{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:39:06Z","timestamp":1787002746950,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"30","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA97098"],"award-info":[{"award-number":["CA97098"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA166480"],"award-info":[{"award-number":["CA166480"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA233084"],"award-info":[{"award-number":["CA233084"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA232979"],"award-info":[{"award-number":["CA232979"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute"},{"name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute"},{"name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The polybromo-associated PBAF (SWI\/SNF) chromatin remodeling complex, which includes PBRM1, ARID2, and BRD7, regulates cell differentiation and genomic integrity. MUC1-C is an oncogenic protein that drives lineage plasticity in prostate cancer (PC) progression. The present work demonstrates that MUC1-C induces\n                    <jats:italic>PBRM1<\/jats:italic>\n                    ,\n                    <jats:italic>ARID2<\/jats:italic>\n                    , and\n                    <jats:italic>BRD7<\/jats:italic>\n                    expression by the previously unrecognized E2F1-mediated activation of their respective promoters. The functional significance of the MUC1-C\u2192PBAF pathway is supported by demonstrating involvement of MUC1-C in associating with nuclear PBAF and driving the NRF2 antioxidant gene transcriptome in PC cells. Mechanistically, MUC1-C forms a complex with NRF2 and PBRM1 on the NRF2 target\n                    <jats:italic>SLC7A11<\/jats:italic>\n                    gene that encodes the xCT cystine-glutamate antiporter, increases chromatin accessibility and induces SLC7A11\/xCT expression. We also show that MUC1-C and PBRM1 are necessary for induction of other NRF2 target genes, including\n                    <jats:italic>G6PD<\/jats:italic>\n                    and\n                    <jats:italic>PGD<\/jats:italic>\n                    that regulate the pentose phosphate pathway. Our results further demonstrate that MUC1-C integrates activation of PBRM1 with the regulation of antioxidant genes, ROS levels, pluripotency factor expression and the cancer stem cell (CSC) state. These findings reveal a role for MUC1-C in regulating PBAF, redox balance and lineage plasticity of PC CSC progression. Our findings also uncover involvement of MUC1-C in integrating the PBAF and BAF pathways in cancer.\n                  <\/jats:p>","DOI":"10.1038\/s41388-021-01899-y","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T12:02:44Z","timestamp":1624449764000},"page":"4930-4940","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cells"],"prefix":"10.1038","volume":"40","author":[{"given":"Masayuki","family":"Hagiwara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Fushimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nami","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atrayee","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Rajabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-8176","authenticated-orcid":false,"given":"Mark D.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1725-6454","authenticated-orcid":false,"given":"Yota","family":"Yasumizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Oya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5743-8888","authenticated-orcid":false,"given":"Donald","family":"Kufe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"1899_CR1","doi-asserted-by":"publisher","first-page":"a026930.","DOI":"10.1101\/cshperspect.a026930","volume":"6","author":"C Hodges","year":"2016","unstructured":"Hodges C, Kirkland JG, Crabtree GR. The many roles of BAF (mSWI\/SNF) and PBAF complexes in cancer. Cold Spring Harb Perspect Med. 2016;6:a026930.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1899_CR2","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.molcel.2014.06.028","volume":"55","author":"A Kakarougkas","year":"2014","unstructured":"Kakarougkas A, Ismail A, Chambers AL, Riballo E, Herbert AD, Kunzel J, et al. Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Mol Cell. 2014;55:723\u201332.","journal-title":"Mol Cell"},{"key":"1899_CR3","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1021\/acschembio.7b00541","volume":"12","author":"S Hopson","year":"2017","unstructured":"Hopson S, Thompson MJ. BAF180: Its roles in DNA repair and consequences in cancer. ACS Chem Biol. 2017;12:2482\u201390.","journal-title":"ACS Chem Biol"},{"key":"1899_CR4","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.isci.2019.04.027","volume":"15","author":"EG Porter","year":"2019","unstructured":"Porter EG, Dhiman A, Chowdhury B, Carter BC, Lin H, Stewart JC, et al. PBRM1 regulates stress response in epithelial cells. iScience. 