{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:34:01Z","timestamp":1770741241547,"version":"3.49.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"22","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100002300","name":"Rivkin Center for Ovarian Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA012197"],"award-info":[{"award-number":["P30CA012197"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA193437"],"award-info":[{"award-number":["CA193437"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"WFBMC Department of Pathology Research Endowment Funds"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1038\/s41388-019-0728-3","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T11:03:38Z","timestamp":1550142218000},"page":"4366-4383","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC"],"prefix":"10.1038","volume":"38","author":[{"given":"Bincy","family":"John","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Naczki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirayu","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alia","family":"Ghoneum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Qasem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyan","family":"Salih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neveen","family":"Said","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"728_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7\u201330.","journal-title":"CA Cancer J Clin"},{"key":"728_CR2","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1038\/onc.2013.321","volume":"33","author":"E Lengyel","year":"2014","unstructured":"Lengyel E, Burdette JE, Kenny HA, Matei D, Pilrose J, Haluska P, et al. Epithelial ovarian cancer experimental models. Oncogene. 2014;33:3619\u201333.","journal-title":"Oncogene"},{"key":"728_CR3","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1038\/nm.2492","volume":"17","author":"KM Nieman","year":"2011","unstructured":"Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011;17:1498\u2013503.","journal-title":"Nat Med"},{"key":"728_CR4","doi-asserted-by":"publisher","first-page":"C444","DOI":"10.1152\/ajpcell.00188.2015","volume":"309","author":"TL Yeung","year":"2015","unstructured":"Yeung TL, Leung CS, Yip KP, Au Yeung CL, Wong ST, Mok SC. Cellular and molecular processes in ovarian cancer metastasis. A review in the theme: cell and molecular processes in cancer metastasis. Am J Physiol Cell Physiol. 2015;309:C444\u2013456.","journal-title":"Am J Physiol Cell Physiol"},{"key":"728_CR5","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1016\/S0002-9440(10)61255-2","volume":"167","author":"N Said","year":"2005","unstructured":"Said N, Motamed K. Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis. Am J Pathol. 2005;167:1739\u201352.","journal-title":"Am J Pathol"},{"key":"728_CR6","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.2353\/ajpath.2007.060903","volume":"170","author":"N Said","year":"2007","unstructured":"Said N, Najwer I, Motamed K. Secreted protein acidic and rich in cysteine (SPARC) inhibits integrin-mediated adhesion and growth factor-dependent survival signaling in ovarian cancer. Am J Pathol. 2007;170:1054\u201363.","journal-title":"Am J Pathol"},{"key":"728_CR7","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1158\/1541-7786.MCR-07-0001","volume":"5","author":"N Said","year":"2007","unstructured":"Said N, Socha MJ, Olearczyk JJ, Elmarakby AA, Imig JD, Motamed K. Normalization of the ovarian cancer microenvironment by SPARC. Mol Cancer Res. 2007;5:1015\u201330.","journal-title":"Mol Cancer Res"},{"key":"728_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1593\/neo.06658","volume":"9","author":"NA Said","year":"2007","unstructured":"Said NA, Najwer I, Socha MJ, Fulton DJ, Mok SC, Motamed K. SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk. Neoplasia. 2007;9:23\u201335.","journal-title":"Neoplasia"},{"key":"728_CR9","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1158\/0008-5472.CAN-10-3323","volume":"71","author":"B Dirat","year":"2011","unstructured":"Dirat B, Bochet L, Dabek M, Daviaud D, Dauvillier S, Majed B, et al. Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 2011;71:2455\u201365.","journal-title":"Cancer Res"},{"key":"728_CR10","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1126\/science.1198973","volume":"333","author":"SK Das","year":"2011","unstructured":"Das SK, Eder S, Schauer S, Diwoky C, Temmel H, Guertl B, et al. Adipose triglyceride lipase contributes to cancer-associated cachexia. Science. 2011;333:233\u20138.","journal-title":"Science"},{"key":"728_CR11","doi-asserted-by":"publisher","first-page":"5280","DOI":"10.3390\/nu6115280","volume":"6","author":"M Ebadi","year":"2014","unstructured":"Ebadi M, Mazurak VC. Evidence and mechanisms of fat depletion in cancer. Nutrients. 2014;6:5280\u201397.","journal-title":"Nutrients"},{"key":"728_CR12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1177\/1753425910386632","volume":"18","author":"J Grisouard","year":"2012","unstructured":"Grisouard J, Bouillet E, Timper K, Radimerski T, Dembinski K, Frey DM, et al. Both inflammatory and classical lipolytic pathways are involved in lipopolysaccharide-induced lipolysis in human adipocytes. Innate Immun. 2012;18:25\u201334.","journal-title":"Innate Immun"},{"key":"728_CR13","doi-asserted-by":"publisher","first-page":"6074","DOI":"10.1158\/1078-0432.CCR-12-2603","volume":"19","author":"LR Howe","year":"2013","unstructured":"Howe LR, Subbaramaiah K, Hudis CA, Dannenberg AJ. Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer. Clin Cancer Res. 2013;19:6074\u201383.","journal-title":"Clin Cancer Res"},{"key":"728_CR14","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s10863-011-9361-8","volume":"43","author":"C Ji","year":"2011","unstructured":"Ji C, Chen X, Gao C, Jiao L, Wang J, Xu G, et al. IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes. J Bioenerg Biomembr. 2011;43:367\u201375.","journal-title":"J Bioenerg Biomembr"},{"key":"728_CR15","doi-asserted-by":"publisher","first-page":"32178","DOI":"10.1074\/jbc.M114.601096","volume":"289","author":"W Zhang","year":"2014","unstructured":"Zhang W, Mottillo EP, Zhao J, Gartung A, VanHecke GC, Lee JF, et al. Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity. J Biol Chem. 2014;289:32178\u201385.","journal-title":"J Biol Chem"},{"key":"728_CR16","doi-asserted-by":"publisher","first-page":"33092","DOI":"10.1074\/jbc.M110.130377","volume":"285","author":"Z Zhang","year":"2010","unstructured":"Zhang Z, Bryan JL, DeLassus E, Chang L-W, Liao W, Sandell LJ. CCAAT\/enhancer-binding protein \u03b2 and NF-\u03baB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1\u03b2. J Biol Chem. 2010;285:33092\u2013103.","journal-title":"J Biol Chem"},{"key":"728_CR17","doi-asserted-by":"publisher","first-page":"E160","DOI":"10.1210\/jc.2013-1708","volume":"99","author":"CL Esteves","year":"2014","unstructured":"Esteves CL, Kelly V, Breton A, Taylor AI, West CC, Donadeu FX, et al. Proinflammatory cytokine induction of 11\u03b2-hydroxysteroid dehydrogenase type 1 (11\u03b2-HSD1) in human adipocytes is mediated by MEK, C\/EBP\u03b2, and NF-\u03baB\/RelA. J Clin Endocrinol Metab. 2014;99:E160\u2013E168.","journal-title":"J Clin Endocrinol Metab"},{"key":"728_CR18","doi-asserted-by":"publisher","first-page":"34349","DOI":"10.1074\/jbc.M112.410613","volume":"287","author":"SM Rahman","year":"2012","unstructured":"Rahman SM, Janssen RC, Choudhury M, Baquero KC, Aikens RM, de la Houssaye BA, et al. CCAAT\/enhancer-binding protein \u03b2 (C\/EBP\u03b2) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice. J Biol Chem. 2012;287:34349\u201360.","journal-title":"J Biol Chem"},{"key":"728_CR19","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1042\/bj20020508","volume":"365","author":"DP Ramji","year":"2002","unstructured":"Ramji DP, Foka P. CCAAT\/enhancer-binding proteins: structure, function and regulation. Biochem J. 2002;365:561\u201375.","journal-title":"Biochem J"},{"key":"728_CR20","doi-asserted-by":"publisher","first-page":"17242","DOI":"10.3390\/ijms151017242","volume":"15","author":"Z Zhang","year":"2014","unstructured":"Zhang Z, Zhang Z, Kang Y, Hou C, Duan X, Sheng P, et al. Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C\/EBP\u03b2 and NF-\u03baB. Int J Mol Sci. 2014;15:17242\u201355.","journal-title":"Int J Mol Sci"},{"key":"728_CR21","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1096\/fj.07-101428","volume":"22","author":"RA Oyesanya","year":"2008","unstructured":"Oyesanya RA, Lee ZP, Wu J, Chen J, Song Y, Mukherjee A, et al. Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells. FASEB J. 2008;22:2639\u201351.","journal-title":"FASEB J"},{"key":"728_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078179","volume":"8","author":"JM Rozenberg","year":"2013","unstructured":"Rozenberg JM, Bhattacharya P, Chatterjee R, Glass K, Vinson C. Combinatorial recruitment of CREB, C\/EBP\u03b2 and c-Jun determines activation of promoters upon keratinocyte differentiation. PLoS ONE. 2013;8:e78179.","journal-title":"PLoS ONE"},{"key":"728_CR23","first-page":"151","volume":"4","author":"N Said","year":"2013","unstructured":"Said N, Theodorescu D. Secreted protein acidic and rich in cysteine (Sparc) in cancer. J Carcinog Mutagen. 2013;4:151.","journal-title":"J Carcinog Mutagen"},{"key":"728_CR24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s12079-009-0076-0","volume":"3","author":"AM Delany","year":"2009","unstructured":"Delany AM, Hankenson KD. Thrombospondin-2 and SPARC\/osteonectin are critical regulators of bone remodeling. J Cell Commun Signal. 2009;3:227\u201338.","journal-title":"J Cell Commun Signal"},{"key":"728_CR25","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s12079-009-0064-4","volume":"3","author":"J Nie","year":"2009","unstructured":"Nie J, Sage EH. SPARC functions as an inhibitor of adipogenesis. J Cell Commun Signal. 2009;3:247\u201354.","journal-title":"J Cell Commun Signal"},{"key":"728_CR26","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jaut.2011.09.002","volume":"37","author":"S Piconese","year":"2011","unstructured":"Piconese S, Costanza M, Tripodo C, Sangaletti S, Musio S, Pittoni P, et al. The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses. J Autoimmun. 2011;37:300\u201310.","journal-title":"J Autoimmun"},{"key":"728_CR27","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1593\/neo.08672","volume":"10","author":"NA Said","year":"2008","unstructured":"Said NA, Elmarakby AA, Imig JD, Fulton DJ, Motamed K. SPARC ameliorates ovarian cancer-associated inflammation. Neoplasia. 2008;10:1092\u2013104.","journal-title":"Neoplasia"},{"key":"728_CR28","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1158\/0008-5472.CAN-11-2178","volume":"72","author":"H Kulbe","year":"2012","unstructured":"Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, et al. A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Res. 2012;72:66\u201375.","journal-title":"Cancer Res"},{"key":"728_CR29","doi-asserted-by":"publisher","first-page":"6045","DOI":"10.1073\/pnas.1030790100","volume":"100","author":"AD Bradshaw","year":"2003","unstructured":"Bradshaw AD, Graves DC, Motamed K, Sage EH. SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proc Natl Acad Sci USA. 2003;100:6045\u201350.","journal-title":"Proc Natl Acad Sci USA"},{"key":"728_CR30","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1038\/cdd.2008.105","volume":"15","author":"SJ Ewing","year":"2008","unstructured":"Ewing SJ, Zhu S, Zhu F, House JS, Smart RC. C\/EBP\u03b2 represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf). Cell Death Differ. 2008;15:1734\u201344.","journal-title":"Cell Death Differ"},{"key":"728_CR31","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1038\/cdd.2012.75","volume":"19","author":"L Guo","year":"2012","unstructured":"Guo L, Li X, Huang JX, Huang HY, Zhang YY, Qian SW, et al. Histone demethylase Kdm4b functions as a co-factor of C\/EBP\u03b2 to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes. Cell Death Differ. 