{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:28:56Z","timestamp":1787048936833,"version":"build-2736575974"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21MH137592"],"award-info":[{"award-number":["R21MH137592"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Social affiliation promotes survival and well-being across species, and proximity to conspecifics is a necessary precondition for affiliative contact. While innate threats reliably increase proximity among conspecifics, whether learned threats have the same effect remains unknown. Here, we report that an auditory conditioned stimulus (CS) induces proximity in mice. In same-sex dyads, fear-conditioned mice increased proximity during CS presentation, independent of freezing levels. This CS-evoked proximity required familiarity between partners and intact basolateral amygdala-to-ventral hippocampus inputs, demonstrated by DREADD-mediated suppression. It also required oxytocin receptor signaling, demonstrated by systemic administration of the antagonist L368,899. These findings suggest that learned and innate threats engage shared neural circuitry for social proximity.<\/jats:p>","DOI":"10.1038\/s41386-026-02492-1","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:42:30Z","timestamp":1784133750000},"page":"1836-1843","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proximity in mice induced by an auditory-conditioned stimulus"],"prefix":"10.1038","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5631-8267","authenticated-orcid":false,"given":"Wataru","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-3987","authenticated-orcid":false,"given":"Alexei","family":"Morozov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2492_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.beproc.2018.03.007","volume":"151","author":"Z Groo","year":"2018","unstructured":"Groo Z, Szenczi P, Banszegi O, Nagy Z, Altbacker V. The influence of familiarity and temperature on the huddling behavior of two mouse species with contrasting social systems. Behav Process. 2018;151:67\u201372.","journal-title":"Behav Process"},{"key":"2492_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105099","volume":"147","author":"S Nunes","year":"2023","unstructured":"Nunes S, Monroy Montemayor MP. Multiple benefits of juvenile play: A ground squirrel\u2019s perspective. Neurosci Biobehav Rev. 2023;147:105099.","journal-title":"Neurosci Biobehav Rev"},{"key":"2492_CR3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1177\/1059712316644966","volume":"24","author":"C Duranton","year":"2016","unstructured":"Duranton C, Gaunet F. Behavioural synchronization from an ethological perspective: Overview of its adaptive value. Adapt Behav. 2016;24:181\u201391.","journal-title":"Adapt Behav"},{"key":"2492_CR4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jtbi.2003.12.005","volume":"228","author":"R James","year":"2004","unstructured":"James R, Bennett PG, Krause J. Geometry for mutualistic and selfish herds: the limited domain of danger. J Theor Biol. 2004;228:107\u201313.","journal-title":"J Theor Biol"},{"key":"2492_CR5","unstructured":"Schachter S. The Psychology of Affiliation: Experimental Studies of the Sources of Gregariousness. Stanford University Press; 1959."},{"key":"2492_CR6","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/oep\/gpab011","volume":"74","author":"K Farrow","year":"2022","unstructured":"Farrow K, Grolleau G, Ibanez L. Does misery love company? An experimental investigation. Oxf Econ Pap. 2022;74:523\u201340.","journal-title":"Oxf Econ Pap"},{"key":"2492_CR7","doi-asserted-by":"crossref","unstructured":"Pitcher TJ. Functions of Shoaling Behaviour in Teleosts. In: TJP, editor The Behaviour of Teleost Fishes. Boston: Springer; 1986.","DOI":"10.1007\/978-1-4684-8261-4"},{"key":"2492_CR8","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/285400a0","volume":"285","author":"T Caraco","year":"1980","unstructured":"Caraco T, Martindale S, Pulliam HR. Avian Flocking in the Presence of a Predator. Nature. 