{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:19:02Z","timestamp":1787980742303,"version":"build-2784847793"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"For the Love of Travis Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"DOI":"10.1038\/s41386-026-02536-6","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:48:15Z","timestamp":1787978895000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of BDNF promoter VI in mediating protective effects of prophylactic (R,S)-ketamine"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1982-1389","authenticated-orcid":false,"given":"Briana K.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-2795","authenticated-orcid":false,"given":"Brenna L.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Darling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2229-177X","authenticated-orcid":false,"given":"Kevin","family":"Bath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-0789","authenticated-orcid":false,"given":"Keri","family":"Martinowich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6926-2020","authenticated-orcid":false,"given":"Christine A.","family":"Denny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"2536_CR1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1176\/appi.ajp.2020.20081251","volume":"178","author":"RS McIntyre","year":"2021","unstructured":"McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, et al. Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: an international expert opinion on the available evidence and implementation. Am J Psychiatry. 2021;178:383\u201399.","journal-title":"Am J Psychiatry"},{"key":"2536_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109345","volume":"224","author":"BK Chen","year":"2023","unstructured":"Chen BK, Denny CA. Weapons of stress reduction: (R,S)-ketamine and its metabolites as prophylactics for the prevention of stress-induced psychiatric disorders. Neuropharmacology. 2023;224:109345.","journal-title":"Neuropharmacology"},{"key":"2536_CR3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.neuropharm.2015.10.034","volume":"102","author":"C Bj\u00f6rkholm","year":"2016","unstructured":"Bj\u00f6rkholm C, Monteggia LM. BDNF - a key transducer of antidepressant effects. Neuropharmacology. 2016;102:72\u20139.","journal-title":"Neuropharmacology"},{"key":"2536_CR4","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.pnpbp.2007.07.027","volume":"32","author":"LSB Garcia","year":"2008","unstructured":"Garcia LSB, Comim CM, Valvassori SS, R\u00e9us GZ, Barbosa LM, Andreazza AC, et al. Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:140\u20134.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2536_CR5","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nature10130","volume":"475","author":"AE Autry","year":"2011","unstructured":"Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng P, et al. NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature. 2011;475:91\u201395.","journal-title":"Nature"},{"key":"2536_CR6","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1038\/npp.2015.349","volume":"41","author":"KR Maynard","year":"2016","unstructured":"Maynard KR, Hill JL, Calcaterra NE, Palko ME, Kardian A, Paredes D, et al. Functional role of BDNF production from unique promoters in aggression and serotonin signaling. Neuropsychopharmacology. 2016;41:1943\u201355.","journal-title":"Neuropsychopharmacology"},{"key":"2536_CR7","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1007\/s00429-017-1405-3","volume":"222","author":"KR Maynard","year":"2017","unstructured":"Maynard KR, Hobbs JW, Sukumar M, Kardian AS, Jimenez DV, Schloesser RJ, et al. BDNF mRNA splice variants differentially impact CA1 and CA3 dendrite complexity and spine morphology in the hippocampus. Brain Struct Funct. 2017;222:3295\u2013307.","journal-title":"Brain Struct Funct"},{"key":"2536_CR8","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1038\/s41593-021-00868-8","volume":"24","author":"J-W Kim","year":"2021","unstructured":"Kim J-W, Autry AE, Na ES, Adachi M, Bj\u00f6rkholm C, Kavalali ET, et al. Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation. Nat Neurosci. 2021;24:1100\u20139.","journal-title":"Nat Neurosci"},{"key":"2536_CR9","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/266730a0","volume":"266","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Le Pichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266:730\u20132.","journal-title":"Nature"},{"key":"2536_CR10","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1038\/s41386-020-0714-z","volume":"45","author":"BK Chen","year":"2020","unstructured":"Chen BK, Luna VM, LaGamma CT, Xu X, Deng S-X, Suckow RF, et al. Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine. Neuropsychopharmacology. 2020;45:1545\u201356.","journal-title":"Neuropsychopharmacology"},{"key":"2536_CR11","doi-asserted-by":"publisher","first-page":"11641","DOI":"10.1523\/JNEUROSCI.23-37-11641.2003","volume":"23","author":"HE Scharfman","year":"2003","unstructured":"Scharfman HE, Mercurio TC, Goodman JH, Wilson MA, MacLusky NJ. Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor. J Neurosci. 2003;23:11641\u201352.","journal-title":"J Neurosci"},{"key":"2536_CR12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.biopsych.2012.03.032","volume":"72","author":"KG Bath","year":"2012","unstructured":"Bath KG, Chuang J, Spencer-Segal JL, Amso D, Altemus M, McEwen BS, et al. Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice. Biol Psychiatry. 2012;72:499\u2013504.","journal-title":"Biol Psychiatry"},{"key":"2536_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2021.104980","volume":"131","author":"BJ Przyby\u0142","year":"2021","unstructured":"Przyby\u0142 BJ, Szlis M, W\u00f3jcik-G\u0142adysz A. Brain-derived neurotrophic factor (BDNF) affects the activity of the gonadotrophic axis in sheep. Horm Behav. 2021;131:104980.","journal-title":"Horm Behav"},{"key":"2536_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104609","volume":"25","author":"Y Chen","year":"2022","unstructured":"Chen Y, Li S, Zhang T, Yang F, Lu B. Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress. iScience. 2022;25:104609.","journal-title":"iScience"},{"key":"2536_CR15","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1095\/biolreprod59.6.1317","volume":"59","author":"W Ma","year":"1998","unstructured":"Ma W, Miao Z, Novotny MV. Role of the adrenal gland and adrenal-mediated chemosignals in suppression of estrus in the house mouse: the lee-boot effect revisited. Biol Reprod. 1998;59:1317\u201320.","journal-title":"Biol Reprod"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02536-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02536-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02536-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:48:19Z","timestamp":1787978899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41386-026-02536-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":15,"alternative-id":["2536"],"URL":"https:\/\/doi.org\/10.1038\/s41386-026-02536-6","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"assertion":[{"value":"30 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"BKC and CAD are named on provisional and non-provisional patent applications for the prophylactic use of (\n                      R,S\n                      )-ketamine against stress-related psychiatric disorders. BKC is currently Special Projects Manager at\n                      NPP\n                      . CAD is a member of the Editorial Board at\n                      NPP\n                      . BW, AD, KB, and KM have no conflicts of interest to disclose.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}