{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:01:26Z","timestamp":1790089286045,"version":"4.0.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00355319"],"award-info":[{"award-number":["RS-2024-00355319"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00441068"],"award-info":[{"award-number":["RS-2024-00441068"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00455884"],"award-info":[{"award-number":["RS-2024-00455884"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-24683010"],"award-info":[{"award-number":["RS-2025-24683010"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1038\/s41386-026-02525-9","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:36:38Z","timestamp":1787135798000},"page":"2258-2268","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anoctamin 2 deletion alters dopamine-related signaling and impairs inhibitory behavioral control in mice"],"prefix":"10.1038","volume":"51","author":[{"given":"Eunsil","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooeun","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Gwang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3073-6521","authenticated-orcid":false,"given":"Joeun","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hae","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Mi","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hoon","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-7890","authenticated-orcid":false,"given":"Jae-Yong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"2525_CR1","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1146\/annurev.physiol.67.032003.154341","volume":"67","author":"C Hartzell","year":"2005","unstructured":"Hartzell C, Putzier I, Arreola J. Calcium-activated chloride channels. Annu Rev Physiol. 2005;67:719\u201358.","journal-title":"Annu Rev Physiol"},{"key":"2525_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/pr.111.005009","volume":"64","author":"F Huang","year":"2012","unstructured":"Huang F, Wong X, Jan LY. International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels. Pharm Rev. 2012;64:1\u201315.","journal-title":"Pharm Rev"},{"key":"2525_CR3","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1126\/science.1163518","volume":"322","author":"A Caputo","year":"2008","unstructured":"Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, et al. TMEM16A is a membrane protein associated with calcium-dependent chloride channel activity. Science. 2008;322:590\u201394.","journal-title":"Science"},{"key":"2525_CR4","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.cell.2008.09.003","volume":"134","author":"BC Schroeder","year":"2008","unstructured":"Schroeder BC, Cheng T, Jan YN, Jan LY. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell. 2008;134:1019\u201329.","journal-title":"Cell"},{"key":"2525_CR5","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1038\/nature07313","volume":"455","author":"YD Yang","year":"2008","unstructured":"Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature. 2008;455:1210\u20135.","journal-title":"Nature"},{"key":"2525_CR6","doi-asserted-by":"publisher","first-page":"6809","DOI":"10.1523\/JNEUROSCI.5546-08.2009","volume":"29","author":"H Stohr","year":"2009","unstructured":"Stohr H, Heisig JB, Benz PM, Schoberl S, Milenkovic VM, Strauss O, et al. TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci. 2009;29:6809\u201318.","journal-title":"J Neurosci"},{"key":"2525_CR7","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00424-009-0684-9","volume":"458","author":"S Pifferi","year":"2009","unstructured":"Pifferi S, Dibattista M, Menini A. TMEM16B induces chloride currents activated by calcium in mammalian cells. Pfl\u00fcgers Arch-Eur J Physiol. 2009;458:1023\u201338.","journal-title":"Pfl\u00fcgers Arch-Eur J Physiol"},{"key":"2525_CR8","doi-asserted-by":"publisher","first-page":"11776","DOI":"10.1073\/pnas.0903304106","volume":"106","author":"AB Stephan","year":"2009","unstructured":"Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, Zhao H. ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc Natl Acad Sci USA. 2009;106:11776\u201381.","journal-title":"Proc Natl Acad Sci USA."