{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:39:15Z","timestamp":1790933955560,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"25","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1038\/s41388-019-0766-x","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T13:04:44Z","timestamp":1551877484000},"page":"4948-4961","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Amplification of SMYD3 promotes tumorigenicity and intrahepatic metastasis of hepatocellular carcinoma via upregulation of CDK2 and MMP2"],"prefix":"10.1038","volume":"38","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin-hui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-hao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-yan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"766_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"LA Torre","year":"2015","unstructured":"Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA A Cancer J Clin. 2015;65:87\u2013108.","journal-title":"CA A Cancer J Clin"},{"key":"766_CR2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0168-8278(02)00360-4","volume":"38","author":"H Imamura","year":"2003","unstructured":"Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, et al. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol. 2003;38:200\u20137.","journal-title":"J Hepatol"},{"key":"766_CR3","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/j.1572-0241.2006.00443.x","volume":"101","author":"F Farinati","year":"2006","unstructured":"Farinati F, Marino D, De Giorgio M, Baldan A, Cantarini M, Cursaro C, et al. Diagnostic and prognostic role of alpha-fetoprotein in hepatocellular carcinoma: both or neither? Am J Gastroenterol. 2006;101:524\u201332.","journal-title":"Am J Gastroenterol"},{"key":"766_CR4","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","volume":"379","author":"A Forner","year":"2012","unstructured":"Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet. 2012;379:1245\u201355.","journal-title":"Lancet"},{"key":"766_CR5","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jhep.2016.10.038","volume":"66","author":"A Notarpaolo","year":"2017","unstructured":"Notarpaolo A, Layese R, Magistri P, Gambato M, Colledan M, Magini G, et al. Validation of the AFP model as a predictor of HCC recurrence in patients with viral hepatitis-related cirrhosis who had received a liver transplant for HCC. J Hepatol. 2017;66:552\u20139.","journal-title":"J Hepatol"},{"key":"766_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-212","volume":"11","author":"WJ Ma","year":"2013","unstructured":"Ma WJ, Wang HY, Teng LS. Correlation analysis of preoperative serum alpha-fetoprotein (AFP) level and prognosis of hepatocellular carcinoma (HCC) after hepatectomy. World J Surg Oncol. 2013;11:212.","journal-title":"World J Surg Oncol"},{"key":"766_CR7","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.cophys.2017.10.001","volume":"1","author":"C Tracy","year":"2018","unstructured":"Tracy C, Warren JS, Szulik M, Wang L, Garcia J, Makaju A, et al. The Smyd family of methyltransferases: role in cardiac and skeletal muscle physiology and pathology. Curr Opin Physiol. 2018;1:140\u201352.","journal-title":"Curr Opin Physiol"},{"key":"766_CR8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/jmcb\/mjr015","volume":"3","author":"S Xu","year":"2011","unstructured":"Xu S, Zhong C, Zhang T, Ding J. Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins. J Mol Cell Biol. 2011;3:293\u2013300.","journal-title":"J Mol Cell Biol"},{"key":"766_CR9","doi-asserted-by":"publisher","first-page":"7935-","DOI":"10.1073\/pnas.0602555103","volume":"103","author":"Xungang Tan","year":"2006","unstructured":"Tan Xungang, Rotllant Josep, Li Huiqing, DeDeyne Patrick, Du SJ. SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos. Proc Natl Acad Sci USA. 2006;103:7935-.","journal-title":"Proc Natl Acad Sci USA"},{"key":"766_CR10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/bjc.2014.543","volume":"112","author":"S Komatsu","year":"2015","unstructured":"Komatsu S, Ichikawa D, Hirajima S, Nagata H, Nishimura Y, Kawaguchi T, et al. Overexpression of SMYD2 contributes to malignant outcome in gastric cancer. Br J Cancer. 2015;112:357\u201364.","journal-title":"Br J Cancer"},{"key":"766_CR11","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/ncb1151","volume":"6","author":"R Hamamoto","year":"2004","unstructured":"Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, et al. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol. 2004;6:731\u201340.","journal-title":"Nat Cell Biol"},{"key":"766_CR12","doi-asserted-by":"publisher","first-page":"4067","DOI":"10.1158\/0008-5472.CAN-08-4097","volume":"69","author":"L Hu","year":"2009","unstructured":"Hu L, Zhu YT, Qi C, Zhu YJ. Identification of Smyd4 as a potential tumor suppressor gene involved in breast cancer development. Cancer Res. 2009;69:4067\u201372.","journal-title":"Cancer Res"},{"key":"766_CR13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.molcel.2012.07.020","volume":"48","author":"JD Stender","year":"2012","unstructured":"Stender JD, Pascual G, Liu W, Kaikkonen MU, Do K, Spann NJ, et al. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell. 2012;48:28\u201338.","journal-title":"Mol Cell"},{"key":"766_CR14","doi-asserted-by":"publisher","first-page":"340","DOI":"10.4161\/epi.19506","volume":"7","author":"GS Aller Van","year":"2012","unstructured":"Van Aller GS, Reynoird N, Barbash O, Huddleston M, Liu S, Zmoos AF, et al. Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Epigenetics. 2012;7:340\u20133.","journal-title":"Epigenetics"},{"key":"766_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022290","volume":"6","author":"KW Foreman","year":"2011","unstructured":"Foreman KW, Brown M, Park F, Emtage S, Harriss J, Das C, et al. Structural and functional profiling of the human histone methyltransferase SMYD3. PloS ONE. 2011;6:e22290.","journal-title":"PloS ONE"},{"key":"766_CR16","doi-asserted-by":"publisher","first-page":"10759","DOI":"10.1158\/0008-5472.CAN-07-1132","volume":"67","author":"M Kunizaki","year":"2007","unstructured":"Kunizaki M, Hamamoto R, Silva FP, Yamaguchi K, Nagayasu T, Shibuya M, et al. The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. Cancer Res. 2007;67:10759\u201365.","journal-title":"Cancer Res"},{"issue":"Suppl 1","key":"766_CR17","doi-asserted-by":"publisher","first-page":"S91","DOI":"10.1007\/s12032-010-9718-6","volume":"28","author":"TN Ren","year":"2011","unstructured":"Ren TN, Wang JS, He YM, Xu CL, Wang SZ, Xi T. Effects of SMYD3 over-expression on cell cycle acceleration and cell proliferation in MDA-MB-231 human breast cancer cells. Med Oncol. 2011;28(Suppl 1):S91\u20138.","journal-title":"Med Oncol"},{"key":"766_CR18","doi-asserted-by":"publisher","first-page":"5718","DOI":"10.3748\/wjg.v13.i43.5718","volume":"13","author":"LB Chen","year":"2007","unstructured":"Chen LB, Xu JY, Yang Z. GBW silencing SMYD3 in hepatoma demethyl RIZI promoter induces apoptosis and inhibits cell proliferation and migration. World J Gastroenterol. 2007;13:5718\u201324.","journal-title":"World J Gastroenterol"},{"key":"766_CR19","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1158\/0008-5472.CAN-06-4126","volume":"67","author":"C Liu","year":"2007","unstructured":"Liu C, Fang X, Ge Z, Jalink M, Kyo S, Bjorkholm M, et al. The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3. Cancer Res. 2007;67:2626\u201331.","journal-title":"Cancer Res"},{"key":"766_CR20","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1158\/0008-5472.CAN-11-1052","volume":"72","author":"AM Cock-Rada","year":"2012","unstructured":"Cock-Rada AM, Medjkane S, Janski N, Yousfi N, Perichon M, Chaussepied M, et al. SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9. Cancer Res. 2012;72:810\u201320.","journal-title":"Cancer Res"},{"key":"766_CR21","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1349-7006.2006.00146.x","volume":"97","author":"R Hamamoto","year":"2006","unstructured":"Hamamoto R, Silva FP, Tsuge M, Nishidate T, Katagiri T, Nakamura Y, et al. Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Cancer Sci. 2006;97:113\u20138.","journal-title":"Cancer Sci"},{"key":"766_CR22","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1093\/jnci\/djt304","volume":"105","author":"C Liu","year":"2013","unstructured":"Liu C, Wang C, Wang K, Liu L, Shen Q, Yan K, et al. SMYD3 as an oncogenic driver in prostate cancer by stimulation of androgen receptor transcription. J Natl Cancer Inst. 2013;105:1719\u201328.","journal-title":"J Natl Cancer Inst"},{"key":"766_CR23","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3892\/or.2014.3307","volume":"32","author":"SW Dong","year":"2014","unstructured":"Dong SW, Zhang H, Wang BL, Sun P, Wang YG, Zhang P. Effect of the downregulation of SMYD3 expression by RNAi on RIZ1 expression and proliferation of esophageal squamous cell carcinoma. Oncol Rep. 2014;32:1064\u201370.","journal-title":"Oncol Rep"},{"key":"766_CR24","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/j.humpath.2011.11.003","volume":"43","author":"C He","year":"2012","unstructured":"He C, Xu J, Zhang J, Xie D, Ye H, Xiao Z. et al. High expression of trimethylated histone H3 lysine 4 is associated with poor prognosis in hepatocellular carcinoma. Hum Pathol. 