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Diabetes"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The beneficial effects of folate have been observed under different conditions, but the available evidence on inflammation and reduction of cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM) is limited. The study aimed to explore the effects of folate on inflammation and homocysteine amongst individuals with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Scopus, and Cochrane Library were used to search for evidence. A random-effect model meta-analysis through Review Manager (version 5.4) and metaHun was performed. Results were reported as standardized mean differences (SMD) and 95% confidence intervals graphically using forest and funnel plots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 9 trials with 426 patients living with T2DM were analyzed. Folic acid supplementation significantly revealed a large effect size on homocysteine levels compared to placebo, SMD\u2009=\u2009\u22121.53, 95%CI (\u22122.14,\u22120.93),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05. Additionally, we observed a medium marginal effect size on C-reactive protein (SMD\u2009=\u2009\u22120.68, 95%CI (\u22121.34, \u22120.01),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05). However, no significant effect on tumor necrosis factor-\u03b1 (SMD\u2009=\u2009\u22120.86, 95%CI (\u22122.65, 0.93),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.34), and interleukin-6 (SMD\u2009=\u2009\u22120.04, 95%CI (\u22121.08, 1.01),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.95) was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Evidence analyzed in this study suggests that folic acid supplementation in T2DM reduces homocysteine and may mitigate CVDs. However, its effect on inflammation is inconclusive.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41387-024-00282-6","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T03:01:49Z","timestamp":1713754909000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Folic acid supplementation on inflammation and homocysteine in type 2 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-7433","authenticated-orcid":false,"given":"Kabelo","family":"Mokgalaboni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Given. 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