},{"key":"2525_CR9","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1152\/physrev.00039.2011","volume":"94","author":"N Pedemonte","year":"2014","unstructured":"Pedemonte N, Galietta LJ. Structure and function of TMEM16 proteins (anoctamins). Physiol Rev. 2014;94:419\u201359.","journal-title":"Physiol Rev"},{"key":"2525_CR10","doi-asserted-by":"crossref","unstructured":"Arreola J, L\u00f3pez-Romero AE, P\u00e9rez-Cornejo P, Rodr\u00edguez-Menchaca AA. Phosphatidylinositol 4, 5-bisphosphate and cholesterol regulators of the calcium-activated chloride channels TMEM16A and TMEM16B. Adv Exp Med Biol. 2023;1422:279\u2013304.","DOI":"10.1007\/978-3-031-21547-6_10"},{"key":"2525_CR11","doi-asserted-by":"crossref","unstructured":"Dibattista M, Pifferi S, Hernandez-Clavijo A, Menini A. The physiological roles of anoctamin2\/TMEM16B and anoctamin1\/TMEM16A in chemical senses. Cell Calcium. 2024;120:102889.","DOI":"10.1016\/j.ceca.2024.102889"},{"key":"2525_CR12","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1085\/jgp.201611622","volume":"148","author":"G Pietra","year":"2016","unstructured":"Pietra G, Dibattista M, Menini A, Reisert J, Boccaccio A. The Ca2+-activated Cl\u2212 channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons. J Gen Physiol. 2016;148:293\u2013311.","journal-title":"J Gen Physiol"},{"key":"2525_CR13","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.neuron.2017.08.010","volume":"95","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, et al. Inferior olivary TMEM16B mediates cerebellar motor learning. Neuron. 2017;95:1103\u201311. e4.","journal-title":"Neuron"},{"key":"2525_CR14","doi-asserted-by":"publisher","first-page":"7102","DOI":"10.1523\/JNEUROSCI.3137-18.2019","volume":"39","author":"L Wang","year":"2019","unstructured":"Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, et al. TMEM16B calcium-activated chloride channels regulate action potential firing in the lateral septum and aggression in male mice. J Neurosci. 2019;39:7102\u201317.","journal-title":"J Neurosci"},{"key":"2525_CR15","doi-asserted-by":"publisher","first-page":"e47106","DOI":"10.7554\/eLife.47106","volume":"8","author":"KX Li","year":"2019","unstructured":"Li KX, He M, Ye W, Simms J, Gill M, Xiang X, et al. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife. 2019;8:e47106.","journal-title":"Elife"},{"key":"2525_CR16","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0896-6273(02)00965-0","volume":"36","author":"RA Wise","year":"2002","unstructured":"Wise RA. Brain reward circuitry: insights from unsensed incentives. Neuron. 2002;36:229\u201340.","journal-title":"Neuron"},{"key":"2525_CR17","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.biopsych.2004.10.020","volume":"57","author":"J Biederman","year":"2005","unstructured":"Biederman J. Attention-deficit\/hyperactivity disorder: a selective overview. Biol Psychiatry. 2005;57:1215\u201320.","journal-title":"Biol Psychiatry"},{"key":"2525_CR18","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1001\/jama.2009.1308","volume":"302","author":"ND Volkow","year":"2009","unstructured":"Volkow ND, Wang GJ, Kollins SH, Wigal TL, Newcorn JH, Telang F, et al. Evaluating dopamine reward pathway in ADHD: clinical implications. JAMA. 2009;302:1084\u201391.","journal-title":"JAMA"},{"key":"2525_CR19","doi-asserted-by":"crossref","unstructured":"Rice ME, Patel JC. Somatodendritic dopamine release: recent mechanistic insights. Philos Trans R Soc Lond B Biol Sci. 2015;370:20140185..","DOI":"10.1098\/rstb.2014.0185"},{"key":"2525_CR20","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1113\/jphysiol.2014.285890","volume":"593","author":"KR Brimblecombe","year":"2015","unstructured":"Brimblecombe KR, Gracie CJ, Platt NJ, Cragg SJ. Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains. J Physiol. 2015;593:929\u201346.","journal-title":"J Physiol"},{"key":"2525_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1113\/jphysiol.2014.275107","volume":"594","author":"X Jin","year":"2016","unstructured":"Jin X, Shah S, Du X, Zhang H, Gamper N. Activation of Ca2+-activated Cl\u2212 channel ANO1 by localized Ca2+ signals. J Physiol. 2016;594:19\u201330.","journal-title":"J Physiol"},{"key":"2525_CR22","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1080\/19336950.2021.1975411","volume":"15","author":"M Hawn","year":"2021","unstructured":"Hawn M, Akin E, Hartzell H, Greenwood I, Leblanc N. Molecular mechanisms of activation and regulation of ANO1-encoded Ca2+-activated Cl-channels. Channels. 