{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:50:58Z","timestamp":1790614258801,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"32","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA181319"],"award-info":[{"award-number":["R01CA181319"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA181319"],"award-info":[{"award-number":["R01CA181319"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA181319"],"award-info":[{"award-number":["R01CA181319"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP20093"],"award-info":[{"award-number":["RP20093"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute"},{"name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2021,8,12]]},"DOI":"10.1038\/s41388-021-01890-7","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T07:03:00Z","timestamp":1625122980000},"page":"5116-5130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["TRIM44 mediated p62 deubiquitination enhances DNA damage repair by increasing nuclear FLNA and 53BP1 expression"],"prefix":"10.1038","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-0110","authenticated-orcid":false,"given":"Lin","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Chin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-5165","authenticated-orcid":false,"given":"Nami","family":"McCarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"1890_CR1","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.molcel.2007.11.015","volume":"28","author":"JW Harper","year":"2007","unstructured":"Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell. 2007;28:739\u201345.","journal-title":"Mol Cell"},{"key":"1890_CR2","first-page":"S3","volume":"25","author":"KC Anderson","year":"2011","unstructured":"Anderson KC. Multiple myeloma: a clinical overview. Oncology. 2011;25:S3\u2013S9. Suppl 2","journal-title":"Oncology"},{"key":"1890_CR3","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1038\/onc.2009.69","volume":"28","author":"S Boehrer","year":"2009","unstructured":"Boehrer S, Ad\u00e8s L, Tajeddine N, Hofmann WK, Kriener S, Bug G, et al. Suppression of the DNA damage response in acute myeloid leukemia versus myelodysplastic syndrome. Oncogene. 2009;28:2205\u201318.","journal-title":"Oncogene"},{"key":"1890_CR4","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1038\/leu.2011.94","volume":"25","author":"DK Walters","year":"2011","unstructured":"Walters DK, Wu X, Tschumper RC, Arendt BK, Huddleston PM, Henderson KJ, et al. Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX. Leukemia. 2011;25:1344\u201353.","journal-title":"Leukemia"},{"key":"1890_CR5","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1158\/1078-0432.CCR-12-1881","volume":"19","author":"NC Munshi","year":"2013","unstructured":"Munshi NC, Anderson KC. New strategies in the treatment of multiple myeloma. Clin Cancer Res. 2013;19:3337\u201344.","journal-title":"Clin Cancer Res"},{"key":"1890_CR6","first-page":"373","volume":"95","author":"TC Michels","year":"2017","unstructured":"Michels TC, Petersen KE. Multiple myeloma: diagnosis and treatment. Am Fam Physician. 2017;95:373\u201383.","journal-title":"Am Fam Physician"},{"key":"1890_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.stem.2010.12.012","volume":"8","author":"C Blanpain","year":"2011","unstructured":"Blanpain C, Mohrin M, Sotiropoulou PA, Passegue E. DNA-damage response in tissue-specific and cancer stem cells. Cell Stem Cell. 2011;8:16\u201329.","journal-title":"Cell Stem Cell"},{"key":"1890_CR8","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1182\/blood-2007-05-089193","volume":"113","author":"MA Shammas","year":"2009","unstructured":"Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Blood. 2009;113:2290\u20137.","journal-title":"Blood"},{"key":"1890_CR9","doi-asserted-by":"publisher","first-page":"e0121581","DOI":"10.1371\/journal.pone.0121581","volume":"10","author":"AB Herrero","year":"2015","unstructured":"Herrero AB, San Miguel J, Gutierrez NC. Deregulation of DNA double-strand break repair in multiple myeloma: implications for genome stability. PloS One. 2015;10:e0121581.","journal-title":"PloS One"},{"key":"1890_CR10","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nrmicro1248","volume":"3","author":"S Nisole","year":"2005","unstructured":"Nisole S, Stoye JP, Saib A. TRIM family proteins: retroviral restriction and antiviral defence. Nat Rev Microbiol. 