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Diabetes"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The mechanisms by which chronic stress increases the risk of non-communicable diseases remain poorly understood. On one hand, chronic stress may increase systemic vascular resistance (SVR) and blood pressure, which may lead to blood vessels injury and altered myocardial perfusion. On the other hand, chronic stress may promote the overconsumption of sugar-containing foods and favor obesity. There is indeed evidence that sweet foods are preferentially consumed to alleviate stress responses. The effects of nutritive and non-nutritive sweeteners (NNS) on hemodynamic stress responses remain however largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective\/design<\/jats:title>\n                    <jats:p>This study aimed at comparing the effects of sucrose-containing and NNS-containing drinks, as compared to unsweetened water, on hemodynamic responses to acute stress in twelve healthy female subjects. Acute stress responses were elicited by a 30-min mental stress (5-min Stroop\u2019s test alternated with 5-min mental arithmetic) and a 3-min cold pressure test (CPT), each preceded by a resting baseline period. Hemodynamic stress responses were investigated by the repeated measurement of mean arterial pressure and the continuous monitoring of cardiac output by thoracic electrical bioimpedance measurement. SVR was selected as a primary outcome because it is a sensitive measure of hemodynamic responses to acute stress procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With all three drinks, SVR were not changed with mental stress (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.437), but were increased with CPT (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.045). Both mental stress and CPT increased mean arterial pressure and heart rate (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cardiac output increased with mental stress (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and remained unchanged with CPT (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.252). No significant differences in hemodynamic responses were observed between water, sucrose and NNS (stress\u2009\u00d7\u2009condition, all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\n                      <jats:italic>&gt;<\/jats:italic>\n                      \u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results demonstrate that sucrose and NNS do not alter hemodynamic responses to two different standardized acute stress protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41387-019-0104-y","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T12:16:06Z","timestamp":1581941766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of nutritive and non-nutritive sweeteners on hemodynamic responses to acute stress: a randomized crossover trial in healthy women"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-3591","authenticated-orcid":false,"given":"J\u00e9r\u00e9my","family":"Cros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Bidlingmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Rosset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Seyssel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Cr\u00e9z\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Stefanoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Schneiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-4692","authenticated-orcid":false,"given":"Luc","family":"Tappy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"104_CR1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1136\/bmj.38693.435301.80","volume":"332","author":"T Chandola","year":"2006","unstructured":"Chandola, T., Brunner, E. & Marmot, M. 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The remaining authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"1"}}