{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:48:00Z","timestamp":1792802880296,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["102-2320-B001-007-MY3"],"award-info":[{"award-number":["102-2320-B001-007-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST105-2320-B-001-012-MY3"],"award-info":[{"award-number":["MOST105-2320-B-001-012-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2811-B-001-044"],"award-info":[{"award-number":["105-2811-B-001-044"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1038\/s41388-018-0507-6","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T10:00:18Z","timestamp":1538128818000},"page":"1432-1447","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia"],"prefix":"10.1038","volume":"38","author":[{"given":"Yun-Jung","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ting","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Chin","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Guang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Liang","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiu-Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Yung","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Fang","family":"Yang-Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey Jong-Young","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"507_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fonc.2014.00170","volume":"4","author":"G Roti","year":"2014","unstructured":"Roti G, Stegmaier K. New approaches to target T-ALL. Front Oncol. 2014;4:170.","journal-title":"Front Oncol"},{"key":"507_CR2","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1002\/(SICI)1097-0142(19990315)85:6<1395::AID-CNCR25>3.0.CO;2-2","volume":"85","author":"LB Silverman","year":"1999","unstructured":"Silverman LB, Gelber RD, Young ML, Dalton VK, Barr RD, Sallan SE. Induction failure in acute lymphoblastic leukemia of childhood. Cancer. 1999;85:1395\u2013404.","journal-title":"Cancer"},{"key":"507_CR3","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1182\/blood-2011-12-399287","volume":"120","author":"N Gokbuget","year":"2012","unstructured":"Gokbuget N, Stanze D, Beck J, Diedrich H, Horst HA, Huttmann A, et al. Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation. Blood. 2012;120:2032\u201341.","journal-title":"Blood"},{"key":"507_CR4","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1309\/AJCPMF03LVSBLHPJ","volume":"144","author":"MJ You","year":"2015","unstructured":"You MJ, Medeiros LJ, Hsi ED. T-lymphoblastic leukemia\/lymphoma. Am J Clin Pathol. 2015;144:411\u201322.","journal-title":"Am J Clin Pathol"},{"key":"507_CR5","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1038\/nm1636","volume":"13","author":"T Palomero","year":"2007","unstructured":"Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med. 2007;13:1203\u201310.","journal-title":"Nat Med"},{"key":"507_CR6","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ccr.2014.01.032","volume":"25","author":"JS Blackburn","year":"2014","unstructured":"Blackburn JS, Liu S, Wilder JL, Dobrinski KP, Lobbardi R, Moore FE, et al. Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt\/mTORC1 pathway activation. Cancer Cell. 2014;25:366\u201378.","journal-title":"Cancer Cell"},{"key":"507_CR7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/leu.2009.209","volume":"24","author":"PY Jotta","year":"2010","unstructured":"Jotta PY, Ganazza MA, Silva A, Viana MB, da Silva MJ, Zambaldi LJ, et al. Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia. Leukemia. 2010;24:239\u201342.","journal-title":"Leukemia"},{"key":"507_CR8","doi-asserted-by":"publisher","first-page":"3762","DOI":"10.1172\/JCI34616","volume":"118","author":"A Silva","year":"2008","unstructured":"Silva A, Yunes JA, Cardoso BA, Martins LR, Jotta PY, Abecasis M, et al. PTEN posttranslational inactivation and hyperactivation of the PI3K\/Akt pathway sustain primary T cell leukemia viability. J Clin Invest. 2008;118:3762\u201374.","journal-title":"J Clin Invest"},{"key":"507_CR9","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1182\/blood-2009-02-206722","volume":"114","author":"A Gutierrez","year":"2009","unstructured":"Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, et al. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood. 2009;114:647\u201350.","journal-title":"Blood"},{"key":"507_CR10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/jb\/mvu037","volume":"156","author":"T Hoshii","year":"2014","unstructured":"Hoshii T, Matsuda S, Hirao A. Pleiotropic roles of mTOR complexes in haemato-lymphopoiesis and leukemogenesis. J Biochem. 2014;156:73\u201383.","journal-title":"J Biochem"},{"key":"507_CR11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149:274\u201393.","journal-title":"Cell"},{"key":"507_CR12","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","volume":"36","author":"MC Mendoza","year":"2011","unstructured":"Mendoza MC, Er EE, Blenis J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem Sci. 2011;36:320\u20138.","journal-title":"Trends Biochem Sci"},{"key":"507_CR13","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1056\/NEJMra055323","volume":"355","author":"PB Crino","year":"2006","unstructured":"Crino PB, Nathanson KL, Henske EP. The tuberous sclerosis complex. N Engl J Med. 2006;355:1345\u201356.","journal-title":"N Engl J Med"},{"key":"507_CR14","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/ncb2763","volume":"15","author":"CC Dibble","year":"2013","unstructured":"Dibble CC, Manning BD. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol. 2013;15:555\u201364.","journal-title":"Nat Cell Biol"},{"key":"507_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrm3025","volume":"12","author":"R Zoncu","year":"2011","unstructured":"Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011;12:21\u201335.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"507_CR16","doi-asserted-by":"publisher","first-page":"13571","DOI":"10.1073\/pnas.202476899","volume":"99","author":"AR Tee","year":"2002","unstructured":"Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA. 2002;99:13571\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"507_CR17","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.molcel.2012.06.009","volume":"47","author":"CC Dibble","year":"2012","unstructured":"Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, et al. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012;47:535\u201346.","journal-title":"Mol Cell"},{"key":"507_CR18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/BJ20080281","volume":"412","author":"J Huang","year":"2008","unstructured":"Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008;412:179\u201390.","journal-title":"Biochem J"},{"key":"507_CR19","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1101\/gad.1110003","volume":"17","author":"K Inoki","year":"2003","unstructured":"Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003;17:1829\u201334.","journal-title":"Genes Dev"},{"key":"507_CR20","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.cell.2013.11.049","volume":"156","author":"S Menon","year":"2014","unstructured":"Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, et al. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 2014;156:771\u201385.","journal-title":"Cell"},{"key":"507_CR21","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.cell.2014.01.024","volume":"156","author":"C Demetriades","year":"2014","unstructured":"Demetriades C, Doumpas N, Teleman AA. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell. 2014;156:786\u201399.","journal-title":"Cell"},{"key":"507_CR22","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1038\/sj.onc.1210778","volume":"27","author":"CJ Kao","year":"2008","unstructured":"Kao CJ, Chiang YJ, Chen PH, Lin KR, Hwang PI, Yang-Yen HF, et al. CBAP interacts with the un-liganded common beta-subunit of the GM-CSF\/IL-3\/IL-5 receptor and induces apoptosis via mitochondrial dysfunction. Oncogene. 2008;27:1397\u2013403.","journal-title":"Oncogene"},{"key":"507_CR23","doi-asserted-by":"publisher","first-page":"7701","DOI":"10.1093\/nar\/gkp854","volume":"37","author":"K Kuchta","year":"2009","unstructured":"Kuchta K, Knizewski L, Wyrwicz LS, Rychlewski L, Ginalski K. Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human. Nucleic Acids Res. 2009;37:7701\u201314.","journal-title":"Nucleic Acids Res"},{"key":"507_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061761","volume":"8","author":"YJ Chiang","year":"2013","unstructured":"Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, et al. CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE. 2013;8:e61761.","journal-title":"PLoS ONE"},{"key":"507_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.474","volume":"5","author":"KC Ho","year":"2014","unstructured":"Ho KC, Chiang YJ, Lai AC, Liao NS, Chang YJ, Yang-Yen HF, et al. CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. Cell Death Dis. 2014;5:e1518.","journal-title":"Cell Death Dis"},{"key":"507_CR26","doi-asserted-by":"publisher","first-page":"5746","DOI":"10.1128\/MCB.02136-06","volume":"27","author":"B Bilanges","year":"2007","unstructured":"Bilanges B, Argonza-Barrett R, Kolesnichenko M, Skinner C, Nair M, Chen M, et al. Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner. Mol Cell Biol. 2007;27:5746\u201364.","journal-title":"Mol Cell Biol"},{"key":"507_CR27","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.molcel.2010.06.022","volume":"39","author":"K Duvel","year":"2010","unstructured":"Duvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell. 2010;39:171\u201383.","journal-title":"Mol Cell"},{"key":"507_CR28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","volume":"12","author":"DA Guertin","year":"2007","unstructured":"Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 2007;12:9\u201322.","journal-title":"Cancer Cell"},{"key":"507_CR29","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.1128\/MCB.00289-08","volume":"28","author":"J Huang","year":"2008","unstructured":"Huang J, Dibble CC, Matsuzaki M, Manning BD. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol. 2008;28:4104\u201315.","journal-title":"Mol Cell Biol"},{"key":"507_CR30","first-page":"269","volume":"332","author":"M Stofega","year":"2006","unstructured":"Stofega M, DerMardirossian C, Bokoch GM. Affinity-based assay of Rho guanosine triphosphatase activation. Methods Mol Biol. 2006;332:269\u201379.","journal-title":"Methods Mol Biol"},{"key":"507_CR31","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","volume":"121","author":"L Ma","year":"2005","unstructured":"Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell. 2005;121:179\u201393.","journal-title":"Cell"},{"key":"507_CR32","doi-asserted-by":"publisher","first-page":"13489","DOI":"10.1073\/pnas.0405659101","volume":"101","author":"PP Roux","year":"2004","unstructured":"Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci USA. 2004;101:13489\u201394.","journal-title":"Proc Natl Acad Sci USA"},{"key":"507_CR33","doi-asserted-by":"publisher","first-page":"ra68","DOI":"10.1126\/scisignal.2005103","volume":"7","author":"MD Dennis","year":"2014","unstructured":"Dennis MD, Coleman CS, Berg A, Jefferson LS, Kimball SR. REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Sci Signal. 2014;7:ra68.","journal-title":"Sci Signal"},{"key":"507_CR34","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1083\/jcb.200507119","volume":"173","author":"SL Cai","year":"2006","unstructured":"Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, et al. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol. 2006;173:279\u201389.","journal-title":"J Cell Biol"},{"key":"507_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10662","volume":"7","author":"C Demetriades","year":"2016","unstructured":"Demetriades C, Plescher M, Teleman AA. Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun. 2016;7:10662.","journal-title":"Nat Commun"},{"key":"507_CR36","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1182\/blood-2004-03-0802","volume":"105","author":"PJ Wermuth","year":"2005","unstructured":"Wermuth PJ, Buchberg AM. Meis1-mediated apoptosis is caspase dependent and can be suppressed by coexpression of HoxA9 in murine and human cell lines. Blood. 2005;105:1222\u201330.","journal-title":"Blood"},{"key":"507_CR37","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ccr.2006.09.012","volume":"10","author":"K Keeshan","year":"2006","unstructured":"Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, et al. Tribbles homolog 2 inactivates C\/EBPalpha and causes acute myelogenous leukemia. Cancer Cell. 2006;10:401\u201311.","journal-title":"Cancer Cell"},{"key":"507_CR38","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.1182\/blood-2009-10-247361","volume":"116","author":"K Keeshan","year":"2010","unstructured":"Keeshan K, Bailis W, Dedhia PH, Vega ME, Shestova O, Xu L, et al. Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood. 2010;116:4948\u201357.","journal-title":"Blood"},{"key":"507_CR39","doi-asserted-by":"publisher","first-page":"21962","DOI":"10.1074\/jbc.M701663200","volume":"282","author":"KR Lin","year":"2007","unstructured":"Lin KR, Lee SF, Hung CM, Li CL, Yang-Yen HF, Yen JJ. Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway. J Biol Chem. 2007;282:21962\u201372.","journal-title":"J Biol Chem"},{"key":"507_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000204","volume":"2","author":"N Nikolaidis","year":"2007","unstructured":"Nikolaidis N, Chalkia D, Watkins DN, Barrow RK, Snyder SH, van Rossum DB, et al. Ancient origin of the new developmental superfamily DANGER. PLoS ONE. 2007;2:e204.","journal-title":"PLoS ONE"},{"key":"507_CR41","doi-asserted-by":"publisher","first-page":"10399","DOI":"10.18632\/oncotarget.3295","volume":"6","author":"A Lonetti","year":"2015","unstructured":"Lonetti A, Cappellini A, Sparta AM, Chiarini F, Buontempo F, Evangelisti C, et al. PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors. Oncotarget. 2015;6:10399\u2013414.","journal-title":"Oncotarget"},{"key":"507_CR42","doi-asserted-by":"publisher","first-page":"8097","DOI":"10.1158\/0008-5472.CAN-10-1814","volume":"70","author":"F Chiarini","year":"2010","unstructured":"Chiarini F, Grimaldi C, Ricci F, Tazzari PL, Evangelisti C, Ognibene A, et al. Activity of the novel dual phosphatidylinositol 3-kinase\/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia. Cancer Res. 2010;70:8097\u2013107.","journal-title":"Cancer Res"},{"key":"507_CR43","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1182\/blood-2001-12-0207","volume":"100","author":"M Ito","year":"2002","unstructured":"Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, et al. NOD\/SCID\/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood. 2002;100:3175\u201382.","journal-title":"Blood"},{"key":"507_CR44","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402\u20138.","journal-title":"Methods"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41388-018-0507-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-018-0507-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-018-0507-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:13:50Z","timestamp":1684617230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-018-0507-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["507"],"URL":"https:\/\/doi.org\/10.1038\/s41388-018-0507-6","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,28]]},"assertion":[{"value":"14 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}