2021;15:569\u2013603.","journal-title":"Channels"},{"key":"2525_CR23","doi-asserted-by":"publisher","first-page":"C395","DOI":"10.1152\/ajpcell.00397.2021","volume":"322","author":"V Yarotskyy","year":"2022","unstructured":"Yarotskyy V, Lark ARS, Nass SR, Hahn YK, Marone MG, McQuiston AR, et al. Chloride channels with ClC-1-like properties differentially regulate the excitability of dopamine receptor D1- and D2-expressing striatal medium spiny neurons. Am J Physiol Cell Physiol. 2022;322:C395\u2013C409.","journal-title":"Am J Physiol Cell Physiol"},{"key":"2525_CR24","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.biopsych.2004.11.024","volume":"57","author":"SV Faraone","year":"2005","unstructured":"Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, et al. Molecular genetics of attention-deficit\/hyperactivity disorder. Biol Psychiatry. 2005;57:1313\u201323.","journal-title":"Biol Psychiatry"},{"key":"2525_CR25","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.physbeh.2007.05.024","volume":"92","author":"RD Heijtz","year":"2007","unstructured":"Heijtz RD, Kolb B, Forssberg H. Motor inhibitory role of dopamine D1 receptors: implications for ADHD. Physiol Behav. 2007;92:155\u201360.","journal-title":"Physiol Behav"},{"key":"2525_CR26","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.nbd.2006.12.011","volume":"26","author":"X Fan","year":"2007","unstructured":"Fan X, Hess EJ. D2-like dopamine receptors mediate the response to amphetamine in a mouse model of ADHD. Neurobiol Dis. 2007;26:201\u201311.","journal-title":"Neurobiol Dis"},{"key":"2525_CR27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00439-009-0694-x","volume":"126","author":"IR Gizer","year":"2009","unstructured":"Gizer IR, Ficks C, Waldman ID. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet. 2009;126:51\u201390.","journal-title":"Hum Genet"},{"key":"2525_CR28","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1080\/09297040600770761","volume":"13","author":"K Rubia","year":"2007","unstructured":"Rubia K, Smith A, Taylor E. Performance of children with attention deficit hyperactivity disorder (ADHD) on a test battery of impulsiveness. Child Neuropsychol. 2007;13:276\u2013304.","journal-title":"Child Neuropsychol"},{"key":"2525_CR29","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1017\/S1355617707070889","volume":"13","author":"L Malloy-Diniz","year":"2007","unstructured":"Malloy-Diniz L, Fuentes D, Leite WB, Correa H, Bechara A. Impulsive behavior in adults with attention deficit\/hyperactivity disorder: characterization of attentional, motor and cognitive impulsiveness. J Int Neuropsychol Soc. 2007;13:693\u201398.","journal-title":"J Int Neuropsychol Soc"},{"key":"2525_CR30","doi-asserted-by":"publisher","first-page":"69R","DOI":"10.1203\/PDR.0b013e318212b40f","volume":"69","author":"D Purper-Ouakil","year":"2011","unstructured":"Purper-Ouakil D, Ramoz N, Lepagnol-Bestel AM, Gorwood P, Simonneau M. Neurobiology of attention deficit\/hyperactivity disorder. Pediatr Res. 2011;69:69R\u201376R.","journal-title":"Pediatr Res"},{"key":"2525_CR31","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1113\/jphysiol.2008.163709","volume":"587","author":"HC Hartzell","year":"2009","unstructured":"Hartzell HC, Yu K, Xiao Q, Chien LT, Qu Z. Anoctamin\/TMEM16 family members are Ca2+-activated Cl\u2212 channels. J Physiol. 2009;587:2127\u201339.","journal-title":"J Physiol"},{"key":"2525_CR32","doi-asserted-by":"publisher","first-page":"7838","DOI":"10.1074\/jbc.M109.065367","volume":"285","author":"R Schreiber","year":"2010","unstructured":"Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, et al. Expression and function of epithelial anoctamins. J Biol Chem. 2010;285:7838\u201345.","journal-title":"J Biol Chem"},{"key":"2525_CR33","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/nn.3111","volume":"15","author":"H Cho","year":"2012","unstructured":"Cho H, Yang YD, Lee J, Lee B, Kim T, Jang Y, et al. The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci. 2012;15:1015\u201321.","journal-title":"Nat Neurosci"},{"key":"2525_CR34","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ceca.2014.02.006","volume":"55","author":"Y Jang","year":"2014","unstructured":"Jang Y, Oh U. Anoctamin 1 in secretory epithelia. Cell Calcium. 