1980;285:400\u201301.","journal-title":"Nature"},{"key":"2492_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1127\/entom.gen\/12\/1986\/71","volume":"12","author":"FK Larsson","year":"1986","unstructured":"Larsson FK. Increased Nest Density of the Digger Wasp Bembix-Rostrata as a Response to Parasites and Predators (Hymenoptera, Sphecidae). Entomol Gen. 1986;12:71\u201375.","journal-title":"Entomol Gen"},{"key":"2492_CR10","doi-asserted-by":"publisher","first-page":"44","DOI":"10.2307\/3677339","volume":"29","author":"JT Forsman","year":"1998","unstructured":"Forsman JT, Monkkonen M, Inkeroinen J, Reunanen P. Aggregate dispersion of birds after encountering a predator: experimental evidence. J Avian Biol. 1998;29:44\u201348.","journal-title":"J Avian Biol"},{"key":"2492_CR11","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/anbe.2002.2030","volume":"65","author":"M Spieler","year":"2003","unstructured":"Spieler M. Risk of predation affects aggregation size: a study with tadpoles of Phrynomantis microps (Anura: Microhylidae). Anim Behav. 2003;65:179\u201384.","journal-title":"Anim Behav"},{"key":"2492_CR12","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.anbehav.2004.07.022","volume":"69","author":"S Creel","year":"2005","unstructured":"Creel S, Winnie JA. Responses of elk herd size to fine-scale spatial and temporal variation in the risk of predation by wolves. Anim Behav. 2005;69:1181\u201389.","journal-title":"Anim Behav"},{"key":"2492_CR13","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12902","volume":"32","author":"O Le Moene","year":"2020","unstructured":"Le Moene O, Ramirez-Renteria ML, Agmo A. Male and female immediate fear reaction to white noise in a semi-natural environment: A detailed behavioural analysis of the role of sex and oestrogen receptors. J Neuroendocrinol. 2020;32:e12902.","journal-title":"J Neuroendocrinol"},{"key":"2492_CR14","doi-asserted-by":"crossref","unstructured":"Chiew SJ, Butler KL, Sherwen SL, Coleman GJ, Melfi V, Burns A, et al. Effect of Covering a Visitor Viewing Area Window on the Behaviour of Zoo-Housed Little Penguins (Eudyptula minor). Animals. 2020;10:1224.","DOI":"10.3390\/ani10071224"},{"key":"2492_CR15","unstructured":"Mawson AR. Mass panic and social attachment: the dynamics of human behavior. Ashgate Publishing, Ltd.: Aldershot, UK; 2012."},{"key":"2492_CR16","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.beproc.2012.03.014","volume":"90","author":"MT Bowen","year":"2012","unstructured":"Bowen MT, Keats K, Kendig MD, Cakic V, Callaghan PD, McGregor LS. Aggregation in quads but not pairs of rats exposed to cat odor or bright light. Behav Process. 2012;90:331\u201336.","journal-title":"Behav Process"},{"key":"2492_CR17","doi-asserted-by":"publisher","first-page":"e68483","DOI":"10.1371\/journal.pone.0068483","volume":"8","author":"MT Bowen","year":"2013","unstructured":"Bowen MT, Kevin RC, May M, Staples LG, Hunt GE, McGregor IS. Defensive aggregation (huddling) in Rattus norvegicus toward predator odor: individual differences, social buffering effects and neural correlates. PLoS ONE. 2013;8:e68483.","journal-title":"PLoS ONE"},{"key":"2492_CR18","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1017\/S1461145714000388","volume":"17","author":"MT Bowen","year":"2014","unstructured":"Bowen MT, McGregor IS. Oxytocin and vasopressin modulate the social response to threat: a preclinical study. Int J Neuropsychopharmacol. 2014;17:1621\u201333.","journal-title":"Int J Neuropsychopharmacol"},{"key":"2492_CR19","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1038\/npp.2015.100","volume":"40","author":"W Ito","year":"2015","unstructured":"Ito W, Erisir A, Morozov A. Observation of Distressed Conspecific as a Model of Emotional Trauma Generates Silent Synapses in the Prefrontal-Amygdala Pathway and Enhances Fear Learning, but Ketamine Abolishes those Effects. Neuropsychopharmacology. 2015;40:2536\u201345.","journal-title":"Neuropsychopharmacology"},{"key":"2492_CR20","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.biopsych.2022.07.016","volume":"93","author":"W Ito","year":"2023","unstructured":"Ito W, Palmer AJ, Morozov A. Social Synchronization of Conditioned Fear in Mice Requires Ventral Hippocampus Input to the Amygdala. Biol Psychiatry. 