{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:36:29Z","timestamp":1786718189627,"version":"build-2736575974"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["Charles University Research Program, Cooperatio-Gastroenterology"],"award-info":[{"award-number":["Charles University Research Program, Cooperatio-Gastroenterology"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["Charles University Research Program, Cooperatio-Gastroenterology"],"award-info":[{"award-number":["Charles University Research Program, Cooperatio-Gastroenterology"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["Charles University Research Program, Cooperatio-Gastroenterology"],"award-info":[{"award-number":["Charles University Research Program, Cooperatio-Gastroenterology"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["Charles University Research Program, Cooperatio-Gastroenterology"],"award-info":[{"award-number":["Charles University Research Program, Cooperatio-Gastroenterology"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["MH CZ DRO-VFN64165"],"award-info":[{"award-number":["MH CZ DRO-VFN64165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["MH CZ DRO-VFN64165"],"award-info":[{"award-number":["MH CZ DRO-VFN64165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["MH CZ DRO-VFN64165"],"award-info":[{"award-number":["MH CZ DRO-VFN64165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU23-01-00288"],"award-info":[{"award-number":["NU23-01-00288"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["MH CZ DRO-VFN64165"],"award-info":[{"award-number":["MH CZ DRO-VFN64165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nutr. Diabetes"],"DOI":"10.1038\/s41387-024-00332-z","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T22:02:53Z","timestamp":1726092173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations of plasma phospholipid cis-vaccenic acid with insulin resistance markers in non-diabetic men with hyperlipidemia"],"prefix":"10.1038","volume":"14","author":[{"given":"Jaroslav","family":"Mac\u00e1\u0161ek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"Sta\u0148kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"\u017d\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00e9ta","family":"R\u016f\u017ei\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radan","family":"Br\u016fha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Kutov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-1817","authenticated-orcid":false,"given":"Marek","family":"Vecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Zeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"332_CR1","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.3390\/molecules23102583","volume":"23","author":"CCCR de Carvalho","year":"2018","unstructured":"de Carvalho CCCR, Caramujo MJ. The various roles of fatty acids. Molecules. 2018;23:2583.","journal-title":"Molecules"},{"key":"332_CR2","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.plipres.2009.12.002","volume":"49","author":"H Guillou","year":"2010","unstructured":"Guillou H, Zadravec D, Martin PG, Jacobsson A. The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice. Prog Lipid Res. 2010;49:186\u201399.","journal-title":"Prog Lipid Res"},{"key":"332_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1620\/tjem.217.287","volume":"217","author":"M Zeman","year":"2009","unstructured":"Zeman M, Vecka M, J\u00e1chymov\u00e1 M, Jir\u00e1k R, Tvrzick\u00e1 E, Sta\u0148kov\u00e1 B, et al. Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression. Tohoku J Exp Med. 2009;217:287\u201393.","journal-title":"Tohoku J Exp Med"},{"key":"332_CR4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/MCO.0b013e3283357287","volume":"13","author":"CE Smith","year":"2010","unstructured":"Smith CE, Ordov\u00e1s JM. Fatty acid interactions with genetic polymorphisms for cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2010;13:139\u201344.