.461","volume":"15","author":"RJ Cole","year":"1992","unstructured":"Cole RJ, Kripke DF, Gruen W, Mullaney DJ, Gillin JC. Automatic Sleep\/Wake Identification From Wrist Activity. Sleep 1992;15:461\u20139.","journal-title":"Sleep"},{"key":"1191_CR44","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.smrv.2013.01.006","volume":"17","author":"EF Camargos","year":"2013","unstructured":"Camargos EF, Louzada FM, N\u00f3brega OT. Wrist actigraphy for measuring sleep in intervention studies with Alzheimer\u2019s disease patients: Application, usefulness, and challenges. Sleep Med Rev. 2013;17:475\u201388.","journal-title":"Sleep Med Rev"},{"key":"1191_CR45","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/intqhc\/mzn054","volume":"21","author":"H Sherman","year":"2009","unstructured":"Sherman H, Castro G, Fletcher M, Hatlie M, Hibbert P, Jakob R, et al. Towards an International Classification for Patient Safety: the conceptual framework. Int J Qual Heal Care. 2009;21:2\u20138.","journal-title":"Int J Qual Heal Care"},{"key":"1191_CR46","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1590\/S1413-81232003000300011","volume":"8","author":"SN Leite","year":"2003","unstructured":"Leite SN, Vasconcellos M, da PC. Ades\u00e3o \u00e0 terap\u00eautica medicamentosa: elementos para a discuss\u00e3o de conceitos e pressupostos adotados na literatura. Cien Saude Colet. 2003;8:775\u201382.","journal-title":"Cien Saude Colet"},{"key":"1191_CR47","unstructured":"Ferreira A de O. Guia Pr\u00e1tico da Farm\u00e1cia Magistral- Vol 1. 4th ed. Pharmabooks, S\u00e3o Paulo; 2011."},{"key":"1191_CR48","unstructured":"Aulton ME. Delineamento de Formas Farmac\u00eauticas. 2a ed. Artmed, Porto Alegre, RS; 2005."},{"key":"1191_CR49","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","volume":"112","author":"J Cohen","year":"1992","unstructured":"Cohen J. A power primer. Psychol Bull. 1992;112:155\u20139.","journal-title":"Psychol Bull"},{"key":"1191_CR50","doi-asserted-by":"crossref","unstructured":"McCleery J, Sharpley AL. Pharmacotherapies for sleep disturbances in dementia. Cochrane Database Syst Rev. 2020;11:1465\u20131858.","DOI":"10.1002\/14651858.CD009178.pub4"},{"key":"1191_CR51","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/psyg.12191","volume":"17","author":"FM Scoralick","year":"2017","unstructured":"Scoralick FM, Louzada LL, Quintas JL, Naves JOS, Camargos EF, N\u00f3brega OT. Mirtazapine does not improve sleep disorders in Alzheimer\u2019s disease: results from a double-blind, placebo-controlled pilot study. Psychogeriatrics. 2017;17:89\u201396.","journal-title":"Psychogeriatrics"},{"key":"1191_CR52","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/alz.12035","volume":"16","author":"WJ Herring","year":"2020","unstructured":"Herring WJ, Ceesay P, Snyder E, Bliwise D, Budd K, Hutzelmann J, et al. Polysomnographic assessment of suvorexant in patients with probable Alzheimer\u2019s disease dementia and insomnia: a randomized trial. Alzheimer\u2019s Dement. 2020;16:541\u201351.","journal-title":"Alzheimer\u2019s Dement"},{"key":"1191_CR53","first-page":"47","volume":"5","author":"J Mouret","year":"1990","unstructured":"Mouret J, Ruel D, Maillard F, Bianchi M. Zopiclone versus triazolam in insomniac geriatric patients: a specific increase in delta sleep with zopiclone. Int Clin Psychopharmacol. 1990;5:47\u201355.","journal-title":"Int Clin Psychopharmacol"},{"key":"1191_CR54","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s002130050007","volume":"147","author":"U Hemmeter","year":"2000","unstructured":"Hemmeter U, M\u00fcller M, Bischof R, Annen B, Holsboer-Trachsler E. Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers. Psychopharmacol (Berl). 2000;147:384\u201396.","journal-title":"Psychopharmacol (Berl)"},{"key":"1191_CR55","first-page":"2785","volume":"231","author":"TRM Leufkens","year":"2014","unstructured":"Leufkens TRM, Ramaekers JG, de Weerd AW, Riedel WJ, Vermeeren A. Residual effects of zopiclone 7.5mg on highway driving performance in insomnia patients and healthy controls: a placebo controlled crossover study. Psychopharmacol (Berl). 2014;231:2785\u201398.","journal-title":"Psychopharmacol (Berl)"},{"key":"1191_CR56","doi-asserted-by":"publisher","first-page":"441","DOI":"10.2165\/00002512-199303050-00006","volume":"3","author":"AN Wadworth","year":"1993","unstructured":"Wadworth AN, McTavish D. Zopiclone. A review of its pharmacological properties and therapeutic efficacy as an hypnotic. Drugs Aging. 