2023;93:322\u201330.","journal-title":"Biol Psychiatry"},{"key":"2492_CR21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/BF03001163","volume":"15","author":"MS Fanselow","year":"1980","unstructured":"Fanselow MS. Conditioned and unconditional components of post-shock freezing. Pavlov J Biol Sci. 1980;15:177\u201382.","journal-title":"Pavlov J Biol Sci"},{"key":"2492_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2025.1617091","volume":"19","author":"M Ritter","year":"2025","unstructured":"Ritter M, Shipley HL, Deiana S, Hengerer B, Wotjak CT, Brecht M, et al. Social context restructures behavioral syntax in mice. Front Behav Neurosci. 2025;19:1617091.","journal-title":"Front Behav Neurosci"},{"key":"2492_CR23","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1038\/s41386-019-0342-7","volume":"44","author":"W Ito","year":"2019","unstructured":"Ito W, Morozov A. Prefrontal-amygdala plasticity enabled by observational fear. Neuropsychopharmacology. 2019;44:1778\u201387.","journal-title":"Neuropsychopharmacology"},{"key":"2492_CR24","unstructured":"Burnham KP, Anderson DR. Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach. Springer: New York, NY; 2010."},{"key":"2492_CR25","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.bbr.2012.08.051","volume":"237","author":"AH Fairless","year":"2013","unstructured":"Fairless AH, Katz JM, Vijayvargiya N, Dow HC, Kreibich AS, Berrettini WH, et al. Development of home cage social behaviors in BALB\/cJ vs. C57BL\/6J mice. Behav Brain Res. 2013;237:338\u201347.","journal-title":"Behav Brain Res"},{"key":"2492_CR26","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1016\/j.cub.2020.04.042","volume":"30","author":"AF Meyer","year":"2020","unstructured":"Meyer AF, O\u2019Keefe J, Poort J. Two Distinct Types of Eye-Head Coupling in Freely Moving Mice. Curr Biol. 2020;30:2116\u201330.e6.","journal-title":"Curr Biol"},{"key":"2492_CR27","doi-asserted-by":"publisher","first-page":"e1003236","DOI":"10.1371\/journal.pcbi.1003236","volume":"9","author":"B Mitchinson","year":"2013","unstructured":"Mitchinson B, Prescott TJ. Whisker movements reveal spatial attention: a unified computational model of active sensing control in the rat. PLoS Comput Biol. 2013;9:e1003236.","journal-title":"PLoS Comput Biol"},{"key":"2492_CR28","doi-asserted-by":"publisher","first-page":"e43590","DOI":"10.1371\/journal.pone.0043590","volume":"7","author":"MA Strodl","year":"2012","unstructured":"Strodl MA, Schausberger P. Social familiarity reduces reaction times and enhances survival of group-living predatory mites under the risk of predation. PLoS ONE. 2012;7:e43590.","journal-title":"PLoS ONE"},{"key":"2492_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-30656-4","volume":"15","author":"R Nakahata","year":"2025","unstructured":"Nakahata R, Takeuchi H. Social familiarity shapes collective decision-making in response to looming stimuli in Medaka fish. Sci Rep. 2025;15:43650.","journal-title":"Sci Rep"},{"key":"2492_CR30","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/s42003-021-02407-4","volume":"4","author":"LE Nadler","year":"2021","unstructured":"Nadler LE, McCormick MI, Johansen JL, Domenici P. Social familiarity improves fast-start escape performance in schooling fish. Commun Biol. 2021;4:897.","journal-title":"Commun Biol"},{"key":"2492_CR31","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/nature21682","volume":"543","author":"BF Grewe","year":"2017","unstructured":"Grewe BF, Grundemann J, Kitch LJ, Lecoq JA, Parker JG, Marshall JD, et al. Neural ensemble dynamics underlying a long-term associative memory. Nature. 2017;543:670\u201375.","journal-title":"Nature"},{"key":"2492_CR32","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/0896-6273(95)90092-6","volume":"15","author":"GJ Quirk","year":"1995","unstructured":"Quirk GJ, Repa C, LeDoux JE. Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat. Neuron. 1995;15:1029\u201339.","journal-title":"Neuron"},{"key":"2492_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175653","volume":"946","author":"H Esaki","year":"2023","unstructured":"Esaki H, Sasaki Y, Nishitani N, Kamada H, Mukai S, Ohshima Y, et al. Role of 5-HT(1A) receptors in the basolateral amygdala on 3,4-methylenedioxymethamphetamine-induced prosocial effects in mice. Eur J Pharm. 