2012;19:1917\u201327.","journal-title":"Cell Death Differ"},{"key":"728_CR32","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1074\/jbc.R114.619957","volume":"290","author":"L Guo","year":"2015","unstructured":"Guo L, Li X, Tang Q-Q. Transcriptional regulation of adipocyte differentiation: a central role for CCAAT\/enhancer-binding protein (C\/EBP) \u03b2. J Biol Chem. 2015;290:755\u201361.","journal-title":"J Biol Chem"},{"key":"728_CR33","doi-asserted-by":"publisher","first-page":"4005","DOI":"10.1158\/0008-5472.CAN-09-3912","volume":"70","author":"L Hernandez","year":"2010","unstructured":"Hernandez L, Hsu S, Davidson B, Birrer MJ, Kohn EC, Annunziata CM. Activation of NF-\u03baB signaling by IKK\u03b2 increases aggressiveness of ovarian cancer. Cancer Res. 2010;70:4005\u201314.","journal-title":"Cancer Res"},{"key":"728_CR34","doi-asserted-by":"publisher","first-page":"6927","DOI":"10.1158\/0008-5472.CAN-17-0366","volume":"77","author":"CD House","year":"2017","unstructured":"House CD, Jordan E, Hernandez L, Ozaki M, James JM, Kim M. et al. NF-kB promotes ovarian tumorigenesis via classical pathways supporting proliferative cancer cells and alternative pathways supporting ALDH+ cancer stem-like cells. Cancer Res. 2017;77:6927\u201340.","journal-title":"Cancer Res"},{"key":"728_CR35","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1593\/neo.12442","volume":"14","author":"NN Al-Hassan","year":"2012","unstructured":"Al-Hassan NN, Behzadian A, Caldwell R, Ivanova VS, Syed V, Motamed K, et al. Differential roles of uPAR in peritoneal ovarian carcinomatosis. Neoplasia. 2012;14:259\u201370.","journal-title":"Neoplasia"},{"key":"728_CR36","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1172\/JCI71241","volume":"123","author":"N Said","year":"2013","unstructured":"Said N, Frierson HF, Sanchez-Carbayo M, Brekken RA, Theodorescu D. Loss of SPARC in bladder cancer enhances carcinogenesis and progression. J Clin Invest. 2013;123:751\u201366.","journal-title":"J Clin Invest"},{"key":"728_CR37","doi-asserted-by":"publisher","first-page":"6408","DOI":"10.1038\/sj.onc.1206737","volume":"22","author":"P Iyengar","year":"2003","unstructured":"Iyengar P, Combs TP, Shah SJ, Gouon-Evans V, Pollard JW, Albanese C, et al. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene. 2003;22:6408\u201323.","journal-title":"Oncogene"},{"key":"728_CR38","doi-asserted-by":"publisher","first-page":"40236","DOI":"10.1074\/jbc.M608048200","volume":"281","author":"M Schweiger","year":"2006","unstructured":"Schweiger M, Schreiber R, Haemmerle G, Lass A, Fledelius C, Jacobsen P, et al. Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem. 2006;281:40236\u201341.","journal-title":"J Biol Chem"},{"key":"728_CR39","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","volume":"18","author":"E Currie","year":"2013","unstructured":"Currie E, Schulze A, Zechner R, Walther Tobias C, Farese Robert V. Cellular fatty acid metabolism and cancer. Cell Metab. 2013;18:153\u201361.","journal-title":"Cell Metab"},{"key":"728_CR40","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1210\/en.2002-221044","volume":"144","author":"AM Delany","year":"2003","unstructured":"Delany AM, Kalajzic I, Bradshaw AD, Sage EH, Canalis E. Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology. 2003;144:2588\u201396.","journal-title":"Endocrinology"},{"key":"728_CR41","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3109\/03008207.2010.483747","volume":"52","author":"J Nie","year":"2011","unstructured":"Nie J, Bradshaw AD, Delany AM, Sage EH. Inactivation of SPARC enhances high-fat diet-induced obesity in mice. Connect Tissue Res. 2011;52:99\u2013108.","journal-title":"Connect Tissue Res"},{"key":"728_CR42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ccr.2014.05.002","volume":"26","author":"S Pradeep","year":"2014","unstructured":"Pradeep S, Kim SW, Wu SY, Nishimura M, Chaluvally-Raghavan P, Miyake T, et al. Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell. 2014;26:77\u201391.","journal-title":"Cancer Cell"},{"key":"728_CR43","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/nrc4019","volume":"15","author":"DD Bowtell","year":"2015","unstructured":"Bowtell DD, Bohm S, Ahmed AA, Aspuria PJ, Bast RC Jr., Beral V, et al. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nat Rev Cancer. 2015;15:668\u201379.","journal-title":"Nat Rev Cancer"},{"key":"728_CR44","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1093\/carcin\/21.4.585","volume":"21","author":"KF Roby","year":"2000","unstructured":"Roby KF, Taylor CC, Sweetwood JP, Cheng Y, Pace JL, Tawfik O, et al. Development of a syngeneic mouse model for events related to ovarian cancer. Carcinogenesis. 2000;21:585\u201391.","journal-title":"Carcinogenesis"},{"key":"728_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-017-0015-9","volume":"3","author":"C Vaysse","year":"2017","unstructured":"Vaysse C, Lomo J, Garred O, Fjeldheim F, Lofteroed T, Schlichting E, et al. Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer. NPJ Breast Cancer. 2017;3:19.","journal-title":"NPJ Breast Cancer"},{"key":"728_CR46","doi-asserted-by":"publisher","first-page":"291546","DOI":"10.1155\/2013\/291546","volume":"2013","author":"G De Pergola","year":"2013","unstructured":"De Pergola G, Silvestris F. Obesity as a major risk factor for cancer. J Obes. 2013;2013:291546.","journal-title":"J Obes"},{"key":"728_CR47","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.2337\/db06-1656","volume":"56","author":"L Fontana","year":"2007","unstructured":"Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes. 2007;56:1010\u20133.","journal-title":"Diabetes"},{"key":"728_CR48","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3389\/fonc.2017.00216","volume":"7","author":"SS Doerstling","year":"2017","unstructured":"Doerstling SS, O\u2019Flanagan CH, Hursting SD. Obesity and cancer metabolism: a perspective on interacting tumor\u2013intrinsic and extrinsic factors. Front Oncol. 2017;7:216.","journal-title":"Front Oncol"},{"key":"728_CR49","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/978-0-387-98094-2_15","volume":"149","author":"MV Barbolina","year":"2009","unstructured":"Barbolina MV, Moss NM, Westfall SD, Liu Y, Burkhalter RJ, Marga F, et al. Microenvironmental regulation of ovarian cancer metastasis. Cancer Treat Res. 2009;149:319\u201334.","journal-title":"Cancer Treat Res"},{"key":"728_CR50","first-page":"177","volume":"22","author":"S Hein","year":"2009","unstructured":"Hein S, Mahner S, Kanowski C, Loning T, Janicke F, Milde-Langosch K. Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines. Oncol Rep. 2009;22:177\u201383.","journal-title":"Oncol Rep"},{"key":"728_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03590-5","volume":"9","author":"D Liu","year":"2018","unstructured":"Liu D, Zhang X-X, Li M-C, Cao C-H, Wan D-Y, Xi B-X, et al. C\/EBP\u03b2 enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation. Nat Commun. 2018;9:1739.","journal-title":"Nat Commun"},{"key":"728_CR52","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature21363","volume":"542","author":"GS Hotamisligil","year":"2017","unstructured":"Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature. 2017;542:177.","journal-title":"Nature"},{"issue":"10","key":"728_CR53","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3390\/cancers10100385","volume":"10","author":"Christine Naczki","year":"2018","unstructured":"Naczki C, John B, Patel C, Lafferty A, Ghoneum A, Afify H. et al. SPARC inhibits metabolic plasticity in ovarian cancer. Cancers. 2018;10:385.","journal-title":"Cancers"},{"key":"728_CR54","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1038\/s41388-017-0093-z","volume":"37","author":"A Ladanyi","year":"2018","unstructured":"Ladanyi A, Mukherjee A, Kenny HA, Johnson A, Mitra AK, Sundaresan S, et al. Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis. Oncogene. 2018;37:2285\u2013301.","journal-title":"Oncogene"},{"key":"728_CR55","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1158\/1078-0432.CCR-14-0445","volume":"20","author":"SL Tucker","year":"2014","unstructured":"Tucker SL, Gharpure K, Herbrich SM, Unruh AK, Nick AM, Crane EK, et al. Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer. Clin Cancer Res. 2014;20:3280\u20138.","journal-title":"Clin Cancer Res"},{"key":"728_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04987-y","volume":"9","author":"KM Gharpure","year":"2018","unstructured":"Gharpure KM, Pradeep S, Sans M, Rupaimoole R, Ivan C, Wu SY, et al. FABP4 as a key determinant of metastatic potential of ovarian cancer. Nat Commun. 2018;9:2923.","journal-title":"Nat Commun"},{"key":"728_CR57","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/onc.2016.256","volume":"36","author":"U Harjes","year":"2017","unstructured":"Harjes U, Bridges E, Gharpure KM, Roxanis I, Sheldon H, Miranda F, et al. Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4. Oncogene. 2017;36:912\u201321.","journal-title":"Oncogene"},{"key":"728_CR58","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ccell.2016.06.020","volume":"30","author":"F Miranda","year":"2016","unstructured":"Miranda F, Mannion D, Liu S, Zheng Y, Mangala LS, Redondo C, et al. Salt-inducible kinase 2 couples ovarian cancer cell metabolism with survival at the adipocyte-rich metastatic niche. Cancer Cell. 2016;30:273\u201389.","journal-title":"Cancer Cell"},{"key":"728_CR59","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1172\/JCI61392","volume":"122","author":"N Said","year":"2012","unstructured":"Said N, Sanchez-Carbayo M, Smith SC, Theodorescu D. RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration. J Clin Invest. 2012;122:1503\u201318.","journal-title":"J Clin Invest"},{"key":"728_CR60","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1172\/JCI42912","volume":"121","author":"N Said","year":"2011","unstructured":"Said N, Smith S, Sanchez-Carbayo M, Theodorescu D. Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer. J Clin Invest. 2011;121:132\u201347.","journal-title":"J Clin Invest"},{"key":"728_CR61","doi-asserted-by":"publisher","first-page":"26098","DOI":"10.1074\/jbc.M116.748129","volume":"291","author":"A Jakobs","year":"2016","unstructured":"Jakobs A, Steinmann S, Henrich SM, Schmidt TJ, Klempnauer K-H. Helenalin acetate, a natural sesquiterpene lactone with anti-inflammatory and anti-cancer activity, disrupts the cooperation of CCAAT box\/enhancer-binding protein \u03b2 (C\/EBP\u03b2) and co-activator p300. J Biol Chem. 2016;291:26098\u2013108.","journal-title":"J Biol Chem"},{"key":"728_CR62","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.cellsig.2012.02.007","volume":"24","author":"R Huber","year":"2012","unstructured":"Huber R, Pietsch D, Panterodt T, Brand K. Regulation of C\/EBP\u03b2 and resulting functions in cells of the monocytic lineage. Cell Signal. 2012;24:1287\u201396.","journal-title":"Cell Signal"},{"key":"728_CR63","doi-asserted-by":"publisher","first-page":"5878","DOI":"10.1158\/0008-5472.CAN-12-1572-T","volume":"72","author":"P Chinnaiyan","year":"2012","unstructured":"Chinnaiyan P, Kensicki E, Bloom G, Prabhu A, Sarcar B, Kahali S, et al. The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism. Cancer Res. 2012;72:5878\u201388.","journal-title":"Cancer Res"},{"key":"728_CR64","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1177\/0300985813505114","volume":"51","author":"NF Cheville","year":"2014","unstructured":"Cheville NF, Stasko J. Techniques in electron microscopy of animal tissue. Vet Pathol. 2014;51:28\u201341.","journal-title":"Vet Pathol"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41388-019-0728-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-019-0728-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-019-0728-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:15:32Z","timestamp":1684617332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-019-0728-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,14]]},"references-count":64,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["728"],"URL":"https:\/\/doi.org\/10.1038\/s41388-019-0728-3","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,14]]},"assertion":[{"value":"23 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}