{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T18:20:07Z","timestamp":1794680407397,"version":"4.9.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1038\/s41388-018-0494-7","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T08:07:39Z","timestamp":1537862859000},"page":"1269-1281","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["E2F1 and E2F7 differentially regulate KPNA2 to promote the development of gallbladder cancer"],"prefix":"10.1038","volume":"38","author":[{"given":"Shanshan","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"494_CR1","doi-asserted-by":"publisher","first-page":"967472","DOI":"10.1155\/2015\/967472","volume":"2015","author":"R Kanthan","year":"2015","unstructured":"Kanthan R, Senger JL, Ahmed S, Kanthan SC. Gallbladder cancer in the 21st century. J Oncol. 2015;2015:967472.","journal-title":"J Oncol"},{"key":"494_CR2","doi-asserted-by":"publisher","first-page":"e555","DOI":"10.1016\/S2214-109X(18)30127-X","volume":"6","author":"H Zeng","year":"2018","unstructured":"Zeng H, Chen W, Zheng R, Zhang S, Ji JS, Zou X, et al. Changing cancer survival in China during 2003\u201315: a pooled analysis of 17 population-based cancer registries. Lancet Glob Health. 2018;6:e555\u201367.","journal-title":"Lancet Glob Health"},{"key":"494_CR3","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/ng.3030","volume":"46","author":"M Li","year":"2014","unstructured":"Li M, Zhang Z, Li X, Ye J, Wu X, Tan Z, et al. Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway. Nat Genet. 2014;46:872\u20136.","journal-title":"Nat Genet"},{"key":"494_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.canlet.2016.12.027","volume":"391","author":"M Li","year":"2017","unstructured":"Li M, Liu F, Zhang Y, Wu X, Wu W, Wang XA, et al. Whole-genome sequencing reveals the mutational landscape of metastatic small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC). Cancer Lett. 2017;391:20\u201327.","journal-title":"Cancer Lett"},{"key":"494_CR5","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.15252\/embr.201744147","volume":"18","author":"XS Wu","year":"2017","unstructured":"Wu XS, Wang F, Li HF, Hu YP, Jiang L, Zhang F, et al. LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis. EMBO Rep. 2017;18:1837\u201353.","journal-title":"EMBO Rep"},{"key":"494_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0444-x","volume":"9","author":"YY Ye","year":"2018","unstructured":"Ye YY, Mei JW, Xiang SS, Li HF, Ma Q, Song XL, et al. MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7. Cell Death Dis. 2018;9:410.","journal-title":"Cell Death Dis"},{"key":"494_CR7","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1159\/000475454","volume":"41","author":"HB Liang","year":"2017","unstructured":"Liang HB, Cao Y, Ma Q, Shu YJ, Wang Z, Zhang F, et al. MYBL2 is a potential prognostic marker that promotes cell proliferation in gallbladder cancer. Cell Physiol Biochem. 2017;41:2117\u201331.","journal-title":"Cell Physiol Biochem"},{"key":"494_CR8","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/cdd.2016.146","volume":"24","author":"YJ Shu","year":"2017","unstructured":"Shu Y-J, Bao R-F, Jiang L, Wang Z, Wang X-A, Zhang F, et al. MicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway. Cell Death Differ. 2017;24:445\u201357.","journal-title":"Cell Death Differ"},{"key":"494_CR9","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1093\/emboj\/17.10.2721","volume":"17","author":"D G\u00f6rlich","year":"1998","unstructured":"G\u00f6rlich D. Transport into and out of the cell nucleus. EMBO J. 1998;17:2721\u20137.","journal-title":"EMBO J"},{"key":"494_CR10","doi-asserted-by":"publisher","first-page":"3950","DOI":"10.1158\/1078-0432.CCR-05-2090","volume":"12","author":"E Dahl","year":"2006","unstructured":"Dahl E, Kristiansen G, Gottlob K, Klaman I, Ebner E, Hinzmann B, et al. Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer. Clin Cancer Res. 2006;12:3950\u201360.","journal-title":"Clin Cancer Res"},{"key":"494_CR11","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/jnci\/djj103","volume":"98","author":"V Winnepenninckx","year":"2006","unstructured":"Winnepenninckx V, Lazar V, Michiels S, Dessen P, Stas M, Alonso SR, et al. Gene expression profiling of primary cutaneous melanoma and clinical outcome. J Natl Cancer Inst. 2006;98:472\u201382.","journal-title":"J Natl Cancer Inst"},{"key":"494_CR12","first-page":"6","volume":"30","author":"M Sakai","year":"2010","unstructured":"Sakai M, Sohda M, miyazaki T, Suzuki S, Sano A, Tanaka N, et al. Significance of karyopherin-\u03b1 2 (KPNA2) expression in esophageal squamous cell carcinoma. Anticancer Res. 2010;30:6.","journal-title":"Anticancer Res"},{"key":"494_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13046-014-0061-1","volume":"33","author":"Zy Hu","year":"2014","unstructured":"Hu Z-y, Yuan S-x, Yang Y, Zhou W-p, Jiang H. Pleomorphic adenoma gene 1 mediates the role of karyopherin alpha 2 and has prognostic significance in hepatocellular carcinoma. J Exp Clin Cancer Res. 2014;33:61.","journal-title":"J Exp Clin Cancer Res"},{"key":"494_CR14","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1074\/mcp.M111.016592","volume":"11","author":"CI Wang","year":"2012","unstructured":"Wang C-I, Chien K-Y, Wang C-L, Liu H-P, Cheng C-C, Chang Y-S, et al. Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in nonsmall cell lung cancer. Mol Cell Proteom. 2012;11:1105\u201322.","journal-title":"Mol Cell Proteom"},{"key":"494_CR15","first-page":"739","volume":"6","author":"J DeGregori","year":"2006","unstructured":"DeGregori J, Johnson DG. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med. 2006;6:739\u201348.","journal-title":"Curr Mol Med"},{"key":"494_CR16","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1158\/0008-5472.CAN-08-2725","volume":"69","author":"L Endo-Munoz","year":"2009","unstructured":"Endo-Munoz L, Dahler A, Teakle N, Rickwood D, Hazar-Rethinam M, Abdul-Jabbar I, et al. E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation. Cancer Res. 2009;69:1800\u20138.","journal-title":"Cancer Res"},{"key":"494_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000912","volume":"2","author":"C Chen","year":"2007","unstructured":"Chen C, Wells AD. Comparative analysis of E2F Family member oncogenic activity. PLoS ONE. 2007;2:e912.","journal-title":"PLoS ONE"},{"key":"494_CR18","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.4161\/cbt.3.12.1494","volume":"3","author":"ME Crosby","year":"2004","unstructured":"Crosby ME, Almasan A. Opposing roles of E2Fs in cell proliferation and death. Cancer Biol Ther. 2004;3:1208\u201311.","journal-title":"Cancer Biol Ther"},{"key":"494_CR19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrm714","volume":"3","author":"JM Trimarchi","year":"2002","unstructured":"Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol. 2002;3:11\u201320.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"494_CR20","doi-asserted-by":"publisher","first-page":"3558","DOI":"10.1093\/nar\/gkq1313","volume":"39","author":"BK Lee","year":"2011","unstructured":"Lee BK, Bhinge AA, Iyer VR. Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39:3558\u201373.","journal-title":"Nucleic Acids Res"},{"key":"494_CR21","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/nature08677","volume":"462","author":"JL Chong","year":"2009","unstructured":"Chong JL, Wenzel PL, Saenz-Robles MT, Nair V, Ferrey A, Hagan JP, et al. E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature. 2009;462:930\u20134.","journal-title":"Nature"},{"key":"494_CR22","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.devcel.2005.08.015","volume":"9","author":"NS Moon","year":"2005","unstructured":"Moon NS, Frolov MV, Kwon EJ, Di Stefano L, Dimova DK, Morris EJ, et al. Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell. 2005;9:463\u201375.","journal-title":"Dev Cell"},{"key":"494_CR23","doi-asserted-by":"publisher","first-page":"5138","DOI":"10.1038\/sj.onc.1207649","volume":"23","author":"N Logan","year":"2004","unstructured":"Logan N, Delavaine L, Graham A, Reilly C, Wilson J, Brummelkamp TR, et al. E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains. Oncogene. 2004;23:5138\u201350.","journal-title":"Oncogene"},{"key":"494_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.tcb.2009.01.002","volume":"19","author":"T Lammens","year":"2009","unstructured":"Lammens T, Li J, Leone G, De Veylder L. Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol. 2009;19:111\u20138.","journal-title":"Trends Cell Biol"},{"key":"494_CR25","doi-asserted-by":"publisher","first-page":"42041","DOI":"10.1074\/jbc.M308105200","volume":"278","author":"A Bruin de","year":"2003","unstructured":"de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem. 2003;278:42041\u20139.","journal-title":"J Biol Chem"},{"key":"494_CR26","doi-asserted-by":"publisher","first-page":"6289","DOI":"10.1093\/emboj\/cdg613","volume":"22","author":"LD Stefano","year":"2003","unstructured":"Stefano LD, Jensen MR, Helin K. E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J. 2003;22:6289\u201398.","journal-title":"EMBO J"},{"key":"494_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027723","volume":"6","author":"PJ Watt van der","year":"2011","unstructured":"van der Watt PJ, Ngarande E, Leaner VD. Overexpression of Kpnbeta1 and Kpnalpha2 importin proteins in cancer derives from deregulated E2F activity. PLoS ONE. 2011;6:e27723.","journal-title":"PLoS ONE"},{"key":"494_CR28","doi-asserted-by":"publisher","first-page":"7632","DOI":"10.1038\/sj.onc.1206840","volume":"22","author":"K Araki","year":"2003","unstructured":"Araki K, Nakajima Y, Eto K, Ikeda MA. Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter. Oncogene. 2003;22:7632\u201341.","journal-title":"Oncogene"},{"key":"494_CR29","doi-asserted-by":"publisher","first-page":"24581","DOI":"10.1074\/jbc.M113.467506","volume":"288","author":"B Liu","year":"2013","unstructured":"Liu B, Shats I, Angus SP, Gatza ML, Nevins JR. Interaction of E2F7 transcription factor with E2F1 and C-terminal-binding protein (CtBP) provides a mechanism for E2F7-dependent transcription repression. J Biol Chem. 2013;288:24581\u20139.","journal-title":"J Biol Chem"},{"key":"494_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.256","volume":"4","author":"L Huang","year":"2013","unstructured":"Huang L, Wang HY, Li JD, Wang JH, Zhou Y, Luo RZ, et al. KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a. Cell Death Dis. 2013;4:e745.","journal-title":"Cell Death Dis"},{"key":"494_CR31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.canlet.2012.12.013","volume":"331","author":"A Christiansen","year":"2013","unstructured":"Christiansen A, Dyrskj\u00f8t L. The functional role of the novel biomarker karyopherin \u03b1 2 (KPNA2) in cancer. Cancer Lett. 2013;331:18\u201323.","journal-title":"Cancer Lett"},{"key":"494_CR32","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1101\/gad.7.10.1850","volume":"7","author":"K Helin","year":"1993","unstructured":"Helin K, Wu C-L, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 1993;7:1850\u201361.","journal-title":"Genes Dev"},{"key":"494_CR33","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.devcel.2007.10.017","volume":"14","author":"J Li","year":"2008","unstructured":"Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, et al. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell. 2008;14:62\u201375.","journal-title":"Dev Cell"},{"key":"494_CR34","first-page":"1833","volume":"15","author":"WC Lin","year":"2001","unstructured":"Lin W-C, Lin F-T, Nevins J. