{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:48:23Z","timestamp":1792673303172,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nutr. Diabetes"],"DOI":"10.1038\/s41387-024-00325-y","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T05:02:48Z","timestamp":1723698168000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Loss of Cldn5 -and increase in Irf7-in the hippocampus and cerebral cortex of diabetic mice at the early symptomatic stage"],"prefix":"10.1038","volume":"14","author":[{"given":"Marta","family":"Car\u00fas-Cadavieco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gonz\u00e1lez de la Fuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7702-0611","authenticated-orcid":false,"given":"In\u00e9s","family":"Berenguer L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Serrano-Lope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Aguado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Guix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-2443","authenticated-orcid":false,"given":"Ernest","family":"Palomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4052-1719","authenticated-orcid":false,"given":"Carlos G.","family":"Dotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"325_CR1","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41574-018-0048-7","volume":"14","author":"GJ Biessels","year":"2018","unstructured":"Biessels GJ, Despa F. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications. Nat Rev Endocrinol. 2018;14:591\u2013604.","journal-title":"Nat Rev Endocrinol"},{"key":"325_CR2","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1017\/S1355617707070312","volume":"13","author":"AMA Brands","year":"2007","unstructured":"Brands AMA, Van den Berg E, Manschot SM, Biessels GJ, Kappelle LJ, De Haan EHF, et al. A detailed profile of cognitive dysfunction and its relation to psychological distress in patients with type 2 diabetes mellitus. J Int Neuropsychol Soc. 2007;13:288\u201397.","journal-title":"J Int Neuropsychol Soc"},{"key":"325_CR3","doi-asserted-by":"publisher","first-page":"e202201789","DOI":"10.26508\/lsa.202201789","volume":"6","author":"M Car\u00fas-Cadavieco","year":"2023","unstructured":"Car\u00fas-Cadavieco M, Berenguer L\u00f3pez I, Montoro Canelo A, Serrano-Lope MA, Gonz\u00e1lez-de la Fuente S, Aguado B, et al. Cognitive decline in diabetic mice predisposed to Alzheimer\u2019s disease is greater than in wild type. Life Sci Alliance. 2023;6:e202201789.","journal-title":"Life Sci Alliance"},{"key":"325_CR4","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1037\/0894-4105.16.2.208","volume":"16","author":"A Wahlin","year":"2002","unstructured":"Wahlin A, Nilsson E, Fastbom J. Cognitive performance in very old diabetic persons: the impact of semantic structure, preclinical dementia, and impending death. Neuropsychology. 2002;16:208\u201316.","journal-title":"Neuropsychology"},{"key":"325_CR5","doi-asserted-by":"publisher","first-page":"e73138","DOI":"10.7554\/eLife.73138","volume":"11","author":"B Antal","year":"2022","unstructured":"Antal B, McMahon LP, Sultan SF, Lithen A, Wexler DJ, Dickerson B, et al. Type 2 diabetes mellitus accelerates brain aging and cognitive decline: complementary findings from UK Biobank and meta-analyses. eLife. 2022;11:e73138.","journal-title":"eLife"},{"key":"325_CR6","doi-asserted-by":"publisher","first-page":"5.47.1","DOI":"10.1002\/0471141755.ph0547s70","volume":"70","author":"BL Furman","year":"2015","unstructured":"Furman BL. Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharm. 2015;70:5.47.1\u20135.47.20.","journal-title":"Curr Protoc Pharm"},{"key":"325_CR7","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.jpain.2007.04.004","volume":"8","author":"MS Johnson","year":"2007","unstructured":"Johnson MS, Ryals JM, Wright DE. Diabetes-induced chemogenic hypoalgesia is paralleled by attenuated stimulus-induced fos expression in the spinal cord of diabetic mice. J Pain. 2007;8:637\u201349.","journal-title":"J Pain"},{"key":"325_CR8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.pain.2008.07.007","volume":"140","author":"MS Johnson","year":"2008","unstructured":"Johnson MS, Ryals JM, Wright DE. Early loss of peptidergic intraepidermal nerve fibers in an STZ-induced mouse model of insensate diabetic neuropathy. Pain. 2008;140:35\u201347.","journal-title":"Pain"},{"key":"325_CR9","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1038\/s41380-022-01492-z","volume":"27","author":"E Palomer","year":"2022","unstructured":"Palomer E, Mart\u00edn-Flores N, Jolly S, Pascual-Vargas P, Benvegn\u00f9 S, Podpolny M, et al. Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters. Mol Psychiatry. 2022;27:3024\u201333.","journal-title":"Mol Psychiatry"},{"key":"325_CR10","doi-asserted-by":"crossref","unstructured":"Neely CLC, Pedemonte KA, Boggs KN, Flinn JM. Nest building behavior as an early indicator of behavioral deficits in mice. J Vis Exp. 2019:e60139.","DOI":"10.3791\/60139-v"},{"key":"325_CR11","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1097\/00008877-199711000-00003","volume":"8","author":"RJ Rodgers","year":"1997","unstructured":"Rodgers RJ. Animal models of \u201canxiety\u201d: where next? Behav Pharm. 1997;8:477\u201396.","journal-title":"Behav Pharm"},{"key":"325_CR12","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1007\/s00018-017-2481-5","volume":"74","author":"VC Figueiredo","year":"2017","unstructured":"Figueiredo VC, Markworth JF, Cameron-Smith D. Considerations on mTOR regulation at serine 2448: implications for muscle metabolism studies. Cell Mol Life Sci CMLS. 2017;74:2537\u201345.","journal-title":"Cell Mol Life Sci CMLS"},{"key":"325_CR13","doi-asserted-by":"publisher","first-page":"a009191","DOI":"10.1101\/cshperspect.a009191","volume":"6","author":"J Boucher","year":"2014","unstructured":"Boucher J, Kleinridders A, Kahn CR. Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol. 2014;6:a009191.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"325_CR14","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.cmet.2017.11.004","volume":"27","author":"A Ardestani","year":"2018","unstructured":"Ardestani A, Lupse B, Kido Y, Leibowitz G, Maedler K. mTORC1 signaling: a double-edged sword in diabetic \u03b2 cells. Cell Metab. 2018;27:314\u201331.","journal-title":"Cell Metab"},{"key":"325_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, Sun SC. NF-\u03baB signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023.","journal-title":"Signal Transduct Target Ther"},{"key":"325_CR16","doi-asserted-by":"crossref","unstructured":"Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, et al. State of the science on brain insulin resistance and cognitive decline due to Alzheimer\u2019s disease. Aging Dis. 2023.","DOI":"10.14336\/AD.2023.0814"},{"key":"325_CR17","doi-asserted-by":"publisher","first-page":"443","DOI":"10.2337\/dc12-0922","volume":"36","author":"AA Willette","year":"2013","unstructured":"Willette AA, Xu G, Johnson SC, Birdsill AC, Jonaitis EM, Sager MA, et al. Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes Care. 2013;36:443\u20139.","journal-title":"Diabetes Care"},{"key":"325_CR18","doi-asserted-by":"publisher","first-page":"7134","DOI":"10.1002\/jcp.30357","volume":"236","author":"H Chiba","year":"2021","unstructured":"Chiba H, Ichikawa-Tomikawa N, Imura T, Sugimoto K. The region-selective regulation of endothelial claudin-5 expression and signaling in brain health and disorders. J Cell Physiol. 2021;236:7134\u201343.","journal-title":"J Cell Physiol"},{"key":"325_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12987-019-0123-z","volume":"16","author":"C Greene","year":"2019","unstructured":"Greene C, Hanley N, Campbell M. Claudin-5: gatekeeper of neurological function. Fluids Barriers CNS. 2019;16:3.","journal-title":"Fluids Barriers CNS"},{"key":"325_CR20","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1136\/svn-2018-000198","volume":"4","author":"L Xu","year":"2019","unstructured":"Xu L, Nirwane A, Yao Y. Basement membrane and blood-brain barrier. Stroke Vasc Neurol. 2019;4:78\u201382.","journal-title":"Stroke Vasc Neurol"},{"key":"325_CR21","doi-asserted-by":"publisher","first-page":"914","DOI":"10.3389\/fphys.2020.00914","volume":"11","author":"JJ Lochhead","year":"2020","unstructured":"Lochhead JJ, Yang J, Ronaldson PT, Davis TP. Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders. Front Physiol. 2020;11:914.","journal-title":"Front Physiol"},{"key":"325_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1190841","volume":"14","author":"F Qing","year":"2023","unstructured":"Qing F, Liu Z. Interferon regulatory factor 7 in inflammation, cancer and infection. Front Immunol. 2023;14:1190841.","journal-title":"Front Immunol"},{"key":"325_CR23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cytogfr.2016.03.002","volume":"29","author":"T Suprunenko","year":"2016","unstructured":"Suprunenko T, Hofer MJ. The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond. Cytokine Growth Factor Rev. 2016;29:35\u201343.","journal-title":"Cytokine Growth Factor Rev"},{"key":"325_CR24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nri3344","volume":"13","author":"MS Diamond","year":"2013","unstructured":"Diamond MS, Farzan M. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Nat Rev Immunol. 2013;13:46\u201357.","journal-title":"Nat Rev Immunol"},{"key":"325_CR25","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.semnephrol.2021.03.005","volume":"41","author":"WL Lau","year":"2021","unstructured":"Lau WL, Tran T, Rhee CM, Kalantar-Zadeh K, Vaziri ND. Diabetes and the gut microbiome. Semin Nephrol. 2021;41:104\u201313.","journal-title":"Semin Nephrol"},{"key":"325_CR26","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.omtn.2022.07.002","volume":"29","author":"M Kujawa","year":"2022","unstructured":"Kujawa M, O\u2019Meara M, Li H, Xu L, Meda Venkata SP, Nguyen H, et al. MicroRNA-466 and microRNA-200 increase endothelial permeability in hyperglycemia by targeting Claudin-5. Mol Ther Nucleic Acids. 2022;29:259\u201371.","journal-title":"Mol Ther Nucleic Acids"},{"key":"325_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13812-z","volume":"10","author":"K Haruwaka","year":"2019","unstructured":"Haruwaka K, Ikegami A, Tachibana Y, Ohno N, Konishi H, Hashimoto A, et al. Dual microglia effects on blood brain barrier permeability induced by systemic inflammation. Nat Commun. 2019;10:5816.","journal-title":"Nat Commun"}],"container-title":["Nutrition & Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41387-024-00325-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41387-024-00325-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41387-024-00325-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T05:03:27Z","timestamp":1723698207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41387-024-00325-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,15]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["325"],"URL":"https:\/\/doi.org\/10.1038\/s41387-024-00325-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.02.565280","asserted-by":"object"}]},"ISSN":["2044-4052"],"issn-type":[{"value":"2044-4052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,15]]},"assertion":[{"value":"17 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"64"}}