{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:41:59Z","timestamp":1787002919002,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2021,4,1]]},"DOI":"10.1038\/s41388-021-01683-y","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T02:03:14Z","timestamp":1614909794000},"page":"2448-2462","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1"],"prefix":"10.1038","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2070-2299","authenticated-orcid":false,"given":"Vipin","family":"Rawat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parmanand","family":"Malvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Della Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6450-2638","authenticated-orcid":false,"given":"Eddy S.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Bugide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-5962","authenticated-orcid":false,"given":"Romi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3306-349X","authenticated-orcid":false,"given":"Narendra","family":"Wajapeyee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"1683_CR1","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1101\/gad.1437206","volume":"20","author":"L Chin","year":"2006","unstructured":"Chin L, Garraway LA, Fisher DE. Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev. 2006;20:2149\u201382.","journal-title":"Genes Dev"},{"key":"1683_CR2","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1101\/gad.191999.112","volume":"26","author":"H Tsao","year":"2012","unstructured":"Tsao H, Chin L, Garraway LA, Fisher DE. Melanoma: from mutations to medicine. Genes Dev. 2012;26:1131\u201355.","journal-title":"Genes Dev"},{"key":"1683_CR3","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","volume":"161","author":"Cancer Genome Atlas Network.","year":"2015","unstructured":"Cancer Genome Atlas Network. Genomic classification of cutaneous melanoma. Cell. 2015;161:1681\u201396.","journal-title":"Cell"},{"key":"1683_CR4","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1056\/NEJMoa1408868","volume":"371","author":"J Larkin","year":"2014","unstructured":"Larkin J, Ascierto PA, Dreno B, Atkinson V, Liszkay G, Maio M, et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N. Engl J Med. 2014;371:1867\u201376.","journal-title":"N. Engl J Med"},{"key":"1683_CR5","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1056\/NEJMoa1406037","volume":"371","author":"GV Long","year":"2014","unstructured":"Long GV, Stroyakovskiy D, Gogas H, Levchenko E, de Braud F, Larkin J, et al. Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N. Engl J Med. 2014;371:1877\u201388.","journal-title":"N. Engl J Med"},{"key":"1683_CR6","doi-asserted-by":"publisher","first-page":"7095","DOI":"10.2147\/OTT.S182721","volume":"11","author":"S Kakadia","year":"2018","unstructured":"Kakadia S, Yarlagadda N, Awad R, Kundranda M, Niu J, Naraev B, et al. Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma. Onco Targets Ther. 2018;11:7095\u2013107.","journal-title":"Onco Targets Ther"},{"key":"1683_CR7","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrclinonc.2017.43","volume":"14","author":"JJ Luke","year":"2017","unstructured":"Luke JJ, Flaherty KT, Ribas A, Long GV. Targeted agents and immunotherapies: optimizing outcomes in melanoma. Nat Rev Clin Oncol. 2017;14:463\u201382.","journal-title":"Nat Rev Clin Oncol"},{"key":"1683_CR8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/PPO.0000000000000303","volume":"24","author":"TS Nowicki","year":"2018","unstructured":"Nowicki TS, Hu-Lieskovan S, Ribas A. Mechanisms of resistance to PD-1 and PD-L1 blockade. Cancer J. 2018;24:47\u201353.","journal-title":"Cancer J"},{"key":"1683_CR9","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1085\/jgp.8.6.519","volume":"8","author":"O Warburg","year":"1927","unstructured":"Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J Gen Physiol. 1927;8:519\u201330.","journal-title":"J Gen Physiol"},{"key":"1683_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/pcmr.12661","volume":"31","author":"GM Fischer","year":"2018","unstructured":"Fischer GM, Vashisht Gopal YN, McQuade JL, Peng W, DeBerardinis RJ, Davies MA. Metabolic strategies of melanoma cells: mechanisms, interactions with the tumor microenvironment, and therapeutic implications. Pigment Cell Melanoma Res. 2018;31:11\u201330.","journal-title":"Pigment Cell Melanoma Res"},{"key":"1683_CR11","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/onc.2016.198","volume":"36","author":"BI Ratnikov","year":"2017","unstructured":"Ratnikov BI, Scott DA, Osterman AL, Smith JW, Ronai ZA. Metabolic rewiring in melanoma. Oncogene. 