{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:03:16Z","timestamp":1790650996129,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100006955","name":"U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA049531"],"award-info":[{"award-number":["R01DA049531"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prenatal opioid exposure is a growing clinical concern, yet the impact of maternal control over drug intake on long-term offspring outcomes remains unclear. Here, we utilized a translational rat model to examine how the mode of oxycodone administration during pregnancy influences substance use vulnerability in adult offspring. Female Sprague-Dawley rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910-11\/group) were assigned to one of three groups: voluntary intravenous self-administration (Oxycodone-Lead), yoked non-contingent oxycodone delivery (Oxycodone-Yoked), or yoked saline control (Saline-Yoked). The dam self-administered oxycodone in 6h sessions for three weeks, 5 days\/week, prior to conception and then daily throughout gestation. Offspring were cross-fostered to drug-na\u00efve dams at birth. In adulthood, male and female offspring were evaluated for oxycodone (0.1\u2009mg\/kg\/infusion) and cocaine (0.5\u2009mg\/kg\/infusion) intravenous self-administration using fixed ratio (7 sessions FR1; 5 sessions FR5) and progressive ratio schedules (3 sessions), as well as drug-seeking under extinction conditions (1 session). Despite equivalent overall drug exposure, offspring of Oxycodone-Yoked dams exhibited enhanced motivated responding and drug-seeking behaviors. Female Oxycodone-Yoked offspring showed increased intake and motivated responding specifically for oxycodone, while Oxycodone-Yoked offspring of both sexes displayed augmented cocaine seeking and drug-seeking under extinction. Pearson\u2019s correlations between maternal intake and offspring behavior were sex- and drug-specific and were only observed in the Oxycodone-Yoked group. These findings indicate that maternal control over drug intake, rather than opioid exposure per se, plays a critical role in shaping neurodevelopmental trajectories underlying substance use vulnerability. This study highlights the importance of considering patterns of maternal opioid use when assessing long-term developmental risks.\n                  <\/jats:p>","DOI":"10.1038\/s41386-026-02422-1","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:23:54Z","timestamp":1777893834000},"page":"1529-1537","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal control during prenatal oxycodone exposure: differential effects of voluntary versus involuntary self-administration on offspring substance use vulnerability in rats"],"prefix":"10.1038","volume":"51","author":[{"given":"Chantal CA","family":"Aaron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri E.","family":"Budge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara B.","family":"Isgate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5317-7174","authenticated-orcid":false,"given":"Fair M.","family":"Vassoler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-7712","authenticated-orcid":false,"given":"Elizabeth M.","family":"Byrnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"2422_CR1","doi-asserted-by":"publisher","first-page":"897","DOI":"10.15585\/mmwr.mm6928a1","volume":"69","author":"JY Ko","year":"2020","unstructured":"Ko JY, D\u2019Angelo DV, Haight SC, Morrow B, Cox S, Salvesen von Essen B, et al. 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