{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:02:12Z","timestamp":1784624532952,"version":"3.55.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","award":["IST-22-1-12204"],"award-info":[{"award-number":["IST-22-1-12204"]}],"id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The off-label use of cannabidiol (CBD) has outpaced investigation. We assessed the effects of CBD in Angelman syndrome model mice lacking the\n                    <jats:italic>Ube3a<\/jats:italic>\n                    gene and found that chronic injection of CBD increased rapid-eye movement sleep during the dark cycle, restored \u201cSiesta\u201d, improved sleep homeostasis, and reduced spontaneous seizures following flurothyl kindling.\n                  <\/jats:p>","DOI":"10.1038\/s41386-026-02462-7","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:13:06Z","timestamp":1781010786000},"page":"1737-1740","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice"],"prefix":"10.1038","volume":"51","author":[{"given":"Tyler","family":"Shannon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Najeeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Jae","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6846-5563","authenticated-orcid":false,"given":"Bin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"2462_CR1","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/epi.12631","volume":"55","author":"O Devinsky","year":"2014","unstructured":"Devinsky O, Cilio MR, Cross H, Fernandez-Ruiz J, French J, Hill C, et al. Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia. 2014;55:791\u2013802.","journal-title":"Epilepsia"},{"key":"2462_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.yebeh.2018.05.013","volume":"86","author":"O Devinsky","year":"2018","unstructured":"Devinsky O, Verducci C, Thiele EA, Laux LC, Patel AD, Filloux F, et al. Open-label use of highly purified CBD (Epidiolex(R)) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes. Epilepsy Behav. 2018;86:131\u201337.","journal-title":"Epilepsy Behav"},{"key":"2462_CR3","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nrneurol.2016.133","volume":"12","author":"K Buiting","year":"2016","unstructured":"Buiting K, Williams C, Horsthemke B. Angelman syndrome\u2014insights into a rare neurogenetic disorder. Nat Rev Neurol. 2016;12:584\u201393.","journal-title":"Nat Rev Neurol"},{"key":"2462_CR4","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/S0896-6273(00)80596-6","volume":"21","author":"YH Jiang","year":"1998","unstructured":"Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G, et al. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron. 1998;21:799\u2013811.","journal-title":"Neuron"},{"key":"2462_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0716-z","volume":"12","author":"AC Wheeler","year":"2017","unstructured":"Wheeler AC, Sacco P, Cabo R. Unmet clinical needs and burden in Angelman syndrome: a review of the literature. Orphanet J Rare Dis. 2017;12:164.","journal-title":"Orphanet J Rare Dis"},{"key":"2462_CR6","doi-asserted-by":"publisher","first-page":"5462","DOI":"10.1172\/JCI130419","volume":"129","author":"B Gu","year":"2019","unstructured":"Gu B, Zhu M, Glass MR, Rougie M, Nikolova VD, Moy SS, et al. Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice. J Clin Investig. 2019;129:5462\u201367.","journal-title":"J Clin Investig"},{"key":"2462_CR7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.smrv.2017.01.002","volume":"37","author":"K Spruyt","year":"2018","unstructured":"Spruyt K, Braam W, Curfs LMG. Sleep in Angelman syndrome: a review of evidence. Sleep Med Rev. 2018;37:69\u201384.","journal-title":"Sleep Med Rev"},{"key":"2462_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-024-03154-5","volume":"19","author":"S Qu","year":"2024","unstructured":"Qu S, Wang J, Guan X, Song C, Wang Y. Sleep disturbance in Angelman syndrome patients. Orphanet J Rare Dis. 2024;19:146.","journal-title":"Orphanet J Rare Dis"},{"key":"2462_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-021-00416-y","volume":"12","author":"NA Copping","year":"2021","unstructured":"Copping NA, Silverman JL. Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome. Mol autism. 2021;12:9.","journal-title":"Mol autism"},{"key":"2462_CR10","doi-asserted-by":"crossref","unstructured":"Lee D, Chen W, Kaku HN, Zhuo X, Chao ES, Soriano A, et al. Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome. Elife. 2023;12:e81892.","DOI":"10.7554\/eLife.81892"},{"key":"2462_CR11","doi-asserted-by":"publisher","first-page":"13587","DOI":"10.1523\/JNEUROSCI.2194-15.2015","volume":"35","author":"JC Ehlen","year":"2015","unstructured":"Ehlen JC, Jones KA, Pinckney L, Gray CL, Burette S, Weinberg RJ, et al. Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact. J Neurosci. 2015;35:13587\u201398.","journal-title":"J Neurosci"},{"key":"2462_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-017-9195-8","volume":"9","author":"MS Sidorov","year":"2017","unstructured":"Sidorov MS, Deck GM, Dolatshahi M, Thibert RL, Bird LM, Chu CJ, et al. Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome: a parallel mouse and human analysis. J Neurodevelopmental Disord. 2017;9:17.","journal-title":"J Neurodevelopmental Disord"},{"key":"2462_CR13","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1002\/acn3.51385","volume":"8","author":"LM Ostrowski","year":"2021","unstructured":"Ostrowski LM, Spencer ER, Bird LM, Thibert R, Komorowski RW, Kramer MA, et al. Delta power robustly predicts cognitive function in Angelman syndrome. Ann Clin Transl Neurol. 2021;8:1433\u201345.","journal-title":"Ann Clin Transl Neurol"},{"key":"2462_CR14","doi-asserted-by":"publisher","first-page":"7485","DOI":"10.1523\/JNEUROSCI.3232-14.2016","volume":"36","author":"SB Kadiyala","year":"2016","unstructured":"Kadiyala SB, Yannix JQ, Nalwalk JW, Papandrea D, Beyer BS, Herron BJ, et al. Eight flurothyl-induced generalized seizures lead to the rapid evolution of spontaneous seizures in mice: a model of epileptogenesis with seizure remission. J Neurosci: Off J Soc Neurosci. 2016;36:7485\u201396.","journal-title":"J Neurosci: Off J Soc Neurosci"},{"key":"2462_CR15","doi-asserted-by":"crossref","unstructured":"Khodadadi H, Salles \u00c9 L, Naeini SE, Bhandari B, Rogers HM, Gouron J, et al. Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer\u2019s Disease. 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The authors declare no additional competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}