2012;43:1425\u201335.","journal-title":"Hum Pathol"},{"key":"766_CR25","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.ccell.2016.01.013","volume":"29","author":"ME Sarris","year":"2016","unstructured":"Sarris ME, Moulos P, Haroniti A, Giakountis A, Talianidis I. Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development. Cancer Cell. 2016;29:354\u201366.","journal-title":"Cancer Cell"},{"key":"766_CR26","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1182\/blood-2005-01-0320","volume":"106","author":"N Raje","year":"2005","unstructured":"Raje N, Kumar S, Hideshima T, Roccaro A, Ishitsuka K, Yasui H, et al. Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma. Blood. 2005;106:1042\u20137.","journal-title":"Blood"},{"key":"766_CR27","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nature24014","volume":"549","author":"HS Venkatesh","year":"2017","unstructured":"Venkatesh HS, Tam LT, Woo PJ, Lennon J, Nagaraja S, Gillespie SM, et al. Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma. Nature. 2017;549:533\u20137.","journal-title":"Nature"},{"key":"766_CR28","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.matbio.2015.01.004","volume":"44-46","author":"S Duarte","year":"2015","unstructured":"Duarte S, Baber J, Fujii T, Coito AJ. Matrix metalloproteinases in liver injury, repair and fibrosis. Matrix Biol. 2015;44-46:147\u201356.","journal-title":"Matrix Biol"},{"key":"766_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1242\/dmm.012062","volume":"7","author":"M Giannandrea","year":"2014","unstructured":"Giannandrea M, Parks WC. Diverse functions of matrix metalloproteinases during fibrosis. Dis Models Mech. 2014;7:193\u2013203.","journal-title":"Dis Models Mech"},{"key":"766_CR30","doi-asserted-by":"publisher","first-page":"19867","DOI":"10.1074\/jbc.M109.021485","volume":"284","author":"H Kim","year":"2009","unstructured":"Kim H, Heo K, Kim JH, Kim K, Choi J, An W. Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription. J Biol Chem. 2009;284:19867\u201377.","journal-title":"J Biol Chem"},{"key":"766_CR31","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1093\/nar\/gkx1259","volume":"46","author":"XD Zhang","year":"2018","unstructured":"Zhang XD, Huang GW, Xie YH, He JZ, Guo JC, Xu XE, et al. The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells. Nucleic Acids Res. 2018;46:1793\u2013809.","journal-title":"Nucleic Acids Res"},{"key":"766_CR32","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1002\/jcp.24975","volume":"230","author":"A Peserico","year":"2015","unstructured":"Peserico A, Germani A, Sanese P, Barbosa AJ, Di Virgilio V, Fittipaldi R, et al. A SMYD3 small-molecule inhibitor impairing cancer cell growth. J Cell Physiol. 2015;230:2447\u201360.","journal-title":"J Cell Physiol"},{"key":"766_CR33","first-page":"1","volume":"9","author":"L Huang","year":"2017","unstructured":"Huang L, Xu AM. SET and MYND domain containing protein 3 in cancer. Am J Transl Res. 2017;9:1\u201314.","journal-title":"Am J Transl Res"},{"key":"766_CR34","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s11605-016-3311-z","volume":"21","author":"S Hao","year":"2017","unstructured":"Hao S, Fan P, Chen S, Tu C, Wan C. Distinct recurrence risk factors for intrahepatic metastasis and multicenter occurrence after surgery in patients with hepatocellular carcinoma. J Gastrointest Surg. 2017;21:312\u201320.","journal-title":"J Gastrointest Surg"},{"key":"766_CR35","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jhep.2016.09.021","volume":"66","author":"M Furuta","year":"2017","unstructured":"Furuta M, Ueno M, Fujimoto A, Hayami S, Yasukawa S, Kojima F, et al. Whole genome sequencing discriminates hepatocellular carcinoma with intrahepatic metastasis from multi-centric tumors. J Hepatol. 2017;66:363\u201373.","journal-title":"J Hepatol"},{"key":"766_CR36","doi-asserted-by":"publisher","first-page":"10573","DOI":"10.3748\/wjg.v21.i37.10573","volume":"21","author":"N Tsuchiya","year":"2015","unstructured":"Tsuchiya N, Sawada Y, Endo I, Saito K, Uemura Y, Nakatsura T. Biomarkers for the early diagnosis of hepatocellular carcinoma. World J Gastroenterol. 