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"332_CR5","doi-asserted-by":"publisher","first-page":"8152","DOI":"10.1002\/jcp.27603","volume":"234","author":"H Yaribeygi","year":"2019","unstructured":"Yaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. Insulin resistance: Review of the underlying molecular mechanisms. J Cell Physiol. 2019;234:8152\u201361.","journal-title":"J Cell Physiol"},{"key":"332_CR6","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1007\/s00125-005-1897-x","volume":"48","author":"E Warensj\u00f6","year":"2005","unstructured":"Warensj\u00f6 E, Ris\u00e9rus U, Vessby B. Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Diabetologia. 2005;48:1999\u20132005.","journal-title":"Diabetologia"},{"key":"332_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41586-019-1797-8","volume":"576","author":"M Roden","year":"2019","unstructured":"Roden M, Shulman GI. The integrative biology of type 2 diabetes. Nature. 2019;576:51\u201360.","journal-title":"Nature"},{"key":"332_CR8","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1146\/annurev.nutr.012809.104726","volume":"30","author":"FR Jornayvaz","year":"2010","unstructured":"Jornayvaz FR, Samuel VT, Shulman GI. The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. Annu Rev Nutr. 2010;30:273\u201390.","journal-title":"Annu Rev Nutr"},{"key":"332_CR9","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1080\/01635581.2012.716138","volume":"64","author":"J Mac\u00e1\u0161ek","year":"2012","unstructured":"Mac\u00e1\u0161ek J, Vecka M, \u017d\u00e1k A, Urb\u00e1nek M, Krechler T, Petru\u017eelka L, et al. Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters. Nutr Cancer. 2012;64:946\u201355.","journal-title":"Nutr Cancer"},{"key":"332_CR10","first-page":"83","volume":"33","author":"T Va\u0159eka","year":"2012","unstructured":"Va\u0159eka T, Vecka M, Jir\u00e1k R, Tvrzick\u00e1 E, Mac\u00e1\u0161ek J, \u017d\u00e1k A, et al. Plasma fatty acid profile in depressive disorder resembles insulin resistance state. Neuro Endocrinol Lett. 2012;33:83\u201386.","journal-title":"Neuro Endocrinol Lett"},{"key":"332_CR11","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12944-015-0123-1","volume":"14","author":"B Sears","year":"2015","unstructured":"Sears B, Perry M. The role of fatty acids in insulin resistance. Lipids Health Dis. 2015;14:121 https:\/\/doi.org\/10.1186\/s12944-015-0123-1","journal-title":"Lipids Health Dis"},{"key":"332_CR12","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S2213-8587(17)30307-8","volume":"5","author":"JHY Wu","year":"2017","unstructured":"Wu JHY, Marklund M, Imamura F, Tintle N, Ardisson Korat AV, de Goede J, et al. Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39\u2008740 adults from 20 prospective cohort studies. Lancet Diabetes Endocrinol. 2017;5:965\u201374.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"332_CR13","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/ajcn\/78.1.91","volume":"78","author":"L Wang","year":"2003","unstructured":"Wang L, Folsom AR, Zheng ZJ, Pankow JS, Eckfeldt JH. Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr. 2003;78:91\u20138.","journal-title":"Am J Clin Nutr"},{"key":"332_CR14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/nu15010030","volume":"15","author":"M Perna","year":"2022","unstructured":"Perna M, Hewlings S. Saturated fatty acid chain length and risk of cardiovascular disease: a systematic review. Nutrients. 2022;15:30.","journal-title":"Nutrients"},{"key":"332_CR15","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.cell.2008.07.048","volume":"134","author":"H Cao","year":"2008","unstructured":"Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 2008;134:933\u201344.","journal-title":"Cell"},{"key":"332_CR16","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1002\/jcp.25715","volume":"232","author":"CO de Souza","year":"2017","unstructured":"de Souza CO, Teixeira AAS, Biondo LA, Lima Junior EA, Batatinha HAP, Rosa Neto JC. Palmitoleic acid improves metabolic functions in fatty liver by PPAR\u03b1-dependent AMPK activation. J Cell Physiol. 