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In 1,159 adolescents, females showed significantly lower concentrations than males across five endocannabinoids (AEA, 2-AG, PEA, OEA, and 2-OG). Sex-by-puberty interactions were significant for AEA, PEA, and OEA. Exploratory analyses revealed sex-specific associations between endocannabinoids and self-reported pain, stress, internalizing, and attentional problems.<\/jats:p>","DOI":"10.1038\/s41386-026-02574-0","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:48:15Z","timestamp":1792108095000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex differences in circulating endocannabinoid concentrations during adolescence: Associations with pubertal development"],"prefix":"10.1038","author":[{"given":"Julia M.","family":"Evanski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristin","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-8083","authenticated-orcid":false,"given":"Adriene M.","family":"Beltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8521-8970","authenticated-orcid":false,"given":"Esmeralda","family":"Hidalgo-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel M.","family":"Portengen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Schrepf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Harte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-655X","authenticated-orcid":false,"given":"Chelsea M.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"2574_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/npp.2017.204","volume":"43","author":"G Donvito","year":"2018","unstructured":"Donvito G, Nass SR, Wilkerson JL, Curry ZA, Schurman LD, Kinsey SG, et al. 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CMK and AMB report grant support from Tonix. The other authors have no conflicts of interest to disclose.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}