{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:46:17Z","timestamp":1792802777112,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["CA168611"],"award-info":[{"award-number":["CA168611"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["CA155649"],"award-info":[{"award-number":["CA155649"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004143","name":"Society of University Surgeons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001424","name":"American Liver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006962","name":"NYU Langone Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1038\/s41388-019-0734-5","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T16:03:30Z","timestamp":1549901010000},"page":"4512-4526","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Targeting SYK signaling in myeloid cells protects against liver fibrosis and hepatocarcinogenesis"],"prefix":"10.1038","volume":"38","author":[{"given":"Alejandro","family":"Torres-Hernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Nikiforov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Tejada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisana","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr","family":"Kalabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Israr Ul","family":"Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Y.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mautin","family":"Hundeyin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Diskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A. Kochen","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berk","family":"Aykut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin A. A.","family":"Shadaloey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Leinwand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"734_CR1","first-page":"1","volume":"53","author":"RN Anderson","year":"2005","unstructured":"Anderson RN, Smith BL. Deaths: leading causes for 2002. Natl Vital Stat Rep. 2005;53:1\u201389.","journal-title":"Natl Vital Stat Rep"},{"key":"734_CR2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0168-8278(02)00413-0","volume":"38","author":"T Poynard","year":"2003","unstructured":"Poynard T, Mathurin P, Lai CL, Guyader D, Poupon R, Tainturier MH, et al. A comparison of fibrosis progression in chronic liver diseases. J Hepatol. 2003;38:257\u201365.","journal-title":"J Hepatol"},{"key":"734_CR3","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.5858\/2007-131-1728-HSCALF","volume":"131","author":"RK Moreira","year":"2007","unstructured":"Moreira RK. Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med. 2007;131:1728\u201334.","journal-title":"Arch Pathol Lab Med"},{"key":"734_CR4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jhep.2005.12.025","volume":"45","author":"A Melhem","year":"2006","unstructured":"Melhem A, Muhanna N, Bishara A, Alvarez CE, Ilan Y, Bishara T, et al. Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC. J Hepatol. 2006;45:60\u201371.","journal-title":"J Hepatol"},{"key":"734_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0168-8278(99)80010-5","volume":"30","author":"C Hellerbrand","year":"1999","unstructured":"Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER, Brenner DA. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. J Hepatol. 1999;30:77\u201387.","journal-title":"J Hepatol"},{"key":"734_CR6","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/hep.26429","volume":"58","author":"JP Pradere","year":"2013","unstructured":"Pradere JP, Kluwe J, De Minicis S, Jiao JJ, Gwak GY, Dapito DH, et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology. 2013;58:1461\u201373.","journal-title":"Hepatology"},{"key":"734_CR7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nri2765","volume":"10","author":"A Mocsai","year":"2010","unstructured":"Mocsai A, Ruland J, Tybulewicz VL. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol. 2010;10:387\u2013402.","journal-title":"Nat Rev Immunol"},{"key":"734_CR8","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1073\/pnas.97.4.1713","volume":"97","author":"RJ Cornall","year":"2000","unstructured":"Cornall RJ, Cheng AM, Pawson T, Goodnow CC. Role of Syk in B-cell development and antigen-receptor signaling. Proc Natl Acad Sci USA. 2000;97:1713\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"734_CR9","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/j.celrep.2015.10.058","volume":"13","author":"L Seifert","year":"2015","unstructured":"Seifert L, Deutsch M, Alothman S, Alqunaibit D, Werba G, Pansari M, et al. Dectin-1 regulates hepatic fibrosis and hepatocarcinogenesis by suppressing TLR4 signaling pathways. Cell Rep. 2015;13:1909\u201321.","journal-title":"Cell Rep"},{"issue":"3","key":"734_CR10","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1002\/hep.29881","volume":"68","author":"Chen Qu","year":"2018","unstructured":"Qu C, Zheng D, Li S, Liu Y, Lidofsky A, Holmes JA et al. Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis. Hepatology. 