2017;232:2168\u201377.","journal-title":"J Cell Physiol"},{"key":"332_CR17","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.numecd.2007.02.017","volume":"18","author":"F Paillard","year":"2008","unstructured":"Paillard F, Catheline D, Duff FL, Bouriel M, Deugnier Y, Pouchard M, et al. Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity. Nutr Metab Cardiovasc Dis. 2008;18:436\u201340.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"332_CR18","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1093\/ajcn\/84.5.1009","volume":"84","author":"F Lindg\u00e4rde","year":"2006","unstructured":"Lindg\u00e4rde F, Vessby B, Ahr\u00e9n B. Serum cholesteryl fatty acid composition and plasma glucose concentrations in Amerindian women. Am J Clin Nutr. 2006;84:1009\u201313.","journal-title":"Am J Clin Nutr"},{"key":"332_CR19","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3945\/ajcn.112.040204","volume":"96","author":"G Zong","year":"2012","unstructured":"Zong G, Ye X, Sun L, Li H, Yu Z, Hu FB, et al. Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese. Am J Clin Nutr. 2012;96:970\u20136.","journal-title":"Am J Clin Nutr"},{"key":"332_CR20","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1194\/jlr.M600177-JLR200","volume":"47","author":"Y Wang","year":"2006","unstructured":"Wang Y, Botolin D, Xu J, Christian B, Mitchell E, Jayaprakasam B, et al. Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res. 2006;47:2028\u201341.","journal-title":"J Lipid Res"},{"key":"332_CR21","doi-asserted-by":"publisher","first-page":"1700504","DOI":"10.1002\/mnfr.201700504","volume":"62","author":"CO de Souza","year":"2018","unstructured":"de Souza CO, Vannice GK, Rosa Neto JC, Calder PC. Is palmitoleic acid a plausible nonpharmacological strategy to prevent or control chronic metabolic and inflammatory disorders? Mol Nutr Food Res. 2018;62:1700504.","journal-title":"Mol Nutr Food Res"},{"key":"332_CR22","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.clnu.2013.07.001","volume":"33","author":"L Djouss\u00e9","year":"2014","unstructured":"Djouss\u00e9 L, Matsumoto C, Hanson NQ, Weir NL, Tsai MY, Gaziano JM. Plasma cis-vaccenic acid and risk of heart failure with antecedent coronary heart disease in male physicians. Clin Nutr. 2014;33:478\u201382.","journal-title":"Clin Nutr"},{"key":"332_CR23","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1210\/jc.2015-4267","volume":"101","author":"LW Johnston","year":"2016","unstructured":"Johnston LW, Harris SB, Retnakaran R, Zinman B, Giacca A, Liu Z, et al. Longitudinal associations of phospholipid and cholesteryl ester fatty acids with disorders underlying diabetes. J Clin Endocrinol Metab. 2016;101:2536\u201344.","journal-title":"J Clin Endocrinol Metab"},{"key":"332_CR24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3945\/ajcn.114.092601","volume":"101","author":"W Ma","year":"2015","unstructured":"Ma W, Wu JHY, Wang Q, Lemaitre RN, Mukamal KJ, Djousse I, et al. Prospective association of fatty acids in de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study1\u20135. Am J Clin Nutr. 2015;101:153\u201363.","journal-title":"Am J Clin Nutr"},{"key":"332_CR25","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/lipd.12212","volume":"55","author":"P Ramos","year":"2020","unstructured":"Ramos P, Bush NC, Jensen MD. Sex and depot differences in palmitoleic acid content of human blood and fat. Lipids. 2020;55:63\u201372.","journal-title":"Lipids"},{"key":"332_CR26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1017\/S0029665108005983","volume":"67","author":"CE Childs","year":"2008","unstructured":"Childs CE, Romeu-Nadal M, Burdge GC, Calder PC. Gender differences in the n-3 fatty acid content of tissues. Proc Nutr Soc. 2008;67:19\u201327.","journal-title":"Proc Nutr Soc"},{"key":"332_CR27","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3389\/fendo.2014.00241","volume":"5","author":"O Varlamov","year":"2015","unstructured":"Varlamov O, Bethea CL, Roberts CT Jr. Sex-specific differences in lipid and glucose metabolism. Front Endocrinol (Lausanne). 2015;5:241.