2023;946:175653.","journal-title":"Eur J Pharm"},{"key":"2492_CR34","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwac179","volume":"10","author":"JA Wei","year":"2023","unstructured":"Wei JA, Han Q, Luo Z, Liu L, Cui J, Tan J, et al. Amygdala neural ensemble mediates mouse social investigation behaviors. Natl Sci Rev. 2023;10:nwac179.","journal-title":"Natl Sci Rev"},{"key":"2492_CR35","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1523\/JNEUROSCI.4257-13.2014","volume":"34","author":"AC Felix-Ortiz","year":"2014","unstructured":"Felix-Ortiz AC, Tye KM. Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J Neurosci. 2014;34:586\u201395.","journal-title":"J Neurosci"},{"key":"2492_CR36","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1172\/JCI131752","volume":"130","author":"OM Folkes","year":"2020","unstructured":"Folkes OM, Baldi R, Kondev V, Marcus DJ, Hartley ND, Turner BD, et al. An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability. J Clin Investig. 2020;130:1728\u201342.","journal-title":"J Clin Investig"},{"key":"2492_CR37","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1016\/j.celrep.2019.05.081","volume":"27","author":"RP Rao","year":"2019","unstructured":"Rao RP, von Heimendahl M, Bahr V, Brecht M. Neuronal Responses to Conspecifics in the Ventral CA1. Cell Rep. 2019;27:3460\u201372.","journal-title":"Cell Rep"},{"key":"2492_CR38","doi-asserted-by":"crossref","unstructured":"Rashid M, Thomas S, Isaac J, Karkare SC, Klein H, Murugan M. A ventral hippocampal-lateral septum pathway regulates social novelty preference. Elife. 2025;13:RP97259.","DOI":"10.7554\/eLife.97259.2"},{"key":"2492_CR39","doi-asserted-by":"publisher","first-page":"e3002722","DOI":"10.1371\/journal.pbio.3002722","volume":"23","author":"D Patterson","year":"2025","unstructured":"Patterson D, Khan N, Collins EA, Stewart NR, Sassaninejad K, Yeates D, et al. Ventral hippocampus to nucleus accumbens shell circuit regulates approach decisions during motivational conflict. PLoS Biol. 2025;23:e3002722.","journal-title":"PLoS Biol"},{"key":"2492_CR40","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1523\/JNEUROSCI.23-08-03483.2003","volume":"23","author":"BJ Aragona","year":"2003","unstructured":"Aragona BJ, Liu Y, Curtis JT, Stephan FK, Wang Z. A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles. J Neurosci. 2003;23:3483\u201390.","journal-title":"J Neurosci"},{"key":"2492_CR41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature12518","volume":"501","author":"G Dolen","year":"2013","unstructured":"Dolen G, Darvishzadeh A, Huang KW, Malenka RC. Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature. 2013;501:179\u201384.","journal-title":"Nature"},{"key":"2492_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111246","volume":"40","author":"B Dai","year":"2022","unstructured":"Dai B, Sun F, Tong X, Ding Y, Kuang A, Osakada T, et al. Responses and functions of dopamine in nucleus accumbens core during social behaviors. Cell Rep. 2022;40:111246.","journal-title":"Cell Rep"},{"key":"2492_CR43","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/s41386-020-0657-4","volume":"45","author":"AV Williams","year":"2020","unstructured":"Williams AV, Duque-Wilckens N, Ramos-Maciel S, Campi KL, Bhela SK, Xu CK, et al. Social approach and social vigilance are differentially regulated by oxytocin receptors in the nucleus accumbens. Neuropsychopharmacology. 2020;45:1423\u201330.","journal-title":"Neuropsychopharmacology"},{"key":"2492_CR44","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1097\/FBP.0000000000000212","volume":"27","author":"CJ Yu","year":"2016","unstructured":"Yu CJ, Zhang SW, Tai FD. Effects of nucleus accumbens oxytocin and its antagonist on social approach behavior. Behav Pharm. 2016;27:672\u201380.","journal-title":"Behav Pharm"},{"key":"2492_CR45","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1038\/s41386-024-01937-9","volume":"49","author":"PX Luo","year":"2024","unstructured":"Luo PX, Serna Godoy A, Zakharenkov HC, Vang N, Wright EC, Balantac TA, et al. Hypocretin in the nucleus accumbens shell modulates social approach in female but not male California mice. Neuropsychopharmacology. 