2017;36:147\u201357.","journal-title":"Oncogene"},{"key":"1683_CR12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.tibs.2014.02.004","volume":"39","author":"I Amelio","year":"2014","unstructured":"Amelio I, Cutruzzola F, Antonov A, Agostini M, Melino G. Serine and glycine metabolism in cancer. Trends Biochem Sci. 2014;39:191\u20138.","journal-title":"Trends Biochem Sci"},{"key":"1683_CR13","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/nrc.2016.81","volume":"16","author":"M Yang","year":"2016","unstructured":"Yang M, Vousden KH. Serine and one-carbon metabolism in cancer. Nat Rev Cancer. 2016;16:650\u201362.","journal-title":"Nat Rev Cancer"},{"key":"1683_CR14","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1021\/cb500683c","volume":"10","author":"J Fan","year":"2015","unstructured":"Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, et al. Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. ACS Chem Biol. 2015;10:510\u20136.","journal-title":"ACS Chem Biol"},{"key":"1683_CR15","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1016\/j.cmet.2019.02.015","volume":"29","author":"MR Sullivan","year":"2019","unstructured":"Sullivan MR, Mattaini KR, Dennstedt EA, Nguyen AA, Sivanand S, Reilly MF, et al. Increased serine synthesis provides an advantage for tumors arising in tissues where serine levels are limiting. Cell Metab. 2019;29:1410\u20131421. e1414.","journal-title":"Cell Metab"},{"key":"1683_CR16","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/nature08822","volume":"463","author":"R Beroukhim","year":"2010","unstructured":"Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, et al. The landscape of somatic copy-number alteration across human cancers. Nature. 2010;463:899\u2013905.","journal-title":"Nature"},{"key":"1683_CR17","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/j.1755-148X.2011.00919.x","volume":"24","author":"E Mullarky","year":"2011","unstructured":"Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW. PHGDH amplification and altered glucose metabolism in human melanoma. Pigment Cell Melanoma Res. 2011;24:1112\u20135.","journal-title":"Pigment Cell Melanoma Res"},{"key":"1683_CR18","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/ng.890","volume":"43","author":"JW Locasale","year":"2011","unstructured":"Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011;43:869\u201374.","journal-title":"Nat Genet"},{"key":"1683_CR19","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s13046-017-0648-4","volume":"36","author":"S Gao","year":"2017","unstructured":"Gao S, Ge A, Xu S, You Z, Ning S, Zhao Y, et al. PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3beta\/beta-catenin\/cyclin D1 signaling pathway in ER-negative breast cancer. J Exp Clin Cancer Res. 2017;36:179.","journal-title":"J Exp Clin Cancer Res"},{"key":"1683_CR20","doi-asserted-by":"publisher","first-page":"6723","DOI":"10.21873\/anticanres.13887","volume":"39","author":"HO Jin","year":"2019","unstructured":"Jin HO, Hong SE, Kim JY, Jang SK, Kim YS, Sim JH, et al. Knock-down of PSAT1 enhances sensitivity of NSCLC cells to glutamine-limiting conditions. Anticancer Res. 2019;39:6723\u201330.","journal-title":"Anticancer Res"},{"key":"1683_CR21","doi-asserted-by":"publisher","first-page":"183","DOI":"10.7150\/ijbs.29203","volume":"15","author":"L Liao","year":"2019","unstructured":"Liao L, Ge M, Zhan Q, Huang R, Ji X, Liang X, et al. PSPH mediates the metastasis and proliferation of non-small cell lung cancer through MAPK signaling pathways. Int J Biol Sci. 2019;15:183\u201394.","journal-title":"Int J Biol Sci"},{"key":"1683_CR22","first-page":"604","volume":"42","author":"SM Park","year":"2019","unstructured":"Park SM, Seo EH, Bae DH, Kim SS, Kim J, Lin W, et al. Phosphoserine phosphatase promotes lung cancer progression through the dephosphorylation of IRS-1 and a noncanonical L-serine-independent pathway. Mol Cells. 2019;42:604\u201316.","journal-title":"Mol Cells"},{"key":"1683_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10508-2","volume":"10","author":"KR Kampen","year":"2019","unstructured":"Kampen KR, Fancello L, Girardi T, Rinaldi G, Planque M, Sulima SO, et al. Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells. Nat Commun. 