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The present longitudinal study provided a unique opportunity to test whether an increase in the reinforcing effects of cocaine developed after prolonged abstinence and if early life stress was a risk factor. Fourteen (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20096 female, 8 male) adult rhesus monkeys, some (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20097) that\u00a0were maltreated as infants by their mothers (MALT), had previously self-administered cocaine under a fixed-ratio (FR) schedule of reinforcement as adolescents, but had not been studied for &gt;3 years. In Experiment 1, cocaine self-administration dose-response curves were redetermined in adulthood when responding was maintained under the identical FR 20 schedule used during adolescence. In Experiment 2, the reinforcing strength of cocaine was evaluated (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912) under a progressive-ratio (PR) schedule of reinforcement. While there were no statistical differences between male and female monkeys on FR responding in adolescents, when redetermined as adults, MALT monkeys showed higher peak response rates relative to adolescence. No such differences were noted in Control monkeys. Under the PR schedule, peak reinforcing strength was not different between groups or sexes. However, higher total adolescent cocaine intake was significantly associated with higher cocaine breakpoints in adulthood. These findings show that after adolescent cocaine self-administration and a long abstinence period, sensitivity to cocaine reinforcement increased, particularly in monkeys who experienced early life stress. Although early life stress (MALT) did not significantly impact measures of cocaine\u2019s reinforcing strength, higher adolescent cocaine intake did.\n                  <\/jats:p>","DOI":"10.1038\/s41386-025-02161-9","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T14:02:45Z","timestamp":1751724165000},"page":"2006-2014","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cocaine self-administration in adult female and male rhesus monkeys: longitudinal comparison with adolescent behavior and role of early life stress"],"prefix":"10.1038","volume":"50","author":[{"given":"Mia I.","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin R.","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison G. 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