2024;49:2000\u201310.","journal-title":"Neuropsychopharmacology"},{"key":"2492_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100365","volume":"15","author":"S Dutta","year":"2021","unstructured":"Dutta S, Beaver J, Halcomb CJ, Jasnow AM. Dissociable roles of the nucleus accumbens core and shell subregions in the expression and extinction of conditioned fear. Neurobiol Stress. 2021;15:100365.","journal-title":"Neurobiol Stress"},{"key":"2492_CR47","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1046\/j.1460-9568.2002.02247.x","volume":"16","author":"KL Thomas","year":"2002","unstructured":"Thomas KL, Hall J, Everitt BJ. Cellular imaging with zif268 expression in the rat nucleus accumbens and frontal cortex further dissociates the neural pathways activated following the retrieval of contextual and cued fear memory. Eur J Neurosci. 2002;16:1789\u201396.","journal-title":"Eur J Neurosci"},{"key":"2492_CR48","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/S0306-4522(96)00632-X","volume":"78","author":"S Campeau","year":"1997","unstructured":"Campeau S, Falls WA, Cullinan WE, Helmreich DL, Davis M, Watson SJ. Elicitation and reduction of fear: behavioural and neuroendocrine indices and brain induction of the immediate-early gene c-fos. Neuroscience. 1997;78:1087\u2013104.","journal-title":"Neuroscience"},{"key":"2492_CR49","doi-asserted-by":"publisher","first-page":"12866","DOI":"10.1523\/JNEUROSCI.1339-11.2011","volume":"31","author":"JM Richard","year":"2011","unstructured":"Richard JM, Berridge KC. Nucleus accumbens dopamine\/glutamate interaction switches modes to generate desire versus dread: D(1) alone for appetitive eating but D(1) and D(2) together for fear. J Neurosci. 2011;31:12866\u201379.","journal-title":"J Neurosci"},{"key":"2492_CR50","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1126\/science.aaf7003","volume":"353","author":"T Okuyama","year":"2016","unstructured":"Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S. Ventral CA1 neurons store social memory. Science. 2016;353:1536\u201341.","journal-title":"Science"},{"key":"2492_CR51","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1126\/science.aaa8120","volume":"347","author":"LJ Young","year":"2015","unstructured":"Young LJ, Barrett CE. Neuroscience. Can oxytocin treat autism? Science. 2015;347:825\u20136.","journal-title":"Science"},{"key":"2492_CR52","volume":"377","author":"P Paletta","year":"2022","unstructured":"Paletta P, Bass N, Kavaliers M, Choleris E. The role of oxytocin in shaping complex social behaviours: possible interactions with other neuromodulators. Philos Trans R Soc Lond Ser B Biol Sci. 2022;377:20210058.","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"2492_CR53","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.biopsych.2017.08.024","volume":"83","author":"N Duque-Wilckens","year":"2018","unstructured":"Duque-Wilckens N, Steinman MQ, Busnelli M, Chini B, Yokoyama S, Pham M, et al. Oxytocin Receptors in the Anteromedial Bed Nucleus of the Stria Terminalis Promote Stress-Induced Social Avoidance in Female California Mice. Biol Psychiatry. 2018;83:203\u201313.","journal-title":"Biol Psychiatry"},{"key":"2492_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.104676","volume":"116","author":"S Haskal de la Zerda","year":"2020","unstructured":"Haskal de la Zerda S, Netser S, Magalnik H, Wagner S. Impaired sex preference, but not social and social novelty preferences, following systemic blockade of oxytocin receptors in adult male mice. Psychoneuroendocrinology. 2020;116:104676.","journal-title":"Psychoneuroendocrinology"},{"key":"2492_CR55","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1248\/bpb.b22-00200","volume":"45","author":"K Takayama","year":"2022","unstructured":"Takayama K, Tobori S, Andoh C, Kakae M, Hagiwara M, Nagayasu K, et al. Autism Spectrum Disorder Model Mice Induced by Prenatal Exposure to Valproic Acid Exhibit Enhanced Empathy-Like Behavior via Oxytocinergic Signaling. Biol Pharm Bull. 2022;45:1124\u201332.","journal-title":"Biol Pharm Bull"},{"key":"2492_CR56","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1126\/science.284.5411.99","volume":"284","author":"JK Parrish","year":"1999","unstructured":"Parrish JK, Edelstein-Keshet L. Complexity, pattern, and evolutionary trade-offs in animal aggregation. Science. 