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Rare heterozygous null mutations in\n                    <jats:italic>SETD1A<\/jats:italic>\n                    , a gene encoding a key epigenetic regulator, have been definitively linked to increased risk for schizophrenia and neurodevelopmental disorders. To investigate how\n                    <jats:italic>SETD1A<\/jats:italic>\n                    haploinsufficiency impacts the function of circuits supporting working memory, this study examined neural oscillatory synchrony across a network of brain regions critical for spatial working memory (SWM) in mice carrying a loss-of-function allele in the orthologous\n                    <jats:italic>Setd1a<\/jats:italic>\n                    gene. Local field potential recordings were performed in the prefrontal cortex, dorsal and ventral hippocampus, and thalamic nucleus reuniens in male and female wildtype and\n                    <jats:italic>Setd1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2013<\/jats:italic>\n                    <\/jats:sup>\n                    mice performing a delayed non-match to sample task of SWM.\n                    <jats:italic>Setd1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2013<\/jats:italic>\n                    <\/jats:sup>\n                    mice exhibited unaltered prefrontal\u2013hippocampal neural oscillatory synchrony across frequencies and task epochs. In contrast,\n                    <jats:italic>Setd1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2013<\/jats:italic>\n                    <\/jats:sup>\n                    mice displayed reduced beta-frequency synchrony between the prefrontal cortex and nucleus reuniens during SWM maintenance and blunted bidirectional modulation of prefrontal\u2013reuniens beta- and gamma-frequency synchrony across task epochs. Moreover, these within-trial beta\u2013gamma synchrony dynamics predicted successful SWM performance in wildtype mice, whereas this relationship was disrupted in\n                    <jats:italic>Setd1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2013<\/jats:italic>\n                    <\/jats:sup>\n                    mice. Collectively, these findings identify behaviorally relevant thalamo\u2013prefrontal synchrony dynamics supporting SWM and provide new insight into how\n                    <jats:italic>SETD1A<\/jats:italic>\n                    haploinsufficiency alters the function of neural circuits supporting cognition.\n                  <\/jats:p>","DOI":"10.1038\/s41386-026-02532-w","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:14:35Z","timestamp":1787001275000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered thalamo\u2013prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5719-1886","authenticated-orcid":false,"given":"Sofiya","family":"Hupalo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9406-7681","authenticated-orcid":false,"given":"David A.","family":"Kupferschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ako","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Railing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxym V.","family":"Myroshnychenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Loewinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7491-4476","authenticated-orcid":false,"given":"Joseph A.","family":"Gogos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5488-8266","authenticated-orcid":false,"given":"Joshua A.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2532_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.tics.2011.11.015","volume":"16","author":"DM Barch","year":"2012","unstructured":"Barch DM, Ceaser A. 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