2019;15:196\u2013210.","journal-title":"iScience"},{"key":"1899_CR5","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1126\/science.aao1710","volume":"359","author":"D Pan","year":"2018","unstructured":"Pan D, Kobayashi A, Jiang P, Ferrari de Andrade L, Tay RE, Luoma AM, et al. A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing. Science. 2018;359:770\u20135.","journal-title":"Science"},{"key":"1899_CR6","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1126\/science.aan5951","volume":"359","author":"D Miao","year":"2018","unstructured":"Miao D, Margolis CA, Gao W, Voss MH, Li W, Martini DJ, et al. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science. 2018;359:801\u20136.","journal-title":"Science"},{"key":"1899_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15959-6","volume":"11","author":"XD Liu","year":"2020","unstructured":"Liu XD, Kong W, Peterson CB, McGrail DJ, Hoang A, Zhang X, et al. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020;11:2135.","journal-title":"Nat Commun"},{"key":"1899_CR8","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1101\/gad.1323805","volume":"19","author":"Z Yan","year":"2005","unstructured":"Yan Z, Cui K, Murray DM, Ling C, Xue Y, Gerstein A, et al. PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes. Genes Dev. 2005;19:1662\u20137.","journal-title":"Genes Dev"},{"key":"1899_CR9","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1158\/0008-5472.CAN-09-2089","volume":"70","author":"MT Harte","year":"2010","unstructured":"Harte MT, O'Brien GJ, Ryan NM, Gorski JJ, Savage KI, Crawford NT, et al. BRD7, a subunit of SWI\/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription. Cancer Res. 2010;70:2538\u201347.","journal-title":"Cancer Res"},{"key":"1899_CR10","doi-asserted-by":"publisher","first-page":"e1500447","DOI":"10.1126\/sciadv.1500447","volume":"1","author":"C Kadoch","year":"2015","unstructured":"Kadoch C, Crabtree GR. Mammalian SWI\/SNF chromatin remodeling complexes and cancer: mechanistic insights gained from human genomics. Sci Adv. 2015;1:e1500447.","journal-title":"Sci Adv"},{"key":"1899_CR11","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/s41588-019-0363-5","volume":"51","author":"J Pan","year":"2019","unstructured":"Pan J, McKenzie ZM, D\u2019Avino AR, Mashtalir N, Lareau CA, St Pierre R, et al. The ATPase module of mammalian SWI\/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting. Nat Genet. 2019;51:618\u201326.","journal-title":"Nat Genet"},{"key":"1899_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14219-6","volume":"11","author":"Y Yasumizu","year":"2020","unstructured":"Yasumizu Y, Rajabi H, Jin C, Hata T, Pitroda S, Long MD, et al. MUC1-C drives lineage plasticity in progression to neuroendocrine prostate cancer. Nat Commun. 2020;11:338.","journal-title":"Nat Commun"},{"key":"1899_CR13","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1038\/s41388-017-0096-9","volume":"37","author":"H Rajabi","year":"2018","unstructured":"Rajabi H, Hiraki M, Kufe D. MUC1-C activates polycomb repressive complexes and downregulates tumor suppressor genes in human cancer cells. Oncogene. 2018;37:2079\u201388.","journal-title":"Oncogene"},{"key":"1899_CR14","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1093\/carcin\/bgaa082","volume":"41","author":"D Kufe","year":"2020","unstructured":"Kufe D. MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment. Carcinogenesis. 2020;41:1173\u201383.","journal-title":"Carcinogenesis"},{"key":"1899_CR15","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1038\/onc.2016.439","volume":"36","author":"M Hiraki","year":"2017","unstructured":"Hiraki M, Maeda T, Bouillez A, Alam M, Tagde A, Hinohara K, et al. MUC1-C activates BMI1 in human cancer cells. Oncogene. 2017;36:2791\u2013801.","journal-title":"Oncogene"},{"key":"1899_CR16","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1158\/1535-7163.MCT-19-0156","volume":"18","author":"T Hata","year":"2019","unstructured":"Hata T, Rajabi H, Yamamoto M, Jin C, Ahmad R, Zhang Y, et al. Targeting MUC1-C inhibits TWIST1 signaling in triple-negative breast cancer. Mol Cancer Ther. 2019;18:1744\u201354.","journal-title":"Mol Cancer Ther"},{"key":"1899_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07850-0","volume":"7","author":"H Rajabi","year":"2017","unstructured":"Rajabi H, Hiraki M, Tagde A, Alam M, Bouillez A, Christensen CL, et al. MUC1-C activates EZH2 expression and function in human cancer cells. Sci Rep. 2017;7:7481.","journal-title":"Sci Rep"},{"key":"1899_CR18","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1158\/0008-5472.CAN-20-2588","volume":"81","author":"M Hagiwara","year":"2020","unstructured":"Hagiwara M, Yasumizu Y, Yamashita N, Rajabi H, Fushimi A, Long MD. MUC1-C activates the BAF (mSWI\/SNF) complex in prostate cancer stem cells. Cancer Res. 2020;81:1111\u201322.","journal-title":"Cancer Res"},{"key":"1899_CR19","doi-asserted-by":"publisher","first-page":"5711","DOI":"10.1158\/0008-5472.CAN-19-1034","volume":"79","author":"T Hata","year":"2019","unstructured":"Hata T, Rajabi H, Takahashi H, Yasumizu Y, Li W, Jin C, et al. MUC1-C activates the NuRD complex to drive dedifferentiation of triple-negative breast cancer cells. Cancer Res. 2019;79:5711\u201322.","journal-title":"Cancer Res"},{"key":"1899_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0608-9","volume":"16","author":"R Ahmad","year":"2017","unstructured":"Ahmad R, Alam M, Hasegawa M, Uchida Y, Al-Obaid O, Kharbanda S, et al. Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer. Mol Cancer. 2017;16:33.","journal-title":"Mol Cancer"},{"key":"1899_CR21","doi-asserted-by":"publisher","first-page":"5718","DOI":"10.1093\/nar\/gkq212","volume":"38","author":"D Malhotra","year":"2010","unstructured":"Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res. 2010;38:5718\u201334.","journal-title":"Nucleic Acids Res"},{"key":"1899_CR22","doi-asserted-by":"publisher","first-page":"9433","DOI":"10.1073\/pnas.1821323116","volume":"116","author":"JKM Lim","year":"2019","unstructured":"Lim JKM, Delaidelli A, Minaker SW, Zhang HF, Colovic M, Yang H, et al. Cystine\/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. Proc Natl Acad Sci USA. 2019;116:9433\u201342.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1899_CR23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","volume":"38","author":"JD Hayes","year":"2020","unstructured":"Hayes JD, Dinkova-Kostova AT, Tew KD. Oxidative stress in cancer. Cancer Cell. 2020;38:167\u201397.","journal-title":"Cancer Cell"},{"key":"1899_CR24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","volume":"34","author":"M Rojo de la Vega","year":"2018","unstructured":"Rojo de la Vega M, Chapman E, Zhang DD. NRF2 and the hallmarks of cancer. Cancer Cell. 2018;34:21\u201343.","journal-title":"Cancer Cell"},{"key":"1899_CR25","doi-asserted-by":"publisher","first-page":"2780.","DOI":"10.3390\/cancers12102780","volume":"12","author":"A Tanabe","year":"2020","unstructured":"Tanabe A, Sahara H. The metabolic heterogeneity and flexibility of cancer stem cells. Cancers. 2020;12:2780.","journal-title":"Cancers"},{"key":"1899_CR26","doi-asserted-by":"publisher","first-page":"137112","DOI":"10.1172\/jci.insight.137112","volume":"5","author":"W Li","year":"2020","unstructured":"Li W, Zhang N, Jin C, Long MD, Rajabi H, Yasumizu Y, et al. MUC1-C drives stemness in progression of colitis to colorectal cancer. JCI Insight. 2020;5:137112.","journal-title":"JCI Insight"},{"key":"1899_CR27","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.molcel.2017.04.006","volume":"66","author":"I Vitale","year":"2017","unstructured":"Vitale I, Manic G, De Maria R, Kroemer G, Galluzzi L. DNA damage in stem cells. Mol Cell. 2017;66:306\u201319.","journal-title":"Mol Cell"},{"key":"1899_CR28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nrg3345","volume":"14","author":"M Papamichos-Chronakis","year":"2013","unstructured":"Papamichos-Chronakis M, Peterson CL. Chromatin and the genome integrity network. Nat Rev Genet. 2013;14:62\u201375.","journal-title":"Nat Rev Genet"},{"key":"1899_CR29","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1177\/1947601910368059","volume":"1","author":"L Huang","year":"2010","unstructured":"Huang L, Liao X, Beckett M, Li Y, Khanna KK, Wang Z, et al. MUC1-C oncoprotein interacts directly with ATM and promotes the DNA damage response to ionizing radiation. Genes Cancer. 2010;1:239\u201350.","journal-title":"Genes Cancer"},{"key":"1899_CR30","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1158\/0008-5472.CAN-18-3259","volume":"79","author":"M Yamamoto","year":"2019","unstructured":"Yamamoto M, Jin C, Hata T, Yasumizu Y, Zhang Y, Hong D, et al. MUC1-C integrates chromatin remodeling and PARP1 activity in the DNA damage response of triple-negative breast cancer cells. Cancer Res. 2019;79:2031\u201341.","journal-title":"Cancer Res"},{"key":"1899_CR31","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/s41568-019-0143-7","volume":"19","author":"LN Kent","year":"2019","unstructured":"Kent LN, Leone G. The broken cycle: E2F dysfunction in cancer. Nat Rev Cancer. 2019;19:326\u201338.","journal-title":"Nat Rev Cancer"},{"key":"1899_CR32","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.celrep.2014.02.012","volume":"6","author":"PM Brownlee","year":"2014","unstructured":"Brownlee PM, Chambers AL, Cloney R, Bianchi A, Downs JA. BAF180 promotes cohesion and prevents genome instability and aneuploidy. Cell Rep. 2014;6:973\u201381.","journal-title":"Cell Rep"},{"key":"1899_CR33","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1126\/science.aao3172","volume":"358","author":"K Somyajit","year":"2017","unstructured":"Somyajit K, Gupta R, Sedlackova H, Neelsen KJ, Ochs F, Rask MB, et al. Redox-sensitive alteration of replisome architecture safeguards genome integrity. Science. 