1999;284:99\u2013101.","journal-title":"Science"},{"key":"2492_CR57","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nature09559","volume":"468","author":"S Ciocchi","year":"2010","unstructured":"Ciocchi S, Herry C, Grenier F, Wolff SB, Letzkus JJ, Vlachos I, et al. Encoding of conditioned fear in central amygdala inhibitory circuits. Nature. 2010;468:277\u201382.","journal-title":"Nature"},{"key":"2492_CR58","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1152\/physrev.00037.2009","volume":"90","author":"HC Pape","year":"2010","unstructured":"Pape HC, Pare D. Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear. Physiol Rev. 2010;90:419\u201363.","journal-title":"Physiol Rev"},{"key":"2492_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06501-w","volume":"9","author":"T Meira","year":"2018","unstructured":"Meira T, Leroy F, Buss EW, Oliva A, Park J, Siegelbaum SA. A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics. Nat Commun. 2018;9:4163.","journal-title":"Nat Commun"},{"key":"2492_CR60","doi-asserted-by":"crossref","unstructured":"AlSubaie R, Wee RW, Ritoux A, Mishchanchuk K, Passlack J, Regester D, et al. Control of parallel hippocampal output pathways by amygdalar long-range inhibition. Elife. 2021;10:e74758.","DOI":"10.7554\/eLife.74758"},{"key":"2492_CR61","doi-asserted-by":"publisher","first-page":"8717","DOI":"10.1523\/JNEUROSCI.0316-19.2019","volume":"39","author":"MM Rogers-Carter","year":"2019","unstructured":"Rogers-Carter MM, Djerdjaj A, Gribbons KB, Varela JA, Christianson JP. Insular Cortex Projections to Nucleus Accumbens Core Mediate Social Approach to Stressed Juvenile Rats. J Neurosci. 2019;39:8717\u201329.","journal-title":"J Neurosci"},{"key":"2492_CR62","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.biopsych.2020.05.021","volume":"88","author":"J Muir","year":"2020","unstructured":"Muir J, Tse YC, Iyer ES, Biris J, Cvetkovska V, Lopez J, et al. Ventral Hippocampal Afferents to Nucleus Accumbens Encode Both Latent Vulnerability and Stress-Induced Susceptibility. Biol Psychiatry. 2020;88:843\u201354.","journal-title":"Biol Psychiatry"},{"key":"2492_CR63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31082-0","volume":"13","author":"DCM Yeates","year":"2022","unstructured":"Yeates DCM, Leavitt D, Sujanthan S, Khan N, Alushaj D, Lee ACH, et al. Parallel ventral hippocampus-lateral septum pathways differentially regulate approach-avoidance conflict. Nat Commun. 2022;13:3349.","journal-title":"Nat Commun"},{"key":"2492_CR64","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1126\/science.1174929","volume":"325","author":"JL Goodson","year":"2009","unstructured":"Goodson JL, Schrock SE, Klatt JD, Kabelik D, Kingsbury MA. Mesotocin and nonapeptide receptors promote estrildid flocking behavior. Science. 2009;325:862\u20136.","journal-title":"Science"},{"key":"2492_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07990-y","volume":"12","author":"A Gemmer","year":"2022","unstructured":"Gemmer A, Mirkes K, Anneser L, Eilers T, Kibat C, Mathuru A, et al. Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio). Sci Rep. 2022;12:4322.","journal-title":"Sci Rep"},{"key":"2492_CR66","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1409316","volume":"18","author":"LK Nerio-Morales","year":"2024","unstructured":"Nerio-Morales LK, Boender AJ, Young LJ, Lamprea MR, Smith AS. Limbic oxytocin receptor expression alters molecular signaling and social avoidance behavior in female prairie voles (Microtus ochrogaster). Front Neurosci. 2024;18:1409316.","journal-title":"Front Neurosci"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02492-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02492-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02492-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:01:57Z","timestamp":1787047317000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02492-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["2492"],"URL":"https:\/\/doi.org\/10.1038\/s41386-026-02492-1","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"3 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}