1993;3:441\u201359.","journal-title":"Drugs Aging"},{"key":"1191_CR57","doi-asserted-by":"crossref","unstructured":"Roehrs TA, Diederichs C, Roth T. Pharmacology of benzodiazepine receptor agonist hypnotics. In: Therapy in sleep medicine. 1st ed. Philadelphia: Saunders, Elsevier; 2011. p. 99\u2013108.","DOI":"10.1016\/B978-1-4377-1703-7.10007-6"},{"key":"1191_CR58","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1046\/j.0306-5251.2003.01852.x","volume":"56","author":"JO Olubodun","year":"2003","unstructured":"Olubodun JO, Ochs HR, Von Moltke LL, Roubenoff R, Hesse LM, Harmatz JS, et al. Pharmacokinetic properties of zolpidem in elderly and young adults: Possible modulation by testosterone in men. Br J Clin Pharm. 2003;56:297\u2013304.","journal-title":"Br J Clin Pharm"},{"key":"1191_CR59","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1007\/s00228-010-0854-x","volume":"66","author":"WJ Cuba\u0142a","year":"2010","unstructured":"Cuba\u0142a WJ, Wiglusz M, Burkiewicz A, Ga\u0142uszko-W\u0119gielnik M. Zolpidem pharmacokinetics and pharmacodynamics in metabolic interactions involving CYP3A: sex as a differentiating factor. Eur J Clin Pharm. 2010;66:955\u2013955.","journal-title":"Eur J Clin Pharm"},{"key":"1191_CR60","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1124\/pr.117.014449","volume":"70","author":"W Sieghart","year":"2018","unstructured":"Sieghart W, Savi\u0107 MM. International Union of Basic and Clinical Pharmacology. CVI: GABA A Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans. Pharm Rev. 2018;70:836\u201378.","journal-title":"Pharm Rev"},{"key":"1191_CR61","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0301-0082(02)00013-8","volume":"67","author":"ER Korpi","year":"2002","unstructured":"Korpi ER, Gr\u00fcnder G, L\u00fcddens H. Drug interactions at GABAA receptors. Prog Neurobiol. 2002;67:113\u201359.","journal-title":"Prog Neurobiol"},{"key":"1191_CR62","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/jnc.14325","volume":"145","author":"A Kwakowsky","year":"2018","unstructured":"Kwakowsky A, Calvo-Flores Guzm\u00e1n B, Pandya M, Turner C, Waldvogel HJ, Faull RL. GABA A receptor subunit expression changes in the human Alzheimer\u2019s disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus. J Neurochem. 2018;145:374\u201392.","journal-title":"J Neurochem"},{"key":"1191_CR63","first-page":"613","volume":"117","author":"RA Rissman","year":"2011","unstructured":"Rissman RA, Mobley WC. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer\u2019s disease. J Neurochem. 2011;117:613\u201322.","journal-title":"J Neurochem"},{"key":"1191_CR64","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1136\/bmj.38623.768588.47","volume":"331","author":"J Glass","year":"2005","unstructured":"Glass J, Lanct\u00f4t KL, Herrmann N, Sproule BA, Busto UE. Sedative hypnotics in older people with insomnia: Meta-analysis of risks and benefits. Br Med J. 2005;331:1169\u201373.","journal-title":"Br Med J"},{"key":"1191_CR65","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1177\/026988119901300109","volume":"13","author":"G Darcourt","year":"1999","unstructured":"Darcourt G, Pringuey D, Salliere D, Lavoisy J. The safety and tolerability of zolpidem - an update. J Psychopharmacol. 1999;13:81\u201393.","journal-title":"J Psychopharmacol"},{"key":"1191_CR66","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00228-003-0591-5","volume":"59","author":"H Allain","year":"2003","unstructured":"Allain H, Bentu\u00e9-Ferrer D, Tarral A, Gandon JM. Effects on postural oscillation and memory functions of a single dose of zolpidem 5mg, zopiclone 3.75mg and lormetazepam 1mg in elderly healthy subjects. A randomized, cross-over, double-blind study versus placebo. Eur J Clin Pharm. 2003;59:179\u201388.","journal-title":"Eur J Clin Pharm"},{"key":"1191_CR67","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1532-5415.2010.03229.x","volume":"59","author":"DJ Frey","year":"2011","unstructured":"Frey DJ, Ortega JD, Wiseman C, Farley CT, Wright KP. Influence of zolpidem and sleep inertia on balance and cognition during nighttime awakening: a randomized placebo-controlled trial. J Am Geriatr Soc. 2011;59:73\u201381.","journal-title":"J Am Geriatr Soc"},{"key":"1191_CR68","doi-asserted-by":"crossref","unstructured":"Machado FV, Louzada LL, Cross NE, Camargos EF, Dang-Vu TT, N\u00f3brega OT. More than a quarter century of the most prescribed sleeping pill: Systematic review of zolpidem use by older adults. Exp Gerontol. 