2017;358:797\u2013802.","journal-title":"Science"},{"key":"1899_CR34","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1182\/blood-2011-07-369686","volume":"119","author":"L Yin","year":"2012","unstructured":"Yin L, Kosugi M, Kufe D. Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by downregulating TIGAR expression and depleting NADPH. Blood. 2012;119:810\u20136.","journal-title":"Blood"},{"key":"1899_CR35","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1158\/1078-0432.CCR-14-3000","volume":"21","author":"M Hasegawa","year":"2015","unstructured":"Hasegawa M, Sinha RK, Kumar M, Alam M, Yin L, Raina D, et al. Intracellular targeting of the oncogenic MUC1-C protein with a novel GO-203 nanoparticle formulation. Clin Cancer Res. 2015;21:2338\u201323347.","journal-title":"Clin Cancer Res"},{"key":"1899_CR36","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/s41588-019-0477-9","volume":"51","author":"S Schick","year":"2019","unstructured":"Schick S, Rendeiro AF, Runggatscher K, Ringler A, Boidol B, Hinkel M, et al. Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Nat Genet. 2019;51:1399\u2013410.","journal-title":"Nat Genet"},{"key":"1899_CR37","doi-asserted-by":"publisher","first-page":"919","DOI":"10.2217\/epi-2017-0034","volume":"9","author":"Q Wu","year":"2017","unstructured":"Wu Q, Lian JB, Stein JL, Stein GS, Nickerson JA, Imbalzano AN. The BRG1 ATPase of human SWI\/SNF chromatin remodeling enzymes as a driver of cancer. Epigenomics. 2017;9:919\u201331.","journal-title":"Epigenomics"},{"key":"1899_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20217-3","volume":"8","author":"JA Guerrero-Martinez","year":"2018","unstructured":"Guerrero-Martinez JA, Reyes JC. High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer. Sci Rep. 2018;8:2043.","journal-title":"Sci Rep"},{"key":"1899_CR39","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1634\/stemcells.2008-0710","volume":"27","author":"BL Kidder","year":"2009","unstructured":"Kidder BL, Palmer S, Knott JG. SWI\/SNF-Brg1 regulates self-renewal and occupies core pluripotency-related genes in embryonic stem cells. Stem Cells. 2009;27:317\u201328.","journal-title":"Stem Cells"},{"key":"1899_CR40","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.stemcr.2014.07.004","volume":"3","author":"X Zhang","year":"2014","unstructured":"Zhang X, Li B, Li W, Ma L, Zheng D, Li L, et al. Transcriptional repression by the BRG1-SWI\/SNF complex affects the pluripotency of human embryonic stem cells. Stem Cell Rep. 2014;3:460\u201374.","journal-title":"Stem Cell Rep"},{"key":"1899_CR41","doi-asserted-by":"publisher","first-page":"e22631.","DOI":"10.7554\/eLife.22631","volume":"6","author":"HW King","year":"2017","unstructured":"King HW, Klose RJ.The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells.eLife. 2017;6:e22631.","journal-title":"eLife"},{"key":"1899_CR42","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1038\/onc.2013.209","volume":"33","author":"X Lu","year":"2014","unstructured":"Lu X, Mazur SJ, Lin T, Appella E, Xu Y. The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis. Oncogene. 2014;33:2655\u201364.","journal-title":"Oncogene"},{"key":"1899_CR43","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1002\/stem.2007","volume":"33","author":"CR Jeter","year":"2015","unstructured":"Jeter CR, Yang T, Wang J, Chao HP, Tang DG. Concise review: NANOG in cancer stem cells and tumor development: an update and outstanding questions. Stem Cells. 2015;33:2381\u201390.","journal-title":"Stem Cells"},{"key":"1899_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/0471142727.mb2129s109","volume":"109","author":"JD Buenrostro","year":"2015","unstructured":"Buenrostro JD, Wu B, Chang HY, Greenleaf WJ. ATAC-seq: a method for assaying chromatin accessibility genome-wide. Curr Protoc Mol Biol. 2015;109:1\u20139.","journal-title":"Curr Protoc Mol Biol"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41388-021-01899-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-021-01899-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41388-021-01899-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T17:22:46Z","timestamp":1684603366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-021-01899-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,23]]},"references-count":44,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2021,7,29]]}},"alternative-id":["1899"],"URL":"https:\/\/doi.org\/10.1038\/s41388-021-01899-y","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,23]]},"assertion":[{"value":"8 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"DK has equity interests in Genus Oncology, Reata Pharmaceuticals and Hillstream BioPharma and is a paid consultant to Reata and CanBas. The other authors declared no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}