2015;21:10573\u201383.","journal-title":"World J Gastroenterol"},{"key":"766_CR37","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/liv.12965","volume":"36","author":"C Corte Della","year":"2016","unstructured":"Della Corte C, Triolo M, Iavarone M, Sangiovanni A. Early diagnosis of liver cancer: an appraisal of international recommendations and future perspectives. Liver Int. 2016;36:166\u201376.","journal-title":"Liver Int"},{"key":"766_CR38","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.3892\/or.2015.4239","volume":"34","author":"B Dai","year":"2015","unstructured":"Dai B, Wan W, Zhang P, Zhang Y, Pan C, Meng G, et al. SET and MYND domain-containing protein 3 is overexpressed in human glioma and contributes to tumorigenicity. Oncol Rep. 2015;34:2722\u201330.","journal-title":"Oncol Rep"},{"key":"766_CR39","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1007\/s13277-014-2891-z","volume":"36","author":"Y Liu","year":"2015","unstructured":"Liu Y, Luo X, Deng J, Pan Y, Zhang L, Liang H. SMYD3 overexpression was a risk factor in the biological behavior and prognosis of gastric carcinoma. Tumour Biol. 2015;36:2685\u201394.","journal-title":"Tumour Biol"},{"key":"766_CR40","doi-asserted-by":"publisher","first-page":"4377","DOI":"10.1007\/s13277-015-3077-z","volume":"36","author":"Y Liu","year":"2015","unstructured":"Liu Y, Liu H, Luo X, Deng J, Pan Y, Liang H. Overexpression of SMYD3 and matrix metalloproteinase-9 are associated with poor prognosis of patients with gastric cancer. Tumour Biol. 2015;36:4377\u201386.","journal-title":"Tumour Biol"},{"key":"766_CR41","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nature13320","volume":"510","author":"PK Mazur","year":"2014","unstructured":"Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, et al. SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature. 2014;510:283\u20137.","journal-title":"Nature"},{"key":"766_CR42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.5230\/jgc.2017.17.e33","volume":"17","author":"L Wang","year":"2017","unstructured":"Wang L, Wang QT, Liu YP, Dong QQ, Hu HJ, Miao Z, et al. ATM signaling pathway is implicated in the SMYD3-mediated proliferation and migration of gastric cancer cells. J Gastric Cancer. 2017;17:295\u2013305.","journal-title":"J Gastric Cancer"},{"key":"766_CR43","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1126\/science.1063127","volume":"293","author":"T Jenuwein","year":"2001","unstructured":"Jenuwein T, Allis CD. Translating the histone code. Science. 2001;293:1074\u201380.","journal-title":"Science"},{"key":"766_CR44","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.tig.2003.09.007","volume":"19","author":"RJ Sims 3rd","year":"2003","unstructured":"Sims RJ 3rd, Nishioka K, Reinberg D. Histone lysine methylation: a signature for chromatin function. Trends Genet. 2003;19:629\u201339.","journal-title":"Trends Genet"},{"key":"766_CR45","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nrg3173","volume":"13","author":"EL Greer","year":"2012","unstructured":"Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012;13:343\u201357.","journal-title":"Nat Rev Genet"},{"key":"766_CR46","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1101\/gad.1035902","volume":"16","author":"A Kuzmichev","year":"2002","unstructured":"Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002;16:2893\u2013905.","journal-title":"Genes Dev"},{"key":"766_CR47","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.canlet.2009.02.015","volume":"280","author":"JN Zou","year":"2009","unstructured":"Zou JN, Wang SZ, Yang JS, Luo XG, Xie JH, Xi T. Knockdown of SMYD3 by RNA interference down-regulates c-Met expression and inhibits cells migration and invasion induced by HGF. Cancer Lett. 2009;280:78\u201385.","journal-title":"Cancer Lett"},{"key":"766_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052703","volume":"7","author":"C Liu","year":"2012","unstructured":"Liu C, Xu D, Han H, Fan Y, Schain F, Xu Z, et al. Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation\/demethylation. PloS ONE 2012;7:e52703.","journal-title":"PloS ONE"},{"key":"766_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197372","volume":"13","author":"MJ Thomenius","year":"2018","unstructured":"Thomenius MJ, Totman J, Harvey D, Mitchell LH, Riera TV, Cosmopoulos K, et al. Small molecule inhibitors and CRISPR\/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLoS ONE 2018;13:e0197372.","journal-title":"PLoS ONE"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41388-019-0766-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-019-0766-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-019-0766-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:15:49Z","timestamp":1684617349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-019-0766-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,6]]},"references-count":49,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["766"],"URL":"https:\/\/doi.org\/10.1038\/s41388-019-0766-x","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,6]]},"assertion":[{"value":"17 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}