2020;136:110962.","DOI":"10.1016\/j.exger.2020.110962"},{"key":"1191_CR69","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000137924","volume":"27","author":"O Dehin","year":"1983","unstructured":"Dehin O, Rundgren A, Borjesson L, Ekelund P, Gatzinska R, Hedenrud B, et al. Zopiclone to Geriatric Patients. Pharmacology. 1983;27:173\u20138.","journal-title":"Pharmacology."},{"key":"1191_CR70","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/sleep\/10.suppl_1.73","volume":"10","author":"HD Klimm","year":"1987","unstructured":"Klimm HD, Dreyfus JF, Delmotte M. Zopiclone Versus Nitrazepam: a Double-Blind Comparative Study of Efficacy and Tolerance in Elderly Patients with Chronic Insomnia. Sleep. 1987;10:73\u20138.","journal-title":"Sleep."},{"key":"1191_CR71","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1185\/03007999709113330","volume":"13","author":"O Dehlin","year":"1997","unstructured":"Dehlin O, Bengtsson C, Rubin B. A comparison of zopiclone and propiomazine as hypnotics in outpatients: A multicentre, double-blind, randomized, parallel-group comparison of zopiclone and propiomazine in insomniacs. Curr Med Res Opin. 1997;13:565\u201372.","journal-title":"Curr Med Res Opin"},{"key":"1191_CR72","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/hup.594","volume":"19","author":"Y D\u00fcndar","year":"2004","unstructured":"D\u00fcndar Y, Dodd S, Strobl J, Boland A, Dickson R, Walley T. Comparative efficacy of newer hypnotic drugs for the short-term management of insomnia: a systematic review and meta-analysis. Hum Psychopharmacol Clin Exp. 2004;19:305\u201322.","journal-title":"Hum Psychopharmacol Clin Exp"},{"key":"1191_CR73","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s40263-014-0198-7","volume":"28","author":"A Winkler","year":"2014","unstructured":"Winkler A, Auer C, Doering BK, Rief W. Drug Treatment of Primary Insomnia: a Meta-Analysis of Polysomnographic Randomized Controlled Trials. CNS Drugs. 2014;28:799\u2013816.","journal-title":"CNS Drugs"},{"key":"1191_CR74","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.euroneuro.2021.04.013","volume":"50","author":"LL Louzada","year":"2021","unstructured":"Louzada LL, Machado FV, N\u00f3brega OT, Camargos EF. Zopiclone to treat insomnia in older adults: a systematic review. Eur Neuropsychopharmacol. 2021;50:75\u201392.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1191_CR75","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1056\/NEJMp1504023","volume":"373","author":"TJ Kaptchuk","year":"2015","unstructured":"Kaptchuk TJ, Miller FG. Placebo Effects in Medicine. N Engl J Med. 2015;373:8\u20139.","journal-title":"N Engl J Med"},{"key":"1191_CR76","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/S0140-6736(09)61706-2","volume":"375","author":"DG Finniss","year":"2010","unstructured":"Finniss DG, Kaptchuk TJ, Miller F, Benedetti F. Biological, clinical, and ethical advances of placebo effects. Lancet. 2010;375:686\u201395.","journal-title":"Lancet."},{"key":"1191_CR77","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nrn3976","volume":"16","author":"TD Wager","year":"2015","unstructured":"Wager TD, Atlas LY. The neuroscience of placebo effects: connecting context, learning and health. Nat Rev Neurosci. 2015;16:403\u201318.","journal-title":"Nat Rev Neurosci"},{"key":"1191_CR78","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5664\/jcsm.6470","volume":"1313","author":"MJ Sateia","year":"2017","unstructured":"Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: an American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017;1313:307\u201349.","journal-title":"J Clin Sleep Med."}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41386-021-01191-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-021-01191-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-021-01191-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T08:05:33Z","timestamp":1675757133000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41386-021-01191-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,11]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["1191"],"URL":"https:\/\/doi.org\/10.1038\/s41386-021-01191-3","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,11]]},"assertion":[{"value":"30 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}