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001;15:1833\u201344.","journal-title":"Genes Dev"},{"key":"494_CR35","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1093\/emboj\/19.4.662","volume":"19","author":"MA Mart\u00ednez-Balb\u00e1s","year":"2000","unstructured":"Mart\u00ednez-Balb\u00e1s MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. Regulation of E2F1 activity by acetylation. EMBO J. 2000;19:662\u201371.","journal-title":"EMBO J"},{"key":"494_CR36","doi-asserted-by":"publisher","first-page":"54140","DOI":"10.1074\/jbc.M410493200","volume":"279","author":"B Wang","year":"2004","unstructured":"Wang B, Liu K, Lin FT, Lin WC. A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem. 2004;279:54140\u201352.","journal-title":"J Biol Chem"},{"key":"494_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.146","volume":"3","author":"J Korah","year":"2012","unstructured":"Korah J, Falah N, Lacerte A, Lebrun JJ. A transcriptionally active pRb-E2F1-P\/CAF signaling pathway is central to TGFbeta-mediated apoptosis. Cell Death Dis. 2012;3:e407.","journal-title":"Cell Death Dis"},{"key":"494_CR38","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/nature09271","volume":"466","author":"J Gao","year":"2010","unstructured":"Gao J, Wang W-Y, Mao Y-W, Gr\u00e4ff J, Guan J-S, Pan L, et al. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 2010;466:1105\u20139.","journal-title":"Nature"},{"key":"494_CR39","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/nsmb.1815","volume":"17","author":"EK Lee","year":"2010","unstructured":"Lee EK, Kim HH, Kuwano Y, Abdelmohsen K, Srikantan S, Subaran SS, et al. hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol. 2010;17:732\u20139.","journal-title":"Nat Struct Mol Biol"},{"key":"494_CR40","doi-asserted-by":"publisher","first-page":"42346","DOI":"10.1074\/jbc.M303304200","volume":"278","author":"L Zannini","year":"2003","unstructured":"Zannini L, Lecis D, Lisanti S, Benetti R, Buscemi G, Schneider C, et al. Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import. J Biol Chem. 2003;278:42346\u201351.","journal-title":"J Biol Chem"},{"key":"494_CR41","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1038\/bjc.2015.165","volume":"112","author":"AT Alshareeda","year":"2015","unstructured":"Alshareeda AT, Negm OH, Green AR, Nolan CC, Tighe P, Albarakati N, et al. KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer. Br J Cancer. 2015;112:1929\u201337.","journal-title":"Br J Cancer"},{"key":"494_CR42","doi-asserted-by":"publisher","first-page":"39594","DOI":"10.1074\/jbc.M508425200","volume":"280","author":"SF Tseng","year":"2005","unstructured":"Tseng S-F, Chang C-Y, Wu K-J, Teng S-C. Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. J Biol Chem. 2005;280:39594\u2013600.","journal-title":"J Biol Chem"},{"key":"494_CR43","doi-asserted-by":"publisher","first-page":"4317","DOI":"10.1002\/j.1460-2075.1993.tb06116.x","volume":"12","author":"LR Bandara","year":"1993","unstructured":"Bandara LR, Buck VM, Zamanian M, Johnston LH, La Thangue NB. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1\/E2F. EMBO J. 1993;12:4317\u201324.","journal-title":"EMBO J"},{"key":"494_CR44","doi-asserted-by":"publisher","first-page":"24642","DOI":"10.1074\/jbc.M500189200","volume":"280","author":"H Ishida","year":"2005","unstructured":"Ishida H, Masuhiro Y, Fukushima A, Argueta JG, Yamaguchi N, Shiota S, et al. Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner. J Biol Chem. 2005;280:24642\u20138.","journal-title":"J Biol Chem"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41388-018-0494-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-018-0494-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-018-0494-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:13:42Z","timestamp":1684617222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-018-0494-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["494"],"URL":"https:\/\/doi.org\/10.1038\/s41388-018-0494-7","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,25]]},"assertion":[{"value":"6 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}