2018; https:\/\/doi.org\/10.1002\/hep.29881 .","journal-title":"Hepatology"},{"key":"734_CR11","doi-asserted-by":"crossref","first-page":"14 30 11","DOI":"10.1002\/0471141755.ph1430s66","volume":"66","author":"T Uehara","year":"2014","unstructured":"Uehara T, Pogribny IP, Rusyn I. The DEN and CCl4-induced mouse model of fibrosis and inflammation-associated hepatocellular carcinoma. Curr Protoc Pharmacol. 2014;66:14 30 11\u201310.","journal-title":"Curr Protoc Pharmacol"},{"key":"734_CR12","first-page":"344","volume":"3","author":"R Weiskirchen","year":"2014","unstructured":"Weiskirchen R, Tacke F. Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary Surg Nutr. 2014;3:344\u201363.","journal-title":"Hepatobiliary Surg Nutr"},{"key":"734_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1172\/JCI88881","volume":"127","author":"Y Koyama","year":"2017","unstructured":"Koyama Y, Brenner DA. Liver inflammation and fibrosis. J Clin Invest. 2017;127:55\u201364.","journal-title":"J Clin Invest"},{"key":"734_CR14","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1172\/JCI24798","volume":"115","author":"TI Novobrantseva","year":"2005","unstructured":"Novobrantseva TI, Majeau GR, Amatucci A, Kogan S, Brenner I, Casola S, et al. Attenuated liver fibrosis in the absence of B cells. J Clin Invest. 2005;115:3072\u201382.","journal-title":"J Clin Invest"},{"key":"734_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/B978-0-12-800267-4.00003-1","volume":"122","author":"A Marcus","year":"2014","unstructured":"Marcus A, Gowen BG, Thompson TW, Iannello A, Ardolino M, Deng W, et al. Recognition of tumors by the innate immune system and natural killer cells. Adv Immunol. 2014;122:91\u2013128.","journal-title":"Adv Immunol"},{"key":"734_CR16","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.it.2009.12.001","volume":"31","author":"G Wick","year":"2010","unstructured":"Wick G, Backovic A, Rabensteiner E, Plank N, Schwentner C, Sgonc R. The immunology of fibrosis: innate and adaptive responses. Trends Immunol. 2010;31:110\u20139.","journal-title":"Trends Immunol"},{"key":"734_CR17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.clim.2008.08.008","volume":"130","author":"G Notas","year":"2009","unstructured":"Notas G, Kisseleva T, Brenner D. NK and NKT cells in liver injury and fibrosis. Clin Immunol. 2009;130:16\u201326.","journal-title":"Clin Immunol"},{"key":"734_CR18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1099\/jmm.0.064220-0","volume":"63","author":"R Kant","year":"2014","unstructured":"Kant R, de Vos WM, Palva A, Satokari R. Immunostimulatory CpG motifs in the genomes of gut bacteria and their role in human health and disease. J Med Microbiol. 2014;63:293\u2013308.","journal-title":"J Med Microbiol"},{"key":"734_CR19","first-page":"11","volume":"2","author":"J Yang","year":"2015","unstructured":"Yang J, Li M, Zheng QC. Emerging role of toll-like receptor 4 in hepatocellular carcinoma. J Hepatocell Carcinoma. 2015;2:11\u201317.","journal-title":"J Hepatocell Carcinoma"},{"key":"734_CR20","first-page":"138","volume":"3","author":"L Yang","year":"2012","unstructured":"Yang L, Seki E. Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms. Front Physiol. 2012;3:138.","journal-title":"Front Physiol"},{"key":"734_CR21","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/jcph.794","volume":"57","author":"G Coffey","year":"2017","unstructured":"Coffey G, Rani A, Betz A, Pak Y, Haberstock-Debic H, Pandey A, et al. PRT062607 achieves complete inhibition of the spleen tyrosine kinase at tolerated exposures following oral dosing in healthy volunteers. J Clin Pharmacol. 2017;57:194\u2013210.","journal-title":"J Clin Pharmacol"},{"key":"734_CR22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jconrel.2018.09.004","volume":"288","author":"DW Kurniawan","year":"2018","unstructured":"Kurniawan DW, Jajoriya AK, Dhawan G, Mishra D, Argemi J, Bataller R, et al. Therapeutic inhibition of spleen tyrosine kinase in inflammatory macrophages using PLGA nanoparticles for the treatment of non-alcoholic steatohepatitis. J Control Release. 2018;288:227\u201338.","journal-title":"J Control Release"},{"key":"734_CR23","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1084\/jem.20161707","volume":"214","author":"D Daley","year":"2017","unstructured":"Daley D, Mani VR, Mohan N, Akkad N, Pandian G, Savadkar S, et al. NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma. J Exp Med. 2017;214:1711\u201324.","journal-title":"J Exp Med"},{"key":"734_CR24","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1084\/jem.20111706","volume":"209","author":"A Ochi","year":"2012","unstructured":"Ochi A, Nguyen AH, Bedrosian AS, Mushlin HM, Zarbakhsh S, Barilla R, et al. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med. 2012;209:1671\u201387.","journal-title":"J Exp Med"},{"key":"734_CR25","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1126\/science.1140485","volume":"317","author":"WE Naugler","year":"2007","unstructured":"Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007;317:121\u20134.","journal-title":"Science"},{"key":"734_CR26","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1002\/hep.27761","volume":"61","author":"M Thapa","year":"2015","unstructured":"Thapa M, Chinnadurai R, Velazquez VM, Tedesco D, Elrod E, Han JH, et al. Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity. Hepatology. 2015;61:2067\u201379.","journal-title":"Hepatology"},{"key":"734_CR27","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.celrep.2016.09.085","volume":"17","author":"LA O\u2019Neill","year":"2016","unstructured":"O\u2019Neill LA. A metabolic roadblock in inflammatory macrophages. Cell Rep. 2016;17:625\u20136.","journal-title":"Cell Rep"},{"key":"734_CR28","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1055\/s-0030-1255353","volume":"30","author":"JP Pradere","year":"2010","unstructured":"Pradere JP, Troeger JS, Dapito DH, Mencin AA, Schwabe RF. Toll-like receptor 4 and hepatic fibrogenesis. Semin Liver Dis. 2010;30:232\u201344.","journal-title":"Semin Liver Dis"},{"key":"734_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1755-1536-3-21","volume":"3","author":"J Guo","year":"2010","unstructured":"Guo J, Friedman SL. Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis. Fibrogenes Tissue Repair. 2010;3:21.","journal-title":"Fibrogenes Tissue Repair"},{"key":"734_CR30","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.ccr.2012.02.007","volume":"21","author":"DH Dapito","year":"2012","unstructured":"Dapito DH, Mencin A, Gwak GY, Pradere JP, Jang MK, Mederacke I, et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell. 2012;21:504\u201316.","journal-title":"Cancer Cell"},{"key":"734_CR31","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/j.1476-5381.2012.02097.x","volume":"167","author":"YI Miller","year":"2012","unstructured":"Miller YI, Choi SH, Wiesner P, Bae YS. The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL. Br J Pharmacol. 2012;167:990\u20139.","journal-title":"Br J Pharmacol"},{"key":"734_CR32","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1080\/14728214.2017.1336538","volume":"22","author":"L Rosamel de","year":"2017","unstructured":"de Rosamel L, Blanc JF. Emerging tyrosine kinase inhibitors for the treatment of hepatocellular carcinoma. Expert Opin Emerg Drugs. 2017;22:175\u201390.","journal-title":"Expert Opin Emerg Drugs"},{"key":"734_CR33","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1056\/NEJMoa0708857","volume":"359","author":"JM Llovet","year":"2008","unstructured":"Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378\u201390.","journal-title":"N Engl J Med"},{"key":"734_CR34","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1158\/1078-0432.CCR-17-0289","volume":"24","author":"M Inarrairaegui","year":"2018","unstructured":"Inarrairaegui M, Melero I, Sangro B. Immunotherapy of hepatocellular carcinoma: facts and hopes. Clin Cancer Res. 2018;24:1518\u201324.","journal-title":"Clin Cancer Res"},{"key":"734_CR35","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/hep.29129","volume":"66","author":"W Wang","year":"2017","unstructured":"Wang W, Xu MJ, Cai Y, Zhou Z, Cao H, Mukhopadhyay P, et al. Inflammation is independent of steatosis in a murine model of steatohepatitis. Hepatology. 2017;66:108\u201323.","journal-title":"Hepatology"},{"key":"734_CR36","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jcmgh.2018.01.003","volume":"5","author":"Z Zhou","year":"2018","unstructured":"Zhou Z, Xu MJ, Cai Y, Wang W, Jiang JX, Varga ZV. et al. Neutrophil-hepatic stellate cell interactions promote fibrosis in experimental steatohepatitis. Cell Mol Gastroenterol Hepatol. 2018;5:399\u2013413.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"734_CR37","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1084\/jem.20142162","volume":"212","author":"CP Zambirinis","year":"2015","unstructured":"Zambirinis CP, Levie E, Nguy S, Avanzi A, Barilla R, Xu Y, et al. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med. 2015;212:2077\u201394.","journal-title":"J Exp Med"},{"key":"734_CR38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29:15\u201321.","journal-title":"Bioinformatics"},{"key":"734_CR39","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W. Feature Counts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014;30:923\u201330.","journal-title":"Bioinformatics"},{"key":"734_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550.","journal-title":"Genome Biol"},{"key":"734_CR41","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498\u2013504.","journal-title":"Genome Res"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41388-019-0734-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-019-0734-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-019-0734-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:15:34Z","timestamp":1684617334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-019-0734-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,11]]},"references-count":41,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["734"],"URL":"https:\/\/doi.org\/10.1038\/s41388-019-0734-5","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,11]]},"assertion":[{"value":"14 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}