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"332_CR28","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1620\/tjem.212.359","volume":"212","author":"A \u017d\u00e1k","year":"2007","unstructured":"\u017d\u00e1k A, Tvrzick\u00e1 E, Vecka M, J\u00e1chymov\u00e1 M, Duffkov\u00e1 L, Sta\u0148kov\u00e1 B, et al. Severity of metabolic syndrome unfavorably influences oxidative stress and fatty acid metabolism in men. Tohoku J Exp Med. 2007;212:359\u201371.","journal-title":"Tohoku J Exp Med"},{"key":"332_CR29","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412\u20139.","journal-title":"Diabetologia"},{"key":"332_CR30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S1570-0232(01)00630-4","volume":"770","author":"M Vecka","year":"2002","unstructured":"Vecka M, Tvrzick\u00e1 E, Sta\u0148kov\u00e1 B, \u017d\u00e1k A. Effect of column and software on gas chromatographic determination of fatty acids. J Chromatogr B Anal Technol Biomed Life Sci. 2002;770:91\u20139.","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"332_CR31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S0003-2670(02)00396-3","volume":"465","author":"E Tvrzick\u00e1","year":"2002","unstructured":"Tvrzick\u00e1 E, Vecka M, Sta\u0148kov\u00e1 B, \u017d\u00e1k A. Analysis of fatty acids in plasma lipoproteins by gas chromatography-flame ionisation detection. Quantitative aspects. Anal Chim Acta. 2002;465:337\u201350.","journal-title":"Anal Chim Acta"},{"key":"332_CR32","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1089\/met.2021.0012","volume":"19","author":"J Mac\u00e1\u0161ek","year":"2021","unstructured":"Mac\u00e1\u0161ek J, Zeman M, \u017d\u00e1k A, Sta\u0148kov\u00e1 B, Vecka M. Altered indices of fatty acid elongases ELOVL6, ELOVL5, and ELOVL2 activities in patients with impaired fasting glycemia. Metab Syndr Relat Disord. 2021;19:386\u201392.","journal-title":"Metab Syndr Relat Disord"},{"key":"332_CR33","doi-asserted-by":"publisher","first-page":"S375","DOI":"10.33549\/physiolres.932868","volume":"63","author":"A \u017d\u00e1k","year":"2014","unstructured":"\u017d\u00e1k A, Burda M, Vecka M, Zeman M, Tvrzick\u00e1 E, Sta\u0148kov\u00e1 B. Fatty acid composition indicates two types of metabolic syndrome independent of clinical and laboratory parameters. Physiol Res. 2014;63:S375\u201385.","journal-title":"Physiol Res"},{"key":"332_CR34","unstructured":"R Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2024"},{"key":"332_CR35","doi-asserted-by":"crossref","unstructured":"Thompson FE, Subar AF. Dietary assessment methodology. In: Coulston AM, Boushey CJ, Ferruzzi MG, editors. Nutrition in the prevention and treatment of disease. USA: Elsevier Inc.; 2013. pp. 5\u201346.","DOI":"10.1016\/B978-0-12-391884-0.00001-9"},{"key":"332_CR36","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.diabet.2019.10.005","volume":"46","author":"NL Weir","year":"2020","unstructured":"Weir NL, Steffen BT, Guan W, Johnson LM, Djousse L, Mukamal KJ, et al. Circulating omega-7 fatty acids are differentially related to metabolic dysfunction and incident type II diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Metab. 2020;46:319\u201325.","journal-title":"Diabetes Metab"},{"key":"332_CR37","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3945\/ajcn.110.005447","volume":"93","author":"J Kr\u00f6ger","year":"2011","unstructured":"Kr\u00f6ger J, Zietemann V, Enzenbach C, Weikert C, Jansen EH, D\u00f6ring F, et al. Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Am J Clin Nutr. 2011;93:127\u201342.","journal-title":"Am J Clin Nutr"},{"key":"332_CR38","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s11154-020-09549-6","volume":"21","author":"K Rehman","year":"2020","unstructured":"Rehman K, Haider K, Jabeen K, Akash MSH. Current perspectives of oleic acid: Regulation of molecular pathways in mitochondrial and endothelial functioning against insulin resistance and diabetes. Rev Endocr Metab Disord. 2020;21:631\u201343.","journal-title":"Rev Endocr Metab Disord"},{"key":"332_CR39","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.2337\/diab.43.11.1353","volume":"43","author":"B Vessby","year":"1994","unstructured":"Vessby B, Aro A, Skarfors E, Berglund L, Salminen I, Lithell H. The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters. Diabetes. 