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Here we identify <jats:italic>COL11A1<\/jats:italic> mutations in 66 of 100 cutaneous squamous cell carcinomas (cSCCs), the second most common U.S. cancer, concentrated in a triple helical region known to produce trans-dominant collagens. Analysis of <jats:italic>COL11A1<\/jats:italic> and other collagen genes found that they are mutated across common epithelial malignancies. Knockout of mutant <jats:italic>COL11A1<\/jats:italic> impairs cSCC tumorigenesis in vivo. Compared to otherwise genetically identical <jats:italic>COL11A1<\/jats:italic> wild-type tissue, gene-edited mutant <jats:italic>COL11A1<\/jats:italic> skin is characterized by induction of \u03b21 integrin targets and accelerated neoplastic invasion. In mosaic tissue, mutant <jats:italic>COL11A1<\/jats:italic> cells enhanced invasion by neighboring wild-type cells. These results suggest that specific collagens are commonly mutated in cancer and that mutant collagens may accelerate this process.<\/jats:p>","DOI":"10.1038\/s41388-021-02013-y","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T16:03:57Z","timestamp":1632845037000},"page":"6299-6307","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Mutant collagen COL11A1 enhances cancerous invasion"],"prefix":"10.1038","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6511-3757","authenticated-orcid":false,"given":"Carolyn S.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zurab","family":"Siprashvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Bencomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara E.","family":"Elcavage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglu","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajani M.","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaira Z.","family":"Aasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-4989","authenticated-orcid":false,"given":"Paul A.","family":"Khavari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"2013_CR1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","volume":"71","author":"RL Siegel","year":"2021","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. 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