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We aim to assess the optimal ethnic-specific WC cut-off point for MS in Indonesia, a multi-ethnic country. Three population-based studies in Indonesia were included for analysis [Flores (<jats:italic>n<\/jats:italic>\u2009=\u20091227, Floresian), Depok (<jats:italic>n<\/jats:italic>\u2009=\u2009904, Sundanese), and Jakarta (<jats:italic>n<\/jats:italic>\u2009=\u20091574, Javanese)]. All subjects were 25\u201365 years old. The receiver operator characteristic curve analysis and Youden index method was used to determine the optimal cut-offs of WC to predict two or more risk factors of MS. In Flores, the cut-offs were 80\u2009cm (Sensitivity and Specificity, AUC, 84% and 73%, 0.86) and 77\u2009cm (86% and 68%, 0.85), for men and women, respectively. While in Depok, the values were 87\u2009cm (87% and 67%, 0.85) and 79\u2009cm (94% and 54%, 0.79), for men and women, respectively. While in Jakarta, the values were 83\u2009cm (92% and 60%, 0.85) and 81\u2009cm (84% and 60%, 0.77), for men and women, respectively. The optimal WC cut-off values for MS were different in those three ethnicities, and in general were lower than the currently used cut-off points for Asian population.<\/jats:p>","DOI":"10.1038\/s41387-020-0123-8","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T16:06:52Z","timestamp":1591632412000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnosing metabolic syndrome in a multi-ethnic country: is an ethnic-specific cut-off point of waist circumference needed?"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-5159","authenticated-orcid":false,"given":"Dicky L.","family":"Tahapary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dante S.","family":"Harbuwono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Em","family":"Yunir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradana","family":"Soewondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"123_CR1","doi-asserted-by":"crossref","unstructured":"Alberti, K. 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