2014;55:355\u201361.","journal-title":"Cell Calcium"},{"key":"2525_CR35","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1085\/jgp.201411348","volume":"145","author":"A Amjad","year":"2015","unstructured":"Amjad A, Hernandez-Clavijo A, Pifferi S, Maurya DK, Boccaccio A, Franzot J, et al. Conditional knockout of TMEM16A\/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol. 2015;145:285\u2013301.","journal-title":"J Gen Physiol"},{"key":"2525_CR36","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948097","volume":"21","author":"CH Cho","year":"2020","unstructured":"Cho CH, Lee S, Kim A, Yarishkin O, Ryoo K, Lee YS, et al. TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety-related behaviors. EMBO Rep. 2020;21:e48097.","journal-title":"EMBO Rep"},{"key":"2525_CR37","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.neuron.2012.01.033","volume":"74","author":"WC Huang","year":"2012","unstructured":"Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY. Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron. 2012;74:179\u201392.","journal-title":"Neuron"},{"key":"2525_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13791","volume":"7","author":"GE Ha","year":"2016","unstructured":"Ha GE, Lee J, Kwak H, Song K, Kwon J, Jung SY, et al. The Ca(2+)-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons. Nat Commun. 2016;7:13791.","journal-title":"Nat Commun"},{"key":"2525_CR39","doi-asserted-by":"publisher","first-page":"e0247801","DOI":"10.1371\/journal.pone.0247801","volume":"16","author":"F Auer","year":"2021","unstructured":"Auer F, Franco Taveras E, Klein U, Kesenheimer C, Fleischhauer D, M\u00f6hrlen F, et al. Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells. PLoS One. 2021;16:e0247801.","journal-title":"PLoS One"},{"key":"2525_CR40","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1471-4159.1982.tb03951.x","volume":"39","author":"G Kapatos","year":"1982","unstructured":"Kapatos G, Zigmond MJ. Influence of calcium on dopamine synthesis and tyrosine hydroxylase activity in rat striatum. J Neurochem. 1982;39:327\u201335.","journal-title":"J Neurochem"},{"key":"2525_CR41","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/302830a0","volume":"302","author":"S El Mestikawy","year":"1983","unstructured":"El Mestikawy S, Glowinski J, Hamon M. Tyrosine hydroxylase activation in depolarized dopaminergic terminals\u2014involvement of Ca2+ -dependent phosphorylation. Nature. 1983;302:830\u201332.","journal-title":"Nature"},{"key":"2525_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0165-0173(02)00274-6","volume":"42","author":"E Davids","year":"2003","unstructured":"Davids E, Zhang K, Tarazi FI, Baldessarini RJ. Animal models of attention-deficit hyperactivity disorder. Brain Res Brain Res Rev. 2003;42:1\u201321.","journal-title":"Brain Res Brain Res Rev"},{"key":"2525_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-2-40","volume":"2","author":"H Forssberg","year":"2006","unstructured":"Forssberg H, Fernell E, Waters S, Waters N, Tedroff J. Altered pattern of brain dopamine synthesis in male adolescents with attention deficit hyperactivity disorder. Behav Brain Funct. 2006;2:40.","journal-title":"Behav Brain Funct"},{"key":"2525_CR44","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s43188-023-00210-3","volume":"40","author":"JY Lee","year":"2024","unstructured":"Lee JY, Yoshida M, Satoh M, Watanabe C. Neurobehavioral effects of exposure to mercury vapor and methylmercury during the postnatal period on mice. Toxicol Res. 2024;40:111\u201324.","journal-title":"Toxicol Res"},{"key":"2525_CR45","first-page":"1","volume":"25","author":"BJ Pillay","year":"2019","unstructured":"Pillay BJ, Meyer A, Mokobane M. Fine motor deficits and attention deficit hyperactivity disorder in primary school children. South Afr J Psychiatry. 2019;25:1\u20137.","journal-title":"South Afr J Psychiatry"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02525-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02525-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02525-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:22:12Z","timestamp":1790086932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02525-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2525"],"URL":"https:\/\/doi.org\/10.1038\/s41386-026-02525-9","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"assertion":[{"value":"4 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}