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Diabetes"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The credibility of nutritional research is dependent on the rigor with which studies are conducted and the ability for independent assessment to be performed. Despite the importance of these, more work is needed in the field of nutrition to buttress the trustworthiness of nutrition research. To develop and apply a process for evaluating the rigor, reproducibility, and verifiability of nutritional research, using the relationship between potato consumption and Colorectal Cancer (CRC) as a case study. We updated existing systematic reviews to include studies on potatoes and CRC, assessing their design, execution, and reporting quality. We attempted to reproduce and verify the results of included studies by requesting raw data from authors and following statistical methods as described in the publications. Rigor was evaluated using four different tools: ROBINS-E, STROBE-Nut, Newcastle-Ottawa scale, and additional criteria related to transparency. Eighteen studies were included, none of which publicly share data. We managed to access data for only two studies, successfully reproducing and verifying the results for one. The majority of studies exhibited a high risk of bias, with significant limitations in reporting quality and methodological rigor. Research on the relationship between potato consumption and CRC risk is insufficiently reproducible and verifiable, undermining the trustworthiness of its findings. This study highlights the need for improving transparency, data sharing, and methodological rigor in nutritional research. Our approach provides a model for assessing the credibility of research in other areas of nutrition.<\/jats:p>","DOI":"10.1038\/s41387-026-00444-8","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:21:03Z","timestamp":1782184863000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the reproducibility and verifiability of nutrition research: a case study of studies assessing the relationship between potatoes and colorectal cancer"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-2764","authenticated-orcid":false,"given":"Yasaman","family":"Jamshidi-Naeini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby J.","family":"Vorland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey","family":"Ortyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Mineo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Still","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korlu","family":"Sorsor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Rodney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xander","family":"Tooze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Flickinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Henschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-9399","authenticated-orcid":false,"given":"David B.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"444_CR1","unstructured":"International Food Information Council. 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Donations to a foundation have been made on his behalf by the Northarvest Bean Growers Association. The institution of DBA (and BH), Indiana University, and the Indiana University Foundation have received funds or donations to support his research or educational activities from: Alliance for Potato Research and Education; American Egg Board; Eli Lilly and Company; Linus Technology; Mars, Inc.; National Cattlemen\u2019s Beef Association; National Pork Board; Pfizer, Inc.; Ro; Takeda Global Research & Development Center, Inc; USDA; WW (formerly Weight Watchers); and numerous other for-profit and non-profit organizations to support the work of the School of Public Health and the university more broadly. BF is Partner & Technical Expert for The Science Angle which offers regulatory and scientific consulting services to the food industry and trade associations. In the 36 months prior to the initial submission, CJV has received honoraria from The Obesity Society, The Alliance for Potato Research and Education, National Cattlemen\u2019s Beef Association, and American Pistachio Growers. The institution of CJV, Indiana University, has received funds to support his research from: National Cattlemen\u2019s Beef Association; Alliance for Potato Research and Education; the Gordon and Betty Moore Foundation; and NIH. In the 36 months prior to the initial submission, YJ-N has received honoraria from The Alliance for Potato Research and Education and The University at Buffalo. At the time of submission of this manuscript, YJ-N is employed by Abbott Diabetes Care (ADC); the conduct of the study and the writing of this manuscript were completed prior to the start of her employment with ADC.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"35"}}