2019;10:2542.","journal-title":"Nat Commun"},{"key":"1683_CR24","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1093\/jnci\/dji427","volume":"97","author":"A McCabe","year":"2005","unstructured":"McCabe A, Dolled-Filhart M, Camp RL, Rimm DL. Automated quantitative analysis (AQUA) of in situ protein expression, antibody concentration, and prognosis. J Natl Cancer Inst. 2005;97:1808\u201315.","journal-title":"J Natl Cancer Inst"},{"key":"1683_CR25","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.mrrev.2011.05.002","volume":"728","author":"F van Zijl","year":"2011","unstructured":"van Zijl F, Krupitza G, Mikulits W. Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat Res. 2011;728:23\u201334.","journal-title":"Mutat Res"},{"key":"1683_CR26","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/nchembio.2070","volume":"12","author":"ME Pacold","year":"2016","unstructured":"Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016;12:452\u20138.","journal-title":"Nat Chem Biol"},{"key":"1683_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/10409230490440541","volume":"39","author":"RP Hausinger","year":"2004","unstructured":"Hausinger RP. FeII\/alpha-ketoglutarate-dependent hydroxylases and related enzymes. Crit Rev Biochem Mol Biol. 2004;39:21\u201368.","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"1683_CR28","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.molcel.2015.09.024","volume":"60","author":"S Li","year":"2015","unstructured":"Li S, Swanson SK, Gogol M, Florens L, Washburn MP, Workman JL, et al. Serine and SAM responsive complex SESAME regulates histone modification crosstalk by sensing cellular metabolism. Mol Cell. 2015;60:408\u201321.","journal-title":"Mol Cell"},{"key":"1683_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ccr.2010.12.014","volume":"19","author":"W Xu","year":"2011","unstructured":"Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011;19:17\u201330.","journal-title":"Cancer Cell"},{"key":"1683_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.trecan.2017.12.005","volume":"4","author":"D Ye","year":"2018","unstructured":"Ye D, Guan KL, Xiong Y. Metabolism, activity, and targeting of D- and L-2-hydroxyglutarates. Trends Cancer. 2018;4:151\u201365.","journal-title":"Trends Cancer"},{"key":"1683_CR31","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cell.2017.11.031","volume":"172","author":"R Su","year":"2018","unstructured":"Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, et al. R-2HG exhibits anti-tumor activity by targeting FTO\/m(6)A\/MYC\/CEBPA signaling. Cell. 2018;172:90\u2013105. e123.","journal-title":"Cell"},{"key":"1683_CR32","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/nchembio.1069","volume":"8","author":"YY Zhan","year":"2012","unstructured":"Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, et al. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol. 2012;8:897\u2013904.","journal-title":"Nat Chem Biol"},{"key":"1683_CR33","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.molcel.2018.01.001","volume":"69","author":"XX Li","year":"2018","unstructured":"Li XX, Wang ZJ, Zheng Y, Guan YF, Yang PB, Chen X, et al. Nuclear receptor Nur77 facilitates melanoma cell survival under metabolic stress by protecting fatty acid oxidation. Mol Cell. 2018;69:480\u2013492. e487.","journal-title":"Mol Cell"},{"key":"1683_CR34","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1056\/NEJMoa1716984","volume":"378","author":"CD DiNardo","year":"2018","unstructured":"DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, et al. Durable remissions with ivosidenib in IDH1-mutated relapsed or refractory AML. N. Engl J Med. 2018;378:2386\u201398.","journal-title":"N. Engl J Med"},{"key":"1683_CR35","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1158\/1535-7163.MCT-18-0863","volume":"18","author":"L Cao","year":"2019","unstructured":"Cao L, Weetall M, Trotta C, Cintron K, Ma J, Kim MJ, et al. Targeting of hematologic malignancies with PTC299, a novel potent inhibitor of dihydroorotate dehydrogenase with favorable pharmaceutical properties. Mol Cancer Ther. 2019;18:3\u201316.","journal-title":"Mol Cancer Ther"},{"key":"1683_CR36","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1083\/jcb.201604085","volume":"214","author":"KR Mattaini","year":"2016","unstructured":"Mattaini KR, Sullivan MR, Vander, Heiden MG. The importance of serine metabolism in cancer. J Cell Biol. 2016;214:249\u201357.","journal-title":"J Cell Biol"},{"key":"1683_CR37","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1309\/AJCPXAYH10WENLTC","volume":"143","author":"JS Koo","year":"2015","unstructured":"Koo JS, Yoon JS. Expression of metabolism-related proteins in lacrimal gland adenoid cystic carcinoma. Am J Clin Pathol. 