1994;43:1353\u20137.","journal-title":"Diabetes"},{"key":"332_CR40","doi-asserted-by":"publisher","first-page":"e000691","DOI":"10.1136\/bmjdrc-2019-000691","volume":"7","author":"W Qureshi","year":"2019","unstructured":"Qureshi W, Santaren ID, Hanley AJ, Watkins SM, Lorenzo C, Wagenknecht LE. Risk of diabetes associated with fatty acids in the de novo lipogenesis pathway is independent of insulin sensitivity and response: the Insulin Resistance Atherosclerosis Study (IRAS). BMJ Open Diabetes Res Care. 2019;7:e000691.","journal-title":"BMJ Open Diabetes Res Care"},{"key":"332_CR41","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1089\/met.2017.0040","volume":"15","author":"M Zeman","year":"2017","unstructured":"Zeman M, Vecka M, Burda M, Tvrzick\u00e1 E, Sta\u0148kov\u00e1 B, Mac\u00e1\u0161ek J, et al. Fatty acid composition of plasma phosphatidylcholine determines body fat parameters in subjects with metabolic syndrome-related traits. Metab Syndr Relat Disord. 2017;15:371\u20138.","journal-title":"Metab Syndr Relat Disord"},{"key":"332_CR42","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2337\/diab.46.1.3","volume":"46","author":"G Boden","year":"1997","unstructured":"Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes. 1997;46:3\u201310.","journal-title":"Diabetes"},{"key":"332_CR43","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.ebiom.2015.09.004","volume":"2","author":"Y Ni","year":"2015","unstructured":"Ni Y, Zhao L, Yu H, Ma X, Bao Y, Rajani C, et al. Circulating unsaturated fatty acids delineate the metabolic status of obese individuals. EBioMedicine. 2015;2:1513\u201322.","journal-title":"EBioMedicine"},{"key":"332_CR44","doi-asserted-by":"publisher","first-page":"3302","DOI":"10.1210\/jc.2012-1428","volume":"97","author":"B Salgin","year":"2012","unstructured":"Salgin B, Ong KK, Thankamony A, Emmett P, Wareham NJ, Dunger DB. Higher fasting plasma free fatty acid levels are associated with lower insulin secretion in children and adults and a higher incidence of type 2 diabetes. J Clin Endocrinol Metab. 2012;97:3302\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"332_CR45","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s001250051620","volume":"44","author":"B Vessby","year":"2001","unstructured":"Vessby B, Uusitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC.KANWU Study et al. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU study. Diabetologia. 2001;44:312\u20139.","journal-title":"Diabetologia"},{"key":"332_CR46","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/0026-0495(92)90111-M","volume":"41","author":"M Parillo","year":"1992","unstructured":"Parillo M, Rivelles AA, Ciardullo AV, Capaldo B, Giacco A, Genovese S, et al. A high monounsaturated-fat\/low-carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients. Metabolism. 1992;41:1373\u20138.","journal-title":"Metabolism"},{"key":"332_CR47","doi-asserted-by":"publisher","first-page":"e0116195","DOI":"10.1371\/journal.pone.0116195","volume":"10","author":"SA Abdelmagid","year":"2015","unstructured":"Abdelmagid SA, Clarke SE, Nielsen DE, Badawi A, El-Sohemy A, Mutch DM, et al. Comprehensive profiling of plasma fatty acid concentrations in young healthy Canadian adults. PLoS ONE. 2015;10:e0116195.","journal-title":"PLoS ONE"},{"key":"332_CR48","first-page":"46","volume":"3","author":"K Chandra","year":"2021","unstructured":"Chandra K, Jain V, Jain SK. Plasma non-esterified fatty acids (NEFA) in type 2 diabetes mellitus: evidence on pathophysiology. J Diabetes Clin Res. 2021;3:46\u201350.","journal-title":"J Diabetes Clin Res"},{"key":"332_CR49","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.jnutbio.2014.02.011","volume":"25","author":"MM Jacome-Sosa","year":"2014","unstructured":"Jacome-Sosa MM, Borthwick F, Mangat R, Uwiera R, Reaney MJ, Shen J, et al. Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome. J Nutr Biochem. 