2005;3:799\u2013808.","journal-title":"Nat Rev Microbiol"},{"key":"1890_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-1-4614-5398-7_6","volume":"770","author":"V Cambiaghi","year":"2012","unstructured":"Cambiaghi V, Giuliani V, Lombardi S, Marinelli C, Toffalorio F, Pelicci PG. TRIM proteins in cancer. Adv Exp Med Biol. 2012;770:77\u201391.","journal-title":"Adv Exp Med Biol"},{"key":"1890_CR12","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1002\/gcc.20551","volume":"47","author":"AK J\u00e4rvinen","year":"2008","unstructured":"J\u00e4rvinen AK, Autio R, Kilpinen S, Saarela M, Leivo I, Gr\u00e9nman R, et al. High-resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx. Genes, Chromosomes Cancer. 2008;47:500\u20139.","journal-title":"Genes, Chromosomes Cancer"},{"key":"1890_CR13","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1007\/s10147-014-0752-9","volume":"20","author":"Q Luo","year":"2015","unstructured":"Luo Q, Lin H, Ye X, Huang J, Lu S, Xu L. Trim44 facilitates the migration and invasion of human lung cancer cells via the NF-kappaB signaling pathway. Int J Clin Oncol. 2015;20:508\u201317.","journal-title":"Int J Clin Oncol"},{"key":"1890_CR14","doi-asserted-by":"crossref","unstructured":"Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, et al. Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma. Tumour Biol. 2017;39:1\u20139.","DOI":"10.1177\/1010428317700409"},{"key":"1890_CR15","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.3727\/096504017X14854310794561","volume":"25","author":"Y Tan","year":"2017","unstructured":"Tan Y, Yao H, Hu J, Liu L. Knockdown of TRIM44 inhibits the proliferation and invasion in prostate cancer cells. Oncol Res. 2017;25:1253\u20139.","journal-title":"Oncol Res"},{"key":"1890_CR16","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1111\/j.1349-7006.2012.02407.x","volume":"103","author":"K Kashimoto","year":"2012","unstructured":"Kashimoto K, Komatsu S, Ichikawa D, Arita T, Konishi H, Nagata H, et al. Overexpression of TRIM44 contributes to malignant outcome in gastric carcinoma. Cancer Sci. 2012;103:2021\u20136.","journal-title":"Cancer Sci"},{"key":"1890_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/cas.13105","volume":"108","author":"Y Yamada","year":"2017","unstructured":"Yamada Y, Takayama KI, Fujimura T, Ashikari D, Obinata D, Takahashi S, et al. A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor. Cancer Sci. 2017;108:32\u201341.","journal-title":"Cancer Sci"},{"key":"1890_CR18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/ijms18091931","volume":"18","author":"H Kawabata","year":"2017","unstructured":"Kawabata H, Azuma K, Ikeda K, Sugitani I, Kinowaki K, Fujii T, et al. TRIM44 is a poor prognostic factor for breast cancer patients as a modulator of NF-kappaB signaling. Int J Mol Sci. 2017;18:18.","journal-title":"Int J Mol Sci"},{"key":"1890_CR19","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/s41375-018-0222-x","volume":"33","author":"Z Chen","year":"2019","unstructured":"Chen Z, Lin TC, Bi X, Lu G, Dawson BC, Miranda R, et al. TRIM44 promotes quiescent multiple myeloma cell occupancy and survival in the osteoblastic niche via HIF-1alpha stabilization. Leukemia. 2019;33:469\u201386.","journal-title":"Leukemia"},{"key":"1890_CR20","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1080\/15548627.2016.1210368","volume":"12","author":"G Hewitt","year":"2016","unstructured":"Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, et al. SQSTM1\/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy. 2016;12:1917\u201330.","journal-title":"Autophagy"},{"key":"1890_CR21","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.cell.2007.09.041","volume":"131","author":"MS Huen","year":"2007","unstructured":"Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, et al. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 2007;131:901\u201314.","journal-title":"Cell"},{"key":"1890_CR22","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1126\/science.1150034","volume":"318","author":"NK Kolas","year":"2007","unstructured":"Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, et al. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science. 2007;318:1637\u201340.","journal-title":"Science"},{"key":"1890_CR23","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.molcel.2010.01.021","volume":"37","author":"E Petermann","year":"2010","unstructured":"Petermann E, Orta ML, Issaeva N, Schultz N, Helleday T. Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell. 2010;37:492\u2013502.","journal-title":"Mol Cell"},{"key":"1890_CR24","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.canlet.2011.08.022","volume":"313","author":"VR Gogineni","year":"2011","unstructured":"Gogineni VR, Nalla AK, Gupta R, Dinh DH, Klopfenstein JD, Rao JS. Chk2-mediated G2\/M cell cycle arrest maintains radiation resistance in malignant meningioma cells. Cancer Lett. 2011;313:64\u201375.","journal-title":"Cancer Lett"},{"key":"1890_CR25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0921-8777(95)00063-1","volume":"363","author":"M Klaude","year":"1996","unstructured":"Klaude M, Eriksson S, Nygren J, Ahnstrom G. The comet assay: mechanisms and technical considerations. Mutat Res. 1996;363:89\u201396.","journal-title":"Mutat Res"},{"key":"1890_CR26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nprot.2006.5","volume":"1","author":"PL Olive","year":"2006","unstructured":"Olive PL, Banath JP. The comet assay: a method to measure DNA damage in individual cells. Nat Protoc. 2006;1:23\u20139.","journal-title":"Nat Protoc"},{"key":"1890_CR27","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.4161\/cc.25951","volume":"12","author":"C Gourzones-Dmitriev","year":"2013","unstructured":"Gourzones-Dmitriev C, Kassambara A, Sahota S, R\u00e8me T, Moreaux J, Bourquard P, et al. DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment. Cell Cycle. 2013;12:2760\u201373.","journal-title":"Cell Cycle"},{"key":"1890_CR28","doi-asserted-by":"publisher","first-page":"e1000855","DOI":"10.1371\/journal.ppat.1000855","volume":"6","author":"U N\u00fcbel","year":"2010","unstructured":"N\u00fcbel U, Dordel J, Kurt K, Strommenger B, Westh H, Shukla SK, et al. A timescale for evolution, population expansion, and spatial spread of an emerging clone of methicillin-resistant Staphylococcus aureus. PLoS Pathog. 2010;6:e1000855.","journal-title":"PLoS Pathog"},{"key":"1890_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrm3719","volume":"15","author":"S Panier","year":"2014","unstructured":"Panier S, Boulton SJ. Double-strand break repair: 53BP1 comes into focus. Nat Rev Mol Cell Biol. 2014;15:7\u201318.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1890_CR30","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1101\/gad.13.20.2633","volume":"13","author":"AJ Pierce","year":"1999","unstructured":"Pierce AJ, Johnson RD, Thompson LH, Jasin M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev. 1999;13:2633\u20138.","journal-title":"Genes Dev"},{"key":"1890_CR31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1128\/MCB.00672-17","volume":"38","author":"KM Ahmed","year":"2018","unstructured":"Ahmed KM, Pandita RK, Singh DK, Hunt CR, Pandita TK. beta1-Integrin impacts Rad51 stability and DNA double-strand break repair by homologous recombination. Mol Cell Biol. 2018;38:38.","journal-title":"Mol Cell Biol"},{"key":"1890_CR32","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.molcel.2016.03.015","volume":"62","author":"JA Pan","year":"2016","unstructured":"Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, et al. TRIM21 ubiquitylates SQSTM1\/p62 and suppresses protein sequestration to regulate redox homeostasis. Mol Cell. 2016;62:149\u201351.","journal-title":"Mol Cell"},{"key":"1890_CR33","doi-asserted-by":"publisher","first-page":"5941","DOI":"10.1074\/jbc.M109.039925","volume":"285","author":"S Pankiv","year":"2010","unstructured":"Pankiv S, Lamark T, Bruun JA, Overvatn A, Bjorkoy G, Johansen T. Nucleocytoplasmic shuttling of p62\/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies. J Biol Chem. 2010;285:5941\u201353.","journal-title":"J Biol Chem"},{"key":"1890_CR34","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.4161\/cc.9.7.11256","volume":"9","author":"A Velkova","year":"2010","unstructured":"Velkova A, Carvalho MA, Johnson JO, Tavtigian SV, Monteiro AN. Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair. Cell Cycle. 2010;9:1421\u201333.","journal-title":"Cell Cycle"},{"key":"1890_CR35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1101\/gad.333237.119","volume":"34","author":"Z Mirman","year":"2020","unstructured":"Mirman Z, de Lange T. 53BP1: a DSB escort. Genes Dev. 2020;34:7\u201323.","journal-title":"Genes Dev"},{"key":"1890_CR36","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/jnci\/dju050","volume":"106","author":"CA Ong","year":"2014","unstructured":"Ong CA, Shannon NB, Ross-Innes CS, O'donovan M, Rueda OM, Hu DE, et al. Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy. J Natl Cancer Inst. 2014;106:106.","journal-title":"J Natl Cancer Inst"},{"key":"1890_CR37","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1182\/blood-2013-07-517136","volume":"123","author":"Z Chen","year":"2014","unstructured":"Chen Z, Orlowski RZ, Wang M, Kwak L, McCarty N. Osteoblastic niche supports the growth of quiescent multiple myeloma cells. Blood. 2014;123:2204\u20138.","journal-title":"Blood"},{"key":"1890_CR38","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/427598a","volume":"427","author":"T Lindahl","year":"2004","unstructured":"Lindahl T. Molecular biology: ensuring error-free DNA repair. Nature. 2004;427:598.","journal-title":"Nature"},{"key":"1890_CR39","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fgene.2015.00157","volume":"6","author":"A Torgovnick","year":"2015","unstructured":"Torgovnick A, Schumacher B. DNA repair mechanisms in cancer development and therapy. Front Genet. 2015;6:157.","journal-title":"Front Genet"},{"key":"1890_CR40","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.tig.2014.06.003","volume":"30","author":"F Dietlein","year":"2014","unstructured":"Dietlein F, Thelen L, Reinhardt HC. Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches. Trends Genet. 2014;30:326\u201339.","journal-title":"Trends Genet"},{"key":"1890_CR41","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/jcp.25053","volume":"231","author":"K Rodgers","year":"2016","unstructured":"Rodgers K, McVey M. Error-prone repair of DNA double-strand breaks. J Cell Physiol. 2016;231:15\u201324.","journal-title":"J Cell Physiol"},{"key":"1890_CR42","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.molcel.2016.05.027","volume":"63","author":"Y Wang","year":"2016","unstructured":"Wang Y, Zhang N, Zhang L, Li R, Fu W, Ma K, et al. Autophagy regulates chromatin ubiquitination in DNA damage response through elimination of SQSTM1\/p62. Mol Cell. 2016;63:34\u201348.","journal-title":"Mol Cell"},{"key":"1890_CR43","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1126\/science.1142204","volume":"318","author":"LJ Terry","year":"2007","unstructured":"Terry LJ, Shows EB, Wente SR. Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport. Science. 2007;318:1412\u20136.","journal-title":"Science"},{"key":"1890_CR44","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.molcel.2009.04.026","volume":"34","author":"V Kirkin","year":"2009","unstructured":"Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell. 2009;34:259\u201369.","journal-title":"Mol Cell"},{"key":"1890_CR45","doi-asserted-by":"publisher","first-page":"22847","DOI":"10.1074\/jbc.M802182200","volume":"283","author":"Y Ichimura","year":"2008","unstructured":"Ichimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, et al. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem. 2008;283:22847\u201357.","journal-title":"J Biol Chem"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-021-01890-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-021-01890-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-021-01890-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T12:06:16Z","timestamp":1628769976000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-021-01890-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":45,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2021,8,12]]}},"alternative-id":["1890"],"URL":"https:\/\/doi.org\/10.1038\/s41388-021-01890-7","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]},"assertion":[{"value":"12 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}