2015;143:584\u201392.","journal-title":"Am J Clin Pathol"},{"key":"1683_CR38","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/annonc\/mdp520","volume":"21","author":"EH Tan","year":"2010","unstructured":"Tan EH, Ramlau R, Pluzanska A, Kuo HP, Reck M, Milanowski J, et al. A multicentre phase II gene expression profiling study of putative relationships between tumour biomarkers and clinical response with erlotinib in non-small-cell lung cancer. Ann Oncol. 2010;21:217\u201322.","journal-title":"Ann Oncol"},{"key":"1683_CR39","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1016\/j.celrep.2017.05.067","volume":"19","author":"B Zhang","year":"2017","unstructured":"Zhang B, Zheng A, Hydbring P, Ambroise G, Ouchida AT, Goiny M, et al. PHGDH defines a metabolic subtype in lung adenocarcinomas with poor prognosis. Cell Rep. 2017;19:2289\u2013303.","journal-title":"Cell Rep"},{"key":"1683_CR40","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.gene.2017.11.014","volume":"642","author":"Z Song","year":"2018","unstructured":"Song Z, Feng C, Lu Y, Lin Y, Dong C. PHGDH is an independent prognosis marker and contributes cell proliferation, migration and invasion in human pancreatic cancer. Gene. 2018;642:43\u201350.","journal-title":"Gene"},{"key":"1683_CR41","first-page":"95","volume":"10","author":"CY Wang","year":"2020","unstructured":"Wang CY, Chiao CC, Phan NN, Li CY, Sun ZD, Jiang JZ, et al. Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer. Am J Cancer Res. 2020;10:95\u2013113.","journal-title":"Am J Cancer Res"},{"key":"1683_CR42","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.21873\/anticanres.11574","volume":"37","author":"K Sato","year":"2017","unstructured":"Sato K, Masuda T, Hu Q, Tobo T, Kidogami S, Ogawa Y, et al. Phosphoserine phosphatase is a novel prognostic biomarker on chromosome 7 in colorectal cancer. Anticancer Res. 2017;37:2365\u201371.","journal-title":"Anticancer Res"},{"key":"1683_CR43","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jdermsci.2011.06.001","volume":"63","author":"MA Bachelor","year":"2011","unstructured":"Bachelor MA, Lu Y, Owens DM. L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis. J Dermatol Sci. 2011;63:164\u201372.","journal-title":"J Dermatol Sci"},{"key":"1683_CR44","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.18632\/oncotarget.1540","volume":"4","author":"J Chen","year":"2013","unstructured":"Chen J, Chung F, Yang G, Pu M, Gao H, Jiang W, et al. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget. 2013;4:2502\u201311.","journal-title":"Oncotarget"},{"key":"1683_CR45","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nature10350","volume":"476","author":"R Possemato","year":"2011","unstructured":"Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 2011;476:346\u201350.","journal-title":"Nature"},{"key":"1683_CR46","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/nrc3557","volume":"13","author":"JW Locasale","year":"2013","unstructured":"Locasale JW. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer. 2013;13:572\u201383.","journal-title":"Nat Rev Cancer"},{"key":"1683_CR47","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/embor.2011.43","volume":"12","author":"R Chowdhury","year":"2011","unstructured":"Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 2011;12:463\u20139.","journal-title":"EMBO Rep"},{"key":"1683_CR48","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1128\/jb.178.1.232-239.1996","volume":"178","author":"G Zhao","year":"1996","unstructured":"Zhao G, Winkler ME. A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. J Bacteriol. 1996;178:232\u20139.","journal-title":"J Bacteriol"},{"key":"1683_CR49","doi-asserted-by":"publisher","first-page":"8444","DOI":"10.1073\/pnas.85.22.8444","volume":"85","author":"TG Hazel","year":"1988","unstructured":"Hazel TG, Nathans D, Lau LF. A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc Natl Acad Sci USA. 1988;85:8444\u20138.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-021-01683-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-021-01683-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-021-01683-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T15:05:10Z","timestamp":1675004710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-021-01683-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":49,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,4,1]]}},"alternative-id":["1683"],"URL":"https:\/\/doi.org\/10.1038\/s41388-021-01683-y","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"assertion":[{"value":"26 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}