2014;25:692\u2013701.","journal-title":"J Nutr Biochem"},{"key":"332_CR50","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1194\/jlr.M006080","volume":"51","author":"S Tripathy","year":"2010","unstructured":"Tripathy S, Torres-Gonzalez M, Jump DB. Elevated hepatic fatty acid elongase-5 activity corrects dietary fat induced hyperglycemia in obese C57BL\/6J mice. J Lipid Res. 2010;51:2642\u201354.","journal-title":"J Lipid Res"},{"key":"332_CR51","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1194\/jlr.M800383-JLR200","volume":"50","author":"YA Moon","year":"2009","unstructured":"Moon YA, Hammer RE, Horton JD. Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice. J Lipid Res. 2009;50:412\u201323.","journal-title":"J Lipid Res"},{"key":"332_CR52","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev-nutr-071812-161139","volume":"33","author":"DB Jump","year":"2013","unstructured":"Jump DB, Tripathy S, Depner CM. Fatty acid-regulated transcription factors in the liver. Annu Rev Nutr. 2013;33:249\u201369.","journal-title":"Annu Rev Nutr"},{"key":"332_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.967375","volume":"9","author":"K Falamarzi","year":"2022","unstructured":"Falamarzi K, Malekpour M, Tafti MF, Azarpira N, Behboodi M, Zarei M. The role of FGF21 and its analogs on liver associated diseases. Front Med (Lausanne). 2022;9:967375.","journal-title":"Front Med (Lausanne)"},{"key":"332_CR54","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.3390\/nu16091254","volume":"16","author":"Y Jia","year":"2024","unstructured":"Jia Y, Yu H, Liang J, Zhang Q, Sun J, Yang H, et al. Increased FGF-21 improves ectopic lipid deposition in the liver and skeletal muscle. Nutrients. 2024;16:1254.","journal-title":"Nutrients"},{"key":"332_CR55","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1093\/ajcn\/88.1.203","volume":"88","author":"E Warensj\u00f6","year":"2008","unstructured":"Warensj\u00f6 E, Sundstr\u00f6m J, Vessby B, Cederholm T, Ris\u00e9rus U. Markers of dietary fat quality and fatty acid desaturation as redictors of total and cardiovascular mortality: a population-based prospective study. Am J Clin Nutr. 2008;88:203\u20139.","journal-title":"Am J Clin Nutr"},{"key":"332_CR56","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0009-9120(95)02043-8","volume":"29","author":"M Ahotupa","year":"1996","unstructured":"Ahotupa M, Ruutu M, M\u00e4ntyl\u00e4 E. Simple methods of quantifying oxidation products and antioxidant potential of low density lipoproteins. Clin Biochem. 1996;29:139\u201344.","journal-title":"Clin Biochem"},{"key":"332_CR57","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/j.1749-6632.2002.tb04289.x","volume":"967","author":"M Zeman","year":"2002","unstructured":"Zeman M, \u017d\u00e1k A, Vecka M, Tvrzick\u00e1 E, Romaniv S, Kon\u00e1rkov\u00e1 M. Treatment of hypertriglyceridaemia with fenofibrate, fatty acid composition of plasma and LDL, and their relations to parameters of lipoperoxidation of LDL. Ann N Y Acad Sci. 2002;967:336\u201341.","journal-title":"Ann N Y Acad Sci"},{"key":"332_CR58","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.biochi.2012.12.014","volume":"95","author":"G Murdolo","year":"2013","unstructured":"Murdolo G, Piroddi M, Luchetti F, Tortoioli C, Canonico B, Zerbinati C, et al. Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance. Biochimie. 2013;95:585\u201394.","journal-title":"Biochimie"}],"container-title":["Nutrition &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41387-024-00332-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41387-024-00332-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41387-024-00332-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T23:03:08Z","timestamp":1726095788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41387-024-00332-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["332"],"URL":"https:\/\/doi.org\/10.1038\/s41387-024-00332-z","relation":{},"ISSN":["2044-4052"],"issn-type":[{"value":"2044-4052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"23 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"73"}}